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Article ; Online: Single-Port Laparoscopic Extraperitoneal Repair of Pediatric Inguinal Hernias and Hydroceles by Using Hernia Crochet Needle With a Cannula.

Lin, Zhixiong / Yan, Lei / Fang, Zhihao / Wu, Dianming / Liu, Mingkun / Fang, Yifan

2024 Volume 31, Issue 2, Page(s) 173–177

Abstract: Purpose: Numerous modifications laparoscopic techniques have mushroomed in recent years. Here we describe a modified technique of extracorporeal ligation of processus vaginalis in children using a hernia crochet needle with a cannula.: Methods: ... ...

Abstract	Purpose: Numerous modifications laparoscopic techniques have mushroomed in recent years. Here we describe a modified technique of extracorporeal ligation of processus vaginalis in children using a hernia crochet needle with a cannula. Methods: Processus vaginalis repair was carried out on patients diagnosed with inguinal hernia or hydroceles using this novel technique between June 2021 and June 2022. The processus vaginalis was closed extracorporeally using a hernia crochet needle with a cannula. In the presence of patent processus vaginalis, the same procedure would be performed on the contralateral side. The primary outcomes was the safety and efficiency of this modified procedure, and the secondary outcomes was the post operative complications. Results: A total of 212 (165 inguinal hernia and 47 hydroceles) children were corrected by this novel technique. The mean operation time was 27.49 min for unilateral inguinal hernia cases and 36.55 min for bilateral cases. The unilateral hydrocele median operation time was 27.83 min and that for the bilateral cases was 37.30 min. During the mean of 10.92 months of follow-up, there was only a boy subject to a metachronous contralateral occurrence of hernia 10 months after surgery, and no other complications (knot reactions, testicular atrophy, postoperative hydrocele or iatrogenic) have been observed yet. Conclusion: This study shown a unique procedure with using a hernia crochet needle with a cannula to be simple, safe, and effective in managing inguinal hernias and hydroceles in the pediatric population.
MeSH term(s)	Male ; Child ; Humans ; Infant ; Hernia, Inguinal/surgery ; Cannula ; Treatment Outcome ; Herniorrhaphy/adverse effects ; Herniorrhaphy/methods ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Testicular Hydrocele/surgery ; Retrospective Studies
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2182571-3
ISSN	1553-3514 ; 1553-3506
ISSN (online)	1553-3514
ISSN	1553-3506
DOI	10.1177/15533506241226497
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Zs.A 4269: Show issues

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Article ; Online: Congenital Defect of the Gastric Musculature Without Perforation.

Lin, Zhixiong / Wang, Rong / Wu, Dianming / Fang, Yifan / Liu, Mingkun

The American journal of gastroenterology

2022 Volume 117, Issue 8, Page(s) 1190

MeSH term(s)	Humans ; Muscle, Smooth ; Stomach/diagnostic imaging
Language	English
Publishing date	2022-03-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	390122-1
ISSN	1572-0241 ; 0002-9270
ISSN (online)	1572-0241
ISSN	0002-9270
DOI	10.14309/ajg.0000000000001758
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Article ; Online: The electrochemically enabled α-C(sp

Fang, Songlin / Zhong, Kaihui / Zeng, Shaogao / Hu, Xinwei / Sun, Pinghua / Ruan, Zhixiong

Chemical communications (Cambridge, England)

2023 Volume 59, Issue 76, Page(s) 11425–11428

Abstract: C-H/N-H cross-coupling has become a key technology for the selective conjugation of azole drug molecules. However, the development of new synthetic models and green chemical methods is imperative to enhance the construction of multi-functional compounds ... ...

Abstract	C-H/N-H cross-coupling has become a key technology for the selective conjugation of azole drug molecules. However, the development of new synthetic models and green chemical methods is imperative to enhance the construction of multi-functional compounds and compounds with unique functional groups. We herein reported an electrochemical synthesis of α-tetrazolyl ketones with excellent yields and broad substrate scope, encompassing electron-donating and electron-withdrawing groups of aryl ketones, heterocycles, and alkyl and various ketone drugs. It was further proved that α-iodoketone was involved in this transformation of the reaction as a critical intermediate.
Language	English
Publishing date	2023-09-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d3cc02852f
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Article ; Online: Pseudomonas benzopyrenica

Dong, Xingchen / Rao, Zihuan / Wu, Siyi / Peng, Fang / Xie, Zhixiong / Long, Yan

International journal of systematic and evolutionary microbiology

2023 Volume 73, Issue 9

Abstract: A Gram-negative, yellow-pigmented, aerobic and rod-shaped bacterium, designated as strain ... ...

Abstract	A Gram-negative, yellow-pigmented, aerobic and rod-shaped bacterium, designated as strain BaP3
MeSH term(s)	Benzo(a)pyrene ; Soil ; Base Composition ; Fatty Acids/chemistry ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA ; DNA, Bacterial/genetics ; Bacterial Typing Techniques ; Pseudomonas/genetics
Chemical Substances	Benzo(a)pyrene (3417WMA06D) ; Soil ; Fatty Acids ; RNA, Ribosomal, 16S ; DNA, Bacterial
Language	English
Publishing date	2023-09-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2002336-4
ISSN	1466-5034 ; 1466-5026
ISSN (online)	1466-5034
ISSN	1466-5026
DOI	10.1099/ijsem.0.006034
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Zs.A 409: Show issues

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Article ; Online: Reciprocal effects of NOM and solution electrolyte ions on aggregation of ferrihydrite nanoparticles.

Li, Zhixiong / Hu, Yandi / Chen, Yufan / Fang, Shiyu / Liu, Yuyan / Tang, Wei / Chen, Jiawei

Chemosphere

2023 Volume 332, Page(s) 138918

Abstract: The effects of natural organic matter (NOM) types and electrolyte ions are crucial to the aggregation of ferrihydrite nanoparticles (Fh NPs) in the environment. Dynamic light scattering (DLS) was employed for the aggregation kinetics of Fh NPs (10 mg/L ... ...

Abstract	The effects of natural organic matter (NOM) types and electrolyte ions are crucial to the aggregation of ferrihydrite nanoparticles (Fh NPs) in the environment. Dynamic light scattering (DLS) was employed for the aggregation kinetics of Fh NPs (10 mg/L as Fe) in the present study. The critical coagulation concentration (CCC) values of Fh NPs aggregation in NaCl were obtained in the presence of 15 mg C/L NOM as SRHA (857.4 mM) > PPHA (752.3 mM) > SRFA > (420.1 mM) > ESHA (141.0 mM) > NOM-free (125.3 mM), indicating Fh NPs aggregation was inhibited as the above order. Comparatively in CaCl
MeSH term(s)	Sodium Chloride ; Calcium Chloride/pharmacology ; Humic Substances/analysis ; Nanoparticles ; Ions ; Electrolytes ; Kinetics
Chemical Substances	ferric oxyhydroxide (87PZU03K0K) ; Sodium Chloride (451W47IQ8X) ; Calcium Chloride (M4I0D6VV5M) ; Humic Substances ; Ions ; Electrolytes
Language	English
Publishing date	2023-05-11
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2023.138918
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Zs.A 2540: Show issues

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Article ; Online: Proanthocyanins and anthocyanins in chestnut (Castanea mollissima) shell extracts: biotransformation in the simulated gastrointestinal model and interaction with gut microbiota in vitro.

Xie, Chenyang / Li, Jie / Fang, Yihe / Ma, Renyi / Dang, Zhixiong / Yang, Fang

Journal of the science of food and agriculture

2023 Volume 103, Issue 7, Page(s) 3659–3673

Abstract: Background: Chestnut (Castanea mollissima) shell is rich in flavonoids and our previous studies showed that proanthocyanins and anthocyanins were the two markedly varied flavonoids in chestnut shell extracts (CSE) during digestion. Here, the ... ...

Abstract	Background: Chestnut (Castanea mollissima) shell is rich in flavonoids and our previous studies showed that proanthocyanins and anthocyanins were the two markedly varied flavonoids in chestnut shell extracts (CSE) during digestion. Here, the biotransformation of proanthocyanins and anthocyanins in a simulated gastrointestinal model, and the interactions between non-absorption CSE (NACSE) and gut microbiota in vitro, were investigated by ultra-high-performance liquid chromatography combined with triple-quadrupole mass spectrometry and 16S rRNA sequencing. Results: Chestnut shell was richer in proanthocyanins and anthocyanins, while the loss of proanthocyanins was greater after digestion. Additionally, the content of anthocyanin decreased after gastric digestion but increased after intestinal digestion and remained stable after fermentation. After fermentation, delphinidin-3-O-sambubioside and pelargonidin-3-O-galactoside were newly formed. Furthermore, microbiome profiling indicated that NACSE promoted the proliferation of beneficial bacteria, while inhibiting pathogenic bacteria. Conclusion: All these data suggest that CSE may be a promising candidate to protect gut health. © 2023 Society of Chemical Industry.
MeSH term(s)	Anthocyanins/chemistry ; Biotransformation ; Digestion ; Flavonoids ; Gastrointestinal Microbiome ; RNA, Ribosomal, 16S ; Fagaceae/chemistry ; Plant Extracts/pharmacology
Chemical Substances	Anthocyanins ; Flavonoids ; RNA, Ribosomal, 16S ; Plant Extracts
Language	English
Publishing date	2023-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.12480
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Article ; Online: The study on synthesis and vitro hypolipidemic activity of novel berberine derivatives nitric oxide donors.

Wang, Kexin / Li, Zhixiong / Zhang, Weicong / Liu, Yu / Wang, Xutong / Sun, Meng / Fang, Xiaodong / Han, Weina

Fitoterapia

2024 , Page(s) 105964

Abstract: Berberine was used as the lead compound in the present study to design and synthesize novel berberine derivatives by splicing bromine bridges of different berberine carbon chain lengths coupled nitric oxide donors, and their lipid lowering activities ... ...

Abstract	Berberine was used as the lead compound in the present study to design and synthesize novel berberine derivatives by splicing bromine bridges of different berberine carbon chain lengths coupled nitric oxide donors, and their lipid lowering activities were assessed in a variety of ways. This experiment synthesized 17 new berberine nitric oxide donor derivatives. Compared with berberine hydrochloride, most of the compounds exhibited certain glycerate inhibitory activity, and compounds 6a, 6b, 6d, 12b and 12d showed higher inhibitory activity than berberine, with 6a, 6b and 6d having significant inhibitory activity. In addition, compound 6a linked to furazolidone nitric oxide donor showed better NO release in experiments; In further mechanistic studies, we screened and got two proteins, PCSK9 and ACLY, and docked two proteins with 17 compounds, and found that most of the compounds bound better with ATP citrate lyase (ACLY), among which there may be a strong interaction between compound 6a and ACLY, and the interaction force was better than the target drug Bempedoic Acid, which meaning that 6a may exert hypolipidemic effects by inhibiting ACLY; moreover, we also found that 6a may had the better performance in gastrointestinal absorption, blood-brain barrier permeability, Egan, Muegge class drug principle model calculation and bioavailability.
Language	English
Publishing date	2024-04-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	412385-2
ISSN	1873-6971 ; 0367-326X
ISSN (online)	1873-6971
ISSN	0367-326X
DOI	10.1016/j.fitote.2024.105964
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Article ; Online: Association of physical activity with socio-economic status and chronic disease in older adults in China

Yi Li / Mingyuan Cui / Yiqun Pang / Bing Zhan / Xiaotian Li / Qiurui Wang / Fang Chen / Zhixiong Zhou / Qingzhu Yang

BMC Public Health, Vol 24, Iss 1, Pp 1-

cross-sectional findings from the survey of CLASS 2020 after the outbreak of COVID-19

2024 Volume 15

Abstract: Abstract Background In 2021, China had a population of 264·01 million individuals over the age of 60, indicating a high prevalence of chronic diseases. Among older adults, physical inactivity (PI) is a significant risk factor for chronic diseases. ... ...

Abstract	Abstract Background In 2021, China had a population of 264·01 million individuals over the age of 60, indicating a high prevalence of chronic diseases. Among older adults, physical inactivity (PI) is a significant risk factor for chronic diseases. However, few studies have been conducted on the correlation of physical activity (PA) with the economic status, geography and chronic disease risks in Chinese elderly. The objectives of this study were to better understand the distribution of PA among older adults in China and its relationship with economic status, geography, and chronic disease risks. Methods This study utilized data from the China Longitudinal Aging Social Survey (CLASS) in 2020, post-COVID-19. The study employed a stratified, multistage, probabilistic sampling approach and included 11,396 adults over the age of 59 from 28 provinces in China. Data on demographics, the duration and intensity of PA, history of diseases and personalized factors influencing PA were collected via structured interviews by researchers. In this study, we conducted a comprehensive analysis, employing a range of statistical methods including descriptive analysis, Wilcoxon rank-sum tests, Bayesian networks, and chi-square tests. Results The prevalence of PI among older adults over 59 in China is 28·82%. Significant regional differences were observed in the duration of PA at different intensities. Older adults residing in more economically developed areas were more likely to engage in moderate-to-vigorous physical activity (MVPA) and exhibited longer sedentary behavior. Economic status and urban-rural disparities consistently emerged as direct influential factors across all intensity types. Chronic disease risks were significantly lower in active older adults compared to inactive ones. Lack of social guidance, family support, and personal inclination towards sedentary behavior were the main personalized factors affecting PA among older adults, and these factors could be relatively easily modified. Conclusions Economic status, ...
Keywords	Physical activity ; Socio-economic ; Association ; Older adults ; Public aspects of medicine ; RA1-1270
Subject code	950
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Proanthocyanins and anthocyanins in chestnut (Castanea mollissima) shell extracts: biotransformation in the simulated gastrointestinal model and interaction with gut microbiota in vitro

Xie, Chenyang / Li, Jie / Fang, Yihe / Ma, Renyi / Dang, Zhixiong / Yang, Fang

Journal of the Science of Food and Agriculture. 2023 May, v. 103, no. 7 p.3659-3673

2023

Abstract: BACKGROUND: Chestnut (Castanea mollissima) shell is rich in flavonoids and our previous studies showed that proanthocyanins and anthocyanins were the two markedly varied flavonoids in chestnut shell extracts (CSE) during digestion. Here, the ... ...

Abstract	BACKGROUND: Chestnut (Castanea mollissima) shell is rich in flavonoids and our previous studies showed that proanthocyanins and anthocyanins were the two markedly varied flavonoids in chestnut shell extracts (CSE) during digestion. Here, the biotransformation of proanthocyanins and anthocyanins in a simulated gastrointestinal model, and the interactions between non‐absorption CSE (NACSE) and gut microbiota in vitro, were investigated by ultra‐high‐performance liquid chromatography combined with triple‐quadrupole mass spectrometry and 16S rRNA sequencing. RESULTS: Chestnut shell was richer in proanthocyanins and anthocyanins, while the loss of proanthocyanins was greater after digestion. Additionally, the content of anthocyanin decreased after gastric digestion but increased after intestinal digestion and remained stable after fermentation. After fermentation, delphinidin‐3‐O‐sambubioside and pelargonidin‐3‐O‐galactoside were newly formed. Furthermore, microbiome profiling indicated that NACSE promoted the proliferation of beneficial bacteria, while inhibiting pathogenic bacteria. CONCLUSION: All these data suggest that CSE may be a promising candidate to protect gut health. © 2023 Society of Chemical Industry.
Keywords	Castanea mollissima ; agriculture ; anthocyanins ; biotransformation ; chestnut shells ; digestion ; fermentation ; intestinal microorganisms ; intestines ; mass spectrometry ; microbiome ; models ; ultra-performance liquid chromatography
Language	English
Dates of publication	2023-05
Size	p. 3659-3673.
Publishing place	John Wiley & Sons, Ltd.
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.12480
Database	NAL-Catalogue (AGRICOLA)

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Article: Adropin inhibits the progression of atherosclerosis in ApoE

Ying, Teng / Wu, LingZhen / Lan, TingXiang / Wei, ZhiXiong / Hu, DanQing / Ke, YiLang / Jiang, Qiong / Fang, Jun

Cell death discovery

2023 Volume 9, Issue 1, Page(s) 402

Abstract: Adropin, a secreted protein, coded by energy homeostasis-associated gene (Enho), is recently reported to modulate atherogenesis, with endothelial-to-mesenchymal transition (EndMT) involved in the early process. We explored whether adropin may alleviate ... ...

Abstract	Adropin, a secreted protein, coded by energy homeostasis-associated gene (Enho), is recently reported to modulate atherogenesis, with endothelial-to-mesenchymal transition (EndMT) involved in the early process. We explored whether adropin may alleviate atherosclerosis by regulating EndMT. We found that an intraperitoneal injection of adropin [105 μg/(kg·d) for 13 weeks] inhibited the progression of high-fat diet (HFD)-induced aortic atherosclerosis in apolipoprotein E-deficient mice (ApoE
Language	English
Publishing date	2023-10-31
Publishing country	United States
Document type	Journal Article
ISSN	2058-7716
ISSN	2058-7716
DOI	10.1038/s41420-023-01697-3
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