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Article ; Online: Half a Century of Graft Survival After Deceased-Donor Kidney Transplantation: A Case Report.

Kremer, Daan / Bakker, Stephan J L / Berger, Stefan P

Kidney international reports

2023 Volume 8, Issue 5, Page(s) 1123–1124

Language	English
Publishing date	2023-03-11
Publishing country	United States
Document type	Journal Article
ISSN	2468-0249
ISSN (online)	2468-0249
DOI	10.1016/j.ekir.2023.03.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Successful Kidney Transplantation Despite Ongoing Chronic Norovirus Infection.

Kremer, Daan / Berger, Stefan P / Verschuuren, Erik A M / Bakker, Stephan J L / Knoester, Marjolein

Kidney international reports

2023 Volume 9, Issue 2, Page(s) 491–494

Language	English
Publishing date	2023-12-02
Publishing country	United States
Document type	Case Reports
ISSN	2468-0249
ISSN (online)	2468-0249
DOI	10.1016/j.ekir.2023.11.028
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Book ; Online: Stable isotope record of planktonic foraminifera of the South Atlantic, supplementary data to: Wefer, Gerold; Berger, Wolfgang H; Bickert, Torsten; Donner, Barbara; Fischer, Gerhard; Kemle-von M?cke, Sylvia; P?tzold, J?rgen; Meinecke, Gerrit; M?ller, Peter J; Mulitza, Stefan; Niebler, Hans-Stefan; Schmidt, Heike; Schneider, Ralph R; Segl, Monika (1996): Late Quaternary surface circulation of the South Atlantic: The stable isotope record and implications for heat transport and productivity. In: Wefer, G; Berger, W H; Siedler, G & Webb, D (eds.), The South Atlantic: Present and Past Circulation, Springer, Berlin, Heidelberg, 461-502

Wefer, Gerold / Berger, Wolfgang H / Bickert, Torsten / Donner, Barbara / Fischer, Gerhard / Kemle-von M?cke, Sylvia / M?ller, Peter J / Meinecke, Gerrit / P?tzold, J?rgen / al., et

1996

Abstract: The central problem of late Quaternary circulation in the South Atlantic is its role in transfer of heat to the North Atlantic, as this modifies amplitude, and perhaps phase, of glacialinterglacial fluctuations. Here we attempt to define the problem and ... ...

Abstract	The central problem of late Quaternary circulation in the South Atlantic is its role in transfer of heat to the North Atlantic, as this modifies amplitude, and perhaps phase, of glacialinterglacial fluctuations. Here we attempt to define the problem and establish ways to attack it. We identify several crucial elements in the dynamics of heat export: (1) warm-water pile-up (and lack thereof) in the Western equatorial Atlantic, (2) general spin-up (or spin-down) of central gyre, tied to SE trades, (3) opening and closing of Cape Valve (Agulhas retroflection), (4) deepwater E-W asymmetry. Means for reconstruction are biogeography, stable isotopes, and productivity proxies. Main results concern overall glacial-interglacial contrast (less pile-up, more spin-up, Cape Valve closed, less NADW during glacial time), dominance of precessional signal in tropics, phase shifts in precessional response. To generate working hypotheses about the dynamics of surface water circulation in the South Atlantic we employ Croll's paradigm that glacial - interglacial fluctuations are analogous to seasonal fluctuations. Our general picture for the last 300 kyrs is that, as concerns the South Atlantic, intensity of surface water (heat) transport depends on the strength of the SE trades. From various lines of evidence it appears that strenger SE trades appeared during glacials and cold substages during interglacials, analogous to conditions in southern winter (August).
Language	English
Dates of publication	1996-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
DOI	10.1594/PANGAEA.738529
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Clinical scales in autoimmune encephalitis-A retrospective monocentric cohort study.

Macher, Stefan / Bsteh, Gabriel / Höftberger, Romana / Berger, Thomas / Rommer, Paulus / Zrzavy, Tobias

Annals of clinical and translational neurology

2023 Volume 10, Issue 10, Page(s) 1768–1775

Abstract: ... at a cut-off value of 2 points (AUC 0.79, 95% CI 0.58-0.99, p = 0.04).: Interpretation: The CASE and ...

Abstract	Objective: Assessing severity of antibody-mediated encephalitis (AE) or paraneoplastic encephalitis (PE) requires valid and reliable scores to guide treatment decisions and predict outcome both in clinical routine and studies. We aimed to validate the prognostic value of the clinical assessment scale in autoimmune encephalitis (CASE) and the anti-NMDAR-encephalitis one-year functional status (NEOS) score in patients suffering from AE and PE in a large monocentric cohort. Methods: We retrospectively applied the CASE and NEOS score to patients with definite AE and PE treated at a tertiary hospital. Correlations were established between the CASE and NEOS score and the modified Rankin scale (mRs). Multivariable analyses were calculated to identify predictors of outcome. Results: Thirty-four patients (27 AE, 7 PE) were included. Correlations between mRS and CASE score were strongest in patients with AE compared to PE at all intervals, but in the subgroups (LGI1, NMDAR, GAD, miscellaneous surface antibodies, PE) the correlation was strongest in the interval after baseline. Patients with AE seemed to display better outcomes compared to PE, which was underlined by multivariable analysis. Improvement was mostly observed within 6-12 months after disease onset, after which little or no further improvement was noted with some exception for two patients with anti-NMDARE who recovered substantially even after 12 months of treatment. The NEOS score significantly predicted the outcome at last follow-up in patients with AE with a sensitivity of 79% at a cut-off value of 2 points (AUC 0.79, 95% CI 0.58-0.99, p = 0.04). Interpretation: The CASE and NEOS score are suitable supplementary tools in addition to the mRS for capturing diverse symptoms, for grading and monitoring symptom severity.
MeSH term(s)	Humans ; Retrospective Studies ; Cohort Studies ; Hashimoto Disease/diagnosis ; Hashimoto Disease/drug therapy ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/diagnosis ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/therapy
Language	English
Publishing date	2023-08-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2740696-9
ISSN	2328-9503 ; 2328-9503
ISSN (online)	2328-9503
ISSN	2328-9503
DOI	10.1002/acn3.51865
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Article ; Online: Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization.

Bauer, Nicolas / Balourdas, Dimitrios-Ilias / Schneider, Joel R / Zhang, Xin / Berger, Lena M / Berger, Benedict-Tilman / Schwalm, Martin P / Klopp, Nick A / Siveke, Jens T / Knapp, Stefan / Joerger, Andreas C

ACS chemical biology

2024 Volume 19, Issue 2, Page(s) 266–279

Abstract: Bromodomain and extra-terminal domain (BET) proteins and histone deacetylases (HDACs) are prime targets in cancer therapy. Recent research has particularly focused on the development of dual BET/HDAC inhibitors for hard-to-treat tumors, such as ... ...

Abstract	Bromodomain and extra-terminal domain (BET) proteins and histone deacetylases (HDACs) are prime targets in cancer therapy. Recent research has particularly focused on the development of dual BET/HDAC inhibitors for hard-to-treat tumors, such as pancreatic cancer. Here, we developed a new series of potent dual BET/HDAC inhibitors by choosing starting scaffolds that enabled us to optimally merge the two functionalities into a single compound. Systematic structure-guided modification of both warheads then led to optimized binders that were superior in potency to both parent compounds, with the best molecules of this series binding to both BRD4 bromodomains as well as HDAC1/2 with EC
MeSH term(s)	Humans ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/chemistry ; Nuclear Proteins/metabolism ; Transcription Factors/metabolism ; Pharmacophore ; Pancreatic Neoplasms/drug therapy ; Carcinoma ; Cell Line, Tumor ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; RNA-Binding Proteins ; Bromodomain Containing Proteins ; Cell Cycle Proteins/metabolism
Chemical Substances	Histone Deacetylase Inhibitors ; Nuclear Proteins ; Transcription Factors ; Antineoplastic Agents ; HEXIM1 protein, human ; RNA-Binding Proteins ; BRD4 protein, human ; Bromodomain Containing Proteins ; Cell Cycle Proteins
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article
ISSN	1554-8937
ISSN (online)	1554-8937
DOI	10.1021/acschembio.3c00427
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Article ; Online: Signaling Network Response to α-Particle-Targeted Therapy with the

Qin, Yun / Imobersteg, Stefan / Frank, Stephan / Blanc, Alain / Chiorazzo, Tanja / Berger, Philipp / Schibli, Roger / Béhé, Martin P / Grzmil, Michal

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2023 Volume 64, Issue 6, Page(s) 873–879

Abstract: α-particle emitters have recently been explored as valuable therapeutic radionuclides. Yet, toxicity to healthy organs and cancer radioresistance limit the efficacy of targeted α-particle therapy (TAT). Identification of the radiation-activated ... ...

Abstract	α-particle emitters have recently been explored as valuable therapeutic radionuclides. Yet, toxicity to healthy organs and cancer radioresistance limit the efficacy of targeted α-particle therapy (TAT). Identification of the radiation-activated mechanisms that drive cancer cell survival provides opportunities to develop new points for therapeutic interference to improve the efficacy and safety of TAT.
MeSH term(s)	Animals ; Mice ; Histone Deacetylase Inhibitors/pharmacology ; Mice, Nude ; Tumor Suppressor Protein p53 ; Cell Line, Tumor ; Vorinostat/pharmacology ; Signal Transduction ; Hydroxamic Acids/pharmacology ; Hydroxamic Acids/therapeutic use
Chemical Substances	Histone Deacetylase Inhibitors ; minigastrin (262J9O2552) ; Tumor Suppressor Protein p53 ; Vorinostat (58IFB293JI) ; Hydroxamic Acids
Language	English
Publishing date	2023-02-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.122.264597
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Zs.A 114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Urinary vanin-1, tubular injury, and graft failure in kidney transplant recipients.

Alkaff, Firas F / Kremer, Daan / Niekolaas, Tessa M / van den Born, Jacob / Rimbach, Gerald / Tseng, Tzu-Ling / Berger, Stefan P / Bakker, Stephan J L / de Borst, Martin H

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2283

Abstract: We investigated whether urinary vascular non-inflammatory molecule-1 (vanin-1), a promising early-onset tubular injury marker, correlates with other established tubular injury markers and is associated with graft failure in kidney transplant recipients ( ... ...

Abstract	We investigated whether urinary vascular non-inflammatory molecule-1 (vanin-1), a promising early-onset tubular injury marker, correlates with other established tubular injury markers and is associated with graft failure in kidney transplant recipients (KTR). We measured 24 h urinary vanin-1 excretion in 656 KTR (age 53 ± 13 years, 43% female, estimated glomerular filtration rate (eGFR) 53 ± 21 mL/min/1.73 m
MeSH term(s)	Humans ; Female ; Male ; Adult ; Middle Aged ; Aged ; Kidney Transplantation/adverse effects ; Lipocalin-2 ; Glomerular Filtration Rate ; Urinary Tract ; Proportional Hazards Models ; Biomarkers ; Kidney ; Transplant Recipients
Chemical Substances	Lipocalin-2 ; Biomarkers
Language	English
Publishing date	2024-01-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52635-x
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Article ; Online: Iron Status and Cause-Specific Mortality After Kidney Transplantation.

Vinke, Joanna Sophia J / Kremer, Daan / Knobbe, Tim J / Grote Beverborg, Niels / Berger, Stefan P / Bakker, Stephan J L / de Borst, Martin H / Eisenga, Michele F

Kidney medicine

2023 Volume 6, Issue 2, Page(s) 100766

Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article
ISSN	2590-0595
ISSN (online)	2590-0595
DOI	10.1016/j.xkme.2023.100766
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Article ; Online: Follow-Up of Offspring Born to Parents With a Solid Organ Transplantation: A Systematic Review.

Meinderts, Jildau R / Prins, Jelmer R / Berger, Stefan P / De Jong, Margriet F C

Transplant international : official journal of the European Society for Organ Transplantation

2022 Volume 35, Page(s) 10565

Abstract: Pregnancy after solid organ transplantation (SOT) has potential risks for the offspring. Most existing research focused on short-term pregnancy outcomes. The aim of this systematic review was to evaluate available data concerning longer term outcomes (>1 ...

Abstract	Pregnancy after solid organ transplantation (SOT) has potential risks for the offspring. Most existing research focused on short-term pregnancy outcomes. The aim of this systematic review was to evaluate available data concerning longer term outcomes (>1 year) of these children. A systematic literature search, following PRISMA guidelines, of PubMed and Embase was performed from the earliest date of inception through to 6th April 2022. Publications on all types of (combined) SOT were eligible for inclusion. In total, 53 articles were included. The majority assessed offspring after kidney (78% of offspring) or liver transplantation (17% of offspring). 33 studies included offspring aged >4 years and five offspring aged >18 years. One study was included on fathers with SOT. The majority of the 1,664 included children after maternal SOT had normal intellectual, psychomotor, and behavioral development. Although prematurity and low birth weight were commonly present, regular growth after 1 year of age was described. No studies reported opportunistic or chronic infections or abnormal response to vaccinations. In general, pregnancy after SOT appears to have reassuring longer term outcomes for the offspring. However, existing information is predominantly limited to studies with young children. Longer prospective studies with follow-up into adulthood of these children are warranted.
MeSH term(s)	Adult ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Humans ; Organ Transplantation/adverse effects ; Parents ; Pregnancy ; Pregnancy Outcome ; Prospective Studies
Language	English
Publishing date	2022-08-05
Publishing country	Switzerland
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.3389/ti.2022.10565
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Article ; Online: Pre-donation Assessment of Cystatin C to Improve Prediction of Pre- and Post-Donation GFR in Potential Living Kidney Donors.

van der Weijden, Jessica / Kremer, Daan / Westenberg, Lisa B / Sanders, Jan-Stephan F / Pol, Robert A / Nolte, Ilja M / De Borst, Martin H / Berger, Stefan P / Bakker, Stephan J L / van Londen, Marco

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2024

Abstract: Background and hypothesis: Accurate estimation of glomerular filtration rate (GFR) is crucial in living kidney donation. While most eGFR equations are based on plasma creatinine, its levels are strongly influenced by muscle mass. Application of cystatin ...

Abstract	Background and hypothesis: Accurate estimation of glomerular filtration rate (GFR) is crucial in living kidney donation. While most eGFR equations are based on plasma creatinine, its levels are strongly influenced by muscle mass. Application of cystatin C (CysC)-based estimates before donation may improve both estimation of current GFR and prediction of post-donation GFR. Methods: We assessed the performance of CKD-EPI equations based on creatinine (eGFRcreat-2009, eGFRcreat-2021), cystatin C (eGFRCysC-2012), or both (eGFRcombined-2012, eGFRcombined-2021) for estimating pre- and post-donation measured GFR in 486 living kidney donors. We subsequently focused on a subgroup of individuals with high/low muscle mass (25% highest/lowest 24-hour urinary creatinine excretion, sex-stratified and height-indexed). Results: Pre-donation eGFRcombined 2012 and eGFRcombined 2021 showed the strongest associations with pre- and post-donation mGFR. Pre-donation eGFRcombined 2021 was most accurate for estimating both pre-donation (bias 0.01±11.9 mL/min/1.73m2) and post-donation mGFR (bias 1.3±8.5 mL/min/1.73 m2). In donors with high/low muscle mass, CysC-based equations (with or without creatinine) performed better compared to equations based on only creatinine. Conclusions: In conclusion, combined eGFR equations yielded a better estimate of pre- and post-donation mGFR, compared to estimates based on creatinine or CysC only. The added value of CysC seems particularly pronounced in donors with high or low muscle mass.
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfae065
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