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Article ; Online: Improving the screening of risk factors in diabetic retinopathy.

Scanlon, Peter H

Expert review of endocrinology & metabolism

2022 Volume 17, Issue 3, Page(s) 235–243

Abstract: ... such as glycemic and B/P control are well known from landmark trials. This review has included these factors ...

Abstract	Introduction: In 2002, Diabetic Retinopathy was reported as the leading cause of blindness in the working age group. The introduction of systematic screening programs in the UK has reduced visual loss and blindness due to diabetic retinopathy, but it does still occur with catastrophic consequences for the individual. Areas covered: The author conducted an ongoing search for articles relating to diabetic retinopathy since 2000 utilizing Zetoc Alert with keywords and contents page lists from relevant journals. This review covers the risk factors for loss of vision due to diabetic retinopathy and discusses ways in which the awareness of these risk factors can be used to further reduce visual loss. Some risk factors such as glycemic and B/P control are well known from landmark trials. This review has included these factors but concentrated more on the evidence behind those risk factors that are not so clearly defined or so well known. Expert opinion: The major risk factors are well known, but one continues to find that people with diabetes lose vision in situations in which a better awareness of the risks by both the individual with diabetes and the health workers involved may have prevented the visual loss.
MeSH term(s)	Blindness/etiology ; Blindness/prevention & control ; Blood Glucose ; Diabetes Mellitus ; Diabetic Retinopathy/diagnosis ; Diabetic Retinopathy/etiology ; Humans ; Risk Factors
Chemical Substances	Blood Glucose
Language	English
Publishing date	2022-06-21
Publishing country	England
Document type	Journal Article ; Review
ISSN	1744-8417
ISSN (online)	1744-8417
DOI	10.1080/17446651.2022.2078305
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Localization of Long Noncoding RNA in Formalin-Fixed, Paraffin-Embedded Vascular Tissue Using In Situ Hybridization.

Scanlon, Jessica P / Baker, Andrew H / Sluimer, Judith C

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2419, Page(s) 659–670

Abstract: In situ hybridization (ISH) is a technique for the detection of the location of RNA within a tissue of interest. This process uses oligonucleotides with complementary sequences to bind to the target RNA, and colorimetric detection to allow for the ... ...

Abstract	In situ hybridization (ISH) is a technique for the detection of the location of RNA within a tissue of interest. This process uses oligonucleotides with complementary sequences to bind to the target RNA, and colorimetric detection to allow for the visualization of this binding. The process of ISH means that the specific location of the RNA in question can be detected, including in which cell types it is present, and the intracellular location. In the case of long noncoding RNA (lncRNA), which do not lead to the production of proteins, ISH is essential for tissue localization. Moreover, RNA abundance is often lower than for protein-coding genes, thus necessitating enhanced detection through double-digoxigenin (DIG) labeling of the probes. Here, we describe the theory and practicalities of performing ISH for lncRNA, with particular reference to vascular tissues.
MeSH term(s)	Digoxigenin ; Formaldehyde ; In Situ Hybridization ; Paraffin Embedding ; RNA, Long Noncoding/genetics
Chemical Substances	RNA, Long Noncoding ; Formaldehyde (1HG84L3525) ; Digoxigenin (NQ1SX9LNAU)
Language	English
Publishing date	2022-03-02
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1924-7_41
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Article ; Online: The ratio of auxin to cytokinin controls leaf development and meristem initiation in Physcomitrium patens.

Cammarata, Joseph / Roeder, Adrienne H K / Scanlon, Michael J

Journal of experimental botany

2023 Volume 74, Issue 21, Page(s) 6541–6550

Abstract: ... that the ratio of auxin to cytokinin is an important determinant of development in P. patens, especially during ... leaf development and branch stem cell initiation. Addition of high levels of auxin to P. patens ...

Abstract	Crosstalk between auxin and cytokinin contributes to widespread developmental processes, including root and shoot meristem maintenance, phyllotaxy, and vascular patterning. However, our understanding of crosstalk between these hormones is limited primarily to angiosperms. The moss Physcomitrium patens (formerly Physcomitrella patens) is a powerful system for studying plant hormone function. Auxin and cytokinin play similar roles in regulating moss gametophore (shoot) architecture, to those in flowering plant shoots. However, auxin-cytokinin crosstalk is poorly understood in moss. Here we find that the ratio of auxin to cytokinin is an important determinant of development in P. patens, especially during leaf development and branch stem cell initiation. Addition of high levels of auxin to P. patens gametophores blocks leaf outgrowth. However, simultaneous addition of high levels of both auxin and cytokinin partially restores leaf outgrowth, suggesting that the ratio of these hormones is the predominant factor. Likewise, during branch initiation and outgrowth, chemical inhibition of auxin synthesis phenocopies cytokinin application. Finally, cytokinin-insensitive mutants resemble plants with altered auxin signaling and are hypersensitive to auxin. In summary, our results suggest that the ratio between auxin and cytokinin signaling is the basis for developmental decisions in the moss gametophore.
MeSH term(s)	Cytokinins/pharmacology ; Indoleacetic Acids/pharmacology ; Bryopsida/genetics ; Meristem ; Bryophyta ; Plant Leaves ; Hormones
Chemical Substances	Cytokinins ; Indoleacetic Acids ; Hormones
Language	English
Publishing date	2023-07-28
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2976-2
ISSN	1460-2431 ; 0022-0957
ISSN (online)	1460-2431
ISSN	0022-0957
DOI	10.1093/jxb/erad299
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Book: Action on diabetic macular oedema (DMO)

Gale, R. / Scanlon, P. H. / Evans, M. / Ghanchi, F. / Yang, Y. / Silvestry, G. / Freeman, M. / Maisey, A. / Napier, J.

2 September 2016, London, UK

(Eye ; volume 31, supplement 1 (May 2017))

2017

Author's details	authors: R Gale, PH Scanlon, M Evans, F Ghanchi, Y Yang, G Silvestry, M Freeman, A Maisey and J Napier
Series title	Eye ; volume 31, supplement 1 (May 2017)
Collection
Language	English
Size	S20 Seiten, Diagramme
Publisher	Springer Nature
Publishing place	London
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT019396484
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

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Zs B 3010 -31,Suppl.1-	verfügbar in Königswinter	Königswinter

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Article ; Online: How can we meet the needs of patients, their families and their communities? A qualitative study including clinicians, consumer representatives, patients, and community members.

Roberts, Natasha / Jacmon, Helene / Scanlon, Brighid / Battersby, Chrissy / Buttrum, Peter / James, Christine

BMC health services research

2023 Volume 23, Issue 1, Page(s) 809

Abstract: Background: The Diversity Working Group was formed in response to Australian Quality and Safety Health Care Standards that require organisations plan service delivery that incorporates information about the diversity of consumers, and those at higher ... ...

Abstract	Background: The Diversity Working Group was formed in response to Australian Quality and Safety Health Care Standards that require organisations plan service delivery that incorporates information about the diversity of consumers, and those at higher risk of harm. Methods: A qualitative gap analysis was conducted by a team from varied professional backgrounds including a clinician researcher, a nurse researcher with expertise in culturally and linguistically diverse care and a consumer representative with expertise in advocacy and carer representation. Qualitative questions were co-designed, using a person-centred care lens. Community organisation members, and clinicians and patients from both ambulatory and inpatient areas were approached. Responses were coded independently and synthesised using a Framework Methodology. Results: In total 3 community organisation members, 40 clinicians and 30 patients consented to participate in the qualitative study over a period of three weeks. There were three key themes across responses, 'What are diverse needs?'; 'Assigning people to a group does not address a need'; 'Unplanned care makes people feel vulnerable'. Those patients who are isolated, for any number of reasons, were identified as at greater risk of harm. Conclusion: Taking a person-centred approach can potentially better understand the needs of patients and communities so that this information can be incorporated into health service delivery. Resources are needed to support patients and their families at times of transition care, particularly when care is unplanned.
MeSH term(s)	Humans ; Australia ; Qualitative Research ; Caregivers ; Health Services ; Inpatients
Language	English
Publishing date	2023-07-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2050434-2
ISSN	1472-6963 ; 1472-6963
ISSN (online)	1472-6963
ISSN	1472-6963
DOI	10.1186/s12913-023-09814-9
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Article ; Online: Comparison of adult hesitancy towards COVID-19 vaccines and vaccines in general in the USA.

Nguyen, Kimberly H / Coy, Kelsey C / Black, Carla L / Scanlon, Paul / Singleton, James A

Vaccine

2023 Volume 42, Issue 3, Page(s) 645–652

Abstract: Background: Adults who are hesitant toward routinely recommended vaccines for adults may also be hesitant toward COVID-19 vaccines. However, the distribution and differences in hesitancy between routinely recommended vaccines and COVID-19 vaccines, and ... ...

Abstract	Background: Adults who are hesitant toward routinely recommended vaccines for adults may also be hesitant toward COVID-19 vaccines. However, the distribution and differences in hesitancy between routinely recommended vaccines and COVID-19 vaccines, and the association of hesitancy regarding routinely recommended vaccines and hesitancy with COVID-19 vaccination status and intent, is unknown. Methods: Using the Research and Development Survey (RANDS) during COVID-19, Round 3, a probability-sampled, nationally representative, web and phone survey fielded from May 17 - June 30, 2021 (n = 5,434), we examined the distribution and difference in prevalence of hesitancy towards COVID-19 and vaccines in general, beliefs associated with vaccine hesitancy, and factors impacting plans to be vaccinated against COVID-19. Results: Reported hesitancy towards COVID-19 vaccines (42.2%) was 6-percentage points higher than hesitancy towards vaccines in general (35.7%). Populations who were most hesitant toward COVID-19 vaccines were younger adults, non-Hispanic Black adults, adults with lower education or income, and adults who were associated with a religion. Beliefs in the social benefit and the importance of vaccination, and the belief that COVID-19 vaccines lower risk for infection, were strongly associated with COVID-19 vaccination and intent to be vaccinated. Conclusions: Vaccine hesitancy for both COVID-19 vaccines and vaccines in general is common. Health providers and public health officials should utilize strategies to address vaccine hesitancy, including providing strong clear recommendations for needed vaccines, addressing safety and effectiveness concerns, and utilizing trusted messengers such as religious and community leaders to improve vaccine confidence.
MeSH term(s)	Adult ; Humans ; COVID-19/prevention & control ; COVID-19 Vaccines ; Vaccination Hesitancy ; United States
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-12-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2023.12.042
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Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

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Article ; Online: The preferences of people with diabetes for diabetic retinopathy screening.

Scanlon, P H

Diabetic medicine : a journal of the British Diabetic Association

2012 Volume 29, Issue 7, Page(s) 836–837

MeSH term(s)	Diabetic Retinopathy/diagnosis ; Diabetic Retinopathy/epidemiology ; Diabetic Retinopathy/prevention & control ; Disease Progression ; Early Diagnosis ; Female ; Humans ; Male ; Mass Screening/methods ; Mass Screening/statistics & numerical data ; Patient Preference ; Patient Selection ; Referral and Consultation ; Risk Assessment ; Severity of Illness Index ; United Kingdom/epidemiology
Language	English
Publishing date	2012-07
Publishing country	England
Document type	Editorial
ZDB-ID	605769-x
ISSN	1464-5491 ; 0742-3071 ; 1466-5468
ISSN (online)	1464-5491
ISSN	0742-3071 ; 1466-5468
DOI	10.1111/j.1464-5491.2012.03630.x
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Article ; Online: Can a Checklist Facilitate Recognition of a Transfusion-Associated Adverse Event by Prelicensure Nurses?

Scott, Sue S / Scanlon, Marcia / McKelvey, Michele / Nathanson, Brian H / Andrzejewski, Chester

Nurse educator

2023 Volume 49, Issue 3, Page(s) 162–166

Abstract: ... identified TAAEs on average 4 minutes sooner than the non-CG ( P < .001). CG subjects were also significantly ...

Abstract	Background: Early identification of a transfusion-associated adverse event (TAAE) is key to patient safety. Research has indicated that use of a TAAE checklist resulted in greater frequency of TAAE recognition behaviors. Purpose: To explore whether use of a TAAE checklist resulted in greater frequency of TAAE recognition behaviors among nursing students. Methods: A prospective, randomized controlled study was conducted with 62 nursing students playing the role of a registered nurse in a simulation of a patient exhibiting clinical indicators of a TAAE. Subjects were randomly assigned to have or not have a TAAE checklist. Time to recognition of the TAAE was measured. Results: The checklist group (CG) identified TAAEs on average 4 minutes sooner than the non-CG ( P < .001). CG subjects were also significantly less likely to miss TAAEs completely. Conclusions: A checklist may improve the safety of transfusions by promoting earlier recognition and treatment of TAAEs.
MeSH term(s)	Humans ; Checklist ; Students, Nursing/psychology ; Students, Nursing/statistics & numerical data ; Prospective Studies ; Female ; Male ; Nursing Education Research ; Education, Nursing, Baccalaureate ; Transfusion Reaction ; Nursing Evaluation Research ; Adult ; Patient Safety ; Young Adult ; Clinical Competence/statistics & numerical data ; Blood Transfusion
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1034267-9
ISSN	1538-9855 ; 0363-3624
ISSN (online)	1538-9855
ISSN	0363-3624
DOI	10.1097/NNE.0000000000001556
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Article ; Online: Lithium Intercalation into the Excitonic Insulator Candidate Ta

Hyde, P A / Cen, J / Cassidy, S J / Rees, N H / Holdship, P / Smith, R I / Zhu, B / Scanlon, D O / Clarke, S J

Inorganic chemistry

2023 Volume 62, Issue 30, Page(s) 12027–12037

Abstract: A new reduced phase derived from the excitonic insulator candidate ... ...

Abstract	A new reduced phase derived from the excitonic insulator candidate Ta
Language	English
Publishing date	2023-07-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.3c01510
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Article ; Online: Why do patients still require surgery for the late complications of Proliferative Diabetic Retinopathy?

Scanlon, P H

Eye (London, England)

2010 Volume 24, Issue 3, Page(s) 435–440

Abstract: Aim: To briefly review and discuss the literature on why patients still require surgery for the late complications of proliferative diabetic retinopathy (PDR).: Methods: Literature review.: Results: The reasons for incomplete coverage of screening ...

Abstract	Aim: To briefly review and discuss the literature on why patients still require surgery for the late complications of proliferative diabetic retinopathy (PDR). Methods: Literature review. Results: The reasons for incomplete coverage of screening and screening failures can be divided into non-modifiable and potentially modifiable risk factors. The non-modifiable group includes duration of diabetes, age, genetic predisposition, ethnic differences, and the various reasons for vitrectomy when optimum laser treatment has been applied at the appropriate stage of the disease process. The potentially modifiable group includes glycaemic control, blood pressure control, lipid control, and cessation of smoking in type 1 diabetes. Other potentially modifiable factors include adequacy of screening, including reaching the regular non-attender, and attempting to modify the psychological factors that lead to late presentations including depression and eating disorders. Other potentially modifiable risk factors are optimising laser treatments and the potential use of anti-VEGF therapy to prevent vitrectomy in iris neovascularisation and neovascular glaucoma. Conclusion: Surgery for the late complications of PDR continues to be required even in some patients who have received optimal medical care and optimal laser treatment. There are certain modifiable risk factors that could be altered and further research is needed in specific fields, particularly with regard to the adequacy of laser treatments, the use of anti-VEGF agents in iris neovascularisation, and in the role of psychological support in reducing the type of late complications leading to surgery for PDR.
MeSH term(s)	Age Factors ; Angiogenesis Inhibitors/therapeutic use ; Diabetic Retinopathy/complications ; Diabetic Retinopathy/genetics ; Diabetic Retinopathy/surgery ; Diabetic Retinopathy/therapy ; Genetic Predisposition to Disease ; Glaucoma/surgery ; Humans ; Laser Coagulation/standards ; Mass Screening/standards ; Neovascularization, Pathologic/prevention & control ; Neovascularization, Pathologic/surgery ; Risk Factors ; Vitrectomy
Chemical Substances	Angiogenesis Inhibitors
Language	English
Publishing date	2010-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/eye.2009.320
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Zs.MO 603: Show issues

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