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Article: Lesion-based indicators predict long-term outcomes of pheochromocytoma and paraganglioma- SIZEPASS.

Hanschell, Helena / Diaz-Cano, Salvador / Blanes, Alfredo / Talat, Nadia / Galatá, Gabriele / Aylwin, Simon / Schulte, Klaus Martin

Frontiers in endocrinology

2023 Volume 14, Page(s) 1235243

Abstract: Aim: We seek a simple and reliable tool to predict malignant behavior of pheochromocytoma and paraganglioma (PPGL).: Methods: This single-center prospective cohort study assessed size of primary PPGLs on preoperative cross-sectional imaging and ... ...

Abstract	Aim: We seek a simple and reliable tool to predict malignant behavior of pheochromocytoma and paraganglioma (PPGL). Methods: This single-center prospective cohort study assessed size of primary PPGLs on preoperative cross-sectional imaging and prospectively scored specimens using the Pheochromocytoma of the Adrenal Gland Scaled Score (PASS). Multiplication of PASS points with maximum lesion diameter (in mm) yielded the SIZEPASS criterion. Local recurrence, metastasis or death from disease were surrogates defining malignancy. Results: 76 consecutive PPGL patients, whereof 58 with pheochromocytoma and 51 female, were diagnosed at a mean age of 52.0 ± 15.2 years. 11 lesions (14.5%) exhibited malignant features at a median follow-up (FU) of 49 months (range 4-172 mo). Median FU of the remaining cohort was 139 months (range 120-226 mo). SIZEPASS classified malignancy with an area under the curve (AUC) of 0.97 (95%CI 0.93-1.01; p<0.0001). Across PPGL, SIZEPASS >1000 outperformed all known predictors of malignancy, with sensitivity 91%, specificity 94%, and accuracy 93%, and an odds ratio of 72 fold (95%CI 9-571; P<0.001). It retained an accuracy >90% in cohorts defined by location (adrenal, extra-adrenal) or mutation status. Conclusions: The SIZEPASS>1000 criterion is a lesion-based, clinically available, simple and effective tool to predict malignant behavior of PPGLs independently of age, sex, location or mutation status.
MeSH term(s)	Humans ; Female ; Adult ; Middle Aged ; Aged ; Pheochromocytoma ; Prospective Studies ; Paraganglioma ; Adrenal Gland Neoplasms ; Adrenal Glands
Language	English
Publishing date	2023-08-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1235243
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Article ; Online: The Role of the Pulmonologist in a Multidisciplinary Amyotrophic Lateral Sclerosis Unit. Challenge, Opportunity, and Privilege.

León Fábregas, Montserrat / Candela Blanes, Alfredo / Marín Royo, Margarita

Archivos de bronconeumologia

2018 Volume 55, Issue 3, Page(s) 120–121

Title translation	El papel del neumólogo en una unidad multidisciplinar de Esclerosis Lateral Amiotrófica. Reto, oportunidad y privilegio.
MeSH term(s)	Amyotrophic Lateral Sclerosis/therapy ; Hospital Units ; Humans ; Patient Care Team ; Physician's Role ; Pulmonary Medicine
Language	Spanish
Publishing date	2018-11-06
Document type	Editorial
ZDB-ID	733126-5
ISSN	1579-2129 ; 0300-2896
ISSN (online)	1579-2129
ISSN	0300-2896
DOI	10.1016/j.arbres.2018.09.008
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Article ; Online: Identifying Types of Dating Violence and Protective Factors among Adolescents in Spain: A Qualitative Analysis of Lights4Violence Materials.

Pérez-Marco, Alfredo / Soares, Panmela / Davó-Blanes, Mari Carmen / Vives-Cases, Carmen

International journal of environmental research and public health

2020 Volume 17, Issue 7

Abstract: Introduction: The Lights4Violence project was created to promote healthy relationships among adolescents using a school intervention in which participants developed video-capsules where they highlighted skills to resolve situations of dating violence. ... ...

Abstract	Introduction: The Lights4Violence project was created to promote healthy relationships among adolescents using a school intervention in which participants developed video-capsules where they highlighted skills to resolve situations of dating violence. This study aims to assess the results of the Lights4Violence training program by identifying different types of violence and positive development assets that Spanish adolescents use in their video-capsule scripts. Methods: A thematic analysis of the Lights4Violence video capsules was carried out. Open coding was used to identify violence patterns. A deductive analysis was used to identify student assets using the "Positive Youth Development Model". Findings: Adolescents describe different patterns of violence, such as psychological violence, sexist violence or verbal violence that is present on the scripts. However, they showed themselves capable of resolving these situations using language and personal empowerment skills as resources. Family, friends and community were identified in adolescents' scenarios as the most frequent assets to address situations of conflict. Conclusion: Adolescents can promote healthy relationships using protective factors against violence. Interventions that use this approach can potentially be useful in preventing violence.
MeSH term(s)	Adolescent ; Adolescent Behavior ; Humans ; Intimate Partner Violence ; Protective Factors ; Spain ; Violence
Language	English
Publishing date	2020-04-03
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph17072443
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Article ; Online: Identifying Types of Dating Violence and Protective Factors among Adolescents in Spain

Alfredo Pérez-Marco / Panmela Soares / Mari Carmen Davó-Blanes / Carmen Vives-Cases

International Journal of Environmental Research and Public Health, Vol 17, Iss 2443, p

A Qualitative Analysis of Lights4Violence Materials

2020 Volume 2443

Abstract	Introduction: The Lights4Violence project was created to promote healthy relationships among adolescents using a school intervention in which participants developed video-capsules where they highlighted skills to resolve situations of dating violence. This study aims to assess the results of the Lights4Violence training program by identifying different types of violence and positive development assets that Spanish adolescents use in their video-capsule scripts. Methods: A thematic analysis of the Lights4Violence video capsules was carried out. Open coding was used to identify violence patterns. A deductive analysis was used to identify student assets using the “Positive Youth Development Model”. Findings: Adolescents describe different patterns of violence, such as psychological violence, sexist violence or verbal violence that is present on the scripts. However, they showed themselves capable of resolving these situations using language and personal empowerment skills as resources. Family, friends and community were identified in adolescents’ scenarios as the most frequent assets to address situations of conflict. Conclusion: Adolescents can promote healthy relationships using protective factors against violence. Interventions that use this approach can potentially be useful in preventing violence.
Keywords	intimate partner violence ; adolescent ; qualitative analysis ; protective factors ; Medicine ; R
Subject code	360
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Role of

Amor-Salamanca, Almudena / Santana Rodríguez, Alfredo / Rasoul, Hazhee / Rodríguez-Palomares, José F / Moldovan, Oana / Hey, Thomas Morris / Delgado, María Gallego / Cuenca, David López / de Castro Campos, Daniel / Basurte-Elorz, María Teresa / Macías-Ruiz, Rosa / Fuentes Cañamero, María Eugenia / Galvin, Joseph / Bilbao Quesada, Raquel / de la Higuera Romero, Luis / Trujillo-Quintero, Juan Pablo / García-Cruz, Loida María / Cárdenas-Reyes, Ivonne / Jiménez-Jáimez, Juan /

García-Hernández, Soledad / Valverde-Gómez, María / Gómez-Díaz, Iria / Limeres Freire, Javier / García-Pinilla, José M / Gimeno-Blanes, Juan R / Savattis, Konstantinos / García-Pavía, Pablo / Ochoa, Juan Pablo

Circulation. Genomic and precision medicine

2024 Volume 17, Issue 2, Page(s) e004404

Abstract: Background: Less than 40% of patients with dilated cardiomyopathy (DCM) have a pathogenic/likely pathogenic genetic variant identified. : Methods: TBX20: Results: TBX20tv: Conclusions: ... ...

Abstract	Background: Less than 40% of patients with dilated cardiomyopathy (DCM) have a pathogenic/likely pathogenic genetic variant identified. Methods: TBX20 Results: TBX20tv Conclusions: TBX20tv
MeSH term(s)	Male ; Humans ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Female ; Cardiomyopathy, Dilated/pathology ; Heart Defects, Congenital/genetics ; Arrhythmias, Cardiac ; Phenotype ; T-Box Domain Proteins/genetics
Chemical Substances	TBX20 protein, human ; T-Box Domain Proteins
Language	English
Publishing date	2024-02-14
Publishing country	United States
Document type	Journal Article
ISSN	2574-8300
ISSN (online)	2574-8300
DOI	10.1161/CIRCGEN.123.004404
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Article ; Online: Aplicación de escalas pronósticas de gravedad en la neumonía por SARS-CoV-2.

Esteban Ronda, Violeta / Ruiz Alcaraz, Sandra / Ruiz Torregrosa, Paloma / Giménez Suau, Mario / Nofuentes Pérez, Ester / León Ramírez, José Manuel / Andrés, Mariano / Moreno-Pérez, Óscar / Candela Blanes, Alfredo / Gil Carbonell, Joan / Merino de Lucas, Esperanza

Medicina clinica

2021 Volume 157, Issue 3, Page(s) 99–105

Abstract: Objectives: Compare the accuracy of PSI, CURB-65, MuLBSTA and COVID-GRAM prognostic scores to predict mortality, the need for invasive mechanical ventilation in patients with pneumonia caused by SARS-CoV-2 and assess the coexistence of bacterial ... ...

Title translation	Application of validated severity scores for pneumonia caused by SARS-CoV-2.
Abstract	Objectives: Compare the accuracy of PSI, CURB-65, MuLBSTA and COVID-GRAM prognostic scores to predict mortality, the need for invasive mechanical ventilation in patients with pneumonia caused by SARS-CoV-2 and assess the coexistence of bacterial respiratory tract infection during admission. Methods: Retrospective observational study that included hospitalized adults with pneumonia caused by SARS-CoV-2 from 15/03 to 15/05/2020. We excluded immunocompromised patients, nursing home residents and those admitted in the previous 14 days for another reasons. Analysis of ROC curves was performed, calculating the area under the curve for the different scales, as well as sensitivity, specificity and predictive values. Results: A total of 208 patients were enrolled, aged 63±17 years, 57,7% were men; 38 patients were admitted to ICU (23,5%), of these patients 33 required invasive mechanical ventilation (86,8%), with an overall mortality of 12,5%. Area under the ROC curves for mortality of the scores were: PSI 0,82 (95% CI: 0,73-0,91), CURB-65 0,82 (0,73-0,91), MuLBSTA 0,72 (0,62-0,81) and COVID-GRAM 0,86 (0,70-1). Area under the curve for needing invasive mechanical ventilation was: PSI 0,73 (95% CI: 0,64-0,82), CURB-65 0,66 (0,55-0,77), MuLBSTA 0,78 (0,69-0,86) and COVID-GRAM 0,76 (0,67-0,85), respectively. Patients with bacterial co-infections of the respiratory tract were 20 (9,6%), the most frequent strains being Pseudomonas aeruginosa and Klebsiella pneumoniae. Conclusions: In our study, the COVID-GRAM score was the most accurate to identify patients with higher mortality with pneumonia caused by SARS-CoV-2; however, none of these scores accurately predicts the need for invasive mechanical ventilation with ICU admission. The 10% of patients admitted presented bacterial respiratory co-infection.
MeSH term(s)	Aged ; COVID-19/pathology ; Female ; Hospitalization ; Humans ; Male ; Middle Aged ; Pneumonia/pathology ; Respiration, Artificial ; Retrospective Studies ; Severity of Illness Index
Language	Spanish
Publishing date	2021-01-28
Publishing country	Spain
Document type	Journal Article ; Observational Study
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2021.01.002
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Article ; Online: Application of validated severity scores for pneumonia caused by SARS-CoV-2.

Medicina clinica (English ed.)

2021 Volume 157, Issue 3, Page(s) 99–105

Abstract: Objectives: Compare the accuracy of PSI, CURB-65, MuLBSTA and COVID-GRAM prognostic scores to predict mortality, the need for invasive mechanical ventilation (IMV) in patients with pneumonia caused by SARS-CoV-2 and assess the coexistence of bacterial ... ...

Abstract	Objectives: Compare the accuracy of PSI, CURB-65, MuLBSTA and COVID-GRAM prognostic scores to predict mortality, the need for invasive mechanical ventilation (IMV) in patients with pneumonia caused by SARS-CoV-2 and assess the coexistence of bacterial respiratory tract infection during admission. Methods: Retrospective observational study that included hospitalized adults with pneumonia caused by SARS-CoV-2 from 15/03 to 15/05/2020. We excluded immunocompromised patients, nursing home residents and those admitted in the previous 14 days for another reasons. Analysis of ROC curves was performed, calculating the area under the curve for the different scales, as well as sensitivity, specificity and predictive values. Results: 208 patients were enrolled, aged 63 ± 17 years, 577% were men. 38 patients were admitted to ICU (235%), of these patients 33 required IMV (868%), with an overall mortality of 125%. Area under the ROC curves for mortality of the scores were: PSI 082 (95% CI 073-091), CURB-65 082 (073-091), MuLBSTA 072 (062-081) and COVID-GRAM 086 (070-1). Area under the curve for needing IMV was: PSI 073 (95% CI 064-082), CURB-65 066 (055-077), MuLBSTA 078 (069-086) and COVID-GRAM 076 (067-085), respectively. Patients with bacterial co-infections of the respiratory tract were 20 (9,6%), the most frequent strains being Conclusions: In our study, the COVID-GRAM score was the most accurate to identify patients with higher mortality with pneumonia caused by SARS-CoV-2; however, none of these scores accurately predicts the need for IMV with ICU admission. 10% of patients admitted presented bacterial respiratory co-infection.
Language	English
Publishing date	2021-06-30
Publishing country	Spain
Document type	Journal Article
ISSN	2387-0206
ISSN (online)	2387-0206
DOI	10.1016/j.medcle.2021.01.011
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Article ; Online: Unraveling the genetics of transformed splenic marginal zone lymphoma.

Grau, Marta / López, Cristina / Navarro, Alba / Frigola, Gerard / Nadeu, Ferran / Clot, Guillem / Bastidas-Mora, Gabriela / Alcoceba, Miguel / Baptista, Maria Joao / Blanes, Margarita / Colomer, Dolors / Costa, Dolors / Domingo-Domènech, Eva / Enjuanes, Anna / Escoda, Lourdes / Forcada, Pilar / Giné, Eva / Lopez-Guerra, Mónica / Ramón, Olga /

Rivas-Delgado, Alfredo / Vicente Folch, Laura / Wotherspoon, Andrew / Climent, Fina / Campo, Elias / López-Guillermo, Armando / Matutes, Estella / Beà, Sílvia

Blood advances

2023 Volume 7, Issue 14, Page(s) 3695–3709

Abstract: The genetic mechanisms associated with splenic marginal zone lymphoma (SMZL) transformation are not well defined. We studied 41 patients with SMZL that eventually underwent large B-cell lymphoma transformation. Tumor material was obtained either only at ... ...

Abstract	The genetic mechanisms associated with splenic marginal zone lymphoma (SMZL) transformation are not well defined. We studied 41 patients with SMZL that eventually underwent large B-cell lymphoma transformation. Tumor material was obtained either only at diagnosis (9 patients), at diagnosis and transformation (18 patients), and only at transformation (14 patients). Samples were categorized in 2 groups: (1) at diagnosis (SMZL, n = 27 samples), and (2) at transformation (SMZL-T, n = 32 samples). Using copy number arrays and a next-generation sequencing custom panel, we identified that the main genomic alterations in SMZL-T involved TNFAIP3, KMT2D, TP53, ARID1A, KLF2, 1q gains, and losses of 9p21.3 (CDKN2A/B) and 7q31-q32. Compared with SMZL, SMZL-T had higher genomic complexity, and higher incidence of TNFAIP3 and TP53 alterations, 9p21.3 (CDKN2A/B) losses, and 6p gains. SMZL and SMZL-T clones arose by divergent evolution from a common altered precursor cell that acquired different genetic alterations in virtually all evaluable cases (92%, 12 of 13 cases). Using whole-genome sequencing of diagnostic and transformation samples in 1 patient, we observed that the SMZL-T sample carried more genomic aberrations than the diagnostic sample, identified a translocation t(14;19)(q32;q13) present in both samples, and detected a focal B2M deletion due to chromothripsis acquired at transformation. Survival analysis showed that KLF2 mutations, complex karyotype, and International Prognostic Index score at transformation were predictive of a shorter survival from transformation (P = .001; P = .042; and P = .007; respectively). In summary, SMZL-T are characterized by higher genomic complexity than SMZL, and characteristic genomic alterations that could represent key players in the transformation event.
MeSH term(s)	Humans ; Splenic Neoplasms/genetics ; Splenic Neoplasms/diagnosis ; Splenic Neoplasms/pathology ; Mutation ; Translocation, Genetic ; Lymphoma, Large B-Cell, Diffuse/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics
Language	English
Publishing date	2023-07-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2022009415
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Article ; Online: Clinico-biological features and outcome of patients with splenic marginal zone lymphoma with histological transformation.

Bastidas-Mora, Gabriela / Beà, Sílvia / Navarro, Alba / Gine, Eva / Costa, Dolors / Delgado, Julio / Baumann, Tycho / Magnano, Laura / Rivas-Delgado, Alfredo / Villamor, Neus / Colomer, Dolors / Lopez-Guerra, Mónica / Rozman, María / Balagué, Olga / Martínez, Daniel / Baptista, Maria Joao / Escoda, Lourdes / Alcoceba, Miguel / Blanes, Margarita /

Climent, Fina / Campo, Elías / Wotherspoon, Andrew / López-Guillermo, Armando / Matutes, Estella

British journal of haematology

2021 Volume 196, Issue 1, Page(s) 146–155

Abstract: We describe 36 patients with splenic marginal zone lymphoma (SMZL) with transformation (SMZL-T), including 15 from a series of 84 patients with SMZL diagnosed at the Hospital Clinic of Barcelona (HCB) and 21 diagnosed with SMZL-T in other centres. In the ...

Abstract	We describe 36 patients with splenic marginal zone lymphoma (SMZL) with transformation (SMZL-T), including 15 from a series of 84 patients with SMZL diagnosed at the Hospital Clinic of Barcelona (HCB) and 21 diagnosed with SMZL-T in other centres. In the HCB cohort, the cumulative incidence of transformation at 5 years was 15%. Predictors for transformation were cytopenias, hypoalbuminaemia, complex karyotype (CK) and both the Intergruppo Italiano Linfomi (ILL) and simplified Haemoglobin, Platelet count, lactate dehydrogenase (LDH) and extrahilar Lymphadenopathy (HPLL)/ABC scores (P < 0·05). The only independent predictor for transformation in multivariate analysis was CK [hazard ratio (HR) 4·025, P = 0·05]. Patients with SMZL-T had a significantly higher risk of death than the remainder (HR 3·89, P < 0·001). Of the 36 patients with SMZL-T, one developed Hodgkin lymphoma and 35 a diffuse large B-cell lymphoma, 71% with a non-germinal centre phenotype. The main features were B symptoms, lymphadenopathy, and high serum LDH. CK was observed in 12/22 (55%) SMZL-T and fluorescence in situ hybridisation detected abnormalities of MYC proto-oncogene, basic helix-loop-helix transcription factor (MYC), B-cell leukaemia/lymphoma 2 (BCL2) and/or BCL6 in six of 14 (43%). In all, 21 patients received immunochemotherapy, six chemotherapy, one radiotherapy and three splenectomy. The complete response (CR) rate was 61% and the median survival from transformation was 4·92 years. Predictors for a worse survival in multivariate analysis were high-risk International Prognostic Index (HR 5·294, P = 0·016) and lack of CR (HR 2·67, P < 0·001).
MeSH term(s)	Adult ; Aged ; Biomarkers, Tumor ; Cell Transformation, Neoplastic ; Cytogenetic Analysis ; Disease Management ; Disease Susceptibility ; Female ; Humans ; Immunohistochemistry ; Immunophenotyping ; In Situ Hybridization, Fluorescence ; Incidence ; Lymphoma, B-Cell, Marginal Zone/diagnosis ; Lymphoma, B-Cell, Marginal Zone/epidemiology ; Lymphoma, B-Cell, Marginal Zone/etiology ; Lymphoma, B-Cell, Marginal Zone/metabolism ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Prognosis ; Spleen/pathology ; Splenic Neoplasms/diagnosis ; Splenic Neoplasms/epidemiology ; Splenic Neoplasms/etiology ; Splenic Neoplasms/metabolism
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2021-09-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.17815
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Article: Histologic criteria for adrenocortical proliferative lesions: value of mitotic figure variability.

Blanes, Alfredo / Diaz-Cano, Salvador J

American journal of clinical pathology

2007 Volume 127, Issue 3, Page(s) 398–408

Abstract: This study compared 3 systems and a newly designed stepwise discriminant diagnostic system (SDDS) to assess accuracy, reproducibility, and reliability in adrenocortical nodular hyperplasia (ACNH; n = 82), adenoma (ACA; n = 78), and carcinoma (ACC; n = 32) ...

Abstract	This study compared 3 systems and a newly designed stepwise discriminant diagnostic system (SDDS) to assess accuracy, reproducibility, and reliability in adrenocortical nodular hyperplasia (ACNH; n = 82), adenoma (ACA; n = 78), and carcinoma (ACC; n = 32) (diagnoses according to World Health Organization criteria; median follow-up, 135 months). In cross-validations, we studied cortex appearance, growth pattern, cytoplasmic features, nuclear parameters, mitotic figure counting (MFC), necrosis, invasion, and stromal-inflammatory reactions. The SDDS independent predictors were MFC/high-power field SD, anisokaryosis, cortex appearance, and stromal reaction, correctly classifying 100% of ACNH, 91% of ACA, and 88% of ACC cases. The Hough system correctly classified 78% of ACNH, 81% of ACA, and 84% of ACC cases; the Weiss and van Slooten systems correctly classified 100% of ACNH, 0% of ACA, and 92% of ACC cases. MFC variability is the most important adrenocortical malignancy criterion. Accurate malignancy diagnosis requires multiple variable evaluations, provided by SDDS (the most specific system) and the Weiss or van Slooten system (the most sensitive). SDDS is the most useful system for distinguishing tumors from ACNH (myxoid stroma and anisokaryosis).
MeSH term(s)	Adrenal Cortex/pathology ; Adrenal Cortex Neoplasms/pathology ; Adrenocortical Adenoma/pathology ; Adrenocortical Carcinoma/pathology ; Adult ; Aged ; Algorithms ; Diagnosis, Differential ; Disease-Free Survival ; Female ; Humans ; Hyperplasia ; Male ; Middle Aged ; Mitosis ; Necrosis ; Neoplasm Staging ; Prognosis ; Reproducibility of Results
Language	English
Publishing date	2007-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2944-0
ISSN	1943-7722 ; 0002-9173
ISSN (online)	1943-7722
ISSN	0002-9173
DOI	10.1309/MCGUQ3R4A4WWN3LB
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