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Article ; Online: Sediment mercury concentration of a subtropical mangrove wetland responded to Hong Kong-Shenzhen industrial development since the 1960s.

Jiang, Jenny J / Yan, Hongyu / Wang, Xufeng / Su, Hong

2023 Volume 192, Page(s) 115047

Abstract: Mercury (Hg) in coastal wetlands is of great concern due to its acute toxicity. We measured the total Hg content (THg) from ... ...

Abstract	Mercury (Hg) in coastal wetlands is of great concern due to its acute toxicity. We measured the total Hg content (THg) from a
MeSH term(s)	Mercury/analysis ; Wetlands ; Hong Kong ; Industrial Development ; Geologic Sediments ; Environmental Monitoring ; China ; Water Pollutants, Chemical/analysis
Chemical Substances	Mercury (FXS1BY2PGL) ; Water Pollutants, Chemical
Language	English
Publishing date	2023-05-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2023.115047
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Article ; Online: Integrated serum pharmacochemistry and network pharmacology to explore the mechanism of Yi-Shan-Hong formula in alleviating chronic liver injury.

Zhao, Xinyi / Su, Hua / Chen, Haiyan / Tang, Xiusong / Li, Wenling / Huang, An / Fang, Gang / Chen, Qing / Luo, Yudong / Pang, Yuzhou

Phytomedicine : international journal of phytotherapy and phytopharmacology

2024 Volume 128, Page(s) 155439

Abstract: ... interventions. The Yi-Shan-Hong (YSH) formula is an empirically derived remedy that has shown effectiveness and ...

Abstract	Background: Chronic liver injury (CLI) is a complex condition that requires effective therapeutic interventions. The Yi-Shan-Hong (YSH) formula is an empirically derived remedy that has shown effectiveness and safety in the management of chronic liver damage. However, the bioactive components and multifaceted mechanisms of YSH remain inadequately understood. Purpose: To examine the bioactive compounds and functional processes that contribute to the therapeutic benefits of YSH against CLI. Methods: Serum pharmacochemistry and network pharmacology were employed to identify active compounds and possible targets of YSH in CLI. In addition, YSH was also given in three doses to Results: The analysis of serum samples successfully detected 25 compounds from YSH. Searches on the databases resulted in 277 genes as being correlated with chemicals in YSH, and 397 genes associated with CLI. In vivo experiments revealed that YSH displayed a notable therapeutic impact on liver injury caused by Conclusion: These findings provide preclinical evidence of YSH's therapeutic value in CLI and highlight its hepatoprotective action via the PI3K/AKT signaling pathway.
Language	English
Publishing date	2024-02-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2024.155439
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Article ; Online: Sediment mercury concentration of a subtropical mangrove wetland responded to Hong Kong-Shenzhen industrial development since the 1960s

Jiang, Jenny J. / Yan, Hongyu / Wang, Xufeng / Su, Hong

Marine Pollution Bulletin. 2023 July, v. 192 p.115047-

2023

Abstract: ... 1975–1984 to Hong Kong industrial sewage pollution. ...

Abstract	Mercury (Hg) in coastal wetlands is of great concern due to its acute toxicity. We measured the total Hg content (THg) from a ²¹⁰Pb-dated sediment core obtained from the Futian mangrove wetland in Shenzhen Bay, South China to explore the historical variation and possible sources. Our results extend the sediment THg record back to 1960 and reveal three distinct intervals. Interval I (1960–1974) has low and increasing THg values, averaging 83.0 μg/kg; Interval II (1975–1984) witnesses a remarkably increase, peaking in 1980 (261.6 μg/kg) then remaining elevated; Interval III (1985–2014) shows a steady reduction, averaging 118.4 μg/kg. The good correlation among THg, TOC, and Hg/TOC, and the downstream decrease in monitoring sediment THg consistently suggest that the bulk THg are mainly sourced from the Shenzhen River discharge. The different timing in industrial development attributes the elevated THg concentrations during 1975–1984 to Hong Kong industrial sewage pollution.
Keywords	acute toxicity ; industrialization ; marine pollution ; mercury ; river flow ; sediments ; sewage ; wetlands ; China ; Mercury (Hg) ; Futian mangrove wetland ; Shenzhen Bay ; Hong Kong
Language	English
Dates of publication	2023-07
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2023.115047
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Article: Enhancing the career capabilities of NEET youth in Hong Kong: an experience-driven framework.

Su, Xuebing / Wong, Victor

International journal for educational and vocational guidance

2022 Volume 22, Issue 3, Page(s) 713–738

Abstract: Inspired by Amartya Sen's conceptualization of capability, this article examined how the introduction of an experience-driven (ED) framework into the capability approach helps inform the delivery of a career support service project targeted at youth aged ...

Abstract	Inspired by Amartya Sen's conceptualization of capability, this article examined how the introduction of an experience-driven (ED) framework into the capability approach helps inform the delivery of a career support service project targeted at youth aged 15-21, who are not in education, employment or training (NEET youth) with difficulties to develop their career capabilities. Based on a thematic analysis of ten individual interview transcripts collected from five career practitioners and five ex-users, the study discussed four interlocking domains of experiences and experience-driven career interventions for enhancing youth's capabilities to aspire and realize aspirations with a transition from the zone of proximal development to the zone of aspired development, namely, recognition, exposures, self-growth and transferability. We recommended further research studies on evaluating the effectiveness of using the ED framework for applying the capability approach to strengthening the career capabilities of service users characterized by diversity and vulnerability in different service settings.
Language	English
Publishing date	2022-02-12
Publishing country	Netherlands
Document type	Journal Article
ISSN	1873-0388
ISSN	1873-0388
DOI	10.1007/s10775-022-09531-5
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Article ; Online: Risk Factors for Myopia in 2 Hong Kong School Systems: A Pilot Study.

Liang, Yuanyuan / Kee, Chea-Su

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)

2022 Volume 11, Issue 1, Page(s) 19–26

Abstract: ... to investigate myopia prevalence and compare risk factors of myopia among Hong Kong Chinese primary school ... in Hong Kong in September and October 2018, respectively. Measurements were performed on children aged 8 to 10 ...

Abstract	Purpose: Myopia has reached "epidemic" proportions, especially in several East Asian countries. Most myopia emerges during childhood, particularly during the school years. The aim of this study was to investigate myopia prevalence and compare risk factors of myopia among Hong Kong Chinese primary school children under 2 different educational systems. Design: Cross-sectional study. Methods: Visual assessments were conducted in 1 government-funded primary school (n = 159) and 1 international school (n = 223) in Hong Kong in September and October 2018, respectively. Measurements were performed on children aged 8 to 10 years old. Noncycloplegic refraction and axial length were measured, respectively. A validated questionnaire focusing on demographic information, nonscreen time (eg, reading and writing on paper materials), screen time (ie, smartphones and tablets usage), time spent on outdoor activities, and other myopia risk factors was completed by parents of participants. Results: The prevalence of myopia [37.5% vs 12.8%, P < 0.001; spherical equivalent refraction (SER) ≤ -1.00 diopter (D)] and refractive astigmatism [25.0% vs 7.2%, P < 0.001; cylinder (Cyl) ≥ 1.00 diopter cylinder (DC)] were significantly higher in the local school than in the international school. Students in the local school were slightly older than those attending the international school (9.17 ± 0.82 years vs 8.95 ± 0.85 years, P = 0.046), and there was no significant difference in gender distribution between the 2 schools (P = 0.51). There were significant differences in the demographic information including parental myopia (P < 0.001), family income (P < 0.001), and parents' educational level (P < 0.001) between the 2 schools. Multiple regression analysis showed that parental myopia history and continuous near work was associated with myopia in the local school, while the father's educational level was related to myopia in the international school. Conclusions: In this pilot study, despite the much higher prevalence of parental myopia and high myopia in the international school, the myopia prevalence among the students is lower in this school than in the local school, suggesting that environmental factors other than genetics might have a stronger protective effect in this school population.
MeSH term(s)	Child ; Cross-Sectional Studies ; Hong Kong/epidemiology ; Humans ; Myopia/epidemiology ; Myopia/etiology ; Pilot Projects ; Prevalence ; Refraction, Ocular ; Risk Factors ; Schools
Language	English
Publishing date	2022-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2756329-7
ISSN	2162-0989 ; 2162-0989
ISSN (online)	2162-0989
ISSN	2162-0989
DOI	10.1097/APO.0000000000000486
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Article: Retraction for Hong et al., "Whole-Genome

Hong, Chang-Young / Lee, Su-Yeon / Ryu, Sun-Hwa / Lee, Sung-Suk / Kim, Myungkil

Genome announcements

2017 Volume 5, Issue 46

Language	English
Publishing date	2017-11-16
Publishing country	United States
Document type	Journal Article ; Retraction of Publication
ZDB-ID	2704277-7
ISSN	2169-8287
ISSN	2169-8287
DOI	10.1128/genomeA.01297-17
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Article ; Online: Pharmacodynamic effects of Dan-hong injection in rats with blood stasis syndrome.

Bi, Cong / Li, Pan-Lin / Liao, Yan / Rao, Hong-Yu / Li, Pei-Bo / Yi, Jing / Wang, Wei-Yue / Su, Wei-Wei

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2019 Volume 118, Page(s) 109187

Abstract: Dan-hong injection (DHI) is extracted from Salvia miltiorrhiza (SM) and Carthamus tinctorius (CT ...

Abstract	Dan-hong injection (DHI) is extracted from Salvia miltiorrhiza (SM) and Carthamus tinctorius (CT) and is widely used for the treatment of cardiovascular diseases. Our previous results showed DHI could improve hemorheology in rats. Since complex cellular interactions such as inflammation and oxidative stress are believed to be implicated in the pathogenesis of cardiovascular events, investigation of such pathological factors will contribute substantially to the understanding of the features and mechanisms of DHI. Therefore, in this study we used a rat model of blood stasis to explore the overall effects of DHI by detecting twenty three indexes, which were related to inflammation, immune response, vascular endothelial function, myocardial energy metabolism, oxidative stress, platelet aggregation, liver and renal function. Meanwhile, the interaction between SM and CT was discussed by comparing the effects of each single herb. DHI could significantly decrease the serum contents of IL-1β, TNF-α, IL-6, IL-8, IgM, IgG, IgA, MPO, hs-CRP, MDA, LDH, CK-MB, PAF, ALP and Cr, while elevate NO, SOD, TP and UA levels, indicating that DHI could inhibit inflammation and platelet aggregation, thereby relieving immune response and peroxidation, protecting vascular endothelial and organ function, and then prevent and treat cardiovascular diseases. In terms of compatibility, SM and CT showed complementary effects on markers of inflammatory and oxidative status, vascular endothelial damage and myocardial energy metabolism. On the other hand, they counteracted each other and SM reduced the side effects of creatinine caused by CT. This study contributes to comprehensively understand the pharmacodynamics effects and mechanism of DHI.
MeSH term(s)	Animals ; Carthamus tinctorius/chemistry ; Coronary Disease/blood ; Coronary Disease/immunology ; Coronary Disease/prevention & control ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/isolation & purification ; Drugs, Chinese Herbal/pharmacology ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/immunology ; Endothelium, Vascular/metabolism ; Hemostasis/drug effects ; Hemostasis/immunology ; Inflammation ; Male ; Oxidative Stress/drug effects ; Rats, Sprague-Dawley ; Salvia miltiorrhiza/chemistry
Chemical Substances	Drugs, Chinese Herbal ; danhong
Language	English
Publishing date	2019-07-11
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2019.109187
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Article ; Online: Measuring Retinal Thickness and Visual Acuity in Eyes with Different Types of Astigmatism in a Cohort of Hong Kong Chinese Adults.

Liang, Dong / Leung, Tsz-Wing / Kee, Chea-Su

Investigative ophthalmology & visual science

2023 Volume 64, Issue 1, Page(s) 2

Abstract: Purpose: The purpose of this study was to investigate optical coherence tomography (OCT)-measured retinal thickness (RT) and best-corrected distance visual acuity (BCDVA) in eyes with different types of astigmatism.: Methods: This is a case-control ... ...

Abstract	Purpose: The purpose of this study was to investigate optical coherence tomography (OCT)-measured retinal thickness (RT) and best-corrected distance visual acuity (BCDVA) in eyes with different types of astigmatism. Methods: This is a case-control study of 101 participants stratified into With-The-Rule (WTR; n = 41), Against-The-Rule (ATR; n = 25), and control (n = 35) groups by noncycloplegic subjective refraction. Inclusion criteria were ages between 18 and 45 years, spherical-equivalent (SE) refraction ≥-10.00 diopters (D), negative cylindrical power (CYL) ≤-0.75 D with axes of 0 to 30 degrees/150 to 180 degrees for WTR and 60 to 120 degrees for ATR, or CYL ≥-0.25 D for controls. Participants suffering from ocular diseases related to retinal defects, having a history of ocular surgery, with BCDVA >0.10 LogMAR, or poor OCT imaging quality were excluded. Fovea-centered scans were performed using spectral-domain OCT (SD-OCT), and RT automatically measured by the inbuilt software. Only right eyes were analyzed. Groups were matched for age, gender, SE, axial length, and corneal curvature. Results: One-way ANOVA showed a significant difference in both BCDVA (P = 0.039) and macular RT (P = 0.028) among the three groups. Bonferroni's post hoc test revealed statistically significant between-group differences in BCDVA (WTR vs. controls, P = 0.041), as well as in RT at inner-nasal (WTR vs. ATR, P = 0.034) and outer-temporal subfields (WTR vs. controls, P = 0.042). BCDVA was positively associated with macular RT (r = 0.206, P = 0.041) after adjusting for age, gender, and axial length. Conclusions: Greater RT and poorer BCDVA were found in eyes with WTR astigmatism. Our findings suggest that the effect of astigmatism on retinal thickness and BCDVA may vary depending on not only magnitude, but also axis of astigmatism.
MeSH term(s)	Humans ; Adult ; Adolescent ; Young Adult ; Middle Aged ; Astigmatism ; Case-Control Studies ; Hong Kong/epidemiology ; East Asian People ; Visual Acuity ; Refraction, Ocular
Language	English
Publishing date	2023-01-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391794-0
ISSN	1552-5783 ; 0146-0404
ISSN (online)	1552-5783
ISSN	0146-0404
DOI	10.1167/iovs.64.1.2
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Article ; Online: Lower-than-standard particulate matter air pollution reduced life expectancy in Hong Kong: A time-series analysis of 8.5 million years of life lost.

Cheng, Jian / Ho, Hung Chak / Webster, Chris / Su, Hong / Pan, Haifeng / Zheng, Hao / Xu, Zhiwei

Chemosphere

2021 Volume 272, Page(s) 129926

Abstract: ... to lower-than-standard particulate matter air pollution in Hong Kong, China.: Methods: We obtained 17 ... in Hong Kong. ...

Abstract	Background: Increasing studies reported increased mortality risk associated with exposure to lower-than-standard air pollution. This study aimed to investigate mortality burden and life expectancy loss due to lower-than-standard particulate matter air pollution in Hong Kong, China. Methods: We obtained 17-year (2000-2016) daily time-series data on mortality, particulate matters with aerodynamic diameters <2.5 μm (PM Results: We estimated 5.2% of total YLL due to PM Conclusions: Exposure to lower-than-standard particulate matters air pollution could shorten life expectancy and incur massive mortality burden in Hong Kong.
MeSH term(s)	Aged ; Air Pollutants/analysis ; Air Pollution/adverse effects ; Air Pollution/analysis ; China ; Environmental Exposure/analysis ; Europe ; Female ; Hong Kong ; Humans ; Life Expectancy ; Male ; Particulate Matter/analysis ; Reference Standards
Chemical Substances	Air Pollutants ; Particulate Matter
Language	English
Publishing date	2021-02-11
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2021.129926
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Article ; Online: Low ambient temperature shortened life expectancy in Hong Kong: A time-series analysis of 1.4 million years of life lost from cardiorespiratory diseases.

Cheng, Jian / Ho, Hung Chak / Su, Hong / Huang, Cunrui / Pan, Rubing / Hossain, Mohammad Zahid / Zheng, Hao / Xu, Zhiwei

Environmental research

2021 Volume 201, Page(s) 111652

Abstract: ... for Hong Kong, China during 2000-2016. Years of life lost (YLL) that considers life expectancy at the time of death was ... effects on cardiorespiratory disease in Hong Kong. ...

Abstract	Ambient temperature is an important contributor to mortality burden worldwide, most of which is from cold exposure. However, little is known about the cold impact on life expectancy loss. This paper aimed to estimate cold-related life expectancy loss from cause-, age-, and gender-specific cardiovascular and respiratory diseases. Daily deaths from cardiovascular and respiratory diseases and weather records were acquired for Hong Kong, China during 2000-2016. Years of life lost (YLL) that considers life expectancy at the time of death was calculated by matching each death by age and sex to annual life tables. Using a generalized additive model that fits temperature-YLL association, we estimated loss of years in life expectancy from cold. Cold was estimated to cause life expectancy loss of 0.9 years in total cardiovascular disease, with more years of loss in males than in females and in people aged 65 years and older than in people aged up to 64 years. Cold-related life expectancy loss in total respiratory diseases was 1.2 years, with more years of loss in females than in males and comparable years of loss in people aged up to 64 years and in people aged 65 years and older. Among cause-specific diseases, we observed the greatest life expectancy loss in pneumonia (1.5 years), followed by ischaemic heart disease (1.2 years), COPD (1.1 years), and stroke (0.3 years). Between two periods of 2000-2007 and 2008-2016, cold-related life expectancy loss due to cardiovascular disease did not decrease and cold-related life expectancy loss due to respiratory disease even increased by five times. Our findings suggest an urgent need to develop prevention measures against adverse cold effects on cardiorespiratory disease in Hong Kong.
MeSH term(s)	Aged ; Cardiovascular Diseases/epidemiology ; China/epidemiology ; Cold Temperature ; Female ; Hong Kong/epidemiology ; Humans ; Life Expectancy ; Male ; Middle Aged ; Research Design ; Respiratory Tract Diseases/epidemiology
Language	English
Publishing date	2021-07-09
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2021.111652
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