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  1. Article: On

    Bonovas, Stefanos / Piovani, Daniele

    Journal of clinical medicine

    2023  Volume 12, Issue 3

    Abstract: At the beginning of our research training, we learned about hypothesis testing, ...

    Abstract At the beginning of our research training, we learned about hypothesis testing,
    Language English
    Publishing date 2023-01-23
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12030900
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Simpson's Paradox in Clinical Research: A Cautionary Tale.

    Bonovas, Stefanos / Piovani, Daniele

    Journal of clinical medicine

    2023  Volume 12, Issue 4

    Abstract: The word paradox comes from the ... ...

    Abstract The word paradox comes from the Greek
    Language English
    Publishing date 2023-02-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12041633
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: On p -Values and Statistical Significance

    Stefanos Bonovas / Daniele Piovani

    Journal of Clinical Medicine, Vol 12, Iss 900, p

    2023  Volume 900

    Abstract: At the beginning of our research training, we learned about hypothesis testing, p -values, and statistical inference [.] ...

    Abstract At the beginning of our research training, we learned about hypothesis testing, p -values, and statistical inference [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Real World-Big Data Analytics in Healthcare.

    Piovani, Daniele / Bonovas, Stefanos

    International journal of environmental research and public health

    2022  Volume 19, Issue 18

    Abstract: The term Big Data is used to describe extremely large datasets that are complex, multi-dimensional, unstructured, and heterogeneous and that are accumulating rapidly and may be analyzed with appropriate informatic and statistical methodologies to reveal ... ...

    Abstract The term Big Data is used to describe extremely large datasets that are complex, multi-dimensional, unstructured, and heterogeneous and that are accumulating rapidly and may be analyzed with appropriate informatic and statistical methodologies to reveal patterns, trends, and associations [...].
    MeSH term(s) Big Data ; Data Science ; Delivery of Health Care ; Health Facilities
    Language English
    Publishing date 2022-09-16
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph191811677
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: UV radiation and air pollution as drivers of major autoimmune conditions.

    Piovani, Daniele / Brunetta, Enrico / Bonovas, Stefanos

    Environmental research

    2023  Volume 224, Page(s) 115449

    Abstract: Autoimmune diseases comprise a very heterogeneous group of disorders characterized by disruptive immune responses against self-antigens, chronic morbidity and increased mortality. The incidence and prevalence of major autoimmune conditions are ... ...

    Abstract Autoimmune diseases comprise a very heterogeneous group of disorders characterized by disruptive immune responses against self-antigens, chronic morbidity and increased mortality. The incidence and prevalence of major autoimmune conditions are particularly high in the western world, at northern latitudes, and in industrialized countries. This study will mainly focus on five major autoimmune conditions, namely type 1 diabetes, multiple sclerosis, inflammatory bowel diseases, rheumatoid arthritis, and autoimmune thyroid disorders. Epidemiological and experimental evidence suggests a protective role of sunlight exposure on the etiology of major autoimmune conditions mediated by the endogenous production of vitamin D and nitric oxide. A historical perspective shows how the rise of anthropogenic air pollutants is temporally associated with dramatic increases in incidence of these conditions. The scattering caused by ambient particulate matter and the presence of tropospheric ozone can reduce the endogenous production of vitamin D and nitric oxide, which are implicated in maintaining the immune homeostasis. Air pollutants have direct detrimental effects on the human body and are deemed responsible of an increasingly higher portion of the annual burden of human morbidity and mortality. Air pollution contributes in systemic inflammation, activates oxidative pathways, induces epigenetic alterations, and modulates the function and phenotype of dendritic cells, Tregs, and T-cells. In this review, we provide epidemiological and mechanistic insights regarding the role of UV-mediated effects in immunity and how anthropic-derived air pollution may affect major autoimmune conditions through direct and indirect mechanisms.
    MeSH term(s) Humans ; Ultraviolet Rays ; Nitric Oxide ; Air Pollution ; Air Pollutants ; Particulate Matter ; Autoimmune Diseases/etiology ; Vitamin D
    Chemical Substances Nitric Oxide (31C4KY9ESH) ; Air Pollutants ; Particulate Matter ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2023-02-09
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2023.115449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 726: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Association of Depression With Incident Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis.

    Piovani, Daniele / Armuzzi, Alessandro / Bonovas, Stefanos

    Inflammatory bowel diseases

    2023  Volume 30, Issue 4, Page(s) 573–584

    Abstract: Background: Individuals with a history of depression/depressive symptoms are suspected to be at increased risk of incident inflammatory bowel diseases (IBDs).: Methods: We systematically searched MEDLINE/PubMed, Embase, and Scopus databases for ... ...

    Abstract Background: Individuals with a history of depression/depressive symptoms are suspected to be at increased risk of incident inflammatory bowel diseases (IBDs).
    Methods: We systematically searched MEDLINE/PubMed, Embase, and Scopus databases for longitudinal studies examining the association between depression/depressive symptoms and subsequent new-onset IBD (ie, Crohn's disease and ulcerative colitis). We included studies in which the exposure was a confirmed diagnosis of depression/depressive symptoms measured through a validated scale. To limit concerns of diagnostic bias and reverse causality, and support temporality between exposure and outcomes, we synthesized estimates corresponding to the longest time lag reported. Two authors extracted study data independently and assessed each study's risk of bias. Maximally adjusted relative risk (RR) estimates were synthesized using random- and fixed-effects models.
    Results: Of 5307 records, 13 studies (8 cohort and 5 nested case-control studies; 9 million individuals) fulfilled the eligibility criteria. Depression was significantly associated with incident Crohn's disease (RRrandom, 1.17; 95% confidence interval, 1.02-1.34; 7 studies, 17 676 cases) and ulcerative colitis (RRrandom, 1.21; 95% confidence interval, 1.10-1.33; 6 studies, 28 165 cases). The primary studies considered pertinent confounders. Several years, on average, separated exposure and outcomes. No evidence of important heterogeneity or publication bias was found. Summary estimates were at low risk of bias, and results were confirmed in multiple sensitivity analyses. No firm conclusions could be drawn regarding a dilution of the association over time.
    Conclusions: Individuals with a history of depression may show small-to-moderate increased risk of IBD even when depression is diagnosed several years before new-onset IBD. Further epidemiological and mechanistic studies should clarify whether these associations are causal.
    MeSH term(s) Humans ; Colitis, Ulcerative/complications ; Colitis, Ulcerative/epidemiology ; Crohn Disease/complications ; Crohn Disease/epidemiology ; Depression/epidemiology ; Depression/etiology ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/epidemiology
    Language English
    Publishing date 2023-06-09
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 1340971-2
    ISSN 1536-4844 ; 1078-0998
    ISSN (online) 1536-4844
    ISSN 1078-0998
    DOI 10.1093/ibd/izad109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4530: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Letter: Potassium-competitive acid blockers may increase the risk of gastric cancer after Helicobacter pylori eradication-a retrospective multicentre-cohort analysis. Authors' reply.

    Piovani, Daniele / Tsantes, Andreas G / Schünemann, Holger J / Bonovas, Stefanos

    Alimentary pharmacology & therapeutics

    2023  Volume 57, Issue 10, Page(s) 1199–1200

    MeSH term(s) Humans ; Stomach Neoplasms ; Helicobacter pylori ; Cohort Studies ; Anti-Bacterial Agents/therapeutic use ; Retrospective Studies ; Helicobacter Infections/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-04-22
    Publishing country England
    Document type Multicenter Study ; Letter ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2206: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Racial Disparities in Infliximab Efficacy for Ulcerative Colitis: Evidence Synthesis and Effect Modification Assessment.

    Bonovas, Stefanos / Tsantes, Andreas G / Sokou, Rozeta / Tsantes, Argirios E / Nikolopoulos, Georgios K / Piovani, Daniele

    Journal of clinical medicine

    2024  Volume 13, Issue 2

    Abstract: An increasing amount of research explores the role of race in clinical phenotypes and outcomes in ulcerative colitis (UC). We aimed to investigate racial differences in infliximab (IFX) treatment efficacy in UC. We used aggregate data from IFX trials and ...

    Abstract An increasing amount of research explores the role of race in clinical phenotypes and outcomes in ulcerative colitis (UC). We aimed to investigate racial differences in infliximab (IFX) treatment efficacy in UC. We used aggregate data from IFX trials and evidence synthesis methods to generate race-specific efficacy estimates. Then, we tested the effect modification by race by comparing the race-specific estimates derived from independent evidence syntheses. We computed ratios of relative risks (RRRs) and performed tests of statistical interaction. We analyzed data from five randomized, placebo-controlled trials evaluating IFX as induction and maintenance therapy for adults with moderate-to-severe UC (875 participants; 45% Asians). We found no substantial evidence of racial differences concerning the efficacy of IFX in inducing clinical response (RRR = 0.89, 95% CI: 0.66-1.20;
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13020319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Non-Communicable Diseases: The Invisible Epidemic.

    Piovani, Daniele / Nikolopoulos, Georgios K / Bonovas, Stefanos

    Journal of clinical medicine

    2022  Volume 11, Issue 19

    Abstract: Historically, communicable diseases, such as HIV/AIDS, viral hepatitis, malaria, poliomyelitis, tuberculosis, influenza and, more recently, the coronavirus disease 2019, have been at the center of global health concerns and initiatives, as they are ... ...

    Abstract Historically, communicable diseases, such as HIV/AIDS, viral hepatitis, malaria, poliomyelitis, tuberculosis, influenza and, more recently, the coronavirus disease 2019, have been at the center of global health concerns and initiatives, as they are transmitted from one person to another with a variety of ways, easily spread across national borders, and threaten the lives of millions of people all over the globe [...].
    Language English
    Publishing date 2022-10-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11195939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Prognostic Role of Neutrophil-to-Lymphocyte Ratio in Patients with COVID-19.

    Piovani, Daniele / Tsantes, Andreas G / Bonovas, Stefanos

    Journal of clinical medicine

    2022  Volume 11, Issue 16

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a major impact on global health, continuing to put strain on healthcare systems and disrupting socioeconomic life [ ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a major impact on global health, continuing to put strain on healthcare systems and disrupting socioeconomic life [...].
    Language English
    Publishing date 2022-08-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11164688
    Database MEDical Literature Analysis and Retrieval System OnLINE

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