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  1. Book ; Thesis: Geriatrisches Assessment für Patienten über 65 Jahre in der Notaufnahme

    Häseler-Ouart, Kristin / Hartmann, Michael / Wedding, Ulrich / Franken, Christian

    systematischer Review und Meta-Analyse ; [kumulative Dissertation]

    2023  

    Title variant fünfundsechzig
    Institution Friedrich-Schiller-Universität Jena
    Author's details von Kristin Häseler-Quart
    Keywords Notaufnahme ; Alter
    Subject Alter Mensch ; Betagter ; Senioren ; Senior
    Language German ; English
    Size 55 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Friedrich-Schiller-Universität Jena, 2023
    Note Zeitschriftenaufsätze in englischer Sprache ; Kumulative Dissertation, enthält Zeitschriftenaufsätze ; Tag der Verteidigung: 03.01.2023
    HBZ-ID HT030354965
    Database Catalogue ZB MED Medicine, Health

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  2. Book ; Thesis: Funktionelle Eigenschaften und Plastizität GABAerger Inhibition im Hippocampus

    Hartmann, Kristin

    2006  

    Author's details vorgelegt von Kristin Hartmann
    Language German
    Size 83 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2006
    HBZ-ID HT015018179
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Cost-Effectiveness Analyses of Non-Pharmacological and Non-Surgical Interventions in Idiopathic Parkinson's Disease: A Systematic Review.

    Hartmann-Nardin, Daniel / Stock, Stephanie / Kalbe, Elke / Folkerts, Ann-Kristin

    Journal of Parkinson's disease

    2024  

    Abstract: Background: Interest in non-pharmacological/non-surgical interventions to treat Parkinson's disease (PD) has substantially increased. Although a few health-economic studies have been conducted, summary information on the cost-effectiveness is still ... ...

    Abstract Background: Interest in non-pharmacological/non-surgical interventions to treat Parkinson's disease (PD) has substantially increased. Although a few health-economic studies have been conducted, summary information on the cost-effectiveness is still scarce.
    Objective: To give an overview of cost-effectiveness analyses (CEA) focusing on non-pharmacological/non-surgical interventions in PD patients.
    Methods: A systematic literature search was conducted in five databases. Studies were included that provided cost-effectiveness analysis (CEA) or cost-utility analysis (CUA) of non-pharmacological/non-surgical interventions in PD patients. Study quality was assessed with the Drummond and CHEERS 2022 checklists respectively, for economic evaluation.
    Results: N = 9 studies published between 2012-2023 were identified. Most studies undertook a CUA (n = 5); n = 3 reported a combination of CEA and CUA, and n = 1 a pure CEA. Most studies (n = 6) examined physical exercise. The CEA studies identified additional costs of 170€ -660€  for the improvement of one single unit of a clinical outcome and savings of 18.40€ -22.80€  per score gained as measured with established instruments. The four studies that found significant quality of life benefits show large variations in the incremental cost effectiveness ratio (ICER) of 3,220€ -214,226€  per quality-adjusted life year (QALY); notably interventions were heterogenous regarding content and intensity.
    Conclusions: Despite increasing numbers of non-pharmacological/non-surgical intervention trials in PD patients, health-economic evaluations are rare. The examined intervention types and health-economic results vary greatly. Together with the heterogeneity of the health-economic studies these factors limit the conclusions that can be drawn. Further research and a standardization of methods is needed to allow decision makers to make meaningful interpretations, and to allocate scarce resources.
    Language English
    Publishing date 2024-02-03
    Publishing country Netherlands
    Document type Systematic Review
    ZDB-ID 2620609-2
    ISSN 1877-718X ; 1877-7171
    ISSN (online) 1877-718X
    ISSN 1877-7171
    DOI 10.3233/JPD-230213
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  4. Book ; Thesis: Zur Problematik der Dignitätsbestimmung pilozytischer Astrozytome

    Hartmann, Kristin

    Reklassifizierung des Eingangsmaterials der Abteilung für Neuropathologie der Jahre 1961 bis 1990 einschließlich katamnestischer Untersuchungen

    1997  

    Author's details eingereicht von Kristin Hartmann geb. Gläser
    Language German
    Size 91, [27] Bl. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Leipzig, Univ., Diss., 1997
    HBZ-ID HT008258918
    Database Catalogue ZB MED Medicine, Health

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  5. Book ; Thesis: Zytokine in Proliferation, Differenzierung und Karzinogenese von Keimzelltumoren des Hodens

    Breitenfeldt, Marie Kristin

    1998  

    Author's details vorgelegt von Marie Kristin Breitenfeldt geb. Hartmann
    Language German
    Size 103 Bl. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Hannover, Med. Hochsch., Diss., 1998
    HBZ-ID HT009226206
    Database Catalogue ZB MED Medicine, Health

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  6. Article ; Online: [No title information]

    Andresen, Ann-Kristin / Hartmann, Marius

    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin

    2019  Volume 191, Issue 10, Page(s) 942–943

    Title translation Neurotoxische und vaskulopathische ZNS-Veränderungen im Rahmen eines chronischen Metamphetamin-Abusus.
    MeSH term(s) Adult ; Amphetamine-Related Disorders/blood ; Amphetamine-Related Disorders/diagnostic imaging ; Basal Ganglia Hemorrhage/chemically induced ; Basal Ganglia Hemorrhage/diagnostic imaging ; Brain/diagnostic imaging ; Brain/drug effects ; Brain Diseases/blood ; Brain Diseases/chemically induced ; Brain Diseases/diagnostic imaging ; Diffusion Magnetic Resonance Imaging ; Facial Paralysis/chemically induced ; Facial Paralysis/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Male ; Methamphetamine/adverse effects ; Methamphetamine/blood ; Paresis/chemically induced ; Paresis/diagnostic imaging ; Tomography, X-Ray Computed
    Chemical Substances Methamphetamine (44RAL3456C)
    Language German
    Publishing date 2019-09-11
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 554830-5
    ISSN 1438-9010 ; 0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
    ISSN (online) 1438-9010
    ISSN 0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
    DOI 10.1055/a-0881-3315
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  7. Article: Neurotoxische und vaskulopathische ZNS-Veränderungen im Rahmen eines chronischen Metamphetamin-Abusus

    Andresen, Ann-Kristin / Hartmann, Marius

    RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren

    2019  Volume 191, Issue 10, Page(s) 942–943

    Language German
    Publishing date 2019-09-11
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 554830-5
    ISSN 1438-9010 ; 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
    ISSN (online) 1438-9010
    ISSN 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
    DOI 10.1055/a-0881-3315
    Database Thieme publisher's database

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  8. Article ; Online: A pharmacist-led pilot using a performance dashboard to improve psychotropic medication use in a skilled nursing facility.

    Bell, Kristin / Hartmann, Christine / Baughman, Amy Wisteria

    BMJ open quality

    2020  Volume 9, Issue 3

    Abstract: Objectives: Inappropriate use of psychotropic medications in the elderly, particularly those with dementia, is a critical safety and quality concern. This pilot quality improvement study used a novel Department of Veterans Affairs (VA) Psychotropic Drug ...

    Abstract Objectives: Inappropriate use of psychotropic medications in the elderly, particularly those with dementia, is a critical safety and quality concern. This pilot quality improvement study used a novel Department of Veterans Affairs (VA) Psychotropic Drug Safety Initiative performance dashboard (PDSI dashboard) to implement a pharmacist-led intervention to improve psychotropic medication prescribing practices in a VA skilled nursing facility (SNF). While clinical dashboard data have become commonplace, literature describing successful implementation for improved clinical care is scant.
    Methods: This study took place from November 2015 to February 2016 at a 112-bed VA SNF. A pharmacist used the PDSI dashboard to identify 'actionable' patients with potentially inappropriate psychotropic prescribing and then completed chart reviews to confirm clinical indications. The pharmacist provided recommendations to providers for dose reductions or deprescribing via in-person communication and notes written in the electronic medical record. SNF providers completed anonymous surveys about their experience in receiving recommendations.
    Results: Over a 5-month period, the PDSI dashboard identified 21 patients with potentially inappropriate psychotropic medication use, with approximately one new patient identified each week. Prescribing recommendations were accepted 66% of the time. All seven SNF providers reported that recommendations were helpful in improving their psychotropic prescribing practices.
    Conclusions: The PDSI dashboard was efficient and effective in identifying patients at risk for inappropriate use of psychotropic medications. A clinical pharmacist was essential for implementing and communicating recommendations from the dashboard to providers.
    MeSH term(s) Aged ; Aged, 80 and over ; Female ; Humans ; Inappropriate Prescribing/prevention & control ; Inappropriate Prescribing/statistics & numerical data ; Male ; New England ; Pharmacists/trends ; Pilot Projects ; Psychotropic Drugs/administration & dosage ; Psychotropic Drugs/therapeutic use ; Quality Improvement ; Skilled Nursing Facilities/organization & administration ; Skilled Nursing Facilities/trends
    Chemical Substances Psychotropic Drugs
    Language English
    Publishing date 2020-09-17
    Publishing country England
    Document type Journal Article
    ISSN 2399-6641
    ISSN (online) 2399-6641
    DOI 10.1136/bmjoq-2020-000997
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  9. Article ; Online: Loss of Homeostatic Microglia Signature in Prion Diseases.

    Wang, Yue / Hartmann, Kristin / Thies, Edda / Mohammadi, Behnam / Altmeppen, Hermann / Sepulveda-Falla, Diego / Glatzel, Markus / Krasemann, Susanne

    Cells

    2022  Volume 11, Issue 19

    Abstract: Prion diseases are neurodegenerative diseases that affect humans and animals. They are always fatal and, to date, no treatment exists. The hallmark of prion disease pathophysiology is the misfolding of an endogenous protein, the cellular prion protein ( ... ...

    Abstract Prion diseases are neurodegenerative diseases that affect humans and animals. They are always fatal and, to date, no treatment exists. The hallmark of prion disease pathophysiology is the misfolding of an endogenous protein, the cellular prion protein (PrP
    MeSH term(s) Animals ; Homeostasis ; Humans ; Mice ; Microglia/metabolism ; Neurodegenerative Diseases/metabolism ; Prion Diseases/metabolism ; Prion Proteins/metabolism ; Prions/metabolism ; Protein Isoforms/metabolism
    Chemical Substances Prion Proteins ; Prions ; Protein Isoforms
    Language English
    Publishing date 2022-09-21
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11192948
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  10. Article ; Online: Geriatric assessment for older adults admitted to the emergency department: A systematic review and meta-analysis.

    Häseler-Ouart, Kristin / Arefian, Habibollah / Hartmann, Michael / Kwetkat, Anja

    Experimental gerontology

    2020  Volume 144, Page(s) 111184

    Abstract: Background: Older adults are the most frequent users of emergency services. Comprehensive geriatric assessment (CGA) can help identify high-risk older adults at an early stage. We conducted a systematic review and meta-analysis to identify and evaluate ... ...

    Abstract Background: Older adults are the most frequent users of emergency services. Comprehensive geriatric assessment (CGA) can help identify high-risk older adults at an early stage. We conducted a systematic review and meta-analysis to identify and evaluate CGA tools used in the emergency department (ED), analyze their predictive validity for adverse outcomes and recommend tools for this particular situation.
    Methods: We systematically searched Medline, Web of Science and CENTRAL for eligible articles published in peer-reviewed journals that observed patients ≥65 years admitted to the ED, used at least one assessment tool and reported adverse outcomes of interest. We performed a descriptive analysis and a bivariate meta-analysis of the diagnostic accuracy and predictive validity of the assessment tools for the chosen adverse outcomes.
    Results: 28 eligible studies were included. The pooled sensitivity (95% CI) of the assessment tools for predicting mortality within short (28-90 days) and long (180-365 days) periods after the first ED visit was 0.77 (0.61-0.89) and 0.79 (0.46-0.96), respectively, with specificity (95% CI) values of 0.45 (0.32-0.59) and 0.37 (0.14-0.65). These findings indicate that the tools used in the included studies had modest predictive accuracy for mortality and were more appropriate for identifying individuals at high risk of readmission in the short term than in the long term.
    Conclusions: Early use of assessment tools in the ED might improve clinical decision making and reduce negative outcomes for older adults.
    Language English
    Publishing date 2020-12-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 390992-x
    ISSN 1873-6815 ; 0531-5565
    ISSN (online) 1873-6815
    ISSN 0531-5565
    DOI 10.1016/j.exger.2020.111184
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