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  1. Book: Meta analysis in infectious diseases

    Falagas, Matthew E.

    (Infectious disease clinics of North America ; 23,2)

    2009  

    Title variant Meta-analysis in infectious diseases
    Author's details guest ed. Metthew E. Falagas
    Series title Infectious disease clinics of North America ; 23,2
    Collection
    Language English
    Size XIII S., S. 182 - 470 : graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015969445
    ISBN 1-4377-0492-1 ; 978-1-4377-0492-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1187 -23,2- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Benefits of prolonged infusion of beta-lactam antibiotics in patients with sepsis: personal perspectives.

    Rafailidis, Petros I / Falagas, Matthew E

    Expert review of anti-infective therapy

    2020  Volume 18, Issue 10, Page(s) 957–966

    Abstract: Introduction: In the current era of relatively scarce antibiotic production and significant levels of antimicrobial resistance, optimization of pharmacokinetics and pharmacodynamics of antibiotic therapy is mandatory. Prolonged infusion of beta-lactam ... ...

    Abstract Introduction: In the current era of relatively scarce antibiotic production and significant levels of antimicrobial resistance, optimization of pharmacokinetics and pharmacodynamics of antibiotic therapy is mandatory. Prolonged infusion of beta-lactam antibiotics in comparison to the intermittent infusion has the theoretical advantage of better patient outcomes. Apparently, conflicting data in the literature possibly underestimate the benefits of prolonged infusion of antibiotic treatment.
    Areas covered: We provide our perspective on the subject based on our experience and by critically evaluating literature data.
    Expert opinion commentary: In our opinion, the available data are suggestive of the beneficial role of prolonged infusion of beta-lactams in regard to piperacillin/tazobactam and carbapenems after administering a loading dose. While more data from randomized controlled trials are necessary to solidify or negate the evident benefits of prolonged infusion of the aforementioned antibiotics, clinicians should strongly consider this mode of administration of relevant antibiotics, especially in patients with severe infections.
    MeSH term(s) Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/pharmacokinetics ; Anti-Bacterial Agents/pharmacology ; Drug Administration Schedule ; Drug Resistance, Bacterial ; Humans ; Infusions, Intravenous ; Sepsis/drug therapy ; Sepsis/microbiology ; Treatment Outcome ; beta-Lactams/administration & dosage ; beta-Lactams/pharmacokinetics ; beta-Lactams/pharmacology
    Chemical Substances Anti-Bacterial Agents ; beta-Lactams
    Language English
    Publishing date 2020-06-21
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2020.1776113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Spotlight on Early COVID-19 Research Productivity: A 1-Year Bibliometric Analysis.

    Giannos, Panagiotis / Kechagias, Konstantinos S / Katsikas Triantafyllidis, Konstantinos / Falagas, Matthew E

    Frontiers in public health

    2022  Volume 10, Page(s) 811885

    Abstract: Coronavirus disease 2019 (COVID-19), one of the most serious public health crises in over a century, has led to an unprecedented surge of publications across all areas of knowledge. This study assessed the early research productivity on COVID-19 in terms ...

    Abstract Coronavirus disease 2019 (COVID-19), one of the most serious public health crises in over a century, has led to an unprecedented surge of publications across all areas of knowledge. This study assessed the early research productivity on COVID-19 in terms of vaccination, diagnosis, treatment, symptoms, risk factors, nutrition, and economy. The Scopus database was searched between January 1, 2020 and December 31, 2020 to initially examine the research productivity on COVID-19, as measured by total publications by the 20 highest-ranked countries according to gross domestic product. The literature search was then refined, and research productivity was assessed across seven major research domains related to COVID-19: vaccination, diagnosis, treatment, symptoms, risk factors, nutrition, and economy. The initial literature search yielded 53,348 publications. Among these, 27,801 publications involved authorship from a single country and 22,119 publications involved authorship from multiple countries. Overall, the United States was the most productive country (
    MeSH term(s) Bibliometrics ; Biomedical Research ; COVID-19 ; Gross Domestic Product ; Humans ; India ; United States
    Language English
    Publishing date 2022-05-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.811885
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Addressing clinical safety of antimicrobial resistance: personal perspectives.

    Rafailidis, Petros I / Falagas, Matthew E

    Expert review of anti-infective therapy

    2019  Volume 17, Issue 11, Page(s) 865–869

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Anti-Bacterial Agents/administration & dosage ; Bacteria/drug effects ; Bacteria/isolation & purification ; Bacterial Infections/drug therapy ; Bacterial Infections/microbiology ; Drug Resistance, Bacterial ; Humans
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2019-11-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2019.1687294
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Continuous or Extended Intravenous Administration of β-Lactam Antibiotics.

    Falagas, Matthew E / Vardakas, Konstantinos Z

    American journal of respiratory and critical care medicine

    2017  Volume 195, Issue 8, Page(s) 1077–1078

    Language English
    Publishing date 2017-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201610-2004LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Early investigational antibiotics for the treatment of acute exacerbations of chronic bronchitis.

    Falagas, Matthew E / Georgiou, Maria

    Expert opinion on investigational drugs

    2017  Volume 26, Issue 3, Page(s) 313–317

    Abstract: Introduction: Acute exacerbations in patients with chronic bronchitis are a leading cause of hospitalizations and death. Bacteria contribute significantly to such exacerbations. The aim of this review was to explore the potential role of investigational ...

    Abstract Introduction: Acute exacerbations in patients with chronic bronchitis are a leading cause of hospitalizations and death. Bacteria contribute significantly to such exacerbations. The aim of this review was to explore the potential role of investigational antibiotics in the treatment of these episodes. Areas covered: The available literature in PubMed database, in websites related to investigational drugs and in websites of the producing companies has been searched. The in vitro activity against pathogens involved in acute exacerbations of chronic bronchitis and the pharmacokinetic profile of antibiotics currently under development were taken into consideration for inclusion in the review. Expert opinion: Several novel antimicrobial agents have completed preclinical and Phase I studies and were well-tolerated. Further investigation is mandatory in order to evaluate their future in treatment of chronic bronchitis exacerbations and discover potential advantages compared to already approved antimicrobials.
    MeSH term(s) Acute Disease ; Animals ; Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/pharmacokinetics ; Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/drug therapy ; Bacterial Infections/microbiology ; Bacterial Infections/pathology ; Bronchitis, Chronic/drug therapy ; Bronchitis, Chronic/microbiology ; Bronchitis, Chronic/pathology ; Drug Design ; Drugs, Investigational/adverse effects ; Drugs, Investigational/pharmacokinetics ; Drugs, Investigational/therapeutic use ; Humans
    Chemical Substances Anti-Bacterial Agents ; Drugs, Investigational
    Language English
    Publishing date 2017-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1080/13543784.2017.1283402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3739: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Colistin versus polymyxin B for the treatment of patients with multidrug-resistant Gram-negative infections: a systematic review and meta-analysis.

    Vardakas, Konstantinos Z / Falagas, Matthew E

    International journal of antimicrobial agents

    2017  Volume 49, Issue 2, Page(s) 233–238

    Abstract: Colistin and polymyxin B (PMB) have different pharmacokinetic profiles and minor differences in antimicrobial activities that may result in discrepancies in mortality and nephrotoxicity. A systematic review and meta-analysis was conducted. PubMed, Scopus ...

    Abstract Colistin and polymyxin B (PMB) have different pharmacokinetic profiles and minor differences in antimicrobial activities that may result in discrepancies in mortality and nephrotoxicity. A systematic review and meta-analysis was conducted. PubMed, Scopus and Cochrane Library databases were searched. There was no significant difference in unadjusted mortality between patients treated with colistin and PMB [risk ratio (RR) = 0.71, 95% confidence interval (CI) 0.45-1.13]. Adjusted data were not available. Unadjusted nephrotoxicity was more common in patients treated with colistin than PMB (RR = 1.55, 95% CI 1.36-1.78). According to the RIFLE (Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease) criteria, there was no difference regarding risk, injury or failure between colistin and PMB. Although episodes of loss of renal function were few in general, they developed primarily in colistin-treated patients (RR = 8.55, 95% CI 1.48-49.49). Colistin was associated with more episodes of nephrotoxicity that also occurred sooner in the analysis of adjusted data (hazard ratio = 2.16, 95% CI 1.43-3.27). Colistin administration was an independent risk factor for nephrotoxicity in two studies. Future studies should evaluate in depth the factors associated with mortality and nephrotoxicity in patients treated with polymyxins and the impact of polymyxin-associated nephrotoxicity on mortality.
    MeSH term(s) Acute Kidney Injury/epidemiology ; Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/therapeutic use ; Colistin/adverse effects ; Colistin/therapeutic use ; Drug Resistance, Multiple, Bacterial ; Gram-Negative Bacteria/drug effects ; Gram-Negative Bacterial Infections/drug therapy ; Gram-Negative Bacterial Infections/microbiology ; Gram-Negative Bacterial Infections/mortality ; Humans ; Polymyxin B/adverse effects ; Polymyxin B/therapeutic use ; Survival Analysis ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents ; Polymyxin B (1404-26-8) ; Colistin (Z67X93HJG1)
    Language English
    Publishing date 2017-02
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article ; Meta-Analysis ; Review
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2016.07.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3368: Show issues Location:
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    Zs.MO 500: Show issues

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  8. Article: Urinary tract infections in patients undergoing radical cystectomy and urinary diversion: challenges and considerations in antibiotic prophylaxis.

    Symeonidis, Evangelos N / Falagas, Matthew E / Dimitriadis, Fotios

    Translational andrology and urology

    2019  Volume 8, Issue 4, Page(s) 286–289

    Language English
    Publishing date 2019-09-17
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2851630-8
    ISSN 2223-4691 ; 2223-4691 ; 2223-4683
    ISSN (online) 2223-4691
    ISSN 2223-4691 ; 2223-4683
    DOI 10.21037/tau.2019.07.12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Developments on antibiotics for multidrug resistant bacterial Gram-negative infections.

    Voulgaris, Georgios L / Voulgari, Maria L / Falagas, Matthew E

    Expert review of anti-infective therapy

    2019  Volume 17, Issue 6, Page(s) 387–401

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Anti-Bacterial Agents/administration & dosage ; Drug Development ; Drug Resistance, Multiple, Bacterial ; Gram-Negative Bacteria/drug effects ; Gram-Negative Bacteria/isolation & purification ; Gram-Negative Bacterial Infections/drug therapy ; Gram-Negative Bacterial Infections/microbiology ; Humans
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2019-05-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2019.1610392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Intravenous fosfomycin for the treatment of patients with central nervous system infections: evaluation of the published evidence.

    Tsegka, Katerina G / Voulgaris, Georgios L / Kyriakidou, Margarita / Falagas, Matthew E

    Expert review of anti-infective therapy

    2020  Volume 18, Issue 7, Page(s) 657–668

    Abstract: Introduction: Central nervous system (CNS) infections have considerable morbidity and mortality. Fosfomycin is a broad spectrum bactericidal antibiotic with favorable pharmacokinetic properties and low toxicity, satisfactory penetration in the ... ...

    Abstract Introduction: Central nervous system (CNS) infections have considerable morbidity and mortality. Fosfomycin is a broad spectrum bactericidal antibiotic with favorable pharmacokinetic properties and low toxicity, satisfactory penetration in the cerebrospinal fluid and is authorized for the treatment of bacterial meningitis.
    Areas covered: The objective of this analysis was to evaluate the available data regarding the effectiveness and safety of intravenous fosfomycin for the treatment of CNS infections. Thirty-two relevant publications were identified. Data from 224 patients who received intravenous fosfomycin as treatment for CNS infections were evaluated. Overall, 93.8% of patients were cured from the infection.
    Expert opinion: The evaluation of the published evidence suggests that fosfomycin may be beneficial in the treatment of patients with CNS infections.
    MeSH term(s) Administration, Intravenous ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/pharmacokinetics ; Bacterial Infections/drug therapy ; Bacterial Infections/microbiology ; Central Nervous System Infections/drug therapy ; Central Nervous System Infections/microbiology ; Dose-Response Relationship, Drug ; Drug Resistance, Multiple, Bacterial ; Fosfomycin/administration & dosage ; Fosfomycin/adverse effects ; Fosfomycin/pharmacokinetics ; Humans ; Meningitis, Bacterial/drug therapy ; Meningitis, Bacterial/microbiology ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents ; Fosfomycin (2N81MY12TE)
    Language English
    Publishing date 2020-05-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2020.1754193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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