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  1. Article ; Online: The mouse to man conundrum: Revisiting an old lung injury model to study repurposed drugs for COVID-19 treatment.

    Ronit, Andreas / Plovsing, Ronni R

    Experimental physiology

    2024  

    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/EP091889
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  2. Article ; Online: The Response of the Peer Review System to the Ebola and Zika Virus Epidemic.

    Ronit, Andreas

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2017  Volume 65, Issue 5, Page(s) 872–873

    MeSH term(s) Hemorrhagic Fever, Ebola/epidemiology ; Humans ; Information Storage and Retrieval ; MEDLINE ; Peer Review ; Periodicals as Topic ; Time ; Zika Virus Infection/epidemiology
    Language English
    Publishing date 2017-10-10
    Publishing country United States
    Document type Letter
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/cix444
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  3. Article ; Online: Lung function trajectories in mild COVID-19 with two-year follow-up.

    Iversen, Katrine K / Ronit, Andreas / Ahlström, Magnus G / Nordestgaard, Børge G / Afzal, Shoaib / Benfield, Thomas

    The Journal of infectious diseases

    2024  

    Abstract: Objective: To characterize lung function dynamics in individuals with mild COVID-19 from pre-infection to two years post-infection.: Methods: We re-invited participants two years after infection from our matched cohort study of the Copenhagen General ...

    Abstract Objective: To characterize lung function dynamics in individuals with mild COVID-19 from pre-infection to two years post-infection.
    Methods: We re-invited participants two years after infection from our matched cohort study of the Copenhagen General Population who had initially been examined 5.4 months after infection. We repeated lung tests and questionnaires. Linear mixed models were used to estimate lung volume changes in individuals with COVID-19 patients versus uninfected controls over two intervals: from pre-infection to six months post-infection and six months post-infection to two years post-infection.
    Results: 52 individuals (48.6%) attended the two-year examination at median 1.9 years (IQR 1.8; 2.4) after COVID-19, all with mild infection. Individuals with COVID-19 had an adjusted excess decline in FEV1 of 13.0 mL per year (CI 23.5; 2.5), p=0.02 from prior infection to 6 months after infection compared to uninfected controls. From 6 to 24 months after infection, they had an excess decline of 7.5 mL per year (CI 25.6; 9.6), p=0.40. A similar pattern was observed for FVC. Participants had a mean increase in DLco of 3.33 (SD 7.97) between the 6- and 24-month examination.
    Conclusion: Our results indicate that mild COVID-19 infection affects lung function at time of infection with limited recovery two years after infection.
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiae037
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  4. Article ; Online: [No title information]

    Ronit, Andreas / Porskrog, Anders / Djebara, Sarah / Bergmann, Sigrid / Pirnay, Jean-Paul / Merabishvili, Maia / Barfod, Toke S / Thomsen, Kim / Brandt, Christian T

    Ugeskrift for laeger

    2024  Volume 186, Issue 3

    Abstract: We present a case report detailing therapeutic application of two lytic antipseudomonal bacteriophages to treat a chronic relapsing Pseudomonas aeruginosa infection of a prosthetic aortic graft. As there are currently no Danish laboratories offering ... ...

    Title translation Bacteriophages for the treatment of pseudomonas-infected vascular prosthesis.
    Abstract We present a case report detailing therapeutic application of two lytic antipseudomonal bacteriophages to treat a chronic relapsing Pseudomonas aeruginosa infection of a prosthetic aortic graft. As there are currently no Danish laboratories offering phages for clinical therapy, and this case, to our knowledge represents the first applied phage therapy in Denmark, the practical and regulatory aspects of offering this treatment option in Denmark is briefly reviewed along with the clinical case.
    MeSH term(s) Humans ; Bacteriophages ; Pseudomonas ; Pseudomonas Phages ; Blood Vessel Prosthesis ; Pseudomonas aeruginosa
    Language Danish
    Publishing date 2024-01-22
    Publishing country Denmark
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
    DOI 10.61409/V09230617
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  5. Article ; Online: [Local immunopathology in COVID-19 associated lung injury].

    Ronit, Andreas / Berg, Ronan Mg / Mogensen, Trine H / Plovsing, Ronni R

    Ugeskrift for laeger

    2022  Volume 184, Issue 23

    Abstract: Mechanisms of COVID-19-induced lung injury involve complex immunopathological events which are currently being elucidated. Studying immune mechanisms at the primary site of injury, i.e. the lower airways, are particularly informative. This review ... ...

    Abstract Mechanisms of COVID-19-induced lung injury involve complex immunopathological events which are currently being elucidated. Studying immune mechanisms at the primary site of injury, i.e. the lower airways, are particularly informative. This review provides a brief introduction to the methods used to perform sampling from the lungs of critically ill patients with COVID-19, key immunopathological findings and a discussion on how immunosuppressants may exert their effects locally.
    MeSH term(s) COVID-19/complications ; Critical Illness ; Humans ; Lung/pathology ; Lung Injury/etiology ; Lung Injury/pathology
    Language Danish
    Publishing date 2022-06-21
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
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  6. Article ; Online: [No title information]

    Al-Zergani, Fatimah / Ronit, Andreas / Theilgaard, Zahra Persson / Ronayne, Aoife / Nielsen, Henrik Vedel / Porskrog, Anders

    Ugeskrift for laeger

    2023  Volume 185, Issue 40

    Abstract: Scrub typhus is caused by the mite-borne bacterium Orientia tsutsugamushi. Imported cases have been suspected in Denmark but no diagnostic method has yet been available to confirm the diagnosis. This is a case report of a 38-year-old male admitted to ... ...

    Title translation Orientia tsutsugamushi detected by microbiome diagnostics.
    Abstract Scrub typhus is caused by the mite-borne bacterium Orientia tsutsugamushi. Imported cases have been suspected in Denmark but no diagnostic method has yet been available to confirm the diagnosis. This is a case report of a 38-year-old male admitted to hospital with high fever, severe malaise and headache after returning from Malaysia. Scrub typhus was suspected and the patient recovered after one week of doxycycline treatment. The pathogen was identified by use of microbiome 16S/18S rRNA next-generation sequencing on ethylenediamine tetraacetic acid (EDTA) blood, which in the future may serve an important role in the investigation of travel-associated infections.
    MeSH term(s) Male ; Humans ; Adult ; Orientia tsutsugamushi/genetics ; Scrub Typhus/complications ; Scrub Typhus/diagnosis ; Scrub Typhus/microbiology ; Travel ; Doxycycline/therapeutic use ; Travel-Related Illness ; RNA, Ribosomal, 16S
    Chemical Substances Doxycycline (N12000U13O) ; RNA, Ribosomal, 16S
    Language Danish
    Publishing date 2023-10-02
    Publishing country Denmark
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
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  7. Article ; Online: Alveolar cytokines and interferon autoantibodies in COVID-19 ARDS.

    Jonassen, Trine B / Jørgensen, Sofie E / Mitchell, Nikki H / Mogensen, Trine H / Berg, Ronan M G / Ronit, Andreas / Plovsing, Ronni R

    Frontiers in immunology

    2024  Volume 15, Page(s) 1353012

    Abstract: Background: Type I interferon (IFN-I) and IFN autoantibodies play a crucial role in controlling SARS-CoV-2 infection. The levels of these mediators have only rarely been studied in the alveolar compartment in patients with COVID-19 acute respiratory ... ...

    Abstract Background: Type I interferon (IFN-I) and IFN autoantibodies play a crucial role in controlling SARS-CoV-2 infection. The levels of these mediators have only rarely been studied in the alveolar compartment in patients with COVID-19 acute respiratory distress syndrome (CARDS) but have not been compared across different ARDS etiologies, and the potential effect of dexamethasone (DXM) on these mediators is not known.
    Methods: We assessed the integrity of the alveolo-capillary membrane, interleukins, type I, II, and III IFNs, and IFN autoantibodies by studying the epithelial lining fluid (ELF) volumes, alveolar concentration of protein, and ELF-corrected concentrations of cytokines in two patient subgroups and controls.
    Results: A total of 16 patients with CARDS (four without and 12 with DXM treatment), eight with non-CARDS, and 15 healthy controls were included. The highest ELF volumes and protein levels were observed in CARDS. Systemic and ELF-corrected alveolar concentrations of interleukin (IL)-6 appeared to be particularly low in patients with CARDS receiving DXM, whereas alveolar levels of IL-8 were high regardless of DXM treatment. Alveolar levels of IFNs were similar between CARDS and non-CARDS patients, and IFNα and IFNω autoantibody levels were higher in patients with CARDS and non-CARDS than in healthy controls.
    Conclusions: Patients with CARDS exhibited greater alveolo-capillary barrier disruption with compartmentalization of IL-8, regardless of DXM treatment, whereas systemic and alveolar levels of IL-6 were lower in the DXM-treated subgroup. IFN-I autoantibodies were higher in the BALF of CARDS patients, independent of DXM, whereas IFN autoantibodies in plasma were similar to those in controls.
    MeSH term(s) Humans ; Cytokines ; COVID-19/complications ; Interleukin-8 ; Autoantibodies ; SARS-CoV-2 ; Interferon Type I ; Interleukin-6 ; Respiratory Distress Syndrome/etiology
    Chemical Substances Cytokines ; Interleukin-8 ; Autoantibodies ; Interferon Type I ; Interleukin-6
    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1353012
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  8. Article ; Online: Publication trends during the HIV pandemic: contributions by country.

    Ronit, Andreas / Ahlström, Magnus G

    AIDS (London, England)

    2017  Volume 31, Issue 11, Page(s) 1646–1647

    MeSH term(s) Bibliometrics ; Global Health ; HIV Infections/epidemiology ; Humans ; Pandemics ; Peer Review, Research
    Language English
    Publishing date 2017-08-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0000000000001548
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  9. Article ; Online: Paper acceptance time in respiratory research: room for improvement?

    Ronit, Andreas / Vestbo, Jørgen

    The European respiratory journal

    2017  Volume 49, Issue 2

    MeSH term(s) Biomedical Research/trends ; Editorial Policies ; Humans ; Peer Review ; PubMed ; Publications/trends ; Pulmonary Medicine/trends
    Language English
    Publishing date 2017-02-08
    Publishing country England
    Document type Letter
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01951-2016
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  10. Article ; Online: A new tidal breathing measurement device detects bronchial obstruction during methacholine challenge test.

    Zachariades, Andreas / Bachar, Nadav / Danino, Noy / Shafran, Inbal / Shtrichman, Ronit / Shuster, Gregory / Voigt, Wieland

    Advances in medical sciences

    2023  Volume 69, Issue 1, Page(s) 1–7

    Abstract: Purpose: Bronchial hyperresponsiveness (BHR), a hallmark of bronchial asthma, is typically diagnosed through a methacholine inhalation test followed by spirometry, known as the methacholine challenge test (MCT). While spirometry relies on proper ... ...

    Abstract Purpose: Bronchial hyperresponsiveness (BHR), a hallmark of bronchial asthma, is typically diagnosed through a methacholine inhalation test followed by spirometry, known as the methacholine challenge test (MCT). While spirometry relies on proper patients' cooperation and precise execution of forced breathing maneuvers, we conducted a comparative analysis with the portable nanomaterial-based sensing device, SenseGuard™, to non-intrusively assess tidal breathing parameters.
    Materials and methods: In this prospective study, 37 adult participants with suspected asthma underwent sequential spirometry and SenseGuard™ measurements after inhaling increasing methacholine doses.
    Results: Among the 37 participants, 18 were MCT responders, 17 were non-responders and 2 were excluded due to uninterpretable data. The MCT responders exhibited a significant lung function difference when comparing the change from baseline to maximum response. This was evident through a notable decrease in forced expiratory volume in 1 ​s (FEV
    Conclusions: This study demonstrates that tidal breathing assessment using SenseGuard™ device reliably detects clinically relevant changes of respiratory parameter during the MCT. It effectively distinguishes between responders and non-responders, with strong agreement to conventional spirometry-measured FEV
    Language English
    Publishing date 2023-12-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2273668-2
    ISSN 1898-4002 ; 1896-1126
    ISSN (online) 1898-4002
    ISSN 1896-1126
    DOI 10.1016/j.advms.2023.11.001
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