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Article ; Online: Comprehensive characterization of early-programmed tumor microenvironment by tumor-associated macrophages reveals galectin-1 as an immune modulatory target in breast cancer.

Chung, Hyewon / Gyu-Mi, Park / Na, Yi Rang / Lee, Yun-Sang / Choi, Hongyoon / Seok, Seung Hyeok

2024 Volume 14, Issue 2, Page(s) 843–860

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Female ; Breast Neoplasms/pathology ; Tumor-Associated Macrophages ; Tumor Microenvironment ; Galectin 1/genetics ; Galectin 1/metabolism ; CD8-Positive T-Lymphocytes ; Macrophages/metabolism ; Immunity
Chemical Substances	Galectin 1 ; 1-nitrohydroxyphenyl-N-benzoylalanine (59921-69-6)
Language	English
Publishing date	2024-01-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.88917
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Article ; Online: Rapid Direct Identification of Microbial Pathogens and Antimicrobial Resistance Genes in Positive Blood Cultures Using a Fully Automated Multiplex PCR Assay.

Kim, Keun Ju / Yun, Seung Gyu / Cho, Yunjung / Lee, Chang Kyu / Nam, Myung-Hyun

Journal of Korean medical science

2024 Volume 39, Issue 17, Page(s) e157

Abstract: This study assessed the performance of the BioFire Blood Culture Identification 2 (BCID2) panel in identifying microorganisms and antimicrobial resistance (AMR) profiles in positive blood cultures (BCs) and its influence on turnaround time (TAT) compared ...

Abstract	This study assessed the performance of the BioFire Blood Culture Identification 2 (BCID2) panel in identifying microorganisms and antimicrobial resistance (AMR) profiles in positive blood cultures (BCs) and its influence on turnaround time (TAT) compared with conventional culture methods. We obtained 117 positive BCs, of these, 102 (87.2%) were correctly identified using BCID2. The discordance was due to off-panel pathogens detected by culture (n = 13), and additional pathogens identified by BCID2 (n = 2). On-panel pathogen concordance between the conventional culture and BCID2 methods was 98.1% (102/104). The conventional method detected 19 carbapenemase-producing organisms, 14 extended-spectrum beta-lactamase-producing Enterobacterales, 18 methicillin-resistant
MeSH term(s)	Multiplex Polymerase Chain Reaction/methods ; Blood Culture ; Humans ; Microbial Sensitivity Tests ; Drug Resistance, Bacterial/genetics ; Bacterial Proteins/genetics ; beta-Lactamases/genetics ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Enterococcus faecium/genetics ; Enterococcus faecium/isolation & purification ; Bacteria/genetics ; Bacteria/isolation & purification ; Bacteria/drug effects ; Vancomycin-Resistant Enterococci/genetics ; Vancomycin-Resistant Enterococci/isolation & purification ; Bacteremia/microbiology ; Bacteremia/diagnosis
Chemical Substances	Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6) ; Anti-Bacterial Agents ; carbapenemase (EC 3.5.2.6)
Language	English
Publishing date	2024-05-06
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	639262-3
ISSN	1598-6357 ; 1011-8934
ISSN (online)	1598-6357
ISSN	1011-8934
DOI	10.3346/jkms.2024.39.e157
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Article ; Online: Comparison of Biotin Interference in Second- and Third-Generation Roche Free Thyroxine Immunoassays.

Choi, Jungim / Yun, Seung Gyu

Annals of laboratory medicine

2019 Volume 40, Issue 3, Page(s) 274–276

MeSH term(s)	Biotin/chemistry ; Humans ; Immunoassay/methods ; Reagent Kits, Diagnostic ; Thyroxine/blood
Chemical Substances	Reagent Kits, Diagnostic ; Biotin (6SO6U10H04) ; Thyroxine (Q51BO43MG4)
Language	English
Publishing date	2019-12-13
Publishing country	Korea (South)
Document type	Comparative Study ; Journal Article
ZDB-ID	2677441-0
ISSN	2234-3814 ; 2234-3814
ISSN (online)	2234-3814
ISSN	2234-3814
DOI	10.3343/alm.2020.40.3.274
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Article ; Online: Enhancement of denitrification by sulfur-based carrier in sequencing batch reactor (SBR) for advanced wastewater treatment.

Park, Cheol-Gyu / Lee, Jin-San / An, Sun-A / Cho, Seong-Min / Min, Inhong / Woo, Yun Chul / Kim, Han-Seung

Chemosphere

2024 Volume 352, Page(s) 141415

Abstract: This study was to enhance the nitrogen removal efficiency in the sequencing batch reactor (SBR) process by adding sulfur-based carriers. The nitrogen removal efficiency of the control group was compared with that of the experimental group through a two- ... ...

Abstract	This study was to enhance the nitrogen removal efficiency in the sequencing batch reactor (SBR) process by adding sulfur-based carriers. The nitrogen removal efficiency of the control group was compared with that of the experimental group through a two-series operation of SBR1 without carrier and SBR2 with the carrier under the condition of no external carbon source. A total nitrogen (T-N) removal efficiency of 6.6%, 72.6%, and 79.9% was observed in SBR1, SBR2 (5%), and (10%), respectively. The T-N removal efficiency was improved in the system with carriers, which showed an increase in the removal efficiency of approximately 91.7%. The results suggest that the inclusion of the carrier led to an elevation in the sulfur ratio, implying an augmented surface area for sulfur-based denitrifying microorganisms. Additionally, CaCO3 contributed essential alkalinity for sulfur denitrification, thereby preventing a decline in pH. Regardless of the carrier, the efficiency of organic matter removal surpassed 89%, indicating that the sulfur-based carrier did not adversely affect the biological reaction associated with organic matter. Therefore, autotrophic denitrification was successfully performed using a sulfur carrier in the SBR process without an external carbon source, improving the nitrogen removal efficiency.
MeSH term(s)	Denitrification ; Bioreactors ; Sulfur ; Water Purification/methods ; Nitrogen ; Carbon
Chemical Substances	Sulfur (70FD1KFU70) ; Nitrogen (N762921K75) ; Carbon (7440-44-0)
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2024.141415
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Article ; Online: Periodontitis and risk of alopecia areata: A nationwide population-based cohort study in Korea.

Kim, Jong-Seung / Lee, Il-Jae / Lee, Min-Gyu / Yeom, Sang-Woo / Nam, Kyung-Hwa / Yun, Seok-Kweon / Park, Jin

Journal of the European Academy of Dermatology and Venereology : JEADV

2022 Volume 37, Issue 3, Page(s) e397–e399

MeSH term(s)	Humans ; Alopecia Areata/epidemiology ; Cohort Studies ; Periodontitis ; Republic of Korea/epidemiology
Language	English
Publishing date	2022-11-25
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1128828-0
ISSN	1468-3083 ; 0926-9959
ISSN (online)	1468-3083
ISSN	0926-9959
DOI	10.1111/jdv.18758
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Article: Noncoding RNAs Associated with Therapeutic Resistance in Pancreatic Cancer.

Son, Seung Wan / Song, Mun Gyu / Yun, Ba Da / Park, Jong Kook

Biomedicines

2021 Volume 9, Issue 3

Abstract: Therapeutic resistance is an inevitable impediment towards effective cancer therapies. Evidence accumulated has shown that the signaling pathways and related factors are fundamentally responsible for therapeutic resistance via regulating diverse cellular ...

Abstract	Therapeutic resistance is an inevitable impediment towards effective cancer therapies. Evidence accumulated has shown that the signaling pathways and related factors are fundamentally responsible for therapeutic resistance via regulating diverse cellular events, such as epithelial-to-mesenchymal transition (EMT), stemness, cell survival/apoptosis, autophagy, etcetera. Noncoding RNAs (ncRNAs) have been identified as essential cellular components in gene regulation. The expression of ncRNAs is altered in cancer, and dysregulated ncRNAs participate in gene regulatory networks in pathological contexts. An in-depth understanding of molecular mechanisms underlying the modulation of therapeutic resistance is required to refine therapeutic benefits. This review presents an overview of the recent evidence concerning the role of human ncRNAs in therapeutic resistance, together with the feasibility of ncRNAs as therapeutic targets in pancreatic cancer.
Language	English
Publishing date	2021-03-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines9030263
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Article ; Online: Statistical classification methods for estimating sex based on five skull traits: A nonmetric assessment using 3D CT models.

Shim, Yun Taek / Kim, Deog-Im / Aum, Nahyun / Choi, Seung Gyu / Lee, Young Seok / Koo, Hyung Nam / Kim, Yi-Suk

Homo : internationale Zeitschrift fur die vergleichende Forschung am Menschen

2023 Volume 74, Issue 1, Page(s) 45–54

Abstract: Five cranial nonmetric traits for sex estimation for sex estimation are classified by score according to geometry. The population of origin is one of the factors influencing cranial nonmetric traits. Moreover, among the five cranial traits, the robust ... ...

Abstract	Five cranial nonmetric traits for sex estimation for sex estimation are classified by score according to geometry. The population of origin is one of the factors influencing cranial nonmetric traits. Moreover, among the five cranial traits, the robust traits for estimating sex varied across population. The aim of this study is to suggest the most useful method for sex estimation and demonstrate the need of a suitable method for each population. One-hundred thirty-five three-dimensional skull images from 21
MeSH term(s)	Female ; Humans ; Male ; Forensic Anthropology/classification ; Forensic Anthropology/methods ; Frontal Bone/anatomy & histology ; Frontal Bone/diagnostic imaging ; Imaging, Three-Dimensional/methods ; Mastoid/anatomy & histology ; Mastoid/diagnostic imaging ; Sex Determination by Skeleton/methods ; Skull/anatomy & histology ; Skull/diagnostic imaging ; Tomography, X-Ray Computed/methods ; East Asian People ; Autopsy ; Cadaver
Language	English
Publishing date	2023-03-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2466-1
ISSN	1618-1301 ; 0018-442X
ISSN (online)	1618-1301
ISSN	0018-442X
DOI	10.1127/homo/2023/1632
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Article ; Online: Exposure dose and temperature of chlorine on deterioration of thin-film composite membranes for reverse osmosis and nanofiltration.

An, Sun-A / Park, Cheol-Gyu / Lee, Jin-San / Cho, Seong-Min / Woo, Yun Chul / Kim, Han-Seung

Chemosphere

2023 Volume 333, Page(s) 138929

Abstract: In this study, the effect of chlorine, which is used as a chemical cleaning agent or disinfection agent on membrane deterioration, was analyzed under various conditions during the membrane process. Reverse osmosis (RO: ESPA2-LD and RE4040-BE) and ... ...

Abstract	In this study, the effect of chlorine, which is used as a chemical cleaning agent or disinfection agent on membrane deterioration, was analyzed under various conditions during the membrane process. Reverse osmosis (RO: ESPA2-LD and RE4040-BE) and nanofiltration (NF: NE4040-70) membranes made of polyamide (PA) thin film composite (TFC) were used for evaluation. Chlorine exposure was performed at doses ranging from 1000 ppm h to 10,000 ppm h using 10 ppm and 100 ppm, and temperatures from 10 °C to 30 °C. Raw water containing NaCl, MgSO
MeSH term(s)	Chlorine/analysis ; Temperature ; Osmosis ; Membranes, Artificial ; Filtration/methods
Chemical Substances	Chlorine (4R7X1O2820) ; Membranes, Artificial
Language	English
Publishing date	2023-05-17
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2023.138929
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Article ; Online: Usefulness of Combining Sputum and Nasopharyngeal Samples for Viral Detection by Reverse Transcriptase PCR in Adults Hospitalized with Acute Respiratory Illness.

Kim, Keun Ju / Yun, Seung Gyu / Cho, Yunjung / Nam, Myung-Hyun / Lee, Chang Kyu

Microbiology spectrum

2022 , Page(s) e0277522

Abstract: Nasopharyngeal swabs (NPS) or washings have traditionally been used to diagnose respiratory tract infections. Reverse transcriptase PCR (RT-PCR) is widely used for rapid viral detection using samples from the upper respiratory tract. However, RT-PCR is ... ...

Abstract	Nasopharyngeal swabs (NPS) or washings have traditionally been used to diagnose respiratory tract infections. Reverse transcriptase PCR (RT-PCR) is widely used for rapid viral detection using samples from the upper respiratory tract. However, RT-PCR is rarely applied to sputum samples, mainly due to the viscosity of sputum. Thus, we assessed the detection rates of respiratory viruses from NPS, sputum samples, and combined NPS and sputum samples using multiplex RT-PCR (Allplex respiratory panels I, II, and III; Seegene, Seoul, South Korea). Paired NPS and sputum samples were collected from 219 patients admitted to the hospital with acute respiratory illnesses from October to December 2019. RT-PCR was performed on each sample for virus detection. Combined samples for virus detection were produced using remnant NPS and sputum samples with a positive virus signal. Respiratory viral nucleic acid was identified in 92 (42%) of 219 patients. Among the 92 viral detections, 61 (28%) were detected by both NPS and sputum samples. Twenty-four (11%) were sputum positive/NPS negative, and seven (3%) were sputum negative/NPS positive. For the combined NPS-sputum samples (
Language	English
Publishing date	2022-11-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.02775-22
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Article: Comparison of Neutralizing Activity between Vaccinated and Unvaccinated Hospitalized COVID-19 Patients Infected with Delta, Omicron BA.1, or Omicron BA.2 Variant.

Kim, Keun Ju / Park, Seo-Jin / Yun, Seung Gyu / Kim, Sang Wook / Nam, Myung-Hyun / Shin, Eun Kyong / Chang, Eun-Ah / Park, Dae Won / Lee, Chang Kyu / Yoon, Young Kyung / Cho, Yunjung

Microorganisms

2024 Volume 12, Issue 3

Abstract: Background: Understanding the immune response to evolving viral strains is crucial for evidence-informed public health strategies. The main objective of this study is to assess the influence of vaccination on the neutralizing activity of SARS-CoV-2 ... ...

Abstract	Background: Understanding the immune response to evolving viral strains is crucial for evidence-informed public health strategies. The main objective of this study is to assess the influence of vaccination on the neutralizing activity of SARS-CoV-2 delta and omicron infection against various SARS-CoV-2 variants. Methods: A total of 97 laboratory-confirmed COVID-19 cases were included. To assess the influence of vaccination on neutralizing activity, we measured the neutralizing activity of SARS-CoV-2 delta or omicron (BA.1 or BA.2) infection against wild-type (WT), delta, BA.1, and BA.2, with the results stratified based on vaccination status. Results: The neutralizing activity against the WT, delta, and omicron variants (BA.1 and BA.2) was significantly higher in the vaccinated patients than those in the unvaccinated patients. In the unvaccinated individuals infected with the delta variant, the decrease in binding to BA.1 and BA.2 was statistically significant (3.9- and 2.7-fold, respectively) compared to the binding to delta. In contrast, vaccination followed by delta breakthrough infection improved the cross-neutralizing activity against omicron variants, with only 1.3- and 1.2-fold decreases in BA.1 and BA.2, respectively. Vaccination followed by infection improved cross-neutralizing activity against WT, delta, and BA.2 variants in patients infected with the BA.1 variant, compared to that in unvaccinated patients. Conclusions: Vaccination followed by delta or BA.1 infection is associated with improved cross-neutralizing activity against different SARS-CoV-2 variants. The enhanced protection provided by breakthrough infections could have practical implications for optimizing vaccination strategies.
Language	English
Publishing date	2024-03-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms12030509
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