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  1. Article ; Online: Oreillons.

    Paccoud, Olivier

    La Revue du praticien

    2023  Volume 73, Issue 5, Page(s) 571–574

    Title translation Mumps.
    MeSH term(s) Humans ; Mumps
    Language French
    Publishing date 2023-06-12
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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    Ua VI Zs.433: Show issues Location:
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  2. Article ; Online: Topical 1% Voriconazole for Mixed Scedosporium and Exophiala Subcutaneous Infection in a Kidney Transplant Recipient.

    Paccoud, Olivier / Sohier, Pierre / Cotteret, Camille / Guégan, Sarah / Lanternier, Fanny

    Acta dermato-venereologica

    2023  Volume 103, Page(s) adv9590

    MeSH term(s) Humans ; Exophiala/drug effects ; Kidney Transplantation/adverse effects ; Scedosporium/drug effects ; Transplant Recipients ; Voriconazole/administration & dosage ; Voriconazole/therapeutic use ; Male ; Adult ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/surgery ; Phaeohyphomycosis/drug therapy
    Chemical Substances Voriconazole (JFU09I87TR)
    Language English
    Publishing date 2023-06-15
    Publishing country Sweden
    Document type Case Reports ; Journal Article
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/actadv.v103.9590
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  3. Article ; Online: A Woman with Relapsed Chronic Lymphocytic Leukemia and Upper Lobe Consolidation.

    Paccoud, Olivier / Barnier, Jean-Philippe / Lanternier, Fanny / Lortholary, Olivier

    Annals of the American Thoracic Society

    2021  Volume 18, Issue 11, Page(s) 1901–1906

    MeSH term(s) Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols ; Female ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Recurrence ; Rituximab
    Chemical Substances Antineoplastic Agents ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2021-11-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202012-1538CC
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    Zs.A 5828: Show issues Location:
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  4. Article ; Online: Cryptococcus gattii

    Paccoud, Olivier / Bougnoux, Marie-Elisabeth / Desnos-Ollivier, Marie / Varet, Bruno / Lortholary, Olivier / Lanternier, Fanny

    Journal of fungi (Basel, Switzerland)

    2021  Volume 7, Issue 3

    Abstract: Recent outbreaks ... ...

    Abstract Recent outbreaks of
    Language English
    Publishing date 2021-03-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof7030212
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  5. Article ; Online: Impact of prior cryptococcal antigen screening on in-hospital mortality in cryptococcal meningitis or fungaemia among HIV-seropositive individuals in South Africa: a cross-sectional observational study.

    Paccoud, Olivier / Shuping, Liliwe / Mashau, Rudzani / Greene, Greg / Quan, Vanessa / Meiring, Susan / Govender, Nelesh P

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  Volume 29, Issue 8, Page(s) 1063–1069

    Abstract: Objectives: We investigated whether patients with cryptococcal meningitis (CM) or fungaemia detected through South Africa's laboratory cryptococcal antigen (CrAg) screening programme had better outcomes than those presenting directly to the hospital.: ...

    Abstract Objectives: We investigated whether patients with cryptococcal meningitis (CM) or fungaemia detected through South Africa's laboratory cryptococcal antigen (CrAg) screening programme had better outcomes than those presenting directly to the hospital.
    Methods: We compared 14-day in-hospital case-fatality ratios of HIV-seropositive individuals with CD4 counts below 100 cells/μL and laboratory-confirmed CM/fungaemia from 2017-2021, with or without evidence of a positive blood CrAg test within 14 days prior to diagnosis. We evaluated whether the impact of prior CrAg screening on mortality varied according to the study period (pre-COVID-19: before March 2020 vs. COVID-19: after March 2020).
    Results: Overall, 24.5% (830/3390) of patients had a prior positive CrAg test within 14 days of diagnosis. CrAg-screened patients were less likely to have an altered mental status at baseline than non-CrAg-screened patients (38.1% [296/776] vs. 42.6% [1010/2372], p = 0.03), and had a lower crude 14-day case-fatality ratio (24.7% [205/830] vs. 28.3% [724/2560]; OR, 0.83 [95% CI, 0.69-0.99]; p = 0.045). Previous CrAg screening was associated with a greater reduction in the crude 14-day mortality during the COVID-19 period (OR, 0.64 [0.47-0.87]; p = 0.005) compared with before (OR, 0.95 [0.76-1.19]; p = 0.68). After adjustment, previous CrAg screening within 14 days was associated with increased survival only during the COVID-19 period (adjusted OR, 0.70 [0.51-0.96]; p = 0.03).
    Discussion: Previous CrAg screening was associated with a survival benefit in patients hospitalized with CM/fungaemia during the COVID-19 period, with fewer patients having an altered mental status at baseline, suggesting that these patients may have been diagnosed with cryptococcosis earlier.
    MeSH term(s) Humans ; Meningitis, Cryptococcal/diagnosis ; AIDS-Related Opportunistic Infections/diagnosis ; HIV Infections/diagnosis ; Fungemia/drug therapy ; Hospital Mortality ; South Africa/epidemiology ; Antifungal Agents/therapeutic use ; COVID-19/diagnosis ; COVID-19/complications ; Cryptococcus ; Antigens, Fungal ; CD4 Lymphocyte Count
    Chemical Substances Antifungal Agents ; Antigens, Fungal
    Language English
    Publishing date 2023-04-21
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.04.016
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    Zs.A 4541: Show issues Location:
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  6. Article ; Online: Correction to: The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study.

    Kas, Aurélie / Soret, Marine / Pyatigorskaya, Nadya / Habert, Marie-Odile / Hesters, Adèle / Le Guennec, Loic / Paccoud, Olivier / Bombois, Stéphanie / Delorme, Cécile

    European journal of nuclear medicine and molecular imaging

    2022  Volume 49, Issue 9, Page(s) 3304

    Language English
    Publishing date 2022-05-15
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-022-05812-x
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    Zs.A 1227: Show issues Location:
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  7. Article ; Online: Cryptococcus gattii in Patients with Lymphoid Neoplasms

    Olivier Paccoud / Marie-Elisabeth Bougnoux / Marie Desnos-Ollivier / Bruno Varet / Olivier Lortholary / Fanny Lanternier

    Journal of Fungi, Vol 7, Iss 212, p

    An Illustration of Evolutive Host–Fungus Interactions

    2021  Volume 212

    Abstract: Recent outbreaks of Cryptococcus gattii (CG) infections in North America have sparked renewed interest in the pathogenic potential of CG, and have underscored notable differences with Cryptococcus neoformans in terms of geographic distribution, pathogen ... ...

    Abstract Recent outbreaks of Cryptococcus gattii (CG) infections in North America have sparked renewed interest in the pathogenic potential of CG, and have underscored notable differences with Cryptococcus neoformans in terms of geographic distribution, pathogen virulence, and host susceptibility. While cases of CG are increasingly reported in patients with a wide variety of underlying conditions, only very few have been reported in patients with lymphoid neoplasms. Herein, we report a case of autochthonous CG meningitis in a patient receiving ibrutinib for chronic lymphocytic leukemia in France, and review available data on the clinical epidemiology of CG infections in patients with lymphoid neoplasms. We also summarise recent data on the host responses to CG infection, as well as the potential management pitfalls associated with its treatment in the haematological setting. The clinical epidemiology, clinical presentation, and course of disease during infections caused by CG involve complex interactions between environmental exposure to CG, infecting genotype, pathogen virulence factors, host susceptibility, and host immune responses. Future treatment guidelines should address the challenges associated with the management of antifungal treatments in the onco-haematological setting and the potential drug-drug interactions.
    Keywords Cryptococcus gattii ; cryptococcosis ; haematological malignancy ; lymphoid neoplasms ; chronic lymphocytic leukemia ; ibrutinib ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Main human inborn errors of immunity leading to fungal infections.

    Cifaldi, Cristina / Ursu, Giorgiana M / D'Alba, Irene / Paccoud, Olivier / Danion, François / Lanternier, Fanny / Chiriaco, Maria

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2022  Volume 28, Issue 11, Page(s) 1435–1440

    Abstract: Background: The host's molecular and genetic features are essential in providing susceptibility to a broad spectrum of fungal infections; most of these do not cause disease in healthy individuals because of mutual benefits with opportunistic fungi ... ...

    Abstract Background: The host's molecular and genetic features are essential in providing susceptibility to a broad spectrum of fungal infections; most of these do not cause disease in healthy individuals because of mutual benefits with opportunistic fungi besides the host's capacity to control the infections. In contrast, patients with primary immunodeficiency can develop mild superficial to life-threatening invasive infections. In the last years, thanks to next-generation sequencing, several inborn-error variants have been discovered in genes encoding protein acting against fungal infections, contributing to better defining the role of innate and adaptive immunity cooperation during infection resolution. Candida fungal infection that sometimes strikes healthy subjects is responsible for the chronic mucocutaneous candidiasis that is one of the principal clinical manifestations occurring in several rare primary immunodeficiencies associated with an inborn error of interleukin-17 (IL-17) immunity.
    Objective: This review aimed to provide an overview of chronic mucocutaneous candidiasis-derived genetic defects, including IL17 deficiencies (IL17A, IL17F, IL17RA, IL17RC), STAT1 gain-of-function deficiency, STAT3 hyper-IgE syndrome, and CARD9 deficiency.
    Sources: We carried out detailed research work to identify interesting articles, commentaries, and reviews in the PubMed literature to ensure a correct and updated narrative review.
    Content: We propose an in-depth description and an update of genetic and cellular mechanisms underlying fungal infections, focusing on the IL17-mediated response, a report of clinical manifestations, and a description of therapeutic options.
    Implications: This narrative review will help clinician to identify the correct management of patients based on molecular and cellular findings underlying pathogenic mechanisms of different inborn errors of immunity. Moreover, enabling clinicians to achieve the genetic diagnosis will be useful to offer genetic counselling intra- and inter-family and to ensure a personalised treatment of patients.
    MeSH term(s) Humans ; Candidiasis, Chronic Mucocutaneous/genetics ; Interleukin-17/genetics ; Mycoses ; Adaptive Immunity ; Candida
    Chemical Substances Interleukin-17
    Language English
    Publishing date 2022-07-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2022.06.031
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  9. Article ; Online: Reply to Million et al.

    Hajage, David / Pourcher, Valérie / Paccoud, Olivier / Bleibtreu, Alexandre / Caumes, Eric / Tubach, Florence

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 72, Issue 9, Page(s) e440–e441

    MeSH term(s) COVID-19/drug therapy ; Compassionate Use Trials ; Humans ; Hydroxychloroquine ; SARS-CoV-2
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH)
    Language English
    Publishing date 2020-08-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa1122
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  10. Article ; Online: Favorable outcome without corticosteroids during post-artesunate delayed hemolysis with positive direct antiglobulin test in severe imported Plasmodium falciparum malaria, France.

    Paccoud, Olivier / Chamillard, Xavier / Kendjo, Eric / Vinatier, Isabelle / Surgers, Laure / Magne, Denis / Wyplosz, Benjamin / Angoulvant, Adéla / Bouchaud, Olivier / Izri, Arezki / Matheron, Sophie / Houzé, Sandrine / Thellier, Marc / Ndour, Alioune P / Buffet, Pierre / Caumes, Eric / Jauréguiberry, Stéphane

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2023  Volume 137, Page(s) 144–148

    Abstract: Objectives: Positive direct antiglobulin tests (DATs) have been reported in cases of post-artesunate delayed hemolysis (PADH), but the causal role of auto-immune hemolysis remains unclear. We aimed to analyze a cohort of patients with PADH and DAT ... ...

    Abstract Objectives: Positive direct antiglobulin tests (DATs) have been reported in cases of post-artesunate delayed hemolysis (PADH), but the causal role of auto-immune hemolysis remains unclear. We aimed to analyze a cohort of patients with PADH and DAT during severe malaria.
    Methods: We describe PADH and DAT results in a 7-year multi-center retrospective cohort of patients receiving artesunate for severe imported malaria.
    Results: Of 337 patients treated with artesunate, 46 (13.6%) had at least one DAT result within 30 days of treatment initiation, and 25/46 (54.3%) had at least one positive DAT. Among 40 patients with available data, 17 (42.5%) experienced PADH. Patient characteristics were similar for patients with a positive or negative DAT, and DAT positivity was not associated with PADH occurrence (P = 0.36). Among patients, 5/13 (38.5%) with a positive DAT after day 7 experienced PADH, compared to 10/13 (76.9%) of those with a negative DAT after day 7 (P = 0.11). Overall, 41% of patients required blood transfusions, and outcome was favorable without corticosteroids, even in cases of PADH.
    Conclusions: DAT does not appear to be a marker of PADH, but rather an indirect marker of an immune-mediated mechanism. DAT positivity should not lead to the administration of systemic corticosteroids during PADH.
    MeSH term(s) Humans ; Artesunate/therapeutic use ; Hemolysis ; Antimalarials/therapeutic use ; Artemisinins/therapeutic use ; Retrospective Studies ; Coombs Test ; Malaria, Falciparum/diagnosis ; Malaria, Falciparum/drug therapy ; Malaria/complications ; France ; Adrenal Cortex Hormones/therapeutic use
    Chemical Substances Artesunate (60W3249T9M) ; Antimalarials ; Artemisinins ; Adrenal Cortex Hormones
    Language English
    Publishing date 2023-11-04
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2023.10.018
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