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  1. Article: Complement in Kidney Transplantation.

    Cernoch, Marek / Viklicky, Ondrej

    Frontiers in medicine

    2017  Volume 4, Page(s) 66

    Abstract: The complement system is considered to be an important part of innate immune system with a significant role in inflammation processes. The activation can occur through classical, alternative, or lectin pathway, resulting in the creation of anaphylatoxins ...

    Abstract The complement system is considered to be an important part of innate immune system with a significant role in inflammation processes. The activation can occur through classical, alternative, or lectin pathway, resulting in the creation of anaphylatoxins C3a and C5a, possessing a vast spectrum of immune functions, and the assembly of terminal complement cascade, capable of direct cell lysis. The activation processes are tightly regulated; inappropriate activation of the complement cascade plays a significant role in many renal diseases including organ transplantation. Moreover, complement cascade is activated during ischemia/reperfusion injury processes and influences delayed graft function of kidney allografts. Interestingly, complement system has been found to play a role in both acute cellular and antibody-mediated rejections and thrombotic microangiopathy. Therefore, complement system may represent an interesting therapeutical target in kidney transplant pathologies.
    Language English
    Publishing date 2017-05-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2017.00066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Complement in Kidney Transplantation

    Marek Cernoch / Ondrej Viklicky

    Frontiers in Medicine, Vol

    2017  Volume 4

    Abstract: The complement system is considered to be an important part of innate immune system with a significant role in inflammation processes. The activation can occur through classical, alternative, or lectin pathway, resulting in the creation of anaphylatoxins ...

    Abstract The complement system is considered to be an important part of innate immune system with a significant role in inflammation processes. The activation can occur through classical, alternative, or lectin pathway, resulting in the creation of anaphylatoxins C3a and C5a, possessing a vast spectrum of immune functions, and the assembly of terminal complement cascade, capable of direct cell lysis. The activation processes are tightly regulated; inappropriate activation of the complement cascade plays a significant role in many renal diseases including organ transplantation. Moreover, complement cascade is activated during ischemia/reperfusion injury processes and influences delayed graft function of kidney allografts. Interestingly, complement system has been found to play a role in both acute cellular and antibody-mediated rejections and thrombotic microangiopathy. Therefore, complement system may represent an interesting therapeutical target in kidney transplant pathologies.
    Keywords complement ; kidney transplantation ; antibody-mediated rejection ; ischemia/reperfusion injury ; anticomplement therapy ; Medicine (General) ; R5-920
    Language English
    Publishing date 2017-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Intrarenal Complement System Transcripts in Chronic Antibody-Mediated Rejection and Recurrent IgA Nephropathy in Kidney Transplantation.

    Cernoch, Marek / Hruba, Petra / Kollar, Marek / Mrazova, Petra / Stranavova, Lucia / Lodererova, Alena / Honsova, Eva / Viklicky, Ondrej

    Frontiers in immunology

    2018  Volume 9, Page(s) 2310

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adolescent ; Adult ; Aged ; Allografts ; Antibody-Dependent Cell Cytotoxicity ; Biopsy ; Child ; Chronic Disease ; Complement System Proteins/genetics ; Complement System Proteins/immunology ; Female ; Gene Expression Profiling ; Glomerulonephritis, IGA/diagnosis ; Glomerulonephritis, IGA/etiology ; Glomerulonephritis, IGA/therapy ; Graft Rejection/genetics ; Graft Rejection/immunology ; Graft Survival/genetics ; Graft Survival/immunology ; Humans ; Isoantibodies/immunology ; Kidney Transplantation/adverse effects ; Male ; Middle Aged ; ROC Curve ; Recurrence ; Transcription, Genetic ; Young Adult
    Chemical Substances Isoantibodies ; Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2018-10-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.02310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Molecular patterns of diffuse and nodular parathyroid hyperplasia in long-term hemodialysis.

    Týcová, Irena / Sulková, Sylvie Dusilová / Štěpánková, Jitka / Krejčík, Zdeněk / Merkerová, Michaela Dostálová / Stránecký, Viktor / Hrubá, Petra / Girmanová, Eva / Černoch, Marek / Lipár, Květoslav / Marada, Tomáš / Povýšil, Ctibor / Viklický, Ondřej

    American journal of physiology. Endocrinology and metabolism

    2016  Volume 311, Issue 4, Page(s) E720–E729

    Abstract: Secondary hyperparathyroidism is a well-known complication of end-stage renal disease (ESRD). Both nodular and diffuse parathyroid hyperplasia occur in ESRD patients. However, their distinct molecular mechanisms remain poorly understood. Parathyroid ... ...

    Abstract Secondary hyperparathyroidism is a well-known complication of end-stage renal disease (ESRD). Both nodular and diffuse parathyroid hyperplasia occur in ESRD patients. However, their distinct molecular mechanisms remain poorly understood. Parathyroid tissue obtained from ESRD patients who had undergone parathyroidectomy was used for Illumina transcriptome screening and subsequently for discriminatory gene analysis, pathway mapping, and gene annotation enrichment analysis. Results were further validated using quantitative RT-PCR on the independent larger cohort. Microarray screening proved homogeneity of gene transcripts in hemodialysis patients compared with the transplant cohort and primary hyperparathyroidism; therefore, further experiments were performed in hemodialysis patients only. Enrichment analysis conducted on 485 differentially expressed genes between nodular and diffuse parathyroid hyperplasia revealed highly significant differences in Gene Ontology terms and the Kyoto Encyclopedia of Genes and Genomes database in ribosome structure (P = 3.70 × 10
    MeSH term(s) Adult ; Aged ; Female ; Focal Nodular Hyperplasia/etiology ; Focal Nodular Hyperplasia/genetics ; Focal Nodular Hyperplasia/therapy ; Gene Expression Profiling ; Gene Expression Regulation/genetics ; Humans ; Hyperparathyroidism, Primary/pathology ; Hyperparathyroidism, Secondary/etiology ; Hyperparathyroidism, Secondary/genetics ; Hyperparathyroidism, Secondary/therapy ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Multigene Family/genetics ; Parathyroid Glands/pathology ; Parathyroid Hormone/blood ; Parathyroidectomy ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; Renal Dialysis ; Transcriptome/genetics
    Chemical Substances Parathyroid Hormone ; RNA, Messenger
    Language English
    Publishing date 2016-10-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603841-4
    ISSN 1522-1555 ; 0193-1849
    ISSN (online) 1522-1555
    ISSN 0193-1849
    DOI 10.1152/ajpendo.00517.2015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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