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  1. Article ; Online: Correction: COVID-19 Vaccine-Induced Myocarditis and Pericarditis: Towards Identification of Risk Factors.

    Zwiers, Laura C / Ong, David S Y / Grobbee, Diederick E

    Global heart

    2024  Volume 19, Issue 1, Page(s) 1

    Abstract: This corrects the article DOI: 10.5334/gh.1252.]. ...

    Abstract [This corrects the article DOI: 10.5334/gh.1252.].
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2629633-0
    ISSN 2211-8179 ; 2211-8160
    ISSN (online) 2211-8179
    ISSN 2211-8160
    DOI 10.5334/gh.1276
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  2. Article ; Online: COVID-19 Vaccine-Induced Myocarditis and Pericarditis: Towards Identification of Risk Factors.

    Zwiers, Laura C / Ong, David S Y / Grobbee, Diederick E

    Global heart

    2023  Volume 18, Issue 1, Page(s) 39

    MeSH term(s) Humans ; COVID-19 Vaccines ; Myocarditis ; COVID-19 ; Pericarditis ; Risk Factors
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-07-31
    Publishing country England
    Document type Editorial
    ZDB-ID 2629633-0
    ISSN 2211-8179 ; 2211-8160
    ISSN (online) 2211-8179
    ISSN 2211-8160
    DOI 10.5334/gh.1252
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  3. Article: Evaluation of a New Standardized Nasal Sampling Method for Detection of SARS-CoV-2 RNA via RT-PCR.

    Koeleman, Johannes G M / Mol, Sander / Brand, Henk / Ong, David S Y

    Microorganisms

    2024  Volume 12, Issue 1

    Abstract: The aim of this study was to compare the diagnostic accuracy of nasal sampling using a novel anterior nasal swab (ANS) (Rhinoswab) versus combined oro-nasopharyngeal (OP/NP) sampling in COVID-19 suspected patients. This prospective observational study ... ...

    Abstract The aim of this study was to compare the diagnostic accuracy of nasal sampling using a novel anterior nasal swab (ANS) (Rhinoswab) versus combined oro-nasopharyngeal (OP/NP) sampling in COVID-19 suspected patients. This prospective observational study was performed from 11 November to 2 December 2021 (part 1), and from 16 January to 22 February 2022 (part 2). Adult patients who attended the emergency room with suspected COVID-19 were asked to participate. One ANS and one OP/NP sample were consecutively collected, and both were analyzed via reverse transcription polymerase chain reaction (RT-PCR). The result of the OP/NP sample was considered to be the reference standard. A total of 412 patients were included, of whom 171 (41.5%) had a positive RT-PCR of the OP/NP swab, whereas 139 (33.7%) were positive on the ANS sample. The overall diagnostic accuracy for ANS sampling in terms of sensitivity, specificity, positive predictive value, and negative predictive value was 80.7% (95% CI 73.8-86.2), 99.6% (95% CI 97.3-100), 99.3% (95% CI 95.5-100), and 87.9% (95% CI 83.3-91.4), respectively. In conclusion, ANS sampling with the Rhinoswab identified 80.7% of all presented COVID-19 patients in an emergency department. Future studies should investigate if nasal Rhinoswab self-sampling is suitable for reliable diagnosis of COVID-19 in an outpatient setting.
    Language English
    Publishing date 2024-01-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12010210
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  4. Article ; Online: Colistin plus meropenem versus colistin alone for invasive infections caused by carbapenem-resistant Acinetobacter baumannii: a rapid systematic review of randomized controlled trials using Bayesian meta-analysis.

    Maraolo, Alberto E / Ong, David S Y

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  Volume 29, Issue 9, Page(s) 1208–1210

    MeSH term(s) Humans ; Acinetobacter baumannii ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bayes Theorem ; Carbapenems/pharmacology ; Colistin/therapeutic use ; Meropenem/therapeutic use ; Microbial Sensitivity Tests ; Randomized Controlled Trials as Topic
    Chemical Substances Anti-Bacterial Agents ; Carbapenems ; Colistin (Z67X93HJG1) ; Meropenem (FV9J3JU8B1)
    Language English
    Publishing date 2023-06-03
    Publishing country England
    Document type Letter ; Meta-Analysis ; Systematic Review
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.05.036
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    Zs.A 4541: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 284: Show issues

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  5. Article ; Online: Comparison between an in-house SARS-CoV-2 ELISpot and the T-Spot® Discovery SARS-CoV-2 for the assessment of T cell responses in prior SARS-CoV-2-infected individuals.

    Mak, Willem A / Koeleman, Johannes G M / Ong, David S Y

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

    2022  Volume 150-151, Page(s) 105158

    MeSH term(s) Antibodies, Viral ; COVID-19 ; Enzyme-Linked Immunospot Assay ; Humans ; SARS-CoV-2 ; T-Lymphocytes
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2022-04-12
    Publishing country Netherlands
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1446080-4
    ISSN 1873-5967 ; 1386-6532
    ISSN (online) 1873-5967
    ISSN 1386-6532
    DOI 10.1016/j.jcv.2022.105158
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    Zs.A 3790: Show issues Location:
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  6. Article: Editorial: Viral Infections in the Intensive Care Unit.

    Maraolo, Alberto E / Barac, Aleksandra / Cremer, Olaf L / Ong, David S Y

    Frontiers in medicine

    2021  Volume 8, Page(s) 716824

    Language English
    Publishing date 2021-06-30
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.716824
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  7. Article: Editorial: Innovative Approaches in Diagnosis of Emerging/Re-emerging Infectious Diseases.

    Barac, Aleksandra / Poljak, Mario / Ong, David S Y

    Frontiers in microbiology

    2020  Volume 11, Page(s) 619498

    Language English
    Publishing date 2020-12-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2020.619498
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  8. Article ; Online: Treatment and long term safety outcomes of Peptide Receptor Radionuclide Therapy for metastatic neuroendocrine tumours: an Asian experience.

    Tham, Wei Ying / Huang, Hian Liang / Tai, David Wai Meng / Allen, John C / Hwang, Jacqueline S G / Loh, Lih Ming / Goh, Brian K P / Ong, Simon Y K / Kek, Peng Chin / Tan, Damien M Y / Ng, David C E / Loke, Kelvin S H

    Neuroendocrinology

    2024  

    Abstract: Peptide-receptor radionuclide therapy (PRRT) is a targeted molecular therapy used to treat neuroendocrine tumours (NET). It has been shown to be effective and well-tolerated in patients with metastatic neuroendocrine tumours in several centres in United ... ...

    Abstract Peptide-receptor radionuclide therapy (PRRT) is a targeted molecular therapy used to treat neuroendocrine tumours (NET). It has been shown to be effective and well-tolerated in patients with metastatic neuroendocrine tumours in several centres in United States (US), Europe and Australia. Tolerability and efficacy data emerging from Asian centres remain few. Epidemiological evidence suggests that there are differences in neuroendocrine neoplasms between the population groups. We aim to describe the treatment and safety outcomes of PRRT in the Asian population. Methods One hundred and seven (107) patients with metastatic neuroendocrine tumour who had undergone PRRT treatment from January 2012 to March 2019 were included in this retrospective study. The response rates using RECIST1.1 and qualitative analysis were examined. The overall and progression free survival curves were also evaluated. Results The median progression free survival was 49 months. Response assessment after completion of treatment showed that 33(37.9%) of 87 patients had partial or complete response. Subgroup analysis comparing high- and low-grade NET showed that there was a significant difference in the time to progression curves. Comparison of the number of cycles and progression free and overall survival also showed a significant difference. Ten patients (9%) had grade 3 or more haematological toxicities. Four patients (4%) had grade 3/4 hepatobiliary toxicities, although the presence of extensive liver metastases was a confounding factor. None of the patients had grade 3/4 acute kidney injury. Conclusion Our results show that PRRT is safe and effective in the treatment of metastatic neuroendocrine tumour in the Asian population. There was a significant difference in the progression free survival curves between low-grade and high-grade NET, and in the progression free and overall survival comparing the number of cycles received.
    Language English
    Publishing date 2024-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 123303-8
    ISSN 1423-0194 ; 0028-3835
    ISSN (online) 1423-0194
    ISSN 0028-3835
    DOI 10.1159/000538523
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 531: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Ancestral SARS-CoV-2 and Omicron BA.5-specific neutralizing antibody and T-cell responses after Omicron bivalent booster vaccination in previously infected and infection-naive individuals.

    Mak, Willem A / Visser, Wendy / van der Vliet, Marijke / Markus, Hilde Y / Koeleman, Johannes G M / Ong, David S Y

    Journal of medical virology

    2023  Volume 95, Issue 8, Page(s) e28989

    Abstract: Coronavirus disease-2019 (COVID-19) bivalent ancestral/Omicron messenger RNA (mRNA) booster vaccinations became available to boost and expand the immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron infections. In a ... ...

    Abstract Coronavirus disease-2019 (COVID-19) bivalent ancestral/Omicron messenger RNA (mRNA) booster vaccinations became available to boost and expand the immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron infections. In a prospective cohort study including 59 healthcare workers, we assessed SARS-CoV-2 ancestral and Omicron BA.5-specific neutralizing antibody and T-cell responses in previously infected and infection-naive individuals. Also, we assessed the effect of an ancestral/Omicron BA.1 bivalent mRNA booster vaccination on these immune responses. 10 months after previous monovalent mRNA vaccinations, ancestral SARS-CoV-2 S1-specific T-cell and anti-RBD IgG responses remained detectable in most individuals and a previous SARS-CoV-2 infection was associated with increased T-cell responses. T-cell responses, anti-RBD IgG, and Omicron BA.5 neutralization activity increased after receiving an ancestral/Omicron BA.1 bivalent booster mRNA vaccination. An Omicron BA.5 infection in addition to bivalent vaccination, led to a higher ratio of Omicron BA.5 to ancestral strain neutralization activity compared to no bivalent vaccination and no recent SARS-CoV-2 infection. In conclusion, SARS-CoV-2 T-cell and antibody responses persist for up to 10 months after a monovalent booster mRNA vaccination. An ancestral/Omicron BA.1 bivalent booster mRNA vaccination increases these immune responses and also induces Omicron BA.5 cross-neutralization antibody activity. Finally, our data indicate that hybrid immunity is associated with improved preservation of T-cell immunity.
    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19/prevention & control ; Prospective Studies ; T-Lymphocytes ; Vaccination ; Antibodies, Neutralizing ; RNA, Messenger ; Immunoglobulin G ; Antibodies, Viral
    Chemical Substances Antibodies, Neutralizing ; RNA, Messenger ; Immunoglobulin G ; Antibodies, Viral
    Language English
    Publishing date 2023-07-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28989
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    Zs.A 1320: Show issues Location:
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  10. Article ; Online: Development of an in-house SARS-CoV-2 interferon-gamma ELISpot and plate reader-free spot detection method.

    Mak, Willem A / Koeleman, Johannes G M / Ong, David S Y

    Journal of virological methods

    2021  Volume 300, Page(s) 114398

    Abstract: Coronavirus disease 2019 (COVID-19) vaccination programs rolled out in an attempt to stop the COVID-19 pandemic. Besides neutralising antibodies, effective T cell responses are also crucial for protection against severe acute respiratory syndrome ... ...

    Abstract Coronavirus disease 2019 (COVID-19) vaccination programs rolled out in an attempt to stop the COVID-19 pandemic. Besides neutralising antibodies, effective T cell responses are also crucial for protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and COVID-19 disease severity. To assess SARS-CoV-2-specific T cell immunity, we developed an interferon-gamma (IFN-γ) enzyme-linked immunospot (ELISpot) that can be deployed in research and diagnostic settings. We optimised our ELISpot by testing multiple antigen concentrations to stimulate peripheral blood mononuclear cells of SARS-CoV-2-unexposed, COVID-19 convalescent and COVID-19 vaccinated volunteers. Also, we developed an ELISpot plate reader-free method to detect and quantify spots, which we compared to manual spot counting and automated analysis by an ELISpot plate reader. We observed strong SARS-CoV-2-reactive T cell responses in COVID-19 convalescent, and COVID-19 vaccinated volunteers but absent or only weak responses in unexposed volunteers. Overall, antigens with concentrations from 0.1 to 5.0 μg/mL per peptide elicited similar T cell responses. Also, our plate reader-free detection method reliably detected and quantified SARS-CoV-2-specific T cells, demonstrated by an excellent reliability when compared to manual analysis and automated analysis by an ELISpot plate reader.
    MeSH term(s) Antibodies, Viral ; COVID-19/immunology ; Enzyme-Linked Immunospot Assay ; Humans ; Immunity, Cellular ; Interferon-gamma ; Leukocytes, Mononuclear ; Pandemics ; Reproducibility of Results ; SARS-CoV-2 ; T-Lymphocytes/immunology
    Chemical Substances Antibodies, Viral ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2021-12-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 8013-5
    ISSN 1879-0984 ; 0166-0934
    ISSN (online) 1879-0984
    ISSN 0166-0934
    DOI 10.1016/j.jviromet.2021.114398
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    Zs.A 1565: Show issues Location:
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