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  1. Article: The Prevalence and Pattern of Anaemia in Type 2 Diabetics in Ogbomosho, An Urban Community in Southwestern Nigeria.

    Olufemi-Aworinde, Kehinde J / Olutogun, Tolulase A / Akande, Joel O / Akande, Roseline O / Odeyemi, Abiona O / Idowu, Olufemi J / Oke, Elizabeth O / Abolarin, Ademola T / Ala, Oluwabukola A

    Anemia

    2022  Volume 2022, Page(s) 7650015

    Abstract: Anaemia is a frequent finding in type 2 diabetes, but it is typically seen with established chronic kidney disease and renal insufficiency. Cases, where anaemia predates renal insufficiency, are associated with a worse prognosis for the type 2 diabetes ... ...

    Abstract Anaemia is a frequent finding in type 2 diabetes, but it is typically seen with established chronic kidney disease and renal insufficiency. Cases, where anaemia predates renal insufficiency, are associated with a worse prognosis for the type 2 diabetes patient and an increased susceptibility to complications. This study aims to determine the prevalence and type of anaemia in persons living with type 2 diabetes without established chronic kidney disease in our environment. The study was a hospital-based cross-sectional study that involved 141 people with known type 2 diabetes as the study group and 140 healthy persons as controls. The study population and the controls were selected using a multistage sampling technique. Data were collected using an interviewer-administered semistructured questionnaire at the Endocrinology clinic, Bowen University Teaching Hospital, Ogbomosho. The data obtained were analyzed using the IBM SPSS version 23.0 (
    Language English
    Publishing date 2022-10-26
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2595393-X
    ISSN 2090-1275 ; 2090-1267
    ISSN (online) 2090-1275
    ISSN 2090-1267
    DOI 10.1155/2022/7650015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Complement-mediated haemolysis and the role of blood transfusion in paroxysmal nocturnal haemoglobinuria.

    Olutogun, Tolulase / Cutini, Ilaria / Notaro, Rosario / Luzzatto, Lucio

    Blood transfusion = Trasfusione del sangue

    2015  Volume 13, Issue 3, Page(s) 363–369

    MeSH term(s) Blood Transfusion ; Complement Activation ; Complement System Proteins/metabolism ; Hemoglobinuria, Paroxysmal/blood ; Hemoglobinuria, Paroxysmal/genetics ; Hemoglobinuria, Paroxysmal/pathology ; Hemoglobinuria, Paroxysmal/therapy ; Hemolysis ; Humans
    Chemical Substances Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2015-07
    Publishing country Italy
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2135732-8
    ISSN 1723-2007 ; 0041-1787
    ISSN 1723-2007 ; 0041-1787
    DOI 10.2450/2015.0249-14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 798: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Total antioxidant status in sickle cell anemia

    Tolulase Aderayo Olutogun / Kehinde Joyce Olufemi-Aworinde / Foluke A Fasola / Gbemi Henry Ano-Edward / Olufemi Opeyemi Aworinde / Anthony O Ajiboye

    Saudi Journal for Health Sciences, Vol 7, Iss 2, Pp 80-

    2018  Volume 82

    Abstract: Background: The homozygous sickle cell anemia (SCA) has an unstable hemoglobin (HbS). The heme group dissociates easily from globin chain and the iron is released and free within the red cell. In addition, the sickle red cells release cell-free ... ...

    Abstract Background: The homozygous sickle cell anemia (SCA) has an unstable hemoglobin (HbS). The heme group dissociates easily from globin chain and the iron is released and free within the red cell. In addition, the sickle red cells release cell-free hemoglobin after undergoing intravascular hemolysis. These contribute to increased reactive oxygen species and oxidative stress ensues. Oxidative stress contributes to complications such as acute chest syndrome and pulmonary hypertension both of which are severe manifestations of SCA. Objectives: In this study, we set out to correlate inflammatory markers of disease severity with oxidative stress. Materials and Methods: We compared the total antioxidant status of 61 steady-state SCA patients with 60 HbAA controls. We then investigated associations between the total antioxidant levels and hematological and clinical indices of the patients in order to establish a relationship between markers of oxidative stress and markers of sickle cell severity. Results: We found that that total antioxidants were significantly lower in SCA compared with control levels (50% lower). The total antioxidants levels were inversely proportional to leukocyte and especially neutrophil cell counts which are pro-inflammatory markers. Conclusion: Oxidative stress which leads to secondary complications correlates with pro-inflammatory markers of clinical severity in SCA.
    Keywords Antioxidant ; sickle cell anemia ; stress ; Medicine ; R
    Subject code 610 ; 571
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Effect of tranexamic acid on coagulation and fibrinolysis in women with postpartum haemorrhage (WOMAN-ETAC): a single-centre, randomised, double-blind, placebo-controlled trial.

    Shakur-Still, Haleema / Roberts, Ian / Fawole, Bukola / Kuti, Modupe / Olayemi, Oladapo O / Bello, Adenike / Huque, Sumaya / Ogunbode, Olayinka / Kotila, Taiwo / Aimakhu, Chris / Okunade, Olujide A / Olutogun, Tolulase / Adetayo, Cecilia O / Dallaku, Kastriot / Mansmann, Ulrich / Hunt, Beverley J / Pepple, Tracey / Balogun, Eni

    Wellcome open research

    2018  Volume 3, Page(s) 100

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2018-08-15
    Publishing country England
    Document type Journal Article
    ISSN 2398-502X
    ISSN 2398-502X
    DOI 10.12688/wellcomeopenres.14722.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Haematological and fibrinolytic status of Nigerian women with post-partum haemorrhage.

    Roberts, Ian / Shakur, Haleema / Fawole, Bukola / Kuti, Modupe / Olayemi, Oladapo / Bello, Adenike / Ogunbode, Olayinka / Kotila, Taiwo / Aimakhu, Chris O / Olutogun, Tolulase / Hunt, Beverley J / Huque, Sumaya

    BMC pregnancy and childbirth

    2018  Volume 18, Issue 1, Page(s) 143

    Abstract: Background: Early treatment with tranexamic acid reduces deaths due to bleeding after post-partum haemorrhage. We report the prevalence of haematological, coagulation and fibrinolytic abnormalities in Nigerian women with postpartum haemorrhage.: ... ...

    Abstract Background: Early treatment with tranexamic acid reduces deaths due to bleeding after post-partum haemorrhage. We report the prevalence of haematological, coagulation and fibrinolytic abnormalities in Nigerian women with postpartum haemorrhage.
    Methods: We performed a secondary analysis of the WOMAN trial to assess laboratory data and rotational thromboelastometry (ROTEM) parameters in 167 women with postpartum haemorrhage treated at University College Hospital, Ibadan, Nigeria. We defined hyper-fibrinolysis as EXTEM maximum lysis (ML) > 15% on ROTEM. We defined coagulopathy as EXTEM clot amplitude at 5 min (A5) < 40 mm or prothrombin ratio > 1.5.
    Results: Among the study cohort, 53 (40%) women had severe anaemia (haemoglobin< 70 g/L) and 17 (13%) women had severe thrombocytopenia (platelet count < 50 × 10
    Conclusion: Our findings suggest that, based on a convenience sample of women from a large teaching hospital in Nigeria, hyper-fibrinolysis may commonly occur in postpartum haemorrhage. Further mechanistic studies are needed to examine hyper-fibrinolysis associated with postpartum haemorrhage. Findings from such studies may optimize treatment approaches for postpartum haemorrhage.
    Trial registration: The Woman trial was registered: NCT00872469; ISRCTN76912190 (Registration date: 22/03/2012).
    MeSH term(s) Adolescent ; Adult ; Anemia/epidemiology ; Blood Coagulation Disorders/epidemiology ; Female ; Fibrinolysis ; Humans ; Middle Aged ; Nigeria ; Postpartum Hemorrhage/blood ; Postpartum Hemorrhage/physiopathology ; Pregnancy ; Prevalence ; Prothrombin/metabolism ; Randomized Controlled Trials as Topic ; Thrombelastography/methods ; Thrombocytopenia/epidemiology ; Young Adult
    Chemical Substances Prothrombin (9001-26-7)
    Language English
    Publishing date 2018-05-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059869-5
    ISSN 1471-2393 ; 1471-2393
    ISSN (online) 1471-2393
    ISSN 1471-2393
    DOI 10.1186/s12884-018-1794-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Effect of tranexamic acid on coagulation and fibrinolysis in women with postpartum haemorrhage (WOMAN-ETAC)

    Haleema Shakur-Still / Ian Roberts / Bukola Fawole / Modupe Kuti / Oladapo O. Olayemi / Adenike Bello / Sumaya Huque / Olayinka Ogunbode / Taiwo Kotila / Chris Aimakhu / Olujide A. Okunade / Tolulase Olutogun / Cecilia O. Adetayo / Kastriot Dallaku / Ulrich Mansmann / Beverley J. Hunt / Tracey Pepple / Eni Balogun

    Wellcome Open Research, Vol

    a single-centre, randomised, double-blind, placebo-controlled trial [version 1; referees: 2 approved]

    2018  Volume 3

    Abstract: Background: Postpartum haemorrhage (PPH) is a leading cause of maternal death. The WOMAN trial showed that tranexamic acid (TXA) reduces death due to bleeding in women with PPH. We evaluated the effect of TXA on fibrinolysis and coagulation in a sample ... ...

    Abstract Background: Postpartum haemorrhage (PPH) is a leading cause of maternal death. The WOMAN trial showed that tranexamic acid (TXA) reduces death due to bleeding in women with PPH. We evaluated the effect of TXA on fibrinolysis and coagulation in a sample of WOMAN trial participants. Methods: Adult women with a clinical diagnosis of PPH were randomised to receive 1 g TXA or matching placebo in the WOMAN trial. Participants in the WOMAN trial at University College Hospital (Ibadan, Nigeria) also had venous blood taken just before administration of the first dose of trial treatment and again 30 (±15) min after the first dose (the ETAC study). We aimed to determine the effects of TXA on fibrinolysis (D-dimer and rotational thromboelastometry maximum clot lysis (ML)) and coagulation (international normalized ratio and clot amplitude at 5 min). We compared outcomes in women receiving TXA and placebo using linear regression, adjusting for baseline measurements. Results: Women (n=167) were randomised to receive TXA (n=83) or matching placebo (n=84). Due to missing data, seven women were excluded from analysis. The mean (SD) D-dimer concentration was 7.1 (7.0) mg/l in TXA-treated women and 9.6 (8.6) mg/l in placebo-treated women (p=0.09). After adjusting for baseline, the D-dimer concentration was 2.16 mg/l lower in TXA-treated women (-2.16, 95% CI -4.31 to 0.00, p=0.05). There was no significant difference in ML between TXA- and placebo-treated women (12.3% (18.4) and 10.7% (12.6), respectively; p=0.52) and no significant difference after adjusting for baseline ML (1.02, 95% CI -3.72 to 5.77, p=0.67). There were no significant effects of TXA on any other parameters. Conclusion: TXA treatment was associated with reduced D-dimer levels but had no apparent effects on thromboelastometry parameters or coagulation tests. Registration: ISRCTN76912190 (initially registered 10/12/2008, WOMAN-ETAC included on 22/03/2012) and NCT00872469 (initially registered 31/03/2009, WOMAN-ETAC included on 22/03/2012).
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2018-08-01T00:00:00Z
    Publisher Wellcome
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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