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  1. Article ; Online: Response to Letter to the Editor Clinical Nutrition.

    van Zanten, Arthur R H / Singer, Pierre

    Clinical nutrition (Edinburgh, Scotland)

    2023  Volume 43, Issue 1, Page(s) 297

    Language English
    Publishing date 2023-11-24
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2023.11.013
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1774: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Argon Humidification Exacerbates Antimicrobial and Anti-MRSA kINPen Plasma Activity.

    Clemen, Ramona / Singer, Debora / Skowski, Henry / Bekeschus, Sander

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 2

    Abstract: Gas plasma is a medical technology with antimicrobial properties. Its main mode of action is oxidative damage via reactive species production. The clinical efficacy of gas plasma-reduced bacterial burden has been shown to be hampered in some cases. Since ...

    Abstract Gas plasma is a medical technology with antimicrobial properties. Its main mode of action is oxidative damage via reactive species production. The clinical efficacy of gas plasma-reduced bacterial burden has been shown to be hampered in some cases. Since the reactive species profile produced by gas plasma jets, such as the kINPen used in this study, are thought to determine antimicrobial efficacy, we screened an array of feed gas settings in different types of bacteria. Antimicrobial analysis was performed by single-cell analysis using flow cytometry. We identified humidified feed gas to mediate significantly greater toxicity compared to dry argon and many other gas plasma conditions. The results were confirmed by inhibition zone analysis on gas-plasma-treated microbial lawns grown on agar plates. Our results may have vital implications for clinical wound management and potentially enhance antimicrobial efficacy of medical gas plasma therapy in patient treatment.
    Language English
    Publishing date 2023-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13020257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Anstieg von Ornithose-Fallmeldungen in Deutschland

    Singer, Regina / Baier, Michael / Wilking, Hendrik / Lachmann, Raskit

    2024  

    Abstract: Seit Dezember 2023 wurde ein Anstieg der gemäß IfSG an das RKI übermittelten Ornithose-Fälle in Deutschland beobachtet. Auch in Dänemark, den Niederlanden, in Österreich und Schweden wurden für den gleichen Zeitraum eine Zunahme von Ornithose-Fällen bei ... ...

    Abstract Seit Dezember 2023 wurde ein Anstieg der gemäß IfSG an das RKI übermittelten Ornithose-Fälle in Deutschland beobachtet. Auch in Dänemark, den Niederlanden, in Österreich und Schweden wurden für den gleichen Zeitraum eine Zunahme von Ornithose-Fällen bei Menschen gemeldet. Es gibt derzeit keine Anzeichen dafür, dass diese Krankheit durch Menschen verbreitet wird und insgesamt ist die Wahrscheinlichkeit einer Übertragung von Mensch zu Mensch sehr gering.
    Keywords Ornithose ; Zoonose ; C. psittaci ; Lungenentzündung ; IfSG ; 610 Medizin und Gesundheit ; ddc:610
    Language German
    Publishing date 2024-03-07
    Publisher Robert Koch-Institut
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Laboratory Criteria for Exclusion and Readmission of Potentially Infectious Persons in Sensitive Settings in the Age of Culture-Independent Diagnostic Tests: Report of a Multidisciplinary Workgroup.

    Besser, John / Singer, Rachael / Jervis, Rachel H / Boxrud, David / Smith, Kirk / Daly, Elizabeth R

    Journal of food protection

    2023  Volume 86, Issue 12, Page(s) 100173

    Abstract: Culture-independent diagnostic tests (CIDTs) are increasingly used for clinical diagnosis of gastrointestinal diseases such as salmonellosis, Shiga toxin-producing E. coli disease, and shigellosis because of their speed, convenience, and generally high- ... ...

    Abstract Culture-independent diagnostic tests (CIDTs) are increasingly used for clinical diagnosis of gastrointestinal diseases such as salmonellosis, Shiga toxin-producing E. coli disease, and shigellosis because of their speed, convenience, and generally high-performance characteristics. These tests are also used to screen potentially infectious asymptomatic persons during outbreak investigations in sensitive settings such as childcare, food service, and healthcare. However, only limited performance data are available for CIDTs used on specimens from asymptomatic persons. The Association of Public Health Laboratories (APHL) and Council of State and Territorial Epidemiologists (CSTE) convened a workgroup to examine the available scientific data to inform interim decision-making related to exclusion and readmission criteria for potentially infectious persons in sensitive settings, the risks and benefits of different testing strategies, and to identify knowledge gaps for further research. This is the report on the Workgroup findings.
    MeSH term(s) Humans ; Escherichia coli ; Escherichia coli Infections/epidemiology ; Laboratories ; Patient Readmission ; Salmonella Infections ; Shiga-Toxigenic Escherichia coli
    Language English
    Publishing date 2023-10-04
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 243284-5
    ISSN 1944-9097 ; 0362-028X
    ISSN (online) 1944-9097
    ISSN 0362-028X
    DOI 10.1016/j.jfp.2023.100173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 2631: Show issues

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  5. Article ; Online: Dentition and weight status in community-dwelling older adults.

    Zelig, Rena / Lyon, Amy / Touger-Decker, Riva / Singer, Steven R / Samavat, Hamed

    Gerodontology

    2024  

    Abstract: Background/objective: Tooth loss is common among older adults and can affect dietary intake and weight status. This study investigated associations between dentition status and body mass index (BMI) in older adults.: Materials and methods: This was a ...

    Abstract Background/objective: Tooth loss is common among older adults and can affect dietary intake and weight status. This study investigated associations between dentition status and body mass index (BMI) in older adults.
    Materials and methods: This was a cross-sectional study of data from a convenience sample of older adults (65-89 years) treated at an urban U.S. dental school clinic. Clinical and demographic data were obtained from electronic health records. Dentition status was determined based on data from odontograms. Multinomial logistic regression was used to estimate the odds ratio (OR) and 95% confidence interval (CI) of having a non-normal weight status for each measure of dentition status, after adjusting for covariates.
    Results: Patients (n = 1765) were 54.1% female, 51.5% White, 41.6% African American and 22.5% Hispanic/Latino. The median (interquartile range [IQR]) age was 71 (67.0-75.0) years; the mean (±SD) BMI was 28.5 (±5.7) kg/m
    Conclusion: Older adults with tooth loss - especially loss of posterior occlusion and lack of a functional dentition - were more likely to be obese than of normal weight.
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 604810-9
    ISSN 1741-2358 ; 0734-0664
    ISSN (online) 1741-2358
    ISSN 0734-0664
    DOI 10.1111/ger.12747
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2593: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Evaluation of Strategies for Transitioning to Annual SARS-CoV-2 Vaccination Campaigns in the United States.

    Wells, Chad R / Pandey, Abhishek / Moghadas, Seyed M / Fitzpatrick, Meagan C / Singer, Burton H / Galvani, Alison P

    Annals of internal medicine

    2024  

    Abstract: Background: The U.S. Food and Drug Administration has proposed administering annual SARS-CoV-2 vaccines.: Objective: To evaluate the effectiveness of an annual SARS-CoV-2 vaccination campaign, quantify the health and economic benefits of a second ... ...

    Abstract Background: The U.S. Food and Drug Administration has proposed administering annual SARS-CoV-2 vaccines.
    Objective: To evaluate the effectiveness of an annual SARS-CoV-2 vaccination campaign, quantify the health and economic benefits of a second dose provided to children younger than 2 years and adults aged 50 years or older, and optimize the timing of a second dose.
    Design: An age-structured dynamic transmission model.
    Setting: United States.
    Participants: A synthetic population reflecting demographics and contact patterns in the United States.
    Intervention: Vaccination against SARS-CoV-2 with age-specific uptake similar to that of influenza vaccination.
    Measurements: Incidence, hospitalizations, deaths, and direct health care cost.
    Results: The optimal timing between the first and second dose delivered to children younger than 2 years and adults aged 50 years or older in an annual vaccination campaign was estimated to be 5 months. In direct comparison with a single-dose campaign, a second booster dose results in 123 869 fewer hospitalizations (95% uncertainty interval [UI], 121 994 to 125 742 fewer hospitalizations) and 5524 fewer deaths (95% UI, 5434 to 5613 fewer deaths), averting $3.63 billion (95% UI, $3.57 billion to $3.69 billion) in costs over a single year.
    Limitations: Population immunity is subject to degrees of immune evasion for emerging SARS-CoV-2 variants. The model was implemented in the absence of nonpharmaceutical interventions and preexisting vaccine-acquired immunity.
    Conclusion: The direct health care costs of SARS-CoV-2, particularly among adults aged 50 years or older, would be substantially reduced by administering a second dose 5 months after the initial dose.
    Primary funding source: Natural Sciences and Engineering Research Council of Canada, Notsew Orm Sands Foundation, National Institutes of Health, Centers for Disease Control and Prevention, and National Science Foundation.
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M23-2451
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    Ua VI Zs.178/2: Show issues Location:
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  7. Article ; Online: The U.S. Needs a National Human Health Observing System.

    Sandifer, Paul A / Singer, Burton H / Colwell, Rita R

    Frontiers in public health

    2021  Volume 9, Page(s) 705597

    Abstract: The COVID-19 pandemic and increasing frequency and severity of environmental disasters reveal an urgent need for a robust health observing/surveillance system. With the possible exception of Brazil, we know of no such comprehensive health observing ... ...

    Abstract The COVID-19 pandemic and increasing frequency and severity of environmental disasters reveal an urgent need for a robust health observing/surveillance system. With the possible exception of Brazil, we know of no such comprehensive health observing capacity. The US should create a national system of linked regionally-based health monitoring systems similar to those for weather, ocean conditions, and climate. Like those for weather, the health observing system should operate continuously, collecting mental, physical, and community health data before, during, and after events. The system should include existing cross-sectional health data surveys, along with significant new investment in regional longitudinal cohort studies. The recently described framework for a Gulf of Mexico Community Health Observing System is suggested as a potential model for development of a nation-wide system.
    MeSH term(s) COVID-19 ; Cross-Sectional Studies ; Humans ; Longitudinal Studies ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-09-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2021.705597
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  8. Article: mRNA Localization and Local Translation of the Microtubule Severing Enzyme, Fidgetin-Like 2, in Polarization, Migration and Outgrowth.

    Birnbaum, Rayna / Biswas, Jeetayu / Singer, Robert H / Sharp, David J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Cell motility requires strict spatiotemporal control of protein expression. During cell migration, mRNA localization and local translation in subcellular areas like the leading edge and protrusions are particularly advantageous for regulating the ... ...

    Abstract Cell motility requires strict spatiotemporal control of protein expression. During cell migration, mRNA localization and local translation in subcellular areas like the leading edge and protrusions are particularly advantageous for regulating the reorganization of the cytoskeleton. Fidgetin-Like 2 (FL2), a microtubule severing enzyme (MSE) that restricts migration and outgrowth, localizes to the leading edge of protrusions where it severs dynamic microtubules. FL2 is primarily expressed during development but in adulthood, is spatially upregulated at the leading edge minutes after injury. Here, we show mRNA localization and local translation in protrusions of polarized cells are responsible for FL2 leading edge expression after injury. The data suggests that the RNA binding protein IMP1 is involved in the translational regulation and stabilization of FL2 mRNA, in competition with the miRNA let-7. These data exemplify the role of local translation in microtubule network reorganization during migration and elucidate an unexplored MSE protein localization mechanism.
    Language English
    Publishing date 2023-04-17
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.17.537087
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  9. Book: BAT-R

    Bös, Klaus / Hocker, Dana / Kraus, Uta / Singer, Johanna / Mechling, Heinz

    Bilder-Angst-Test - Revision : Test zur Erfassung der Bewegungsangst bei 7- bis 11-Jährigen : Manual

    2019  

    Title variant Bilder-Angst-Test - Revision
    Author's details Klaus Bös, Dana Hocker, Uta Kraus, Johanna Singer, Heinz Mechling
    Keywords Bewegung ; Angststörung ; Kinderpsychologie
    Subject Entwicklungspsychologie ; Kind ; Kindespsychologie ; Kindheitspsychologie ; Pathologische Angst ; Pathologischer Angstzustand ; Körperbewegung ; Motion ; Movement
    Language German
    Size 67 Seiten, Illustrationen
    Edition 1. Auflage
    Publisher Hogrefe
    Publishing place Göttingen
    Publishing country Germany
    Document type Book
    Accompanying material 25 Fragebogen, 25 Auswertungsbogen [in Mappe]
    HBZ-ID HT020212970
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2020 C 14 order for loan Magazin
    Zusammengebunden: Manual, 1 Fragebogen, 1 Antwortbogen

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  10. Article: Correction: Maskato et al. Prospective Feasibility and Revalidation of the Equine Acute Abdominal Pain Scale (EAAPS) in Clinical Cases of Colic in Horses.

    Maskato, Yamit / Dugdale, Alexandra H A / Singer, Ellen R / Kelmer, Gal / Sutton, Gila A

    Animals : an open access journal from MDPI

    2022  Volume 12, Issue 8

    Abstract: The authors wish to make the following corrections to this paper [ ... ]. ...

    Abstract The authors wish to make the following corrections to this paper [...].
    Language English
    Publishing date 2022-04-13
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani12081001
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