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  1. Article: Familial Deep Vein Thrombosis in a Child With Antithrombin III Deficiency: A Case Report.

    Kale, Shivani / Jadhav, Devika / Tambolkar, Sampada / Daru, Avinash

    Cureus

    2024  Volume 16, Issue 2, Page(s) e54157

    Abstract: Deep vein thrombosis (DVT) is caused by a clot (thrombus) formed in the deep veins, usually the legs. The incidence of DVT is notably less prevalent in children than in adults. Here, we present a rare case of DVT in an eight-year-old female child with a ... ...

    Abstract Deep vein thrombosis (DVT) is caused by a clot (thrombus) formed in the deep veins, usually the legs. The incidence of DVT is notably less prevalent in children than in adults. Here, we present a rare case of DVT in an eight-year-old female child with a significant family history involving the untimely death of the maternal aunt. The child presented with pain and edema in the left lower limb causing immobilization without any obvious cause. The clinical features suggested the possibility of DVT. On further evaluation and radiological investigations, the diagnosis of DVT was confirmed. A complete thrombophilia workup was done showing antithrombin (AT) III deficiency. The patient was then started on low-molecular-weight heparin, leading to improvement in the symptoms. Oral rivaroxaban was continued for the patient on discharge.
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.54157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Late-Onset Dilated Cardiomyopathy in Auto Immune-Mediated Complete Congenital Heart Block: A Case Report.

    Dharmagadda, Amulya / Tambolkar, Sampada / Chavan, Sanjay / Garlapati, Srinija

    Cureus

    2024  Volume 16, Issue 2, Page(s) e54222

    Abstract: Complete congenital heart block (CHB), a rare and fatal bradyarrhythmia observed in children, carries significant mortality and morbidity. When congenital heart block occurs in isolation with a structurally normal heart, it prompts suspicion of an ... ...

    Abstract Complete congenital heart block (CHB), a rare and fatal bradyarrhythmia observed in children, carries significant mortality and morbidity. When congenital heart block occurs in isolation with a structurally normal heart, it prompts suspicion of an autoimmune etiology, wherein maternal antibodies are transmitted transplacentally, impacting the fetal conducting system. The manifestation of congenital complete atrioventricular block (CCAVB) can lead to complications such as dilated cardiomyopathies, arrhythmias, and fibroelastosis in certain cases. Notably, dilated cardiomyopathy is a significant prognostic factor in children diagnosed with congenital heart block. Pathological investigations have revealed the presence of antibodies, complements, and indicators of inflammation or fibrosis across the myocardium, emphasizing the shared molecular mechanisms between CCAVB and the development of dilated cardiomyopathy (DCM). This article presents the case of a one-year-old female child who presented with signs of dilated cardiomyopathy, later identified through retrospective evaluation as having autoimmune congenital heart block. The mother of the child was diagnosed with Sjogren's syndrome, characterized by positive anti-RO titers. Remarkably, the child remained asymptomatic for a year without the need for pacing intervention. The child's condition was successfully stabilized with appropriate treatment, and plans for pacemaker insertion will be considered once specific criteria are met. The onset of cardiomyopathy in a known case of CCAVB should serve as a crucial alert for prognostic considerations and the potential necessity for early-pacing intervention.
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.54222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Association of Helicobacter pylori in Children With Self-Hand Hygiene, Maternal Hand Hygiene, Cooking, and Feeding Practices.

    Thorat, Janhavi V / Tambolkar, Sampada / Chitale, Mukta M / Biradar, Vishnu / Jadhav, Renuka S

    Cureus

    2024  Volume 16, Issue 3, Page(s) e56554

    Abstract: Background and ... ...

    Abstract Background and objective
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.56554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Comparison of public health measures taken during Spanish flu and COVID-19 pandemics: A Narrative Review.

    Tambolkar, Sampada / Pustake, Manas / Giri, Purushottam / Tambolkar, Isha

    Journal of family medicine and primary care

    2022  Volume 11, Issue 5, Page(s) 1642–1647

    Abstract: The similarity of the consequences of COVID-19 reminded us of the destruction caused by the Spanish flu over a century ago and led us to find similarities in the way the two pandemics were handled. PRISMA Guideline was followed for a systematic search to ...

    Abstract The similarity of the consequences of COVID-19 reminded us of the destruction caused by the Spanish flu over a century ago and led us to find similarities in the way the two pandemics were handled. PRISMA Guideline was followed for a systematic search to identify eligible published articles. Information about the public health measures adopted during both the pandemics was taken from literature. It was found that there are parallels between the two pandemics in terms of general unpreparedness, attitudes of the community and government, and various policy issues. All the measures implemented in 2020 were the same as those implemented in 1918-1919, with the same trend, uncertainty, early relaxing, and rapid reversals. Even from a scientific standpoint, all the elements were already known. All the issues such as social isolation, intra-family spread, personal protective equipment, medicine types (quinine, aspirin, anti-inflammatories, etc.), immunization requirements, and so on had already been addressed. No doubt, we do have technology today at our disposal for managing the spread of the disease and even spread awareness among people much easily. We also have taken many steps forward in the world of globalization, which make the progression and spread of the pandemic very fast as well. Both factors tend to counter each other and hence make timely public health intervention as important (if not more) today as it was yesterday. When possible, approaches and goals should be found on scientific facts and include ethical input. Finally, we must take careful notice of past local and national lessons to avoid repeating the mistakes done in the past. The development of a strategy ahead of time that includes all levels of government health infrastructure and outlines clear lines of duties and functions is critical. The main objective of this article was to compare the public health measures undertaken during the pandemic of Spanish Flu and the pandemic of COVID-19, and assess the similarities and differences in the public health measures taken during these pandemics. The correlation of the public health measures and the outcomes was assessed and the implication of this article was to be pandemic-ready in the future.
    Language English
    Publishing date 2022-05-14
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2735275-4
    ISSN 2278-7135 ; 2249-4863
    ISSN (online) 2278-7135
    ISSN 2249-4863
    DOI 10.4103/jfmpc.jfmpc_1612_21!
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Isolated Malignant Pleural Effusion in a Child: Unusual Presentation of Acute Leukemia.

    Garlapati, Srinija / Tambolkar, Sampada / Verma, Sarita / Pathak, Nakul V / Patil, Manojkumar G

    Cureus

    2024  Volume 16, Issue 2, Page(s) e54232

    Abstract: Pleural effusion in the pediatric population is an abnormal pathology characterized by the accumulation of fluids between the parietal and visceral pleura. The etiology of this excessive fluid accumulation can be attributed to both infectious and non- ... ...

    Abstract Pleural effusion in the pediatric population is an abnormal pathology characterized by the accumulation of fluids between the parietal and visceral pleura. The etiology of this excessive fluid accumulation can be attributed to both infectious and non-infectious factors. Notably,
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.54232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Extensively Drug-Resistant Typhoid Fever: A Call to Action.

    Pustake, Manas / Giri, Purushottam / Tambolkar, Sampada / Nayak, Shreeja

    Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine

    2022  Volume 47, Issue 1, Page(s) 153–154

    Language English
    Publishing date 2022-03-16
    Publishing country India
    Document type Journal Article
    ZDB-ID 2085330-0
    ISSN 1998-3581 ; 0970-0218
    ISSN (online) 1998-3581
    ISSN 0970-0218
    DOI 10.4103/ijcm.ijcm_1008_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Comparison of public health measures taken during Spanish flu and COVID-19 pandemics

    Sampada Tambolkar / Manas Pustake / Purushottam Giri / Isha Tambolkar

    Journal of Family Medicine and Primary Care, Vol 11, Iss 5, Pp 1642-

    A Narrative Review

    2022  Volume 1647

    Abstract: The similarity of the consequences of COVID-19 reminded us of the destruction caused by the Spanish flu over a century ago and led us to find similarities in the way the two pandemics were handled. PRISMA Guideline was followed for a systematic search to ...

    Abstract The similarity of the consequences of COVID-19 reminded us of the destruction caused by the Spanish flu over a century ago and led us to find similarities in the way the two pandemics were handled. PRISMA Guideline was followed for a systematic search to identify eligible published articles. Information about the public health measures adopted during both the pandemics was taken from literature. It was found that there are parallels between the two pandemics in terms of general unpreparedness, attitudes of the community and government, and various policy issues. All the measures implemented in 2020 were the same as those implemented in 1918–1919, with the same trend, uncertainty, early relaxing, and rapid reversals. Even from a scientific standpoint, all the elements were already known. All the issues such as social isolation, intra-family spread, personal protective equipment, medicine types (quinine, aspirin, anti-inflammatories, etc.), immunization requirements, and so on had already been addressed. No doubt, we do have technology today at our disposal for managing the spread of the disease and even spread awareness among people much easily. We also have taken many steps forward in the world of globalization, which make the progression and spread of the pandemic very fast as well. Both factors tend to counter each other and hence make timely public health intervention as important (if not more) today as it was yesterday. When possible, approaches and goals should be found on scientific facts and include ethical input. Finally, we must take careful notice of past local and national lessons to avoid repeating the mistakes done in the past. The development of a strategy ahead of time that includes all levels of government health infrastructure and outlines clear lines of duties and functions is critical. The main objective of this article was to compare the public health measures undertaken during the pandemic of Spanish Flu and the pandemic of COVID-19, and assess the similarities and differences in the public ...
    Keywords covid-19 pandemics ; public health measures ; spanish flu ; Medicine ; R
    Subject code 900
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Extensively drug-resistant typhoid fever

    Manas Pustake / Purushottam Giri / Sampada Tambolkar / Shreeja Nayak

    Indian Journal of Community Medicine, Vol 47, Iss 1, Pp 153-

    A call to action

    2022  Volume 154

    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Rare occurrence of Coxsackievirus B4 along with Coxsackieviruses A6 and A10 from hand, foot and mouth disease

    Sampada Tambolkar / Manasi Chavan / Prachi Prasad / Avinash Lendave / Chandrashekhar Raut / Sharad Agarkhedkar / Jitendra Bhawalkar

    Journal of Krishna Institute of Medical Sciences University, Vol 12, Iss 03, Pp 3-

    2023  Volume 11

    Abstract: Background: Hand, Foot and Mouth Disease (HFMD) has been widely spread in Asia and resulted in a high disease burden among children in many countries. It remains a common problem in India, yet its etiology is largely unknown as diagnosis is based on ... ...

    Abstract Background: Hand, Foot and Mouth Disease (HFMD) has been widely spread in Asia and resulted in a high disease burden among children in many countries. It remains a common problem in India, yet its etiology is largely unknown as diagnosis is based on clinical characteristics. Aim and Objectives: To investigate the circulation of strains, clinical, molecular and virological aspects of the disease. Material and Methods: Vesicular lesion and throat swab specimens were referred from eight children for laboratory diagnosis of HFMD. The detection of enteroviruses was performed by nested PCR, virus isolation using HeLa cell line and sequencing of 5′UTR. Results: Coxsackieviruses A6, A10 and B4 were identified by nested PCR, isolated in HeLa cell line and reconfirmed. The phylogenetic analysis of Coxsackieviruses A6, A10 and B4 showed similarity with Beijing-China, Pune-India, and France respectively. Conclusion: The findings of this study indicate the co-circulation of Coxsackieviruses A6, A10 and B4. Coxsackievirus B4 was isolated and detected for the first time from Pune, India. Additionally, results emphasize the importance of virus isolation using cell lines for laboratory diagnosis. Point-of-Care testing and vaccine development would be beneficial towards control and prevention of HFMD.
    Keywords coxsackievirus b4 ; enteroviruses ; hand ; foot and mouth disease ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Krishna Institute of Medical Sciences University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Study of respiratory diseases, children residing in stone quarry

    Sampada A Tambolkar / Ambrish D Mishra / Manojkumar G Patil / Shradha R Salunkhe / Sharad R Agarkhedkar

    Medical Journal of Dr. D.Y. Patil Vidyapeeth, Vol 15, Iss 5, Pp 687-

    2022  Volume 690

    Abstract: Objective: The aim is to study respiratory diseases in children staying in a stone quarry. Methods: Prospective longitudinal study. All 85 children staying in the stone quarry near Pune were followed for respiratory symptoms and nutritional status by ... ...

    Abstract Objective: The aim is to study respiratory diseases in children staying in a stone quarry. Methods: Prospective longitudinal study. All 85 children staying in the stone quarry near Pune were followed for respiratory symptoms and nutritional status by monthly visits for a period of 18 months. At the time of enrolment, Hemogram, Chest X- ray Postero-anterior view (PA), Tuberculin Test (TT), Peak Expiratory Flow Rate{PEFR }(Of children age: 5-12 yrs.) was done. Results: In those 85 children, there were 394 episodes of respiratory infections (3.09 episodes per child per year). They had 53 episodes of pneumonia requiring admission. TT test was positive in 9.4%of children. Eosinophilia was present in 16.47% of children. PEFR in these children was significantly lower than that of children of the same height (P < 0.05); 64.2% of all children were malnourished; 42.8% had moderate malnutrition and 21.4% had severe malnutrition. None of them had received even vaccines provided under EPI completely. Conclusion: Children staying in the stone quarry have frequent respiratory infections. They have a higher rate of pneumonia requiring admission. TT positivity is high. They have a lower PEFR. Immunization coverage is poor.
    Keywords pneumonia ; respiratory disease ; stone quarry ; Medicine ; R
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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