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Article ; Online: Fever, Myalgias, and Weakness in a Patient with HIV.

Lobo Antuña, Marta / Suárez, Edwin Uriel / Calpena Martínez, Silvia / Lage Estebañez, Fernando / Fortes Alén, Jose / de Górgolas Hernández-Mora, Miguel

The American journal of medicine

2022 Volume 135, Issue 7, Page(s) 848–850

MeSH term(s)	Fever/etiology ; Frailty ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Myalgia/etiology
Language	English
Publishing date	2022-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2022.01.052
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Article ; Online: Actualización de las complicaciones pulmonares de la malaria.

Cabezón Estévanez, Itxasne / Górgolas Hernández-Mora, Miguel

Medicina clinica

2016 Volume 146, Issue 8, Page(s) 354–358

Abstract: Malaria is the most important parasitic disease worldwide, being a public health challenge in more than 90 countries. The incidence of pulmonary manifestations has increased in recent years. Acute respiratory distress syndrome is the most severe form ... ...

Title translation	Pulmonary complications of malaria: An update.
Abstract	Malaria is the most important parasitic disease worldwide, being a public health challenge in more than 90 countries. The incidence of pulmonary manifestations has increased in recent years. Acute respiratory distress syndrome is the most severe form within the pulmonary complications of malaria, with high mortality despite proper management. This syndrome manifests with sudden dyspnoea, cough and refractory hypoxaemia. Patients should be admitted to intensive care units and treated with parenteral antimalarial drug treatment and ventilatory and haemodynamic support without delay. Therefore, dyspnoea in patients with malaria should alert clinicians, as the development of respiratory distress is a poor prognostic factor.
MeSH term(s)	Combined Modality Therapy ; Humans ; Malaria, Falciparum/complications ; Prognosis ; Respiratory Distress Syndrome, Adult/diagnosis ; Respiratory Distress Syndrome, Adult/mortality ; Respiratory Distress Syndrome, Adult/parasitology ; Respiratory Distress Syndrome, Adult/therapy
Language	Spanish
Publishing date	2016-04-15
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2015.11.043
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Article ; Online: Assessing the Virologic Impact of Archived Resistance in the Dolutegravir/Lamivudine 2-Drug Regimen HIV-1 Switch Study TANGO through Week 144.

Wang, Ruolan / Wright, Jonathan / Saggu, Parminder / Ait-Khaled, Mounir / Moodley, Riya / Parry, Chris M / Lutz, Thomas / Podzamczer, Daniel / Moore, Richard / Górgolas Hernández-Mora, Miguel / Kinder, Clifford / Wynne, Brian / van Wyk, Jean / Underwood, Mark

Viruses

2023 Volume 15, Issue 6

Abstract: The TANGO study (ClinicalTrials.gov, NCT03446573) demonstrated that switching to dolutegravir/lamivudine (DTG/3TC) was non-inferior to continuing tenofovir alafenamide-based regimens (TBR) through week 144. Retrospective baseline proviral DNA genotypes ... ...

Abstract	The TANGO study (ClinicalTrials.gov, NCT03446573) demonstrated that switching to dolutegravir/lamivudine (DTG/3TC) was non-inferior to continuing tenofovir alafenamide-based regimens (TBR) through week 144. Retrospective baseline proviral DNA genotypes were performed for 734 participants (post-hoc analysis) to assess the impact of archived, pre-existing drug resistance on 144-week virologic outcomes by last on-treatment viral load (VL) and Snapshot. A total of 320 (86%) participants on DTG/3TC and 318 (85%) on TBR had both proviral genotype data and ≥1 on-treatment post-baseline VL results and were defined as the proviral DNA resistance analysis population. Archived International AIDS Society-USA major nucleoside reverse transcriptase inhibitor, non-nucleoside reverse transcriptase inhibitor, protease inhibitor, and integrase strand transfer inhibitor resistance-associated mutations (RAMs) were observed in 42 (7%), 90 (14%), 42 (7%), and 11 (2%) participants, respectively, across both groups; 469 (74%) had no major RAMs at baseline. M184V/I (1%), K65N/R (<1%), and thymidine analogue mutations (2%) were infrequent. Through week 144, >99% of participants on DTG/3TC and 99% on TBR were virologically suppressed (last on-treatment VL <50 copies/mL) regardless of the presence of major RAMs. Results from the sensitivity analysis by Snapshot were consistent with the last available on-treatment VL. In TANGO, archived, pre-existing major RAMs did not impact virologic outcomes through week 144.
MeSH term(s)	Humans ; Lamivudine/therapeutic use ; Reverse Transcriptase Inhibitors/therapeutic use ; HIV Infections/drug therapy ; HIV-1/genetics ; Retrospective Studies ; Treatment Outcome ; Heterocyclic Compounds, 3-Ring/therapeutic use ; HIV Seropositivity ; Anti-HIV Agents/therapeutic use ; Viral Load
Chemical Substances	Lamivudine (2T8Q726O95) ; Reverse Transcriptase Inhibitors ; dolutegravir (DKO1W9H7M1) ; Heterocyclic Compounds, 3-Ring ; Anti-HIV Agents
Language	English
Publishing date	2023-06-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15061350
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Article ; Online: Histiocytoid Sweet Syndrome associated with anorectal lymphogranuloma venereum in a patient with HIV infection.

Al-Hayani, Aws Waleed M / Alemany, Iris Martínez / Santonja, Carlos / Úbeda, Alfonso Cabello / Pérez, Laura Prieto / Ceballos-Rodríguez, María Carmen / Acosta, Irene Carrillo / Hernández-Mora, Miguel de Górgolas / Álvarez, Beatriz Álvarez

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2021 Volume 115, Page(s) 106–108

Abstract: Sweet Syndrome belongs to a group of diseases known as neutrophilic dermatoses. An uncommon variant named Histiocytoid Sweet Syndrome (HSS) can be associated with a variety of conditions, including cancer, infections, drug toxicity and others. Here we ... ...

Abstract	Sweet Syndrome belongs to a group of diseases known as neutrophilic dermatoses. An uncommon variant named Histiocytoid Sweet Syndrome (HSS) can be associated with a variety of conditions, including cancer, infections, drug toxicity and others. Here we present an instance of HSS in an HIV-positive patient in an infectious disease setting.
MeSH term(s)	Chlamydia trachomatis ; HIV Infections/complications ; Homosexuality, Male ; Humans ; Lymphogranuloma Venereum/complications ; Lymphogranuloma Venereum/diagnosis ; Lymphogranuloma Venereum/drug therapy ; Male ; Sweet Syndrome/complications ; Sweet Syndrome/diagnosis ; Sweet Syndrome/drug therapy
Language	English
Publishing date	2021-11-25
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2021.11.030
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Article ; Online: Podoconiosis: enfermedad olvidada por la sociedad y la comunidad médica.

Prieto-Pérez, Laura / Soriano Cea, Juan José / Górgolas Hernández-Mora, Miguel

Medicina clinica

2015 Volume 145, Issue 10, Page(s) 446–451

Abstract: Podoconiosis, mossy foot or endemic non-filarial elephantiasis, is a geochemical disease that causes lower limb lymphedema; it is directly related to walking barefoot over soils of volcanic origin, in areas with a high pluviometric annual index. It has a ...

Title translation	Podoconiosis, a society and medical community neglected disease.
Abstract	Podoconiosis, mossy foot or endemic non-filarial elephantiasis, is a geochemical disease that causes lower limb lymphedema; it is directly related to walking barefoot over soils of volcanic origin, in areas with a high pluviometric annual index. It has a specific geographical distribution, affecting around 5% population in areas where it is endemic. It is debilitating and disfiguring disease, which frequently leads to social margination. Podoconiosis is totally preventable and, once a diagnosis is established, it may improve with simple therapeutic measures.
MeSH term(s)	Diagnosis, Differential ; Elephantiasis/diagnosis ; Elephantiasis/epidemiology ; Elephantiasis/etiology ; Elephantiasis/therapy ; Global Health ; Humans ; Neglected Diseases/diagnosis ; Neglected Diseases/epidemiology ; Neglected Diseases/etiology ; Neglected Diseases/therapy ; Risk Factors
Language	Spanish
Publishing date	2015-11-20
Publishing country	Spain
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2014.12.020
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Article: Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Intravenous Infusions of PF-07304814 (Lufotrelvir) in Participants Hospitalized With COVID-19.

Robinson, Philip / Toussi, Sima S / Aggarwal, Sudeepta / Bergman, Arthur / Zhu, Tong / Hackman, Frances / Sathish, Jean G / Updyke, Lawrence / Loudon, Peter / Krishna, Ganesh / Clevenbergh, Philippe / Hernandez-Mora, Miguel Gorgolas / Cisneros Herreros, Jose Miguel / Albertson, Timothy E / Dougan, Michael / Thacker, Amber / Baniecki, Mary Lynn / Soares, Holly / Whitlock, Mark /

Nucci, Gianluca / Menon, Sandeep / Anderson, Annaliesa S / Binks, Michael

Open forum infectious diseases

2023 Volume 10, Issue 8, Page(s) ofad355

Abstract: Background: An urgent need remains for antiviral therapies to treat patients hospitalized with COVID-19. PF-07304814-the prodrug (lufotrelvir) and its active moiety (PF-00835231)-is a potent inhibitor of the SARS-CoV-2 3CL protease.: Method: Eligible ...

Abstract	Background: An urgent need remains for antiviral therapies to treat patients hospitalized with COVID-19. PF-07304814-the prodrug (lufotrelvir) and its active moiety (PF-00835231)-is a potent inhibitor of the SARS-CoV-2 3CL protease. Method: Eligible participants were 18 to 79 years old and hospitalized with confirmed COVID-19. This first-in-human phase 1b study was designed with 2 groups: single ascending dose (SAD) and multiple ascending dose (MAD). Participants could receive local standard-of-care therapy. In SAD, participants were randomized to receive a 24-hour infusion of lufotrelvir/placebo. In MAD, participants were randomized to receive a 120-hour infusion of lufotrelvir/placebo. The primary endpoint was to assess the safety and tolerability of lufotrelvir. The secondary endpoint was to evaluate the pharmacokinetics of lufotrelvir and PF-00835231. Results: In SAD, participants were randomized to receive 250 mg lufotrelvir (n = 2), 500 mg lufotrelvir (n = 2), or placebo (n = 4) by continuous 24-hour infusion. In MAD, participants were randomized to receive 250 mg lufotrelvir (n = 7), 500 mg lufotrelvir (n = 6), or placebo (n = 4) by continuous 120-hour infusion. No adverse events or serious adverse events were considered related to lufotrelvir. At doses of 250 and 500 mg, concentrations for the prodrug lufotrelvir and active moiety PF-00835231 increased in a dose-related manner. Unbound concentrations of the lufotrelvir active metabolite reached steady state approximately 2- and 4-fold that of in vitro EC Conclusions: These safety and pharmacokinetic findings support the continued evaluation of lufotrelvir in clinical studies.
Language	English
Publishing date	2023-07-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofad355
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Article ; Online: Respuesta.

Salinas Botrán, Alejandro / Ramos Rincón, José Manuel / de Górgolas Hernández-Mora, Miguel

Medicina clinica

2013 Volume 141, Issue 7, Page(s) 321

Title translation	Reply.
MeSH term(s)	Cardiovascular Diseases/epidemiology ; Global Health ; Humans
Language	Spanish
Publishing date	2013-10-05
Publishing country	Spain
Document type	Comment ; Letter
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2013.05.016
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Article ; Online: Enfermedad cardiovascular: una visión desde la salud global.

Salinas Botrán, Alejandro / Ramos Rincón, José Manuel / de Górgolas Hernández-Mora, Miguel

Medicina clinica

2013 Volume 141, Issue 5, Page(s) 210–216

Abstract: Globalization has facilitated the movement of large number of people around the world, leading modern clinicians to attend patients with rare or forgotten diseases. In the last few years many doctors are working in developing countries as volunteers or ... ...

Title translation	Cardiovascular disease: a view from global health perspective.
Abstract	Globalization has facilitated the movement of large number of people around the world, leading modern clinicians to attend patients with rare or forgotten diseases. In the last few years many doctors are working in developing countries as volunteers or expatriates. The aim of this article is to summarize the basic epidemiological, clinical and therapeutic knowledge of the main cardiovascular diseases that a medical doctor from a developed country may attend in a tropical rural hospital, or with challenging diseases in patients coming from developing countries.
MeSH term(s)	Africa ; Asia ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/epidemiology ; Comorbidity ; Developed Countries ; Developing Countries ; Emigrants and Immigrants ; Endemic Diseases ; Ethnic Groups ; Global Health ; HIV Infections/epidemiology ; Humans ; Internationality ; Prevalence ; Rural Population ; Travel ; Tropical Medicine
Language	Spanish
Publishing date	2013-09-07
Publishing country	Spain
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2013.01.015
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Article ; Online: Contents and quality of travel tips on malaria in English and Spanish travel blogs.

Linares-Rufo, Manuel / Santos-Larrégola, Laura / Hernández-de-Mora, Miguel Górgolas / Ramos-Rincón, José-Manuel

Malaria journal

2021 Volume 20, Issue 1, Page(s) 342

Abstract: Background: Europe has about 10,000 imported cases of malaria each year, or around 80 cases per 100,000 trips to endemic areas. Non-use of chemoprophylaxis in travellers remains the main reason for this. The proliferation of online travel blogs as a ... ...

Abstract	Background: Europe has about 10,000 imported cases of malaria each year, or around 80 cases per 100,000 trips to endemic areas. Non-use of chemoprophylaxis in travellers remains the main reason for this. The proliferation of online travel blogs as a source of advice (sometimes the only one used) for preparing a trip to an endemic area may play a role in the decision to use chemoprophylaxis. The aim of this study was to analyse the information offered on malaria in the main travel blogs in English and Spanish. Methods: Five hundred travel blogs in English and 100 in Spanish, considered highly relevant were analysed. The relevance were according to different metrics: (1) Alexa Rank; (2) social networks (RRSS) measuring the total followers of Facebook, Twitter, Instagram and YouTube; (3) number of monthly visits using the SEMrush tool; (4) domain authority; and (5) number of backlinks or incoming links using the SEMrush tool. Results: Of the included travel blogs, 57% of those in English and 64% of those in Spanish offered information on malaria, and 79 and 75%, respectively, featured a discussion on malaria written as a blog post or in forum comments. Information on chemoprophylaxis was available in 56.1% of English-language blogs and 10.7% of Spanish-speaking blogs, while its side effects were discussed in 38.6 and 68.8%, respectively (p < 0.001). Content analysis revealed that the information was usually insufficient, incomplete or, more seriously, inaccurate. In many cases, this could discourage users from taking appropriate preventive measures. Conclusions: Travel blogs in English and Spanish provide low-quality information on malaria. The so-called "travel influencers" must communicate reliable, verified and quality information on malaria on their channels in a way that could contribute to reducing the burden of the disease in travellers.
MeSH term(s)	Antimalarials/therapeutic use ; Blogging/statistics & numerical data ; Chemoprevention/statistics & numerical data ; Language ; Malaria/prevention & control ; Travel
Chemical Substances	Antimalarials
Language	English
Publishing date	2021-08-16
Publishing country	England
Document type	Journal Article
ISSN	1475-2875
ISSN (online)	1475-2875
DOI	10.1186/s12936-021-03864-2
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Article: Gnatostomiasis: una enfermedad creciente en viajeros.

de Górgolas Hernández-Mora, Miguel / Fernández Guerrero, Manuel L

Medicina clinica

2005 Volume 125, Issue 5, Page(s) 190–192

Title translation	Gnathostomiasis: an increasing disease among travellers.
MeSH term(s)	Animals ; Antiparasitic Agents/therapeutic use ; Gnathostoma/isolation & purification ; Humans ; Spirurida Infections/diagnosis ; Spirurida Infections/drug therapy ; Spirurida Infections/epidemiology ; Travel
Chemical Substances	Antiparasitic Agents
Language	Spanish
Publishing date	2005-07-11
Publishing country	Spain
Document type	Journal Article
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1157/13077142
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