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  1. Article ; Online: Meta-analysis of regional citrate versus heparin anticoagulation for continuous renal replacement therapy.

    Volbeda, Meint / Franssen, Casper F M

    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

    2024  Volume 28, Issue 3, Page(s) 475–476

    MeSH term(s) Humans ; Anticoagulants/administration & dosage ; Anticoagulants/therapeutic use ; Heparin/administration & dosage ; Heparin/therapeutic use ; Continuous Renal Replacement Therapy/methods ; Citric Acid/administration & dosage
    Chemical Substances Anticoagulants ; Heparin (9005-49-6) ; Citric Acid (2968PHW8QP)
    Language English
    Publishing date 2024-01-03
    Publishing country Australia
    Document type Letter ; Meta-Analysis ; Comparative Study
    ZDB-ID 2119809-3
    ISSN 1744-9987 ; 1091-6660 ; 1744-9979
    ISSN (online) 1744-9987
    ISSN 1091-6660 ; 1744-9979
    DOI 10.1111/1744-9987.14104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5208: Show issues Location:
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  2. Article ; Online: De nieuwe donorwet en orgaandonatie.

    Volbeda, Meint / Herfs, Anne C S

    Nederlands tijdschrift voor geneeskunde

    2020  Volume 164

    Abstract: On 1 July 2020, the new Dutch Donor Act with an Active Donor Registration system will become effective. Consequent changes in clinical practice and matters related to dealing with a patient's family are described by means of an illustrative case history ... ...

    Title translation The new Dutch Donor Act and Organ Donation.
    Abstract On 1 July 2020, the new Dutch Donor Act with an Active Donor Registration system will become effective. Consequent changes in clinical practice and matters related to dealing with a patient's family are described by means of an illustrative case history of a 53-year-old fictive female patient. Furthermore, the implications of an earlier change in the Dutch Donor Act in 2013 are discussed.
    MeSH term(s) Female ; Humans ; Middle Aged ; Netherlands ; Tissue Donors/legislation & jurisprudence ; Tissue and Organ Procurement/legislation & jurisprudence
    Language Dutch
    Publishing date 2020-06-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
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  3. Article ; Online: Longitudinal NGAL and cystatin C plasma profiles present a high level of heterogeneity in a mixed ICU population.

    Jou-Valencia, Daniela / Volbeda, Meint / Zijlstra, Jan G / Kootstra-Ros, Jenny E / Moser, Jill / van Meurs, Matijs / Koeze, Jacqueline

    BMC nephrology

    2024  Volume 25, Issue 1, Page(s) 43

    Abstract: Background: NGAL and Cystatin C (CysC) as biomarkers for the early detection of AKI are subject to both pathophysiological, as well as patient related heterogeneity. The aim of this study was to investigate the timeline of plasma levels of NGAL and CysC ...

    Abstract Background: NGAL and Cystatin C (CysC) as biomarkers for the early detection of AKI are subject to both pathophysiological, as well as patient related heterogeneity. The aim of this study was to investigate the timeline of plasma levels of NGAL and CysC during the first seven days of ICU admission in a mixed ICU population and to relate these to AKI severity during ICU stay. Via these means we aimed to bring clarity to the previously reported heterogeneity of these renal biomarkers.
    Methods: Prospective Observation Cohort. Consecutive patients admitted to adult ICU at an academic hospital in the Netherlands between 18-02-2014 and 31-03-2014 were included. Urine output, serum creatinine, plasma NGAL and CysC were recorded during the first seven days of ICU admission. Biomarker expression was analyzed based on KDIGO score and time of AKI diagnosis.
    Results: 335 patients were included, 110 met KDIGO criteria for AKI. NGAL and CysC plasma levels were higher in AKI patients compared to non-AKI, high variability in individual values resulted in 56% of AKI patients having a false negative, and 32% of non-AKI patients having a false positive. Individual biomarker levels were variable, and no pattern based on KDIGO score was observed.
    Conclusions: Plasma NGAL and CysC as biomarkers for the early AKI detection may be subject to pathophysiological, and patient related heterogeneity. Further understanding of individual biomarker profiles may help in their application amongst mixed ICU populations.
    Trial registration: The need for informed consent was waived by the Institutional Ethical Review Board of the University Medical Center Groningen (METc 2013 - 174) by Prof. dr. W.A. Kamps on May 17th 2013.
    MeSH term(s) Adult ; Humans ; Lipocalin-2 ; Prospective Studies ; Cystatin C ; Acute Kidney Injury ; Biomarkers ; Creatinine ; Intensive Care Units
    Chemical Substances Lipocalin-2 ; Cystatin C ; Biomarkers ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041348-8
    ISSN 1471-2369 ; 1471-2369
    ISSN (online) 1471-2369
    ISSN 1471-2369
    DOI 10.1186/s12882-024-03477-2
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  4. Article ; Online: Letter Regarding "Association Between CKD, Obesity, Cardiometabolic Risk Factors, and Severe COVID-19 Outcomes".

    Volbeda, Meint / Jou-Valencia, Daniela / van den Heuvel, Marius C / Moser, Jill / van Meurs, Matijs / Franssen, Casper F M

    Kidney international reports

    2023  Volume 8, Issue 9, Page(s) 1899–1900

    Language English
    Publishing date 2023-07-28
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2023.04.032
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  5. Article ; Online: Renal Replacement Therapy in Acute Kidney Injury: Follow the Platelets.

    de Pont, Anne-Cornélie J M / Volbeda, Meint

    Critical care medicine

    2019  Volume 47, Issue 4, Page(s) 620–621

    MeSH term(s) Acute Kidney Injury ; Blood Platelets ; Humans ; Renal Replacement Therapy ; Thrombocytopenia
    Language English
    Publishing date 2019-03-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000003689
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  6. Article ; Online: Extracorporeal Treatment for Paraquat Poisoning.

    de Pont, Anne Cornélie J M / Volbeda, Meint

    Critical care medicine

    2018  Volume 46, Issue 10, Page(s) e1015–e1016

    MeSH term(s) Hemofiltration ; Hemoperfusion ; Paraquat ; Prospective Studies ; Treatment Outcome
    Chemical Substances Paraquat (PLG39H7695)
    Language English
    Publishing date 2018-10-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000003282
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  7. Article ; Online: The Role of Platelets in Extracorporeal Circuit Thrombogenesis.

    de Pont, Anne-Cornélie J M / Volbeda, Meint

    Critical care medicine

    2018  Volume 46, Issue 6, Page(s) e618

    MeSH term(s) Blood Platelets ; Cognition ; Humans ; Intensive Care Units ; Surveys and Questionnaires ; Survivors
    Language English
    Publishing date 2018-05-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000003018
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  8. Article ; Online: Old Wine in New Bottles: Continuous Versus Intermittent Renal Replacement Therapy in the ICU.

    de Pont, Anne-Cornélie / Volbeda, Meint

    Critical care medicine

    2018  Volume 46, Issue 2, Page(s) 340–341

    MeSH term(s) Humans ; Intensive Care Units ; Kidney ; Patient Discharge ; Renal Replacement Therapy
    Language English
    Publishing date 2018-02-14
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000002854
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  9. Article ; Online: Criteria for Continuous Kidney Replacement Therapy Cessation in ICU Patients.

    Volbeda, Meint / Oord, Martha / Koeze, Jacqueline / Keus, Eric / van der Horst, Iwan C C / Franssen, Casper F M

    Blood purification

    2022  Volume 52, Issue 1, Page(s) 32–40

    Abstract: Introduction: In intensive care unit (ICU) patients with acute kidney injury, specific recommendations to guide the decision to cease continuous kidney replacement therapy (CKRT) are lacking.: Methods: We performed a survey to identify criteria ... ...

    Abstract Introduction: In intensive care unit (ICU) patients with acute kidney injury, specific recommendations to guide the decision to cease continuous kidney replacement therapy (CKRT) are lacking.
    Methods: We performed a survey to identify criteria currently used to cease CKRT in real-life clinical practice in the Netherlands. We used an online questionnaire with multiple choice questions designed with web-based software from SurveyMonkey.
    Results: We received 169 completed questionnaires from intensivists (n = 126) and nephrologists (n = 43). Essential determinants for the cessation of CKRT were a spontaneously increasing diuresis (indicated by 92% of the respondents), absence of fluid overload (indicated by 88% of the respondents), and improvement in creatinine clearance (indicated by 61% of the respondents; intensivists 56%; nephrologists 77%, p = 0.03). Most often mentioned cut-off values used for increase in diuresis were 0.25 and 0.5 mL/kg/h (35% and 33%, respectively). Actual CKRT cessation was often postponed until the filter clots or until circuit disconnection is needed because of patient transport for diagnostic or intervention procedures (indicated by 58% of the respondents). Expected discharge from the ICU was the most frequently reported determinant to switch from CKRT to hemodialysis (indicated by 67% of the respondents).
    Conclusions: CKRT cessation in clinical practice is mostly based on spontaneously increasing diuresis, absence of fluid overload, and improvement in creatinine clearance and is often delayed until filter clotting or disconnection of the circuit because of logistic reasons.
    MeSH term(s) Humans ; Creatinine ; Continuous Renal Replacement Therapy/methods ; Renal Dialysis/adverse effects ; Acute Kidney Injury/therapy ; Acute Kidney Injury/etiology ; Intensive Care Units ; Renal Replacement Therapy/methods
    Chemical Substances Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2022-04-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 605548-5
    ISSN 1421-9735 ; 0253-5068
    ISSN (online) 1421-9735
    ISSN 0253-5068
    DOI 10.1159/000524180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: How clinicians discuss patients' donor registrations of consent and presumed consent in donor conversations in an opt-out system: a qualitative embedded multiple-case study.

    van Oosterhout, Sanne P C / van der Niet, Anneke G / Abdo, W Farid / Boenink, Marianne / Cherpanath, Thomas G V / Epker, Jelle L / Kotsopoulos, Angela M / van Mook, Walther N K A / Sonneveld, Hans P C / Volbeda, Meint / Olthuis, Gert / van Gurp, Jelle L P

    Critical care (London, England)

    2023  Volume 27, Issue 1, Page(s) 299

    Abstract: Background: The Netherlands introduced an opt-out donor system in 2020. While the default in (presumed) consent cases is donation, family involvement adds a crucial layer of influence when applying this default in clinical practice. We explored how ... ...

    Abstract Background: The Netherlands introduced an opt-out donor system in 2020. While the default in (presumed) consent cases is donation, family involvement adds a crucial layer of influence when applying this default in clinical practice. We explored how clinicians discuss patients' donor registrations of (presumed) consent in donor conversations in the first years of the opt-out system.
    Methods: A qualitative embedded multiple-case study in eight Dutch hospitals. We performed a thematic analysis based on audio recordings and direct observations of donor conversations (n = 15, 7 consent and 8 presumed consent) and interviews with the clinicians involved (n = 16).
    Results: Clinicians' personal considerations, their prior experiences with the family and contextual factors in the clinicians' profession defined their points of departure for the conversations. Four routes to discuss patients' donor registrations were constructed. In the Consent route (A), clinicians followed patients' explicit donation wishes. With presumed consent, increased uncertainty in interpreting the donation wish appeared and prompted clinicians to refer to "the law" as a conversation starter and verify patients' wishes multiple times with the family. In the Presumed consent route (B), clinicians followed the law intending to effectuate donation, which was more easily achieved when families recognised and agreed with the registration. In the Consensus route (C), clinicians provided families some participation in decision-making, while in the Family consent route (D), families were given full decisional capacity to pursue optimal grief processing.
    Conclusion: Donor conversations in an opt-out system are a complex interplay between seemingly straightforward donor registrations and clinician-family interactions. When clinicians are left with concerns regarding patients' consent or families' coping, families are given a larger role in the decision. A strict uniform application of the opt-out system is unfeasible. We suggest incorporating the four previously described routes in clinical training, stimulating discussions across cases, and encouraging public conversations about donation.
    MeSH term(s) Humans ; Tissue and Organ Procurement ; Presumed Consent ; Tissue Donors ; Qualitative Research ; Communication ; Decision Making
    Language English
    Publishing date 2023-07-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-023-04581-9
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