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  1. Book: Ying cang fa cang dun huang yi shu yan jiu an hao suo yin

    Shen, Guomei / Li, Defan

    (Guo jia tu shu guan dun huang yan jiu zi liao cong kan ; 國家圖書館敦煌研究資料叢刊)

    2009  

    Author's details Shen guo mei, li de fan bian
    Series title Guo jia tu shu guan dun huang yan jiu zi liao cong kan
    國家圖書館敦煌研究資料叢刊
    Language Chinese
    Size S. 1077-2166
    Edition Di 1 ban
    Publisher Guo jia tu shu guan chu ban she
    Publishing place Bei jing
    Document type Book
    ISBN 9787501335770 ; 750133577X
    Database Former special subject collection: coastal and deep sea fishing

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  2. Book: Ying cang fa cang dun huang yi shu yan jiu an hao suo yin

    Shen, Guomei / Li, Defan

    (Guo jia tu shu guan dun huang yan jiu zi liao cong kan ; 國家圖書館敦煌研究資料叢刊)

    2009  

    Author's details Shen guo mei, li de fan bian
    Series title Guo jia tu shu guan dun huang yan jiu zi liao cong kan
    國家圖書館敦煌研究資料叢刊
    Language Chinese
    Size 1, 2, 1, 1076 S
    Edition Di 1 ban
    Publisher Guo jia tu shu guan chu ban she
    Publishing place Bei jing
    Document type Book
    ISBN 9787501335770 ; 750133577X
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Book: Ying cang fa cang dun huang yi shu yan jiu an hao suo yin

    Shen, Guomei / Li, Defan

    (Guo jia tu shu guan dun huang yan jiu zi liao cong kan ; 國家圖書館敦煌研究資料叢刊)

    2009  

    Author's details Shen guo mei, li de fan bian
    Series title Guo jia tu shu guan dun huang yan jiu zi liao cong kan
    國家圖書館敦煌研究資料叢刊
    Language Chinese
    Edition Di 1 ban
    Publisher Guo jia tu shu guan chu ban she
    Publishing place Bei jing
    Document type Book
    ISBN 9787501335770 ; 750133577X
    Database Former special subject collection: coastal and deep sea fishing

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    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Book: Ying cang fa cang dun huang yi shu yan jiu an hao suo yin

    Shen, Guomei / Li, Defan

    (Guo jia tu shu guan dun huang yan jiu zi liao cong kan ; 國家圖書館敦煌研究資料叢刊)

    2009  

    Author's details Shen guo mei, li de fan bian
    Series title Guo jia tu shu guan dun huang yan jiu zi liao cong kan
    國家圖書館敦煌研究資料叢刊
    Language Chinese
    Size S. 2167-3249
    Edition Di 1 ban
    Publisher Guo jia tu shu guan chu ban she
    Publishing place Bei jing
    Document type Book
    ISBN 9787501335770 ; 750133577X
    Database Former special subject collection: coastal and deep sea fishing

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  5. Article ; Online: Complementary and alternative medicine for treatment of irritable bowel syndrome.

    Shen, Yi-Hao A / Nahas, Richard

    Canadian family physician Medecin de famille canadien

    2009  Volume 55, Issue 2, Page(s) 143–148

    Abstract: Objective: To review the evidence supporting selected complementary and alternative medicine approaches used in the treatment of irritable bowel syndrome (IBS).: Quality of evidence: MEDLINE (from January 1966), EMBASE (from January 1980), and the ... ...

    Abstract Objective: To review the evidence supporting selected complementary and alternative medicine approaches used in the treatment of irritable bowel syndrome (IBS).
    Quality of evidence: MEDLINE (from January 1966), EMBASE (from January 1980), and the Cochrane Database of Systematic Reviews were searched until March 2008, combining the terms irritable bowel syndrome or irritable colon with complementary therapies, alternative medicine, acupuncture, fiber, peppermint oil, herbal, traditional, yoga, massage, meditation, mind, relaxation, probiotic, hypnotherapy, psychotherapy, cognitive therapy, or behavior therapy. Results were screened to include only clinical trials, systematic reviews, and meta-analyses. Level I evidence was available for most interventions.
    Main message: Soluble fibre improves constipation and global IBS symptoms. Peppermint oil alleviates IBS symptoms, including abdominal pain. Probiotic trials show overall benefit for IBS but there is little evidence supporting the use of any specific strain. Hypnotherapy and cognitive-behavioural therapy are also effective therapeutic options for appropriate patients. Certain herbal formulas are supported by limited evidence, but safety is a potential concern. All interventions are supported by systematic reviews or meta-analyses.
    Conclusion: Several complementary and alternative therapies can be recommended as part of an evidence-based approach to the treatment of IBS; these might provide patients with satisfactory relief and improve the therapeutic alliance.
    MeSH term(s) Complementary Therapies/methods ; Complementary Therapies/statistics & numerical data ; Dietary Supplements ; Drugs, Chinese Herbal/therapeutic use ; Female ; Follow-Up Studies ; Humans ; Hypnosis/methods ; Irritable Bowel Syndrome/diagnosis ; Irritable Bowel Syndrome/therapy ; Male ; Ontario ; Patient Satisfaction ; Phytotherapy/methods ; Probiotics/therapeutic use ; Quality of Life ; Randomized Controlled Trials as Topic ; Risk Assessment ; Sensitivity and Specificity ; Sickness Impact Profile ; Treatment Outcome
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2009-02-18
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 603565-6
    ISSN 1715-5258 ; 0008-350X
    ISSN (online) 1715-5258
    ISSN 0008-350X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2236: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 5: Show issues

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  6. Article ; Online: The association between circulating fatty acids and stroke in hypertensive patients.

    Peng, Hao / Cai, Xiao-Qin / Zhen, Juanying / Shen, Jiangshan Jane / Shen, Heng-Shan / Wu, Xin-Han / Zhou, Yi-Bin / Ren, Lijie / Wu, Jun / Xu, Aimin / Tsang, Tim K / Cheung, Bernard Man Yung / Li, Chao

    The American journal of the medical sciences

    2024  

    Abstract: Background: Stroke is prevalent in hypertensive population. It has been suggested that unsaturated fatty acids (USFA) have protective effect on stroke. The effect of saturated fatty acids (SFAs) on stroke is still unclear. Therefore, we studied the ... ...

    Abstract Background: Stroke is prevalent in hypertensive population. It has been suggested that unsaturated fatty acids (USFA) have protective effect on stroke. The effect of saturated fatty acids (SFAs) on stroke is still unclear. Therefore, we studied the relationship between circulating fatty acids and acute ischemic stroke (AIS) in hypertensive patients.
    Methods: Eighty-nine pairs including 100 men and 78 women matched by sex and age were recruited. Each pair included a hypertensive patient within 48h of AIS onset and a hypertensive patient without stroke. Six circulating fatty acids were methylated before concentration determination which was repeated twice with percent recovery estimated.
    Results: There were differences in educational level (P = 0.002) and occupation (P < 0.001) between stroke and non-stroke participants. All the 6 fatty acid levels were higher in non-stroke participants (P = 0.017 for palmitoleic acid, 0.001 for palmitic acid, <0.001 for linoleic acid, <0.001 for behenic acid, <0.001 for nervonic acid and 0.002 for lignoceric acid). In logistic regression analysis, AIS was inversely associated with fatty acid levels except for lignoceric acid. After adjustment for education and occupation, the palmitoleic acid and palmitic acid levels were no longer inversely associated with AIS. After further adjustment for systolic blood pressure, smoking, drinking, total cholesterol and triglyceride, the inverse associations of linoleic acid (OR = 0.965, 95%CI = 0.942-0.990, P = 0.005), behenic acid (OR = 0.778, 95%CI = 0.664-0.939, P = 0.009), nervonic acid (OR = 0.323, 95%CI = 0.121-0.860, P = 0.024) with AIS remained significant.
    Conclusions: Circulating fatty acids except lignoceric acid were inversely associated with AIS. Both USFAs and SFAs may have beneficial effect on stroke prevention in hypertensive population.
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2024.02.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.2/10: Show issues Location:
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  7. Article ; Online: Excessive processing and acetylation of OPA1 aggravate age-related hearing loss via the dysregulation of mitochondrial dynamics.

    Zhang, Andi / Pan, Yi / Wang, Hao / Ding, Rui / Zou, Tianyuan / Guo, Dongye / Shen, Yilin / Ji, Peilin / Huang, Weiyi / Wen, Qing / Wang, Quan / Hu, Haixia / Wu, Jichang / Xiang, Mingliang / Ye, Bin

    Aging cell

    2024  Volume 23, Issue 4, Page(s) e14091

    Abstract: The pathogenesis of age-related hearing loss (ARHL) remains unclear. OPA1 is the sole fusion protein currently known to be situated in the inner mitochondrial membrane, which is pivotal for maintaining normal mitochondrial function. While it has already ... ...

    Abstract The pathogenesis of age-related hearing loss (ARHL) remains unclear. OPA1 is the sole fusion protein currently known to be situated in the inner mitochondrial membrane, which is pivotal for maintaining normal mitochondrial function. While it has already been demonstrated that mutations in OPA1 may lead to hereditary deafness, its involvement in the occurrence and development of ARHL has not been previously explored. In our study, we constructed D-gal-induced senescent HEI-OC1 cells and the cochlea of C57BL/6J mice with a mutated SUMOylation site of SIRT3 using CRISPR/Cas9 technology. We found enhanced L-OPA1 processing mediated by activated OMA1, and increased OPA1 acetylation resulting from reductions in SIRT3 levels in senescent HEI-OC1 cells. Consequently, the fusion function of OPA1 was inhibited, leading to mitochondrial fission and pyroptosis in hair cells, ultimately exacerbating the aging process of hair cells. Our results suggest that the dysregulation of mitochondrial dynamics in cochlear hair cells in aged mice can be ameliorated by activating the SIRT3/OPA1 signaling. This has the potential to alleviate the senescence of cochlear hair cells and reduce hearing loss in mice. Our study highlights the significant roles played by the quantities of long and short chains and the acetylation activity of OPA1 in the occurrence and development of ARHL. This finding offers new perspectives and potential targets for the prevention and treatment of ARHL.
    MeSH term(s) Mice ; Animals ; GTP Phosphohydrolases/genetics ; GTP Phosphohydrolases/metabolism ; Mitochondrial Dynamics/genetics ; Sirtuin 3/genetics ; Sirtuin 3/metabolism ; Acetylation ; Mice, Inbred C57BL ; Presbycusis
    Chemical Substances GTP Phosphohydrolases (EC 3.6.1.-) ; Sirtuin 3 (EC 3.5.1.-)
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.14091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6581: Show issues Location:
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  8. Article ; Online: Synergistic Structure and Iron-Vacancy Engineering Realizing High Initial Coulombic Efficiency and Kinetically Accelerated Lithium Storage in Lithium Iron Oxide.

    Wu, Naiteng / Shen, Jinke / Yong, Kai / Chen, Chengqian / Li, Jian / Xie, Yi / Guo, Donglei / Liu, Guilong / Li, Jin / Cao, Ang / Liu, Xianming / Mi, Hongyu / Wu, Hao

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2023  Volume 10, Issue 9, Page(s) e2206574

    Abstract: Transition metal oxides with high capacity still confront the challenges of low initial coulombic efficiency (ICE, generally <70%) and inferior cyclic stability for practical lithium-storage. Herein, a hollow slender carambola-like ... ...

    Abstract Transition metal oxides with high capacity still confront the challenges of low initial coulombic efficiency (ICE, generally <70%) and inferior cyclic stability for practical lithium-storage. Herein, a hollow slender carambola-like Li
    Language English
    Publishing date 2023-01-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202206574
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Neutralizing antibodies from the rare convalescent donors elicited antibody-dependent enhancement of SARS-CoV-2 variants infection.

    Mu, Song / Song, Shuyi / Hao, Yanan / Luo, Feiyang / Wu, Ruixin / Wang, Yi / Han, Xiaojian / Li, Tingting / Hu, Chao / Li, Shenglong / Shen, Meiying / Huang, Jingjing / Wang, Wang / Wang, Yingming / Jin, Aishun

    Frontiers in medicine

    2022  Volume 9, Page(s) 952697

    Abstract: Currently, neutralizing antibody and vaccine strategies have been developed by targeting the SARS-CoV-2 strain identified during the early phase of the pandemic. Early studies showed that the ability of SARS-CoV-2 RBD or NTD antibodies to elicit ... ...

    Abstract Currently, neutralizing antibody and vaccine strategies have been developed by targeting the SARS-CoV-2 strain identified during the early phase of the pandemic. Early studies showed that the ability of SARS-CoV-2 RBD or NTD antibodies to elicit infection enhancement
    Language English
    Publishing date 2022-10-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.952697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Developmental Population Pharmacokinetics-Pharmacodynamics of Meropenem in Chinese Neonates and Young Infants: Dosing Recommendations for Late-Onset Sepsis.

    Wu, Yue-E / Kou, Chen / Li, Xue / Tang, Bo-Hao / Yao, Bu-Fan / Hao, Guo-Xiang / Zheng, Yi / van den Anker, John / You, Dian-Ping / Shen, A-Dong / Zhao, Wei

    Children (Basel, Switzerland)

    2022  Volume 9, Issue 12

    Abstract: The pharmacokinetic (PK) studies of meropenem in Chinese newborns with late-onset sepsis (LOS) are still lacking. Causative pathogens of LOS and their susceptibility patterns in China differ from the data abroad. We, therefore, conducted a developmental ... ...

    Abstract The pharmacokinetic (PK) studies of meropenem in Chinese newborns with late-onset sepsis (LOS) are still lacking. Causative pathogens of LOS and their susceptibility patterns in China differ from the data abroad. We, therefore, conducted a developmental population pharmacokinetic−pharmacodynamic analysis in Chinese newborns with the goal to optimize meropenem dosing regimens for LOS therapy. An opportunistic sampling strategy was used to collect meropenem samples, followed by model building and validation. A Monte Carlo simulation was performed to show the probability of target attainment (PTA) for various dosages. The information from 78 newborns (postmenstrual age: 27.4−46.1 weeks) was compiled and had a good fit to a 1-compartment model that had first order elimination. The median (range) values of estimated weight−normalized volume of distribution (V)and clearance (CL) were 0.60 (0.51−0.69) L/kg and 0.16 (0.04−0.51) L/h/kg, respectively. Covariate analysis revealed that postnatal age (PNA), gestational age (GA) and current weight (CW) were the most important factors in describing meropenem PK. Simulation results showed for LOS with a minimal inhibitory concentration (MIC) of 8 mg/L, the doses of 30 mg/kg 3 times daily (TID) as a 1-h infusion for newborns with GA ≤ 37 weeks and 40 mg/kg TID as a 3-h infusion for those with GA > 37 weeks were optimal, with PTA of 71.71% and 75.08%, respectively. In conclusion, we proposed an evidence-based dosing regimen of meropenem for LOS in Chinese newborns by using the population pharmacokinetic−pharmacodynamic analysis, based on domestic common pathogens and their susceptibility patterns.
    Language English
    Publishing date 2022-12-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children9121998
    Database MEDical Literature Analysis and Retrieval System OnLINE

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