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  1. Book: Neurosurgical pain management

    Follett, Kenneth A.

    2004  

    Author's details Kenneth A. Follett
    Keywords Neuralgia / surgery ; Neuralgia / rehabilitation ; Neurosurgical Procedures / methods ; Treatment Outcome ; Schmerztherapie ; Neurochirurgie
    Subject Nervenchirurgie ; Schmerz
    Language English
    Size XIV, 287 S. : Ill.
    Publisher Elsevier
    Publishing place Philadelphia
    Publishing country United States
    Document type Book
    HBZ-ID HT014117554
    ISBN 0-7216-9241-9 ; 978-0-7216-9241-8
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Analgesic use matters: a response to Dr. Yoshihara.

    Follett, Kenneth A

    Pain medicine (Malden, Mass.)

    2014  Volume 15, Issue 12, Page(s) 2162–2163

    MeSH term(s) Analgesics/therapeutic use ; Humans ; Pain/etiology ; Pain/surgery ; Pain, Postoperative/drug therapy ; Spine/surgery
    Chemical Substances Analgesics
    Language English
    Publishing date 2014-12
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 2015903-1
    ISSN 1526-4637 ; 1526-2375
    ISSN (online) 1526-4637
    ISSN 1526-2375
    DOI 10.1111/pme.12608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Human iPSC-derived photoreceptor transplantation in the cone dominant 13-lined ground squirrel.

    Yu, Ching Tzu / Kandoi, Sangeetha / Periasamy, Ramesh / Reddy, L Vinod K / Follett, Hannah M / Summerfelt, Phyllis / Martinez, Cassandra / Guillaume, Chloe / Bowie, Owen / Connor, Thomas B / Lipinski, Daniel M / Allen, Kenneth P / Merriman, Dana K / Carroll, Joseph / Lamba, Deepak A

    Stem cell reports

    2024  Volume 19, Issue 3, Page(s) 331–342

    Abstract: Several retinal degenerations affect the human central retina, which is primarily comprised of cones and is essential for high acuity and color vision. Transplanting cone photoreceptors is a promising strategy to replace degenerated cones in this region. ...

    Abstract Several retinal degenerations affect the human central retina, which is primarily comprised of cones and is essential for high acuity and color vision. Transplanting cone photoreceptors is a promising strategy to replace degenerated cones in this region. Although this approach has been investigated in a handful of animal models, commonly used rodent models lack a cone-rich region and larger models can be expensive and inaccessible, impeding the translation of therapies. Here, we transplanted dissociated GFP-expressing photoreceptors from retinal organoids differentiated from human induced pluripotent stem cells into the subretinal space of damaged and undamaged cone-dominant 13-lined ground squirrel eyes. Transplanted cell survival was documented via noninvasive high-resolution imaging and immunohistochemistry to confirm the presence of human donor photoreceptors for up to 4 months posttransplantation. These results demonstrate the utility of a cone-dominant rodent model for advancing the clinical translation of cell replacement therapies.
    MeSH term(s) Animals ; Humans ; Retinal Cone Photoreceptor Cells/transplantation ; Induced Pluripotent Stem Cells/transplantation ; Retina ; Retinal Degeneration/therapy ; Sciuridae
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2024.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Referring Service Effect on Muscle Biopsy Diagnosis and Management in Myopathy.

    Tenny, Steven O / Schmidt, Kyle P / Follett, Kenneth A

    Cureus

    2018  Volume 10, Issue 6, Page(s) e2800

    Abstract: Introduction Requests for muscle biopsy for evaluation of myopathy originate from a variety of different specialties. It is unknown whether the specialty of the referring service affects the likelihood of diagnostic biopsy or the therapeutic usefulness ... ...

    Abstract Introduction Requests for muscle biopsy for evaluation of myopathy originate from a variety of different specialties. It is unknown whether the specialty of the referring service affects the likelihood of diagnostic biopsy or the therapeutic usefulness of a biopsy. Methods We reviewed 106 consecutive muscle biopsies requested by healthcare providers in neurology, rheumatology, family medicine, oncology, and gastroenterology. We tested for an association between referring service and whether the biopsy yielded a definitive pathology result or provided therapeutically useful results. Results Half of the biopsies (49%) returned definitive pathology and 88% of the biopsies provided information that contributed to therapeutic decisions. The diagnostic yield for muscle biopsies referred by different services was not statistically significant (p-value 0.1344) nor was the therapeutic yield statistically significant for muscle biopsies referred by different services (p-value 0.5525). Discussion The specialty of the service that requests a muscle biopsy does not influence the likelihood of obtaining a definitive pathological diagnosis or therapeutically useful information. Other factors may be more important in determining the likelihood of obtaining a clinically useful biopsy result.
    Language English
    Publishing date 2018-06-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.2800
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Association of Preoperative Diagnosis with Clinical Yield of Muscle Biopsy.

    Tenny, Steven O / Schmidt, Kyle P / Follett, Kenneth A

    Cureus

    2018  Volume 10, Issue 10, Page(s) e3449

    Abstract: Background: Muscle biopsy is a common diagnostic marker for myopathy assessment; however, it has a relatively low pathologic yield of less than 60%. Additionally, both diagnostic and non-diagnostic muscle biopsies can provide guidance for treatment, i.e, ...

    Abstract Background: Muscle biopsy is a common diagnostic marker for myopathy assessment; however, it has a relatively low pathologic yield of less than 60%. Additionally, both diagnostic and non-diagnostic muscle biopsies can provide guidance for treatment, i.e, provide therapeutic usefulness.
    Purpose: We designed a study to determine if having a documented definitive preoperative differential diagnosis would affect the pathologic yield and therapeutic usefulness of muscle biopsies for myopathy.  Methods: This was a retrospective, single institution chart review of 106 consecutive muscle biopsies in adult patients, which looked at the presence or absence of a definitive preoperative differential diagnosis and relation to diagnostic yield and therapeutic usefulness of muscle biopsies.  Results: Of 106 muscle biopsies, 50 biopsies (47%) had a definitive preoperative differential diagnosis, 52 biopsies (49%) returned definitive pathology, and 93 biopsies (88%) provided therapeutic information. The presence of a documented differential diagnosis increased the odds of pathologic yield by 3.73 (p-value < 0.01) and therapeutic usefulness by 3.40 (p-value 0.08). If pathology was diagnostic then the therapeutic usefulness of the biopsy was 4.54 times more likely (p-value < 0.01).  Conclusion: Documentation of a definitive preoperative differential diagnosis, when pursuing muscle biopsy for myopathy, is associated with an increased pathologic diagnostic yield. Definitive pathology was associated with an increase in the therapeutic usefulness of the muscle biopsy.
    Language English
    Publishing date 2018-10-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.3449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pain medicine: The case for an independent medical specialty and training programs.

    Dubois, Michel Y / Follett, Kenneth A

    Academic medicine : journal of the Association of American Medical Colleges

    2014  Volume 89, Issue 6, Page(s) 863–868

    Abstract: Over the last 30 years, pain has become one of the most dynamic areas of medicine and a public health issue. According to a recent Institute of Medicine report, pain affects approximately 100 million Americans at an estimated annual economic cost of $560 ...

    Abstract Over the last 30 years, pain has become one of the most dynamic areas of medicine and a public health issue. According to a recent Institute of Medicine report, pain affects approximately 100 million Americans at an estimated annual economic cost of $560 to $635 billion and is poorly treated overall. The American Board of Medical Specialties (ABMS) recognizes a pain subspecialty, but pain care delivery has struggled with increasing demand and developed in an inconsistent and uncoordinated fashion. Pain education is insufficient and highly variable. Multiple pain professional organizations have led to fragmentation of the field and lack of interdisciplinary agreement, resulting in confusion regarding who speaks for pain medicine. In this Perspective, the authors argue that ABMS recognition of pain medicine as an independent medical specialty would provide much needed structure and oversight for the field and would generate credibility for the specialty and its providers among medical peers, payers, regulatory and legislative agencies, and the public at large. The existing system, managed by three ABMS boards, largely excludes other specialties that contribute to pain care, fails to provide leadership from a single professional organization, provides suboptimal training exposure to pain medicine, and lengthens training, which results in inefficient use of time and educational resources. The creation of a primary ABMS conjoint board in pain medicine with its own residency programs and departments would provide better coordinated training, ensure the highest degree of competence of pain medicine specialists, and improve the quality of pain care and patient safety.
    MeSH term(s) Certification/organization & administration ; Chronic Pain/therapy ; Clinical Competence ; Delivery of Health Care/organization & administration ; Education, Medical, Graduate/organization & administration ; Humans ; Internship and Residency/organization & administration ; Medicine/organization & administration ; Pain Management ; Specialty Boards ; United States
    Language English
    Publishing date 2014-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 96192-9
    ISSN 1938-808X ; 1040-2446
    ISSN (online) 1938-808X
    ISSN 1040-2446
    DOI 10.1097/ACM.0000000000000265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Bilateral deep brain stimulation of the ventral intermediate nucleus of the thalamus for posttraumatic midbrain tremor.

    Follett, Matthew A / Torres-Russotto, Diego / Follett, Kenneth A

    Neuromodulation : journal of the International Neuromodulation Society

    2013  Volume 17, Issue 3, Page(s) 289–291

    MeSH term(s) Aged ; Atrophy ; Brain Damage, Chronic/etiology ; Brain Damage, Chronic/pathology ; Brain Injuries/complications ; Deep Brain Stimulation/methods ; Encephalomalacia/etiology ; Encephalomalacia/pathology ; Female ; Humans ; Magnetic Resonance Imaging ; Severity of Illness Index ; Stroke, Lacunar/complications ; Thalamus/blood supply ; Tremor/etiology ; Tremor/therapy ; Ventral Thalamic Nuclei/physiopathology
    Language English
    Publishing date 2013-09-05
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 1500372-3
    ISSN 1525-1403 ; 1094-7159
    ISSN (online) 1525-1403
    ISSN 1094-7159
    DOI 10.1111/ner.12096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Rates, causes, risk factors, and outcomes of readmission following deep brain stimulation for movement disorders: Analysis of the U.S. Nationwide Readmissions Database.

    Rumalla, Kavelin / Smith, Kyle A / Follett, Kenneth A / Nazzaro, Jules M / Arnold, Paul M

    Clinical neurology and neurosurgery

    2018  Volume 171, Page(s) 129–134

    Abstract: Objective: Deep brain stimulation (DBS) surgery has proven benefit for several movement disorders and medically-refractory psychiatric conditions and is considered a fairly safe procedure. We sought to determine the national rates, causes, predictors, ... ...

    Abstract Objective: Deep brain stimulation (DBS) surgery has proven benefit for several movement disorders and medically-refractory psychiatric conditions and is considered a fairly safe procedure. We sought to determine the national rates, causes, predictors, and outcomes associated with 30-day and 90-day readmission.
    Patients and methods: The Nationwide Readmissions Database was queried (January-September 2013) using ICD-9-CM codes, identifying patients who underwent DBS for movement disorder (Parkinson's disease [PD], essential tremor [ET], or dystonia). Variables included categorical age, gender, insurance, comorbidities, type of movement disorder, length of stay (LOS), total costs, and discharge disposition.
    Results: A total of 3392 DBS patients were identified [PD (70.7%), ET (25.6%), dystonia (3.7%)]. The mean age was 64.8 ± 0.4 years old and 37% were female. The rates of unplanned readmissions was 1.9% at 30-days and 4.3% at 90 days. The overall NRD incidence (all patient populations) of 30-day readmission is 11.6%. Readmissions most frequently resulted from surgical complications including hematoma and attention to surgical wounds. Elderly, obese, and those with comorbidities such as history of stroke or CAD are at highest risk. The average LOS, mean total cost, and rate of adverse discharge were worse for 30-day (9 days, $64,520, 71.7%) compared to 90-day readmission (6 days, $52,183, 56.5%).
    Conclusion: All-cause, unplanned readmission for DBS was 1.9% within 30-days and 4.3% within 90-days. Risk factors for readmission in our study, such as advanced age and multiple medical comorbidities, are not unique to DBS. Unplanned readmissions are much rarer following DBS compared to most hospital discharges but can occasionally lead to additional costs and rare complications including hematoma, stroke, and wound infection. DBS should continue to be viewed as a safe and effective treatment modality for a wide range of neurological ailments.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Deep Brain Stimulation/methods ; Essential Tremor/surgery ; Female ; Humans ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Movement Disorders/therapy ; Patient Discharge ; Patient Readmission/statistics & numerical data ; Postoperative Complications/epidemiology ; Risk Factors ; Time Factors ; Treatment Outcome ; United States ; Young Adult
    Language English
    Publishing date 2018-06-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2018.06.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Comparison of pallidal and subthalamic deep brain stimulation for the treatment of levodopa-induced dyskinesias.

    Follett, Kenneth A

    Neurosurgical focus

    2004  Volume 17, Issue 1, Page(s) E3

    Abstract: Deep brain stimulation (DBS) can relieve dyskinesias effectively and safely. This modality is applied most commonly in the treatment of dyskinesias associated with levodopa therapy for Parkinson disease. The subthalamic nucleus (STN) and globus pallidus ... ...

    Abstract Deep brain stimulation (DBS) can relieve dyskinesias effectively and safely. This modality is applied most commonly in the treatment of dyskinesias associated with levodopa therapy for Parkinson disease. The subthalamic nucleus (STN) and globus pallidus internus (GPi) are the most common surgical targets. Deep brain stimulation of the GP has a direct antidyskinetic effect, whereas relief of dyskinesias by DBS of the STN depends on postoperative reduction of dopaminergic medications. Outcomes are similar for DBS in these two sites despite the different mechanisms by which the stimulation relieves dyskinesias. Deep brain stimulation of the STN has become the surgical treatment of choice in many movement disorders programs but this modality has not been compared with DBS of the GPi in randomized controlled trials, and the superiority of one site over the other remains unproven. In the absence of data demonstrating superiority, selection of the stimulation target should be individualized to meet the needs of each patient. Selection of the target should be based on the patient's most disabling symptoms, response to medications (including side effects), and the goals of therapy, with consideration given to the different antidyskinetic effects of DBS of the STN and GPi.
    MeSH term(s) Antiparkinson Agents/adverse effects ; Antiparkinson Agents/therapeutic use ; Combined Modality Therapy ; Dyskinesia, Drug-Induced/etiology ; Dyskinesia, Drug-Induced/therapy ; Dyskinesias/therapy ; Electric Stimulation Therapy/methods ; Electrodes, Implanted ; Globus Pallidus/physiopathology ; Humans ; Levodopa/adverse effects ; Levodopa/therapeutic use ; Organ Specificity ; Parkinson Disease/drug therapy ; Parkinson Disease/therapy ; Subthalamic Nucleus/physiopathology ; Thalamus/physiopathology ; Treatment Outcome
    Chemical Substances Antiparkinson Agents ; Levodopa (46627O600J)
    Language English
    Publishing date 2004-07-15
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 2026589-X
    ISSN 1092-0684 ; 1092-0684
    ISSN (online) 1092-0684
    ISSN 1092-0684
    DOI 10.3171/foc.2004.17.1.3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Intrathecal analgesia and catheter-tip inflammatory masses.

    Follett, Kenneth A

    Anesthesiology

    2003  Volume 99, Issue 1, Page(s) 5–6

    MeSH term(s) Analgesia/adverse effects ; Analgesics/administration & dosage ; Analgesics/therapeutic use ; Animals ; Catheterization/adverse effects ; Chronic Disease ; Granuloma/etiology ; Granuloma/pathology ; Inflammation/etiology ; Inflammation/pathology ; Infusion Pumps, Implantable/adverse effects ; Injections, Spinal ; Pain/drug therapy ; Sheep
    Chemical Substances Analgesics
    Language English
    Publishing date 2003-04-21
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 269-0
    ISSN 0003-3022
    ISSN 0003-3022
    DOI 10.1097/00000542-200307000-00004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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