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  1. Article: The Pharmacological Activity of the Wenjing Decoction in Recurrent Spontaneous Abortion.

    Cao, Linhui / Chen, Hui / Huang, Yanxia / Chen, Liudan / Kang, Mengru / Liang, Junxiong

    Evidence-based complementary and alternative medicine : eCAM

    2021  Volume 2021, Page(s) 8861394

    Abstract: ... with the use of traditional Chinese medicine preparation, the Wenjing decoction. This study aimed to identify ... the therapeutic mechanism of Wenjing decoction on specific target proteins involved in RSA.: Methods: Wenjing ... of Wenjing decoction in RSA. ...

    Abstract Background: Recurrent spontaneous abortion (RSA) is intractable infertility and can be ameliorated with the use of traditional Chinese medicine preparation, the Wenjing decoction. This study aimed to identify the therapeutic mechanism of Wenjing decoction on specific target proteins involved in RSA.
    Methods: Wenjing decoction contains Wuzhuyu, Danggui, Chuanxiong, Guizhi, Shengjiang, Banxia, Gancao, Ejiao, Mudanpi, Chishao, Dangshen, and Maidong. Using TCMSP and BATMAN databases, we queried for active ingredients and predicted their target proteins by BATMAN. Using the edgeR package, we analyzed the differentially expressed genes (DEGs) in the GSE121950 database between control samples and RSA (
    Results: In total, 31, 2, 7, 7, 5, 13, 93, 11, 29, and 21 active ingredients were identified from Wuzhuyu, Danggui, Chuanxiong, Guizhi, Shengjiang, Banxia, Gancao, Mudanpi, Chishao, and Dangshen, respectively. Additionally, 100 intersected target proteins were revealed by the Venn diagram. Moreover, 98 functional terms and 24 pathways (including C-type lectin receptor signaling pathway, chemokine signaling pathway, leukocyte transendothelial migration, fluid shear stress, and atherosclerosis, and AGE-RAGE signaling pathway in diabetic complications) were enriched. In the PPI network, 10 proteins involved in these five pathways were identified, namely, TNF-
    Conclusion: The abovementioned genes and pathways might be involved in the pharmacological activity of Wenjing decoction in RSA.
    Language English
    Publishing date 2021-04-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2021/8861394
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  2. Article ; Online: The Pharmacological Activity of the Wenjing Decoction in Recurrent Spontaneous Abortion

    Linhui Cao / Hui Chen / Yanxia Huang / Liudan Chen / Mengru Kang / Junxiong Liang

    Evidence-Based Complementary and Alternative Medicine, Vol

    2021  Volume 2021

    Abstract: ... with the use of traditional Chinese medicine preparation, the Wenjing decoction. This study aimed to identify ... the therapeutic mechanism of Wenjing decoction on specific target proteins involved in RSA. Methods. Wenjing ...

    Abstract Background. Recurrent spontaneous abortion (RSA) is intractable infertility and can be ameliorated with the use of traditional Chinese medicine preparation, the Wenjing decoction. This study aimed to identify the therapeutic mechanism of Wenjing decoction on specific target proteins involved in RSA. Methods. Wenjing decoction contains Wuzhuyu, Danggui, Chuanxiong, Guizhi, Shengjiang, Banxia, Gancao, Ejiao, Mudanpi, Chishao, Dangshen, and Maidong. Using TCMSP and BATMAN databases, we queried for active ingredients and predicted their target proteins by BATMAN. Using the edgeR package, we analyzed the differentially expressed genes (DEGs) in the GSE121950 database between control samples and RSA (n = 3). The interaction between DEGs and the predicted target proteins was identified by the Venn diagram. Using the Cytoscape software and clusterProfiler package, enrichment analysis was conducted for the intersected target proteins. Additionally, the protein-protein interaction (PPI) network and pharmacological network were generated using the Cytoscape software. Results. In total, 31, 2, 7, 7, 5, 13, 93, 11, 29, and 21 active ingredients were identified from Wuzhuyu, Danggui, Chuanxiong, Guizhi, Shengjiang, Banxia, Gancao, Mudanpi, Chishao, and Dangshen, respectively. Additionally, 100 intersected target proteins were revealed by the Venn diagram. Moreover, 98 functional terms and 24 pathways (including C-type lectin receptor signaling pathway, chemokine signaling pathway, leukocyte transendothelial migration, fluid shear stress, and atherosclerosis, and AGE-RAGE signaling pathway in diabetic complications) were enriched. In the PPI network, 10 proteins involved in these five pathways were identified, namely, TNF-α (tumor necrosis factor-α), IL-10 (interleukin-10), TLR4 (Toll-like receptor 4), JUN (Jun proto-oncogene), IL-1B (interleukin-1-beta), CYBB (cytochrome b558 heavy chain gene), PTGS2 (prostaglandin-endoperoxide synthase 2), APOE (apolipoprotein E), SPI1 (salmonella pathogenicity island 1), and MPO ...
    Keywords Other systems of medicine ; RZ201-999
    Subject code 572 ; 570
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Protocol to separate small and large extracellular vesicles from mouse and human cardiac tissues.

    Liang, Wenjing / Najor, Rita H / Gustafsson, Åsa B

    STAR protocols

    2024  Volume 5, Issue 1, Page(s) 102914

    Abstract: ... details on the use and execution of this protocol, please refer to Liang et al. (2023). ...

    Abstract Extracellular vesicles (EVs) are secreted by cells under various conditions and can contribute to the disease progression in tissues. Here, we present a protocol to separate small and large EVs from mouse hearts and cardiac tissues collected from patients. We describe steps for utilizing enzymatic digestion for release of EVs from interstitial space followed by differential centrifugation and immunoaffinity purification. The isolated EVs can be used for various experiments to gain insight into their in vivo functions. For complete details on the use and execution of this protocol, please refer to Liang et al. (2023).
    MeSH term(s) Humans ; Mice ; Animals ; Extracellular Vesicles ; Heart ; Centrifugation
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2024.102914
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  4. Article ; Online: Merkel cell carcinoma in a 38-year-old man: a case report.

    Liu, Yixin / Liang, Wenjing / Chen, Qiongrong / Wei, Yongchang

    Anais brasileiros de dermatologia

    2023  Volume 98, Issue 6, Page(s) 860–863

    MeSH term(s) Male ; Humans ; Adult ; Carcinoma, Merkel Cell/pathology ; Skin Neoplasms/pathology
    Language English
    Publishing date 2023-06-29
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 433655-0
    ISSN 1806-4841 ; 0365-0596
    ISSN (online) 1806-4841
    ISSN 0365-0596
    DOI 10.1016/j.abd.2022.05.009
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  5. Article ; Online: Teaching the "Four Ming Acupressure Points" massage method for adolescent myopia prevention and treatment.

    Mei, Wenjing / Su, Wei / Liang, Jing / Yu, Juan

    Asian journal of surgery

    2023  Volume 46, Issue 12, Page(s) 5985–5986

    MeSH term(s) Humans ; Adolescent ; Acupressure/methods ; Pain Management/methods ; Massage/methods
    Language English
    Publishing date 2023-09-16
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.09.019
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  6. Article: The combination use of inclisiran and statins versus statins alone in the treatment of dyslipidemia in mainland China: a cost-effectiveness analysis.

    Zhou, Wenjing / Liang, Zhuoru / Lou, Xiaohuan / Wang, Nansong / Liu, Xinyu / Li, Ruoxi / Pai, Pearl

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1283922

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2024-02-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1283922
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  7. Article: Effects of Exogenous Isosteviol on the Physiological Characteristics of

    Xia, Wenjing / Meng, Wangang / Peng, Yueqin / Qin, Yutian / Zhang, Liang / Zhu, Nianqing

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 2

    Abstract: In this paper, the effect of isosteviol on the physiological metabolism ... ...

    Abstract In this paper, the effect of isosteviol on the physiological metabolism of
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13020217
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  8. Article ; Online: ReeGAN: MRI image edge-preserving synthesis based on GANs trained with misaligned data.

    Lu, Xiangjiang / Liang, Xiaoshuang / Liu, Wenjing / Miao, Xiuxia / Guan, Xianglong

    Medical & biological engineering & computing

    2024  Volume 62, Issue 6, Page(s) 1851–1868

    Abstract: As a crucial medical examination technique, different modalities of magnetic resonance imaging (MRI) complement each other, offering multi-angle and multi-dimensional insights into the body's internal information. Therefore, research on MRI cross- ... ...

    Abstract As a crucial medical examination technique, different modalities of magnetic resonance imaging (MRI) complement each other, offering multi-angle and multi-dimensional insights into the body's internal information. Therefore, research on MRI cross-modality conversion is of great significance, and many innovative techniques have been explored. However, most methods are trained on well-aligned data, and the impact of misaligned data has not received sufficient attention. Additionally, many methods focus on transforming the entire image and ignore crucial edge information. To address these challenges, we propose a generative adversarial network based on multi-feature fusion, which effectively preserves edge information while training on noisy data. Notably, we consider images with limited range random transformations as noisy labels and use an additional small auxiliary registration network to help the generator adapt to the noise distribution. Moreover, we inject auxiliary edge information to improve the quality of synthesized target modality images. Our goal is to find the best solution for cross-modality conversion. Comprehensive experiments and ablation studies demonstrate the effectiveness of the proposed method.
    MeSH term(s) Magnetic Resonance Imaging/methods ; Humans ; Image Processing, Computer-Assisted/methods ; Algorithms ; Neural Networks, Computer
    Language English
    Publishing date 2024-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 282327-5
    ISSN 1741-0444 ; 0025-696X ; 0140-0118
    ISSN (online) 1741-0444
    ISSN 0025-696X ; 0140-0118
    DOI 10.1007/s11517-024-03035-w
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  9. Article ; Online: High Value-Added Application of Natural Products in Crop Protection: Discovery and Exploration of Caffeoyl and Flavonoid Derivatives from

    Hao, Nan / Liang, Shuangshuang / Sun, Wenjing / Zhang, SunAo / Wang, Yuanyuan / Tian, Xiangrong

    Journal of agricultural and food chemistry

    2024  Volume 72, Issue 14, Page(s) 7919–7932

    Abstract: Nine caffeoyl derivatives ( ...

    Abstract Nine caffeoyl derivatives (
    MeSH term(s) Animals ; Insecticides/pharmacology ; Insecticides/chemistry ; Moths ; Clematis/chemistry ; Flavonoids/pharmacology ; Biological Products/pharmacology ; Crop Protection
    Chemical Substances Insecticides ; Flavonoids ; Biological Products
    Language English
    Publishing date 2024-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c09623
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  10. Article ; Online: Discovery of New Botanical Insecticides: Identification and Insecticidal Activity of Saponins from

    Hao, Nan / Qi, Yinyin / Zhao, Long / Liang, Shuangshuang / Sun, Wenjing / Zhang, Sunao / Tian, Xiangrong

    Journal of agricultural and food chemistry

    2024  Volume 72, Issue 9, Page(s) 4596–4609

    Abstract: To discover new botanical products-based insecticide candidates, 14 triterpenoid saponins ( ...

    Abstract To discover new botanical products-based insecticide candidates, 14 triterpenoid saponins (
    MeSH term(s) Animals ; Insecticides/chemistry ; Saponins/chemistry ; Clematis/chemistry ; Pisum sativum ; Molecular Docking Simulation ; Moths ; Larva ; Aphids ; Chitinases
    Chemical Substances Insecticides ; Saponins ; Chitinases (EC 3.2.1.14)
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c06557
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