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  1. Book ; Online: Therapeutic Modulation of the Complement System: Clinical Indications and Emerging Drug Leads

    Lambris, John D. / Mastellos, Dimitrios C. / Reis, Edimara S.

    2020  

    Keywords Medicine ; Immunology ; complement system ; clinical trials ; therapeutics ; diseases ; drug candidates
    Size 1 electronic resource (185 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230739
    ISBN 9782889634705 ; 2889634701
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Immune responses to biosurfaces

    Lambris, John D.

    mechanisms and therapeutic interventions

    (Advances in experimental medicine and biology ; 865)

    2015  

    Author's details John D. Lambris ... ed
    Series title Advances in experimental medicine and biology ; 865
    Collection
    Keywords biomaterials ; cell surface ; cell therapy ; biomedical implant ; immune response ; organ transplantation
    Language English
    Size XII, 242 S. : Ill., graph. Darst., 235 mm x 155 mm
    Publisher Springer
    Publishing place Cham u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT018756177
    ISBN 978-3-319-18602-3 ; 978-3-319-18603-0 ; 3-319-18602-7 ; 3-319-18603-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Zs A 3192 -865- not available for loan Zeitschriften-Lesesaal

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  3. Book ; Conference proceedings: XXIV. International Complement Workshop

    Lambris, John D.

    October 10 - 15, 2012, Chania, Crete, Greece

    (Immunobiology ; 217,11)

    2012  

    Event/congress International Complement Workshop (24, 2012, Chania)
    Author's details guest ed.: John D. Lambris
    Series title Immunobiology ; 217,11
    Collection
    Language English
    Size S. 1025 - 1222, XXVII S. : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    Note Enth. auch: Abstracts
    HBZ-ID HT017418798
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Ud II Zs 32 -217- verfügbar in Königswinter Königswinter

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  4. Article ; Online: Recent developments in C3-targeted complement therapeutics.

    Mastellos, Dimitrios C / Lambris, John D

    Seminars in immunology

    2022  , Page(s) 101645

    Language English
    Publishing date 2022-07-29
    Publishing country England
    Document type Editorial
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2022.101645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2843: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Book ; Conference proceedings: Current topics in complement II

    Lambris, John D.

    (Advances in experimental medicine and biology ; 632)

    2008  

    Event/congress Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (4, 2007, Portocheli)
    Author's details [4th Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 10 - 17, 2007) in Porto Heli, Greece]. John D. Lambris, ed
    Series title Advances in experimental medicine and biology ; 632
    Collection
    Keywords Complement System Proteins / immunology
    Language English
    Size XXX, 316 S. : Ill., graph. Darst., 235 mm x 155 mm
    Publisher Springer Science+Business Media
    Publishing place New York
    Publishing country Germany
    Document type Book ; Conference proceedings
    HBZ-ID HT015743329
    ISBN 978-0-387-78951-4 ; 0-387-78951-0 ; 9780387789521 ; 0387789529
    Database Catalogue ZB MED Medicine, Health

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  6. Book ; Conference proceedings: Current topics in complement

    Lambris, John D.

    (Advances in experimental medicine and biology ; 586)

    2006  

    Event/congress Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (3, 2005, Rodos)
    Author's details [Third Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics, June 5 - 10, 2005]. Ed. by John D. Lambris
    Series title Advances in experimental medicine and biology ; 586
    Collection
    Language English
    Size XXII, 406 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT014791674
    ISBN 978-0-387-32231-5 ; 978-0387-32231-5 ; 0387-32231-0 ; 0-387-32231-0
    Database Catalogue ZB MED Medicine, Health

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  7. Article ; Online: Complement-targeted therapeutics: An emerging field enabled by academic drug discovery.

    Lamers, Christina / Ricklin, Daniel / Lambris, John D

    American journal of hematology

    2023  Volume 98 Suppl 4, Page(s) S82–S89

    Abstract: Within a short few years, the number of complement inhibitors that are either approved for therapeutic application or evaluated in late-stage clinical trials has expanded remarkably. The sudden emergence of this target area in the pipelines of many ... ...

    Abstract Within a short few years, the number of complement inhibitors that are either approved for therapeutic application or evaluated in late-stage clinical trials has expanded remarkably. The sudden emergence of this target area in the pipelines of many biotech start-ups and even large pharmaceutical companies appears even more surprising when considering that the involvement of the complement system in various clinical conditions had long been recognized. In many aspects, however, the complement system is far from being a traditional drug target, which may explain the delayed breakthrough of this therapeutic strategy. While complement modulation is now considered an attractive "platform technology" with applications in a wide spectrum of disorders, the broad yet heterogeneous disease involvement of the complement system has long restricted its placement in traditional drug discovery programs. Concerns about the safety of complement-targeted interventions, the large number and high plasma concentrations of target proteins, and the complexity of the complement system's engagement in biological processes are among other factors that kept complement off the drug discovery radar for decades. Alongside technical advances and financial incentives, the innovation and persistence of academic and clinical researchers have been the critical driving force to navigate complement therapeutics out of the shadow into the spotlight. In this commentary, we document this remarkable development using select examples and aim to venture some predictions where this promising field may be headed to.
    MeSH term(s) Humans ; Complement Activation ; Complement System Proteins ; Drug Discovery ; Complement Inactivating Agents/pharmacology ; Complement Inactivating Agents/therapeutic use
    Chemical Substances Complement System Proteins (9007-36-7) ; Complement Inactivating Agents
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1251: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: A guide to complement biology, pathology and therapeutic opportunity.

    Mastellos, Dimitrios C / Hajishengallis, George / Lambris, John D

    Nature reviews. Immunology

    2023  Volume 24, Issue 2, Page(s) 118–141

    Abstract: Complement has long been considered a key innate immune effector system that mediates host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader involvement of complement in fundamental biological processes extending far beyond ... ...

    Abstract Complement has long been considered a key innate immune effector system that mediates host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader involvement of complement in fundamental biological processes extending far beyond its traditional realm in innate immunity. Complement engages in intricate crosstalk with multiple pattern-recognition and signalling pathways both in the extracellular and intracellular space. Besides modulating host-pathogen interactions, this crosstalk guides early developmental processes and distinct cell trajectories, shaping tissue immunometabolic and regenerative programmes in different physiological systems. This Review provides a guide to the system-wide functions of complement. It highlights illustrative paradigm shifts that have reshaped our understanding of complement pathobiology, drawing examples from evolution, development of the central nervous system, tissue regeneration and cancer immunity. Despite its tight spatiotemporal regulation, complement activation can be derailed, fuelling inflammatory tissue pathology. The pervasive contribution of complement to disease pathophysiology has inspired a resurgence of complement therapeutics with major clinical developments, some of which have challenged long-held dogmas. We thus highlight major therapeutic concepts and milestones in clinical complement intervention.
    MeSH term(s) Humans ; Complement System Proteins ; Immunity, Innate ; Complement Activation ; Biological Phenomena ; Biology
    Chemical Substances Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2023-09-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-023-00926-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 34: Show issues

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  9. Book ; Conference proceedings: Inflammation and retinal disease

    Lambris, John D. / Adamis, Anthony P.

    complement biology and pathology

    (Advances in experimental medicine and biology ; 703)

    2010  

    Event/congress Conference on Inflammation and Retinal Disease: Complement Biology and Pathology (1, 2007)
    Author's details John D. Lambris ; Anthony P. Adamis ed. [First Aegean Conferences Conference on Inflammation and Retinal Disease: Complement Biology and Pathology (June 10 -17, 2007) in Crete, Greece ...]
    Series title Advances in experimental medicine and biology ; 703
    Collection
    Language English
    Size XIII, 167 S. : Ill., graph. Darst., 235 mm x 155 mm
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT016772383
    ISBN 978-1-441-95634-7 ; 9781441956354 ; 1-441-95634-4 ; 1441956352
    Database Catalogue ZB MED Medicine, Health

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  10. Book ; Conference proceedings: Complement therapeutics

    Lambris, John D. / Holers, V. Michael / Ricklin, Daniel

    [Fifth International Complement Therapeutics Conference (June 22 - 27, 2011) in Rhodes, Greece]

    (Advances in experimental medicine and biology ; 735)

    2013  

    Event/congress International Complements Therapeutics Conference (5, 2011, Rhodos)
    Author's details John D. Lambris ; V. Michael Holers ; Daniel Ricklin ed
    Series title Advances in experimental medicine and biology ; 735
    Collection
    Keywords Complement (Immunology)
    Language English
    Size VIII, 320 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT017420044
    ISBN 978-1-4614-4117-5 ; 1-4614-4117-X ; 9781461441182 ; 1461441188
    Database Catalogue ZB MED Medicine, Health

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