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  1. Article ; Online: Compassionate use of others' immunity - understanding gut microbiome in Covid-19.

    Thalanayar Muthukrishnan, Prashanth / Faillace, Robert

    Critical care (London, England)

    2020  Volume 24, Issue 1, Page(s) 358

    MeSH term(s) Betacoronavirus ; COVID-19 ; Compassionate Use Trials ; Coronavirus Infections ; Critical Illness ; Gastrointestinal Microbiome ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-18
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03043-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5517: Show issues Location:
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  2. Article ; Online: Compassionate use of others’ immunity — understanding gut microbiome in Covid-19

    Prashanth Thalanayar Muthukrishnan / Robert Faillace

    Critical Care, Vol 24, Iss 1, Pp 1-

    2020  Volume 2

    Keywords Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; covid19
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Leading From Darkness to Light: Understanding Chronic Disease and Coronavirus: An Integrative Perspective.

    Muthukrishnan, Prashanth Thalanayar / Vishwanathan, Swati

    Integrative medicine (Encinitas, Calif.)

    2020  Volume 19, Issue 4, Page(s) 8–12

    Abstract: Disease is defined as complex interaction of 3 things: disease-causing agent, host and environment. The government, CDC and hospital administrations have had reasonable success with the effects of social distancing and coronavirus testing; kudos to them. ...

    Abstract Disease is defined as complex interaction of 3 things: disease-causing agent, host and environment. The government, CDC and hospital administrations have had reasonable success with the effects of social distancing and coronavirus testing; kudos to them. That addresses 1 of the 3 main factors of a disease; i.e. disease -causing agent. However, there are 2 other ingredients in the complex of a disease; i.e. the host of the disease and finally the environment of the disease. We are the hosts and it is time we take ownership of this ourselves and join the effort with the government towards understanding the dysregulated immune response seen in severe covid-19 and enable the public in strengthening the inner environment and the host immune response. Social distancing can be complete only when the host is prepared to fight the war in the coming fall and winter seasons. The outer environment seems to spontaneously recharging itself as a consequence of social distancing.
    Keywords covid19
    Language English
    Publishing date 2020-10-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2100529-1
    ISSN 1945-7081 ; 1546-993X
    ISSN (online) 1945-7081
    ISSN 1546-993X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5748: Show issues Location:
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  5. Article ; Online: Compassionate use of others’ immunity — understanding gut microbiome in Covid-19

    Thalanayar Muthukrishnan, Prashanth / Faillace, Robert

    Critical Care

    2020  Volume 24, Issue 1

    Keywords Critical Care and Intensive Care Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2041406-7
    ISSN 1364-8535
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03043-w
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Updates in Stroke Care.

    Thalanayar Muthukrishnan, Prashanth / Siddiqui, Mohammed S / Baba, Ridhwan Y

    American journal of respiratory and critical care medicine

    2018  Volume 197, Issue 10, Page(s) 1340–1343

    MeSH term(s) Brain Ischemia ; Humans ; Stroke ; Thrombectomy ; Time-to-Treatment
    Language English
    Publishing date 2018-03-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201702-0413RR
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article: Pre-diagnosis Multidisciplinary Tumor Board and Time to Staging in Lung Cancer: The Case Western MetroHealth Experience.

    Thalanayar Muthukrishnan, Prashanth / Ratnam, Maya / Nguyen, Minh-Tri / Le, Michael / Gunzler, Douglas / Bruno, Debora / Infeld, Michael

    Cureus

    2020  Volume 12, Issue 1, Page(s) e6595

    Abstract: Introduction National guidelines support the discussion of cancer patients by multidisciplinary tumor boards (MTB). We researched whether early pre-diagnosis multidisciplinary tumor board discussions are associated with shorter times to staging in lung ... ...

    Abstract Introduction National guidelines support the discussion of cancer patients by multidisciplinary tumor boards (MTB). We researched whether early pre-diagnosis multidisciplinary tumor board discussions are associated with shorter times to staging in lung cancer. Methods We reviewed our institution's lung cancer and MTB registries to retrospectively study if an early discussion at pre-diagnostic MTB (pd-MTB) influenced the timeliness of diagnostic evaluation. Over 14 months, 161 consecutive patients with a diagnosis of lung cancer were included. Fifty-five patients were presented at pd-MTB while 106 (controls) patients were not. The primary outcome was the difference in the time interval from suspicious imaging (Ix) to completion of staging (Sx). Outcomes were adjusted for key confounders with a multiple regression analysis. Results For stages I, II, and III lung cancer, where time to therapy matters, early discussion of patients with nodules suspicious for malignancy at pd-MTB was associated with no time delays when compared to patients who were not discussed in pd-MTB. The mean time intervals for imaging to staging (with standard deviations) are 65 days in controls (sd = 42.67) and 75 days (sd = 58.27) in tumor board cases (p=0.39). Adjusting for confounders with a multiple regression analysis among all stages revealed a similar lack of difference in time intervals to diagnosis, staging, and therapy. Conclusion Our stage I-III lung cancer cases (pd-MTB) completed staging in a timely manner, similar to controls (no pd-MTB). The severity of illness at presentation and the availability of diagnostic services and others likely influence the results. Our manuscript shares important numerical data on timelines during cancer diagnosis and treatment. Using this data, prospective registries examining the process workflow may help standardize cancer quality goals and maximize referrals from primary-care/specialty providers. The key findings in our study create a paradigm for future studies to create and achieve "door-to-balloon" time targets for lung cancer care (akin to cardiac care) across different styles of tumor boards.
    Language English
    Publishing date 2020-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.6595
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Necrotizing epiglottitis treated with early surgical debridement: A case report.

    Richardson, Clare / Muthukrishnan, Prashanth Thalanayar / Hamill, Chelsea / Krishnan, Vidya / Johnson, Freedom

    American journal of otolaryngology

    2018  Volume 39, Issue 6, Page(s) 785–787

    Abstract: Objective: Necrotizing supraglottitis is a rare but potentially morbid infection most often seen in immunocompromised patients. All reported cases have utilized intravenous antibiotic therapy as the mainstay of treatment and many have had associated ... ...

    Abstract Objective: Necrotizing supraglottitis is a rare but potentially morbid infection most often seen in immunocompromised patients. All reported cases have utilized intravenous antibiotic therapy as the mainstay of treatment and many have had associated morbidities.
    Methods: We describe a case of a 50-year-old previously healthy female who presented with necrotizing epiglottis and was treated with immediate surgical debridement followed by directed antibiotic therapy.
    Results: Our patient rapidly recovered with no further invasive interventions. On follow up she had no further complications or functional deficits.
    Conclusions: Although uncommon, providers should be aware of the potential benefits of early debridement when treating patients with similar pathology. Early surgical intervention should be considered to avoid local tissue loss, airway interventions, and long-term sequelae.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Candidiasis/diagnosis ; Candidiasis/therapy ; Debridement ; Epiglottitis/diagnosis ; Epiglottitis/etiology ; Epiglottitis/therapy ; Fasciitis, Necrotizing/diagnosis ; Fasciitis, Necrotizing/etiology ; Fasciitis, Necrotizing/therapy ; Female ; Humans ; Middle Aged ; Neisseriaceae Infections/diagnosis ; Neisseriaceae Infections/therapy ; Streptococcal Infections/diagnosis ; Streptococcal Infections/therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2018-07-25
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2018.07.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1637: Show issues Location:
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