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  1. Article: Concomitant Cox-Maze IV techniques during mitral valve surgery.

    Lawrance, Christopher P / Henn, Matthew C / Damiano, Ralph J

    Annals of cardiothoracic surgery

    2015  Volume 4, Issue 5, Page(s) 483–486

    Language English
    Publishing date 2015-04-15
    Publishing country China
    Document type Journal Article
    ZDB-ID 2713627-9
    ISSN 2304-1021 ; 2225-319X
    ISSN (online) 2304-1021
    ISSN 2225-319X
    DOI 10.3978/j.issn.2225-319X.2014.12.06
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Surgery for Atrial Fibrillation.

    Lawrance, Christopher P / Henn, Matthew C / Damiano, Ralph J

    Heart failure clinics

    2016  Volume 12, Issue 2, Page(s) 235–243

    Abstract: Atrial fibrillation is the most common cardiac arrhythmia, and its treatment options include drug therapy or catheter-based or surgical interventions. The surgical treatment of atrial fibrillation has undergone multiple evolutions over the last several ... ...

    Abstract Atrial fibrillation is the most common cardiac arrhythmia, and its treatment options include drug therapy or catheter-based or surgical interventions. The surgical treatment of atrial fibrillation has undergone multiple evolutions over the last several decades. The Cox-Maze procedure went on to become the gold standard for the surgical treatment of atrial fibrillation and is currently in its fourth iteration (Cox-Maze IV). This article reviews the indications and preoperative planning for performing a Cox-Maze IV procedure. This article also reviews the literature describing the surgical results for both approaches including comparisons of the Cox-Maze IV to the previous cut-and-sew method.
    MeSH term(s) Ablation Techniques/adverse effects ; Ablation Techniques/methods ; Aftercare ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/surgery ; Catheter Ablation/adverse effects ; Catheter Ablation/methods ; Humans ; Intraoperative Care/methods ; Minimally Invasive Surgical Procedures/methods ; Recurrence ; Treatment Outcome
    Language English
    Publishing date 2016-03-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2212019-1
    ISSN 1551-7136
    ISSN 1551-7136
    DOI 10.1016/j.hfc.2015.08.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Surgical ablation for atrial fibrillation: techniques, indications, and results.

    Lawrance, Christopher P / Henn, Matthew C / Damiano, Ralph J

    Current opinion in cardiology

    2015  Volume 30, Issue 1, Page(s) 58–64

    Abstract: Purpose of review: The aim of this review is to focus specifically on the indications, evolution of technique, and results of surgical ablation for atrial fibrillation.: Recent findings: With the introduction of the Cox-Maze IV procedure utilizing ... ...

    Abstract Purpose of review: The aim of this review is to focus specifically on the indications, evolution of technique, and results of surgical ablation for atrial fibrillation.
    Recent findings: With the introduction of the Cox-Maze IV procedure utilizing bipolar radiofrequency ablation and cryoablation, long-term studies have demonstrated a significant decrease in aortic cross-clamp times and major complications with a comparable rate of restoration of sinus rhythm. New hybrid approaches utilizing both catheter-based ablation and minimally invasive surgical approaches have been developed, but have not been standardized. Early studies have demonstrated reasonable success rates of hybrid procedures, with advantages that include confirmation of conduction block, decreased surgical morbidity, and possibly reduced morbidity. However, hybrid approaches have the disadvantage of significantly increased operative times.
    Summary: The Cox-Maze IV is currently the gold standard for surgical treatment of atrial fibrillation. New hybrid approaches have potential advantages with promising early results, but a standard lesion set, improvement in operative times, and long-term results still need to be evaluated.
    MeSH term(s) Atrial Fibrillation/diagnosis ; Atrial Fibrillation/mortality ; Atrial Fibrillation/therapy ; Cardiac Catheterization/methods ; Catheter Ablation/methods ; Catheter Ablation/mortality ; Cryosurgery/methods ; Electrocardiography/methods ; Female ; Follow-Up Studies ; Humans ; Length of Stay ; Male ; Operative Time ; Patient Selection ; Postoperative Care/methods ; Risk Assessment ; Severity of Illness Index ; Survival Rate ; Treatment Outcome
    Language English
    Publishing date 2015-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 645186-x
    ISSN 1531-7080 ; 0268-4705
    ISSN (online) 1531-7080
    ISSN 0268-4705
    DOI 10.1097/HCO.0000000000000125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Surgery for atrial fibrillation.

    Lawrance, Christopher P / Henn, Matthew C / Damiano, Ralph J

    Cardiology clinics

    2014  Volume 32, Issue 4, Page(s) 563–571

    Abstract: Atrial fibrillation is the most common cardiac arrhythmia, and its treatment options include drug therapy or catheter-based or surgical interventions. The surgical treatment of atrial fibrillation has undergone multiple evolutions over the last several ... ...

    Abstract Atrial fibrillation is the most common cardiac arrhythmia, and its treatment options include drug therapy or catheter-based or surgical interventions. The surgical treatment of atrial fibrillation has undergone multiple evolutions over the last several decades. The Cox-Maze procedure went on to become the gold standard for the surgical treatment of atrial fibrillation and is currently in its fourth iteration (Cox-Maze IV). This article reviews the indications and preoperative planning for performing a Cox-Maze IV procedure. This article also reviews the literature describing the surgical results for both approaches including comparisons of the Cox-Maze IV to the previous cut-and-sew method.
    MeSH term(s) Atrial Fibrillation/diagnosis ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/surgery ; Catheter Ablation/adverse effects ; Catheter Ablation/methods ; Heart Atria/pathology ; Heart Atria/physiopathology ; Heart Atria/surgery ; Heart Conduction System/physiopathology ; Heart Conduction System/surgery ; Humans ; Intraoperative Care/methods ; Minimally Invasive Surgical Procedures ; Outcome Assessment (Health Care) ; Recurrence
    Language English
    Publishing date 2014-11
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1196385-2
    ISSN 1558-2264 ; 0733-8651
    ISSN (online) 1558-2264
    ISSN 0733-8651
    DOI 10.1016/j.ccl.2014.07.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Sex-Related Differences in Ventricular Tachyarrhythmia Events in Patients With Implantable Cardioverter-Defibrillator and Prior Ventricular Tachyarrhythmias.

    Krzowski, Bartosz / Kutyifa, Valentina / Vloka, Margot / Huang, David T / Attari, Mehran / Aktas, Mehmet / Shah, Abrar H / Musat, Dan / Rosenthal, Lawrance / McNitt, Scott / Polonsky, Bronislava / Schuger, Claudio / Natale, Andrea / Ziv, Ohad / Beck, Christopher / Daubert, James P / Goldenberg, Ilan / Zareba, Wojciech

    JACC. Clinical electrophysiology

    2023  Volume 10, Issue 2, Page(s) 284–294

    Abstract: ... HR: 0.67; P = 0.029), VT/VF (HR: 0.68; P = 0.049), VT/VF treated with antitachycardia pacing (HR: 0 ... 59; P = 0.019), and VT/VF treated with ICD shock (HR: 0.54; P = 0.035). The risk of recurrent VT/VF ... was also significantly lower in women (HR: 0.35; P < 0.001). HR for death was similar ...

    Abstract Background: Data on the risk of ventricular tachycardia (VT), ventricular fibrillation (VF), and death by sex in patients with prior VT/VF are limited.
    Objectives: This study aimed to assess sex-related differences in implantable cardioverter-defibrillator (ICD)-treated VT/VF events and death in patients implanted for secondary prevention or primary prevention ICD indications who experienced VT/VF before enrollment in the RAID (Ranolazine Implantable Cardioverter-Defibrillator) trial.
    Methods: Sex-related differences in the first and recurrent VT/VF requiring antitachycardia pacing or ICD shock and death were evaluated in 714 patients.
    Results: There were 124 women (17%) and 590 men observed during a mean follow-up of 26.81 ± 14.52 months. Compared to men, women were at a significantly lower risk of VT/VF/death (HR: 0.67; P = 0.029), VT/VF (HR: 0.68; P = 0.049), VT/VF treated with antitachycardia pacing (HR: 0.59; P = 0.019), and VT/VF treated with ICD shock (HR: 0.54; P = 0.035). The risk of recurrent VT/VF was also significantly lower in women (HR: 0.35; P < 0.001). HR for death was similar to the other endpoints (HR: 0.61; P = 0.162). In comparison to men, women presented with faster VT rates (196 ± 32 beats/min vs 177 ± 30 beats/min, respectively; P = 0.002), and faster shock-requiring VT/VF rates (258 ± 56 beats/min vs 227 ± 57 beats/min, respectively; P = 0.30). There was a significant interaction for the risk of VT/VF by race (P = 0.013) with White women having significantly lower risk than White men (HR: 0.36; P < 0.001), whereas Black women had a similar risk to Black men (HR: 1.06; P = 0.851).
    Conclusions: Women with a history of prior VT/VF experienced a lower risk recurrent VT/VF requiring ICD therapy when compared to men. Black Women had a risk similar to men, whereas the lower risk for VT/VF in women was observed primarily in White women. (Ranolazine Implantable Cardioverter-Defibrillator Trial; NCT01215253).
    MeSH term(s) Male ; Humans ; Female ; Defibrillators, Implantable/adverse effects ; Ranolazine ; Tachycardia, Ventricular ; Ventricular Fibrillation ; Arrhythmias, Cardiac/etiology
    Chemical Substances Ranolazine (A6IEZ5M406)
    Language English
    Publishing date 2023-11-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2023.09.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Right ventricular assist device with membrane oxygenator support for right ventricular failure following implantable left ventricular assist device placement.

    Leidenfrost, Jeremy / Prasad, Sunil / Itoh, Akinobu / Lawrance, Christopher P / Bell, Jennifer M / Silvestry, Scott C

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2016  Volume 49, Issue 1, Page(s) 73–77

    Abstract: ... alone (45.6 ± 15.9 vs 64.6 ± 6.5, P = 0.001). Support was weaned in 66% (10 of 15 ... oxygenation (P = 0.42). The RVAD was removed after 10.4 ± 9.4 vs 5 ± 2.99 days for patients with a RVAD ... with membrane oxygenation (P = 0.1). Patients with RVAD with membrane oxygenation had a 30-day mortality rate ...

    Abstract Objectives: Cardiogenic shock from refractory right ventricular (RV) failure during left ventricular assist device placement is associated with high morbidity and mortality. The addition of extracorporeal membrane oxygenation to RV mechanical assistance may help RV recovery and lead to improved outcomes.
    Methods: We retrospectively reviewed all implanted continuous-flow left ventricular assist devices from April 2009 to June 2013. RV mechanical support was utilized for RV failure defined as haemodynamic instability despite vasopressors, pulmonary vascular dilators and inotropic therapy. RV assist devices were utilized with and without in-line membrane oxygenation.
    Results: During the study period, 267 continuous-flow left ventricular assist devices were implanted. RV mechanical support was utilized in 27 (10%) patients; 12 (46%) had the addition of in-line extracorporeal membrane oxygenation. The mean age of patients with a right ventricular assist device with membrane oxygenation was lower than that in patients with a right ventricular assist device alone (45.6 ± 15.9 vs 64.6 ± 6.5, P = 0.001). Support was weaned in 66% (10 of 15) of patients with right ventricular assist device (RVAD) alone vs 83% (10 of 12) of those with RVAD with membrane oxygenation (P = 0.42). The RVAD was removed after 10.4 ± 9.4 vs 5 ± 2.99 days for patients with a RVAD with membrane oxygenation (P = 0.1). Patients with RVAD with membrane oxygenation had a 30-day mortality rate of 8 vs 47% for those with RVAD alone (P = 0.04). The survival rate after discharge was 86, 63 and 54% at 3, 6 and 12 months for both groups combined.
    Conclusions: Patients with a RVAD with membrane oxygenation support for acute RV failure after continuous-flow left ventricular assist device implantation had a lower 30-day mortality than those with a RVAD alone. Patients who survive to discharge have a reasonable 1-year survival. Combining membrane oxygenation with RVAD support appears to offer a short-term survival benefit in patients with RV failure after continuous-flow left ventricular assist device implantation.
    MeSH term(s) Adult ; Aged ; Combined Modality Therapy ; Extracorporeal Membrane Oxygenation/methods ; Female ; Follow-Up Studies ; Heart-Assist Devices ; Humans ; Male ; Middle Aged ; Oxygenators, Membrane ; Risk Assessment ; Severity of Illness Index ; Survival Analysis ; Time Factors ; Treatment Outcome ; Ventricular Dysfunction, Left/diagnosis ; Ventricular Dysfunction, Left/mortality ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Dysfunction, Left/surgery ; Ventricular Dysfunction, Right/mortality ; Ventricular Dysfunction, Right/physiopathology ; Ventricular Dysfunction, Right/surgery
    Language English
    Publishing date 2016-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezv116
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  7. Article: How I do it: minimally invasive Cox-Maze IV procedure.

    Saint, Lindsey L / Lawrance, Christopher P / Leidenfrost, Jeremy E / Robertson, Jason O / Damiano, Ralph J

    Annals of cardiothoracic surgery

    2014  Volume 3, Issue 1, Page(s) 117–119

    Language English
    Publishing date 2014-02-03
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2713627-9
    ISSN 2304-1021 ; 2225-319X
    ISSN (online) 2304-1021
    ISSN 2225-319X
    DOI 10.3978/j.issn.2225-319X.2013.12.01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Surgical techniques used for the treatment of atrial fibrillation.

    Robertson, Jason O / Lawrance, Christopher P / Maniar, Hersh S / Damiano, Ralph J

    Circulation journal : official journal of the Japanese Circulation Society

    2013  Volume 77, Issue 8, Page(s) 1941–1951

    Abstract: The use of surgical lesion sets for the treatment of atrial fibrillation has been increasing, particularly in patients with complicated anatomical substrates and those undergoing concomitant surgery. Preferences in terms of lesion set, surgical approach ... ...

    Abstract The use of surgical lesion sets for the treatment of atrial fibrillation has been increasing, particularly in patients with complicated anatomical substrates and those undergoing concomitant surgery. Preferences in terms of lesion set, surgical approach and ablation technology vary by center. This review discusses both the surgical techniques and the outcomes for the most commonly performed procedures in the context of recent consensus guidelines. The Cox-Maze IV, pulmonary vein isolation, extended left atrial lesion sets, the hybrid approach and ganglionated plexus ablation are each reviewed in an attempt to provide insight into current clinical practice and patient selection.
    MeSH term(s) Atrial Fibrillation/pathology ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/surgery ; Cardiac Surgical Procedures/methods ; Cardiac Surgical Procedures/standards ; Humans
    Language English
    Publishing date 2013-07-03
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.cj-13-0721
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  9. Article: Medical and Surgical Management of a Descending Aorta Penetrating Atherosclerotic Ulcer and Associated Ascending Intramural Hematoma.

    Henn, Matthew C / Lawrance, Christopher P / Braverman, Alan C / Sanchez, Luis / Lawton, Jennifer S

    Aorta (Stamford, Conn.)

    2014  Volume 2, Issue 2, Page(s) 77–81

    Abstract: A 69-year-old man presented with chest pain and a computed tomography scan demonstrated an acute penetrating atherosclerotic ulcer (PAU) of the proximal descending aorta with an associated intramural hematoma (IMH) extending retrograde to the aortic root ...

    Abstract A 69-year-old man presented with chest pain and a computed tomography scan demonstrated an acute penetrating atherosclerotic ulcer (PAU) of the proximal descending aorta with an associated intramural hematoma (IMH) extending retrograde to the aortic root and distally to the renal arteries. He successfully underwent endovascular repair of the PAU and medical management of the associated ascending intramural hematoma with complete resolution at 6 months.
    Language English
    Publishing date 2014-04-01
    Publishing country Germany
    Document type Case Reports
    ISSN 2325-4637
    ISSN 2325-4637
    DOI 10.12945/j.aorta.2014.13-060
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  10. Article ; Online: The Electrophysiologic Effects of Acute Mitral Regurgitation in a Canine Model.

    Lawrance, Christopher P / Henn, Matthew C / Miller, Jacob R / Kopek, Michael A / Zhang, Andrew J / Schuessler, Richard B / Damiano, Ralph J

    The Annals of thoracic surgery

    2017  Volume 103, Issue 4, Page(s) 1277–1284

    Abstract: Background: Atrial fibrillation (AF) occurs in 30% of patients with mitral regurgitation referred for surgical intervention. However, the underlying mechanisms in this population are poorly understood. This study examined the effects of acute left ... ...

    Abstract Background: Atrial fibrillation (AF) occurs in 30% of patients with mitral regurgitation referred for surgical intervention. However, the underlying mechanisms in this population are poorly understood. This study examined the effects of acute left atrial volume overload on atrial electrophysiology and the inducibility of AF.
    Methods: Ten canines underwent insertion of an atrioventricular shunt between the left ventricle and left atrium. Shunt and aortic flows were calculated, and the shunt was titrated to a shunt fraction to 40% to 50% of cardiac output. An epicardial plaque with 250 bipolar electrodes was used to determine activation and refractory periods. Biatrial pressures and volumes, conduction times, and atrial fibrillation inducibility were recorded. Data were collected at baseline and 20 minutes after shunt opening and closure.
    Results: Mean shunt flow was 1.3 ± 0.5 L/min with a shunt fraction of 43% ± 6% simulating moderate to severe mitral regurgitation. Compared with baseline, left atrial volumes and maximum pressures increased by 27% and 29%, respectively, after shunt opening. Biatrial effective refractory periods did not change significantly after shunt opening or closure. Conduction times increased by 9% with shunt opening and returned to baseline after closure. AF duration or inducibility did not change with shunt opening.
    Conclusions: This canine model of mitral regurgitation demonstrated that acute left atrial volume overload did not increase the inducibility of atrial arrhythmias in contrast with experimental and clinical findings of chronic left atrial volume overload. This suggests that the substrates for AF in patients with mitral regurgitation are a result of chronic remodeling.
    MeSH term(s) Acute Disease ; Animals ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/etiology ; Atrial Fibrillation/physiopathology ; Atrial Pressure ; Disease Models, Animal ; Dogs ; Heart Conduction System/physiopathology ; Mitral Valve Insufficiency/complications ; Mitral Valve Insufficiency/physiopathology
    Language English
    Publishing date 2017-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2016.08.011
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