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Article ; Online: Neoadjuvant immunotherapy for resectable hepatocellular carcinoma - Authors' reply.

Marron, Thomas U / Schwartz, Myron E / Miller, Elizabeth / Thanigaimani, Pradeep / Lowy, Israel / Thurston, Gavin / Merad, Miriam

The lancet. Gastroenterology & hepatology

2022 Volume 7, Issue 6, Page(s) 505

MeSH term(s)	Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/therapy ; Humans ; Immunologic Factors ; Immunotherapy ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy ; Neoadjuvant Therapy
Chemical Substances	Immunologic Factors
Language	English
Publishing date	2022-05-12
Publishing country	Netherlands
Document type	Letter ; Comment
ISSN	2468-1253
ISSN (online)	2468-1253
DOI	10.1016/S2468-1253(22)00122-4
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Article: A Global Longitudinal Study Examining Social Restrictions Severity on Loneliness, Social Anxiety, and Depression.

Lim, Michelle H / Qualter, Pamela / Thurston, Lily / Eres, Robert / Hennessey, Alexandra / Holt-Lunstad, Julianne / Lambert, Gavin W

Frontiers in psychiatry

2022 Volume 13, Page(s) 818030

Abstract: Purpose: Social restrictions and government-mandated lockdowns implemented worldwide to kerb the SARS-CoV-2 virus disrupted our social interactions, behaviours, and routines. While many studies have examined how the pandemic influenced loneliness and ... ...

Abstract	Purpose: Social restrictions and government-mandated lockdowns implemented worldwide to kerb the SARS-CoV-2 virus disrupted our social interactions, behaviours, and routines. While many studies have examined how the pandemic influenced loneliness and poor mental health, such as depression, almost none have focussed on social anxiety. Further, how the change in social restrictions affected change in mental-health and well-being has not yet been explored. Methods: This is a longitudinal cohort study in community dwellers who were surveyed across three timepoints in the first six months of the pandemic. We measured loneliness, social anxiety, depression, and social restrictions severity that were objectively coded in a sample from Australia, United States, and United Kingdom ( Results: Loneliness reduced, depression marginally reduced, and social anxiety symptoms increased as social restrictions eased. Specific demographic factors (e.g., younger age, unemployment, lower wealth, and living alone) all influenced loneliness, depression, and social anxiety at baseline. No demographic factors influenced changes for loneliness; we found that those aged over 25 years reduced faster on depression, while those younger than 25 years and unemployed increased faster on social anxiety over time. Conclusion: We found evidence that easing social restrictions brought about additional burden to people who experienced higher social anxiety symptoms. As country-mandated lockdown and social restrictions eased, people are more likely report higher social anxiety as they readjust into their social environment. Mental health practitioners are likely to see higher levels of social anxiety in vulnerable communities even as social restrictions ease.
Language	English
Publishing date	2022-03-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2022.818030
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Article ; Online: Data linkage and pain medication in people with cerebral palsy: a cross-sectional study.

Garca Jalon, Elena Guiomar / Maguire, Aideen / Perra, Oliver / Gavin, Anna / O'Reilly, Dermot / Thurston, Allen

Developmental medicine and child neurology

2021 Volume 63, Issue 9, Page(s) 1085–1092

Abstract: Aim: To explore data linkage and pain medication as a proxy for pain, to assess differences in pain medication between the cerebral palsy (CP) and the general populations, and to identify factors associated with pain medication in CP.: Method: This ... ...

Abstract	Aim: To explore data linkage and pain medication as a proxy for pain, to assess differences in pain medication between the cerebral palsy (CP) and the general populations, and to identify factors associated with pain medication in CP. Method: This cross-sectional study linked the Northern Ireland CP Register and two administrative health care databases for people resident in Northern Ireland born between 1981 and 2008. Pain medication as a proxy was validated by replicating analyses from the Study of Participation of Children with Cerebral Palsy Living in Europe (SPARCLE) studies. Logistic regression compared pain medication in the CP and general populations. Multi-level regression models assessed factors associated with pain medication in the CP cohort. Results: The sample size was 701 075, of whom 1430 (0.2%) were people with CP. There were 358 969 males and 340 677 females in the general population, and 810 males and 620 females in the CP population, with an age range of 4 to 31 years in both groups. The validation exercise produced results similar to the SPARCLE studies. More people with CP received pain medication (61% vs 50.9%) and had twice the odds of being prescribed opioid analgesics (odds ratio [OR]=2.81, 95% confidence interval [CI] 2.32-3.40). Among those with CP, the odds of being prescribed pain medication were higher for: females (OR=1.34, 95% CI 1.06-1.70), younger age (OR=1.60, 95% CI 1.02-2.51), Gross Motor Function Classification System level V (OR=2.60, 95% CI 1.52-4.47), seizures (OR=2.55, 95% CI 1.68-3.87), and higher deprivation score (OR=2.06, 95% CI 1.41-3.24). Interpretation: Pain medication is an effective proxy for pain. More people with CP were prescribed pain medication than the general population. Pain medication for people with CP is not only dependent on physiological and clinical characteristics, but also environmental factors. What this paper adds Data linkage using pain medication as a proxy for experiencing pain is a valid method. People with cerebral palsy (CP) are more likely to experience pain than the general population. People with CP have over twice the odds of receiving opioids compared to the general population. The odds of being prescribed pain medication were higher for females with CP. Prescription of pain medication among those with CP is not only dependent on clinical characteristics, but also environmental factors.
MeSH term(s)	Adolescent ; Adult ; Analgesics/therapeutic use ; Cerebral Palsy/complications ; Cerebral Palsy/physiopathology ; Child ; Child, Preschool ; Cohort Studies ; Cross-Sectional Studies ; Europe ; Female ; Humans ; Information Storage and Retrieval/methods ; Male ; Odds Ratio ; Pain/complications ; Pain/drug therapy ; Pain Management/statistics & numerical data ; Validation Studies as Topic ; Young Adult
Chemical Substances	Analgesics
Language	English
Publishing date	2021-03-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80369-8
ISSN	1469-8749 ; 0012-1622
ISSN (online)	1469-8749
ISSN	0012-1622
DOI	10.1111/dmcn.14854
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Article ; Online: Spontaneous tumor regression mediated by human T cells in a humanized immune system mouse model.

Patel, A K / Dhanik, Ankur / Lim, Wei Keat / Adler, Christina / Ni, Min / Wei, Yi / Zhong, Maggie / Nguyen, Cindy / Zhong, Jun / Lu, Yi-Fen / Thurston, Gavin / Macdonald, Lynn / Murphy, Andrew / Gurer, Cagan / Frleta, Davor

Communications biology

2023 Volume 6, Issue 1, Page(s) 444

Abstract: Immunodeficient mice reconstituted with a human immune system (HIS mice) give rise to human T cells, which make them an attractive system to study human immune responses to tumors. However, such HIS mice typically exhibit sub-optimal responses to immune ... ...

Abstract	Immunodeficient mice reconstituted with a human immune system (HIS mice) give rise to human T cells, which make them an attractive system to study human immune responses to tumors. However, such HIS mice typically exhibit sub-optimal responses to immune challenges as well as fail to develop antigen-specific B or T cell memory. Here we report HIS mice mediate spontaneous regression of human B cell lymphoma Raji. Tumor regression was dependent on CD4+ and CD8+ T cell responses and resulted in T cell memory. The T cell memory elicited was mainly Raji-specific, however some level of cross-protection was also elicited to a related B cell lymphoma cell line Ramos. Single-cell RNAseq analysis indicated activation of CD8+ T cells in regressing Raji tumors as well as clonal expansion of specific T cell receptors (TCRs). Cloning of TCRs from Raji-infiltrating T cells into a Jurkat reporter cell line showed reactivity specific for Raji tumor cells. Overall, we report a platform for studying in vivo human T cell tumor immunity by highlighting spontaneous Raji tumor regression, clonal TCR expansion, and T cell memory in HIS mice.
MeSH term(s)	Humans ; Mice ; Animals ; CD8-Positive T-Lymphocytes ; Receptors, Antigen, T-Cell/metabolism ; Jurkat Cells ; Lymphoma, B-Cell/metabolism
Chemical Substances	Receptors, Antigen, T-Cell
Language	English
Publishing date	2023-04-22
Publishing country	England
Document type	Journal Article
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-023-04824-z
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Article ; Online: A Bispecific METxMET Antibody-Drug Conjugate with Cleavable Linker Is Processed in Recycling and Late Endosomes.

Perez Bay, Andres E / Faulkner, Devon / DaSilva, John O / Young, Tara M / Yang, Katie / Giurleo, Jason T / Ma, Dangshe / Delfino, Frank J / Olson, William C / Thurston, Gavin / Daly, Christopher / Andreev, Julian

Molecular cancer therapeutics

2023 Volume 22, Issue 3, Page(s) 357–370

Abstract: Most antibody-drug conjugates (ADC) approved for the treatment of cancer contain protease-cleavable linkers. ADCs that traffic to lysosomes traverse highly acidic late endosomes, while ADCs that recycle to the plasma membrane traffic through mildly ... ...

Abstract	Most antibody-drug conjugates (ADC) approved for the treatment of cancer contain protease-cleavable linkers. ADCs that traffic to lysosomes traverse highly acidic late endosomes, while ADCs that recycle to the plasma membrane traffic through mildly acidic sorting and recycling endosomes. Although endosomes have been proposed to process cleavable ADCs, the precise identity of the relevant compartments and their relative contributions to ADC processing remain undefined. Here we show that a METxMET biparatopic antibody internalizes into sorting endosomes, rapidly traffics to recycling endosomes, and slowly reaches late endosomes. In agreement with the current model of ADC trafficking, late endosomes are the primary processing site of MET, EGFR, and prolactin receptor ADCs. Interestingly, recycling endosomes contribute up to 35% processing of the MET and EGFR ADCs in different cancer cells, mediated by cathepsin-L, which localizes to this compartment. Taken together, our findings provide insight into the relationship between transendosomal trafficking and ADC processing and suggest that receptors that traffic through recycling endosomes might be suitable targets for cleavable ADCs.
MeSH term(s)	Humans ; Immunoconjugates/pharmacology ; Antibodies ; Cancer Vaccines ; Endosomes ; ErbB Receptors
Chemical Substances	Immunoconjugates ; Antibodies ; Cancer Vaccines ; ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2023-03-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2063563-1
ISSN	1538-8514 ; 1535-7163
ISSN (online)	1538-8514
ISSN	1535-7163
DOI	10.1158/1535-7163.MCT-22-0414
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Article ; Online: Angiopoietin-2-Dependent Spatial Vascular Destabilization Promotes T-cell Exclusion and Limits Immunotherapy in Melanoma.

Park, Ha-Ram / Shiva, Anahita / Cummings, Portia / Kim, Seoyeon / Kim, Sungsoo / Lee, Eunhyeong / Leong, Alessandra / Chowdhury, Subrata / Shawber, Carrie / Carvajal, Richard / Thurston, Gavin / An, Joon-Yong / Lund, Amanda W / Yang, Hee Won / Kim, Minah

Cancer research

2023 Volume 83, Issue 12, Page(s) 1968–1983

Abstract: T-cell position in the tumor microenvironment determines the probability of target encounter and tumor killing. CD8+ T-cell exclusion from the tumor parenchyma is associated with poor response to immunotherapy, and yet the biology that underpins this ... ...

Abstract	T-cell position in the tumor microenvironment determines the probability of target encounter and tumor killing. CD8+ T-cell exclusion from the tumor parenchyma is associated with poor response to immunotherapy, and yet the biology that underpins this distinct pattern remains unclear. Here we show that the vascular destabilizing factor angiopoietin-2 (ANGPT2) causes compromised vascular integrity in the tumor periphery, leading to impaired T-cell infiltration to the tumor core. The spatial regulation of ANGPT2 in whole tumor cross-sections was analyzed in conjunction with T-cell distribution, vascular integrity, and response to immunotherapy in syngeneic murine melanoma models. T-cell exclusion was associated with ANGPT2 upregulation and elevated vascular leakage at the periphery of human and murine melanomas. Both pharmacologic and genetic blockade of ANGPT2 promoted CD8+ T-cell infiltration into the tumor core, exerting antitumor effects. Importantly, the reversal of T-cell exclusion following ANGPT2 blockade not only enhanced response to anti-PD-1 immune checkpoint blockade therapy in immunogenic, therapy-responsive mouse melanomas, but it also rendered nonresponsive tumors susceptible to immunotherapy. Therapeutic response after ANGPT2 blockade, driven by improved CD8+ T-cell infiltration to the tumor core, coincided with spatial TIE2 signaling activation and increased vascular integrity at the tumor periphery where endothelial expression of adhesion molecules was reduced. These data highlight ANGPT2/TIE2 signaling as a key mediator of T-cell exclusion and a promising target to potentiate immune checkpoint blockade efficacy in melanoma. Significance: ANGPT2 limits the efficacy of immunotherapy by inducing vascular destabilization at the tumor periphery to promote T-cell exclusion.
MeSH term(s)	Humans ; Mice ; Animals ; Angiopoietin-2/genetics ; Immune Checkpoint Inhibitors ; Melanoma/therapy ; Immunotherapy ; CD8-Positive T-Lymphocytes/metabolism ; Tumor Microenvironment
Chemical Substances	Angiopoietin-2 ; Immune Checkpoint Inhibitors
Language	English
Publishing date	2023-04-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-22-2838
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Article ; Online: Molecular assessment of intratumoral immune cell subsets and potential mechanisms of resistance to odronextamab, a CD20×CD3 bispecific antibody, in patients with relapsed/refractory B-cell non-Hodgkin lymphoma.

Brouwer-Visser, Jurriaan / Fiaschi, Nathalie / Deering, Raquel P / Cygan, Kamil J / Scott, Darius / Jeong, Se / Boucher, Lauren / Gupta, Namita T / Gupta, Suraj / Adler, Christina / Topp, Max S / Bannerji, Rajat / Duell, Johannes / Advani, Ranjana H / Flink, Dina M / Chaudhry, Aafia / Thurston, Gavin / Ambati, Srikanth R / Jankovic, Vladimir

Journal for immunotherapy of cancer

2024 Volume 12, Issue 3

Abstract: Background: Patients with relapsed/refractory B-cell non-Hodgkin lymphoma (R/R B-NHL) have a significant need for effective treatment options. Odronextamab is an Fc-silenced, human, CD20×CD3 bispecific antibody that targets CD20-expressing cells via T- ... ...

Abstract	Background: Patients with relapsed/refractory B-cell non-Hodgkin lymphoma (R/R B-NHL) have a significant need for effective treatment options. Odronextamab is an Fc-silenced, human, CD20×CD3 bispecific antibody that targets CD20-expressing cells via T-cell-mediated cytotoxicity independent of T-cell/major histocompatibility complex interaction. Phase I results in patients with R/R B-NHL demonstrated that odronextamab monotherapy could achieve deep and durable responses with a generally manageable safety profile (ELM-1; NCT02290951). As part of a biomarker analysis of the same study, we investigated potential biomarkers and mechanisms of resistance to odronextamab. Methods: Patients with R/R B-NHL enrolled in ELM-1 received one time per week doses of intravenous odronextamab for 4×21 day cycles, then doses every 2 weeks thereafter. Patient tumor biopsies were obtained at baseline, on-treatment, and at progression. Immune cell markers were analyzed by immunohistochemistry, flow cytometry, single-cell RNA sequencing, and whole genome sequencing. Results: Baseline tumor biopsies showed that almost all patients had high proportions of B cells that expressed the CD20 target antigen, whereas expression of other B-cell surface antigens (CD19, CD22, CD79b) was more variable. Responses to odronextamab in patients with diffuse large B-cell lymphoma were not related to the relative level of baseline CD20 expression, cell of origin, or high-risk molecular subtype. A potential link was observed between greater tumor programmed cell death-ligand 1 expression and increased likelihood of response to odronextamab. Similarly, a trend was observed between clinical response and increased levels of CD8 T cells and regulatory T cells at baseline. We also identified an on-treatment pharmacodynamic shift in intratumoral immune cell subsets. Finally, loss of CD20 expression through inactivating gene mutations was identified as a potential mechanism of resistance in patients who were treated with odronextamab until progression, as highlighted in two detailed patient cases reported here. Conclusions: This biomarker analysis expands on clinical findings of odronextamab in patients with R/R B-NHL, providing verification of the suitability of CD20 as a therapeutic target, as well as evidence for potential mechanisms of action and resistance.
MeSH term(s)	Humans ; Antineoplastic Agents/therapeutic use ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/genetics ; Treatment Outcome ; Antibodies, Bispecific/pharmacology ; Antibodies, Bispecific/therapeutic use ; Antigens, CD20
Chemical Substances	Antineoplastic Agents ; Antibodies, Bispecific ; Antigens, CD20
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2719863-7
ISSN	2051-1426 ; 2051-1426
ISSN (online)	2051-1426
ISSN	2051-1426
DOI	10.1136/jitc-2023-008338
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Article ; Online: Human CD4 cytotoxic T lymphocytes mediate potent tumor control in humanized immune system mice.

Lin, Wen / Singh, Varan / Springer, Raynel / Choonoo, Gabrielle / Gupta, Namita / Patel, Aditi / Frleta, Davor / Zhong, Jun / Owczarek, Tomasz / Decker, Corinne / Macdonald, Lynn / Murphy, Andrew / Thurston, Gavin / Mohrs, Markus / Ioffe, Ella / Lu, Yi-Fen

Communications biology

2023 Volume 6, Issue 1, Page(s) 447

Abstract: Efficacy of immune checkpoint inhibitors in cancers can be limited by CD8 T cell dysfunction or HLA-I down-regulation. Tumor control mechanisms independent of CD8/HLA-I axis would overcome these limitations. Here, we report potent CD4 T cell-mediated ... ...

Abstract	Efficacy of immune checkpoint inhibitors in cancers can be limited by CD8 T cell dysfunction or HLA-I down-regulation. Tumor control mechanisms independent of CD8/HLA-I axis would overcome these limitations. Here, we report potent CD4 T cell-mediated tumor regression and memory responses in humanized immune system (HIS) mice implanted with HT-29 colorectal tumors. The regressing tumors showed increased CD4 cytotoxic T lymphocyte (CTL) infiltration and enhanced tumor HLA-II expression compared to progressing tumors. The intratumoral CD4 T cell subset associated with tumor regression expressed multiple cytotoxic markers and exhibited clonal expansion. Notably, tumor control was abrogated by depletion of CD4 but not CD8 T cells. CD4 T cells derived from tumor-regressing mice exhibited HLA-II-dependent and tumor-specific killing ex vivo. Taken together, our study demonstrates a critical role of human CD4 CTLs in mediating tumor clearance independent of CD8 T cells and provides a platform to study human anti-tumor immunity in vivo.
MeSH term(s)	Humans ; Mice ; Animals ; T-Lymphocytes, Cytotoxic ; CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; Neoplasms/metabolism
Language	English
Publishing date	2023-04-25
Publishing country	England
Document type	Journal Article
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-023-04812-3
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Article ; Online: Rapid TCR:Epitope Ranker (RAPTER): a primary human T cell reactivity screening assay pairing epitope and TCR at single cell resolution.

Scientific reports

2023 Volume 13, Issue 1, Page(s) 8452

Abstract: Identifying epitopes that T cells respond to is critical for understanding T cell-mediated immunity. Traditional multimer and other single cell assays often require large blood volumes and/or expensive HLA-specific reagents and provide limited phenotypic ...

Abstract	Identifying epitopes that T cells respond to is critical for understanding T cell-mediated immunity. Traditional multimer and other single cell assays often require large blood volumes and/or expensive HLA-specific reagents and provide limited phenotypic and functional information. Here, we present the Rapid TCR:Epitope Ranker (RAPTER) assay, a single cell RNA sequencing (scRNA-SEQ) method that uses primary human T cells and antigen presenting cells (APCs) to assess functional T cell reactivity. Using hash-tag oligonucleotide (HTO) coding and T cell activation-induced markers (AIM), RAPTER defines paired epitope specificity and TCR sequence and can include RNA- and protein-level T cell phenotype information. We demonstrate that RAPTER identified specific reactivities to viral and tumor antigens at sensitivities as low as 0.15% of total CD8
MeSH term(s)	Humans ; Epitopes, T-Lymphocyte ; CD8-Positive T-Lymphocytes ; Receptors, Antigen, T-Cell/genetics ; Cell Membrane
Chemical Substances	Epitopes, T-Lymphocyte ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2023-05-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-35710-7
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Article ; Online: Angiopoietin-2 blockade suppresses growth of liver metastases from pancreatic neuroendocrine tumors by promoting T cell recruitment.

Lee, Eunhyeong / O'Keefe, Sophie / Leong, Alessandra / Park, Ha-Ram / Varadarajan, Janani / Chowdhury, Subrata / Hiner, Shannon / Kim, Sungsoo / Shiva, Anahita / Friedman, Richard A / Remotti, Helen / Fojo, Tito / Yang, Hee Won / Thurston, Gavin / Kim, Minah

The Journal of clinical investigation

2023 Volume 133, Issue 20

Abstract: Improving the management of metastasis in pancreatic neuroendocrine tumors (PanNETs) is critical, as nearly half of patients with PanNETs present with liver metastases, and this accounts for the majority of patient mortality. We identified angiopoietin-2 ...

Abstract	Improving the management of metastasis in pancreatic neuroendocrine tumors (PanNETs) is critical, as nearly half of patients with PanNETs present with liver metastases, and this accounts for the majority of patient mortality. We identified angiopoietin-2 (ANGPT2) as one of the most upregulated angiogenic factors in RNA-Seq data from human PanNET liver metastases and found that higher ANGPT2 expression correlated with poor survival rates. Immunohistochemical staining revealed that ANGPT2 was localized to the endothelial cells of blood vessels in PanNET liver metastases. We observed an association between the upregulation of endothelial ANGPT2 and liver metastatic progression in both patients and transgenic mouse models of PanNETs. In human and mouse PanNET liver metastases, ANGPT2 upregulation coincided with poor T cell infiltration, indicative of an immunosuppressive tumor microenvironment. Notably, both pharmacologic inhibition and genetic deletion of ANGPT2 in PanNET mouse models slowed the growth of PanNET liver metastases. Furthermore, pharmacologic inhibition of ANGPT2 promoted T cell infiltration and activation in liver metastases, improving the survival of mice with metastatic PanNETs. These changes were accompanied by reduced plasma leakage and improved vascular integrity in metastases. Together, these findings suggest that ANGPT2 blockade may be an effective strategy for promoting T cell infiltration and immunostimulatory reprogramming to reduce the growth of liver metastases in PanNETs.
MeSH term(s)	Animals ; Humans ; Mice ; Angiopoietin-2/genetics ; Angiopoietin-2/metabolism ; Endothelial Cells/metabolism ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Mice, Transgenic ; Neuroendocrine Tumors/drug therapy ; Neuroendocrine Tumors/genetics ; Neuroendocrine Tumors/metabolism ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; T-Lymphocytes/pathology ; Tumor Microenvironment
Chemical Substances	Angiopoietin-2 ; Ang2 protein, mouse (EC 3.1.27.5) ; VPS51 protein, human
Language	English
Publishing date	2023-10-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI167994
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