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Article ; Online: Outcomes of Emergency Department Patients With Opioid Use Disorder Utilizing a Virtual Addiction Bridge Clinic: A Case Series.

Wills, Brandon K / Ringwood, Katy J / Davis, Theresa T / Provost, Rosellen / Bachireddy, Chethan / Wang, Jennifer / Keyser-Marcus, Lori / Moeller, F Gerard

Journal of addiction medicine

2023 Volume 17, Issue 6, Page(s) 729–731

Abstract: ... discharge among patients with opioid use disorder (OUD) enrolled in a virtual Addiction Bridge Clinic (ABC ... at 6 months after the index ED visit.: Conclusions: A telehealth-enabled virtual addiction bridge ... to improve subsequent addiction treatment engagement after a virtual addiction bridge clinic visit. ...

Abstract	Objectives: Within the last decade, there has been a dramatic increase in the rate of emergency department (ED) visits and death from opioid overdose. Those who present to the ED are at high risk for subsequent morbidity and mortality. Despite effective treatment, many patients do not get rapidly connected to outpatient care. The aim of this investigation was to describe outpatient treatment engagement after ED discharge among patients with opioid use disorder (OUD) enrolled in a virtual Addiction Bridge Clinic (ABC). Methods: This was a retrospective case series describing an ED-initiated referral for rapid telehealth follow-up among patients with OUD. The primary outcome was addiction treatment engagement among those who completed the initial virtual ABC visit (engaged in ABC) vs. those who did not complete an ABC visit (Not engaged in ABC) at 1 week, 1 month, and 3 and 6 months timepoint intervals after the initial ED presentation. Results: Of the N = 201 patients referred to the ABC between March and December 2021, a majority were Black (71%) and male (77%). Of the 201 referrals, 85 (42%) completed an initial ABC telehealth visit. Subsequent treatment engagement was 26% at 1 week, 26% at 1 month, 22% at 3 months, and 18% at 6 months after the index ED visit. Conclusions: A telehealth-enabled virtual addiction bridge clinic is one potential approach to reduce barriers to rapid treatment access. Strategies are needed to improve subsequent addiction treatment engagement after a virtual addiction bridge clinic visit.
MeSH term(s)	Humans ; Male ; Retrospective Studies ; Opioid-Related Disorders ; Opiate Overdose ; Ambulatory Care ; Emergency Service, Hospital
Language	English
Publishing date	2023-09-20
Publishing country	Netherlands
Document type	Journal Article
ISSN	1935-3227
ISSN (online)	1935-3227
DOI	10.1097/ADM.0000000000001222
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Article: Bridging the Gap: Utilizing a Pediatric Trauma Care Coordinator to Reduce Disparities for Pediatric Trauma Follow-Up Care.

McRoberts, Christina M / Bohlen, Nie / Wills, Hale E

Journal of trauma nursing : the official journal of the Society of Trauma Nurses

2019 Volume 26, Issue 4, Page(s) 193–198

Abstract: ... and developed a novel pediatric trauma care coordinator (PTCC) nursing position to bridge the gap ...

Abstract	An American College of Surgeons-verified Level I pediatric trauma center found that some children with severe and complex injuries experienced disruptions in trauma follow-up care because of the lack of centralized care coordination after hospital discharge. A review of the literature identified little guidance to address this issue. A quality improvement project assessed the gaps in care, identified high-risk patients, and developed a novel pediatric trauma care coordinator (PTCC) nursing position to bridge the gap. Enhancements to the trauma registry software helped create a log of family and provider communication events with and interventions by the PTCC. High-risk patients were defined as those with either a traumatic brain injury plus 1 other organ system injury requiring surgical specialist follow-up, or those with 3 or more different organ system injuries requiring follow-up with a surgical specialist. Costly return to health care (CRH), which we defined as emergency department visits for 72 hr or less or unplanned readmissions of 30 day or less after hospital discharge was selected as the primary outcome measure and assessed during the pre- and postimplementation periods. In the 12-month preimplementation period, 14 patients had a CRH rate of 14%, compared with the 12-month postimplementation period in which 18 patients had a CRH rate of 0%. Patients received a mean of 21.2 communication events and 14.1 intervention events from the PTCC in the postimplementation period. This report details the process of developing and implementing a PTCC nursing position, the tasks involved, and the initial results of this novel program.
MeSH term(s)	Aftercare/standards ; Brain Injuries, Traumatic/nursing ; Child ; Child Health Services/standards ; Cohort Studies ; Emergency Service, Hospital ; Female ; Humans ; Male ; Nursing, Supervisory ; Pediatric Nursing ; Quality Improvement ; Rhode Island ; Trauma Centers
Language	English
Publishing date	2019-07-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1281159-2
ISSN	1078-7496
ISSN	1078-7496
DOI	10.1097/JTN.0000000000000448
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Article: Microvascular Fluid Exchange: Implications of the Revised Starling Model for Resuscitation of Dengue Shock Syndrome.

Trung, Dinh The / Trieu, Huynh Trung / Wills, Bridget A

Frontiers in medicine

2020 Volume 7, Page(s) 601520

Abstract: Dengue is the most common mosquito-borne viral infection in the world. The most feared complication is a poorly understood vasculopathy that occurs in only a small minority of symptomatic individuals, especially children and young adults, but can result ... ...

Abstract	Dengue is the most common mosquito-borne viral infection in the world. The most feared complication is a poorly understood vasculopathy that occurs in only a small minority of symptomatic individuals, especially children and young adults, but can result in potentially fatal dengue shock syndrome (DSS). Based mainly on expert opinion, WHO management guidelines for DSS recommend prompt infusion of a crystalloid fluid bolus followed by a tapering crystalloid fluid regimen, supplemented if necessary by boluses of synthetic colloid solutions. However, following publication of a number of major trials undertaken in other, primarily adult, critical care scenarios, use of both synthetic colloid solutions and of fluid boluses for volume expansion have become controversial. Synthetic colloids tend to be used for severe DSS cases in order to boost intravascular oncotic pressure, based on the classic Starling hypothesis in which opposing hydrostatic and oncotic forces determine fluid flow across the microvascular barrier. However, the revised Starling model emphasizes the critical contribution of the endothelial glycocalyx layer (EGL), indicating that it is the effective oncotic pressure gradient across the EGL not endothelial cells
Language	English
Publishing date	2020-12-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2020.601520
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Article ; Online: The disparity of priapulid, archaeopriapulid and palaeoscolecid worms in the light of new data.

Wills, M A / Gerber, S / Ruta, M / Hughes, M

Journal of evolutionary biology

2012 Volume 25, Issue 10, Page(s) 2056–2076

Abstract: Priapulids and their extinct relatives, the archaeopriapulids and palaeoscolecids, are vermiform, carnivorous ecdysozoans with an armoured, extensible proboscis. These worms were an important component of marine communities during the Palaeozoic, but ... ...

Abstract	Priapulids and their extinct relatives, the archaeopriapulids and palaeoscolecids, are vermiform, carnivorous ecdysozoans with an armoured, extensible proboscis. These worms were an important component of marine communities during the Palaeozoic, but were especially abundant and diverse in the Cambrian. Today, they comprise just seven genera in four families. Priapulids were among the first groups used to test hypotheses concerning the morphological disparity of Cambrian fossils relative to the extant fauna. A previous study sampled at the generic level, concluding that Cambrian genera embodied marginally less morphological diversity than their extant counterparts. Here, we sample predominantly at the species level and include numerous fossils and some extant forms described in the last fifteen years. Empirical morphospaces for priapulids, archaeopriapulids and palaeoscolecids are relatively insensitive to changes in the taxon or character sample: their overall form has altered little, despite the markedly improved sampling. Cambrian and post-Cambrian genera occupy adjacent rather than broadly overlapping regions of these spaces, and Cambrian species still show lower morphological disparity than their post-Cambrian counterparts. Crucially, the significance of this difference has increased with improved taxon sampling over research time. In contrast with empirical morphospaces, the phylogeny of priapulids, archaeopriapulids and palaeoscolecids derived from morphological characters is extremely sensitive to details of taxon sampling and the manner in which characters are weighted. However, the extant Priapulidae and Halicryptidae invariably resolve as sister families, with this entire clade subsequently being sister group to the Maccabeidae. In our most inclusive trees, the extant Tubiluchidae are separated from these other living taxa by a number of small, intervening fossil clades.
MeSH term(s)	Animals ; Biological Evolution ; Extinction, Biological ; Genetic Speciation ; Genetic Variation ; Invertebrates/genetics
Language	English
Publishing date	2012-10
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1465318-7
ISSN	1420-9101 ; 1010-061X
ISSN (online)	1420-9101
ISSN	1010-061X
DOI	10.1111/j.1420-9101.2012.02586.x
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Article ; Online: Implementing a dengue vaccination programme-who, where and how?

E Clapham, Hannah / A Wills, Bridget

Transactions of the Royal Society of Tropical Medicine and Hygiene

2018 Volume 112, Issue 8, Page(s) 367–368

Abstract: The complex interaction between dengue viruses and the human immune system means that development of a safe, effective dengue vaccine was never going to be simple. The only currently licenced dengue vaccine (Dengvaxia®) does, indeed, have a complex ... ...

Abstract	The complex interaction between dengue viruses and the human immune system means that development of a safe, effective dengue vaccine was never going to be simple. The only currently licenced dengue vaccine (Dengvaxia®) does, indeed, have a complex immune profile depending on recipients' immune status, meaning that use of this vaccine is not straightforward. This commentary reviews the recommendations for vaccine use to date, and discusses issues and opportunities related to the implementation of vaccination programmes in light of these recommendations. Future dengue vaccines may also have similar profiles, so it is vital that these issues are addressed now to ensure optimal use of vaccination in the fight against dengue globally.
MeSH term(s)	Antibody-Dependent Enhancement ; Dengue/prevention & control ; Dengue/virology ; Dengue Vaccines/immunology ; Dengue Virus/classification ; Dengue Virus/immunology ; Global Health ; Humans ; Immunization Programs ; Patient Selection ; Program Development ; Serogroup ; Severe Dengue ; Vaccination
Chemical Substances	Dengue Vaccines
Language	English
Publishing date	2018-07-06
Publishing country	England
Document type	Journal Article
ZDB-ID	441375-1
ISSN	1878-3503 ; 0035-9203
ISSN (online)	1878-3503
ISSN	0035-9203
DOI	10.1093/trstmh/try070
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Article ; Online: Microvascular Fluid Exchange

Dinh The Trung / Huynh Trung Trieu / Bridget A. Wills

Frontiers in Medicine, Vol

Implications of the Revised Starling Model for Resuscitation of Dengue Shock Syndrome

2020 Volume 7

Abstract	Dengue is the most common mosquito-borne viral infection in the world. The most feared complication is a poorly understood vasculopathy that occurs in only a small minority of symptomatic individuals, especially children and young adults, but can result in potentially fatal dengue shock syndrome (DSS). Based mainly on expert opinion, WHO management guidelines for DSS recommend prompt infusion of a crystalloid fluid bolus followed by a tapering crystalloid fluid regimen, supplemented if necessary by boluses of synthetic colloid solutions. However, following publication of a number of major trials undertaken in other, primarily adult, critical care scenarios, use of both synthetic colloid solutions and of fluid boluses for volume expansion have become controversial. Synthetic colloids tend to be used for severe DSS cases in order to boost intravascular oncotic pressure, based on the classic Starling hypothesis in which opposing hydrostatic and oncotic forces determine fluid flow across the microvascular barrier. However, the revised Starling model emphasizes the critical contribution of the endothelial glycocalyx layer (EGL), indicating that it is the effective oncotic pressure gradient across the EGL not endothelial cells per se that opposes filtration. Based on several novel concepts that are integral to the revised Starling model, we review the clinical features of DSS and discuss a number of implications that are relevant for fluid management. We also highlight the need for context-specific clinical trials that address crucially important questions around the management of DSS.
Keywords	revised Starling model ; dengue shock syndrome ; fluid management ; endothelial glycocalyx layer ; tight junction ; colloid ; Medicine (General) ; R5-920
Subject code	532
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: Neurosyphilis Presenting with Facial Nodules.

Shen, Nancy W / Wills, Abby C / Bryer, Bridget M

The American journal of medicine

2023 Volume 137, Issue 4, Page(s) 318–320

MeSH term(s)	Humans ; Neurosyphilis/complications ; Neurosyphilis/diagnosis ; Neurosyphilis/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Head
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2023.11.008
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Article ; Online: Dengue.

Wilder-Smith, Annelies / Ooi, Eng-Eong / Horstick, Olaf / Wills, Bridget

Lancet (London, England)

2019 Volume 393, Issue 10169, Page(s) 350–363

Abstract: Mortality from severe dengue is low, but the economic and resource burden on health services remains substantial in endemic settings. Unfortunately, progress towards development of effective therapeutics has been slow, despite notable advances in the ... ...

Abstract	Mortality from severe dengue is low, but the economic and resource burden on health services remains substantial in endemic settings. Unfortunately, progress towards development of effective therapeutics has been slow, despite notable advances in the understanding of disease pathogenesis and considerable investment in antiviral drug discovery. For decades antibody-dependent enhancement has been the prevalent model to explain dengue pathogenesis, but it was only recently demonstrated in vivo and in clinical studies. At present, the current mainstay of management for most symptomatic dengue patients remains careful observation and prompt but judicious use of intravenous hydration therapy for those with substantial vascular leakage. Various new promising technologies for diagnosis of dengue are currently in the pipeline. New sample-in, answer-out nucleic acid amplification technologies for point-of-care use are being developed to improve performance over current technologies, with the potential to test for multiple pathogens using a single specimen. The search for biomarkers that reliably predict development of severe dengue among symptomatic individuals is also a major focus of current research efforts. The first dengue vaccine was licensed in 2015 but its performance depends on serostatus. There is an urgent need to identify correlates of both vaccine protection and disease enhancement. A crucial assessment of vector control tools should guide a research agenda for determining the most effective interventions, and how to best combine state-of-the-art vector control with vaccination.
MeSH term(s)	Animals ; Arthropod Vectors ; Dengue/epidemiology ; Dengue Vaccines ; Dengue Virus/pathogenicity ; Drug Discovery ; Global Health ; Humans ; Nucleic Acid Amplification Techniques/methods ; Serogroup ; Vaccination/methods
Chemical Substances	Dengue Vaccines
Language	English
Publishing date	2019-01-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(18)32560-1
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Article ; Online: Fourth Controlled Human Infection Model (CHIM) meeting, CHIM regulatory issues, May 24, 2023.

Biologicals : journal of the International Association of Biological Standardization

2024 Volume 85, Page(s) 101745

Abstract: Many aspects of Controlled Human Infection Models (CHIMs, also known as human challenge studies and human infection studies) have been discussed extensively, including Good Manufacturing Practice (GMP) production of the challenge agent, CHIM ethics, ... ...

Abstract	Many aspects of Controlled Human Infection Models (CHIMs, also known as human challenge studies and human infection studies) have been discussed extensively, including Good Manufacturing Practice (GMP) production of the challenge agent, CHIM ethics, environmental safety in CHIM, recruitment, community engagement, advertising and incentives, pre-existing immunity, and clinical, immunological, and microbiological endpoints. The fourth CHIM meeting focused on regulation of CHIM studies, bringing together scientists and regulators from high-, middle-, and low-income countries, to discuss barriers and hurdles in CHIM regulation. Valuable initiatives for regulation of CHIMs have already been undertaken but further capacity building remains essential. The Wellcome Considerations document is a good starting point for further discussions.
Language	English
Publishing date	2024-02-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1017370-5
ISSN	1095-8320 ; 1045-1056
ISSN (online)	1095-8320
ISSN	1045-1056
DOI	10.1016/j.biologicals.2024.101745
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Article: Visual and Biochemical Evidence of Glycocalyx Disruption in Human Dengue Infection, and Association With Plasma Leakage Severity.

Lam, Phung Khanh / McBride, Angela / Le, Duyen Huynh Thi / Huynh, Trieu Trung / Vink, Hans / Wills, Bridget / Yacoub, Sophie

Frontiers in medicine

2020 Volume 7, Page(s) 545813

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2020-10-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2020.545813
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