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Article ; Online: Spontaneous Rupture of a Neglected Huge Hydrocephalus.

Gothwal, Sunil / Meena, Kuldeep / Meena, Kailash Kumar

2021 Volume 88, Issue 11, Page(s) 1145–1146

MeSH term(s)	Humans ; Hydrocephalus/diagnostic imaging ; Rupture, Spontaneous
Language	English
Publishing date	2021-01-06
Publishing country	India
Document type	Journal Article
ZDB-ID	218231-2
ISSN	0973-7693 ; 0019-5456
ISSN (online)	0973-7693
ISSN	0019-5456
DOI	10.1007/s12098-020-03648-7
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Article ; Online: To estimate prevalence of pulmonary arterial hypertension in HIV patients and its association with CD4 cell count

Garima Mahajan / H.C. Barjatya / B.L. Bhakar / Sunil Kumar Gothwal / Trivendra Jangir

Clinical Epidemiology and Global Health, Vol 25, Iss , Pp 101479- (2024)

1481

Abstract: Introduction: HIV infection is considered as one of the leading infectious cause of pulmonary arterial hypertension (PAH) and it exhibits higher rate of development of this condition than general population. The prevalence of HIV associated PAH has not ... ...

Abstract	Introduction: HIV infection is considered as one of the leading infectious cause of pulmonary arterial hypertension (PAH) and it exhibits higher rate of development of this condition than general population. The prevalence of HIV associated PAH has not been established accurately and varies based on factors such as geographical distribution, gender, duration of HIV and ART etc. This study aims to estimate the prevalence of PAH in HIV infected patients who are on first line ART and to study the association of PAH with CD4 count and viral load. Methods: This cross-sectional study was conducted on 150 HIV positive patients who visited medical OPD and ART centre, JLN medical college and hospital, Ajmer and were above 18 years of age and were on first line ART. PAH was identified through transthoracic doppler echocardiographic screening and systolic pulmonary artery pressure (sPAP) estimation of more than 35 mmHg was used to diagnose PAH. Result: In this study, out of 150 patients, PAH was diagnosed in 12 patients and hence the prevalence of PAH came out to be 8 % (95 % CI: 3.65; 12.34). Significant association of PAH has been observed with viral load (p value = 0.04). While no significant association has been found between PAH and CD4 count. Conclusion: PAH in HIV patients was found to be 8% which is considerably higher than the already established global prevalence. Hence, PAH should be an important consideration for clinicians in differential diagnosis of dyspnea in HIV patients.
Keywords	PAH ; HIV ; CD4 ; sPAP ; Public aspects of medicine ; RA1-1270
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Congenital Self Healing Langerhans Cell Histiocytosis.

Gothwal, Sunil / Gupta, Anand Kumar / Choudhary, Ramesh

Indian journal of pediatrics

2017 Volume 85, Issue 4, Page(s) 316–317

MeSH term(s)	Histiocytosis, Langerhans-Cell/congenital ; Humans ; Remission, Spontaneous
Language	English
Publishing date	2017-09-19
Publishing country	India
Document type	Letter
ZDB-ID	218231-2
ISSN	0973-7693 ; 0019-5456
ISSN (online)	0973-7693
ISSN	0019-5456
DOI	10.1007/s12098-017-2469-z
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Article ; Online: Effect of antiretroviral therapy on lipid profile in newly diagnosed HIV-infected children of immune stage III and IV

Neelam Singh / Vijendra Kumar Garg / Rohitash Meena / Rambabu Sharma / Sunil Gothwal

CHRISMED Journal of Health and Research, Vol 9, Iss 3, Pp 159-

2022 Volume 163

Abstract: Background: There are increasing concerns about the adverse effects of highly active antiretroviral therapy (HAART) on lipid profiles. Limited studies reported the adverse effects of HAART on lipid profiles from the Indian subcontinent. Methods: This ... ...

Abstract	Background: There are increasing concerns about the adverse effects of highly active antiretroviral therapy (HAART) on lipid profiles. Limited studies reported the adverse effects of HAART on lipid profiles from the Indian subcontinent. Methods: This observational study was conducted at a tertiary care hospital in North Western India. The objective of the study was to find out the adverse effects on lipid profiles after HAART initiation in newly diagnosed HIV-infected children of immune stage III and IV in the 18 months to 16 year age group. These 43 children were evaluated every 3 months for lipid profile for 1 year. Results: There was a nonsignificant increase in total lipid and phospholipid levels and a statistically significant increase in triglycerides (TGs), cholesterol, low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) levels after initiation of HAART therapy and a statistically significant decline in high-density lipoprotein (HDL) level after initiation of HAART therapy in immune phase III. The mean level of total lipid profile, phospholipids, cholesterol, HDL, LDL, VLDL, and TGs before starting of treatment was 474 mg/dl, 147 mg/dl, 126.8 mg/dl, 44.7 mg/dl, 94.3 mg/dl, 22.9 mg/dl, and110 mg/dl in immune stage IV, respectively. After starting treatment, the mean level of total lipid profile, phospholipids, cholesterol, HDL, LDL, VLDL, and TGs was 495.7 mg/dl, 164 mg/dl, 146.5 mg/dl, 38.9 mg/dl, 108.5 mg/dl, 28.9 mg/dl, and 127.3 mg/dl in immune stage IV, respectively. There was a statistically significant increase in total lipid, TG, phospholipid, cholesterol, LDL, and VLDL levels. There was a statistically significant decline in HDL level after initiation of HAART therapy in immune stage IV. Conclusions: We concluded that there was a significant alteration in lipid profile in HIV-infected children of immune stage III and IV with HAART.
Keywords	highly active antiretroviral therapy ; hiv infection ; lipid profile ; Medicine ; R ; Nursing ; RT1-120
Subject code	616
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
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Article ; Online: Increased concentration of serum gamma-glutamyl transferase in ischemic stroke patients.

Kalirawna, Teja Ram / Rohilla, Jitendra / Bairwa, Shyam Sunder / Gothwal, Sunil Kumar / Tak, Pinki / Jain, Rajesh

Brain circulation

2021 Volume 7, Issue 2, Page(s) 71–76

Abstract: Background: Stroke is responsible for the largest proportion of neurological disorders causing a significant morbidity. Gamma-glutamyl transferase (GGT) enzyme has an active involvement in atherosclerosis through its role in oxidative and inflammatory ... ...

Abstract	Background: Stroke is responsible for the largest proportion of neurological disorders causing a significant morbidity. Gamma-glutamyl transferase (GGT) enzyme has an active involvement in atherosclerosis through its role in oxidative and inflammatory mechanisms. Recent evidence suggests that serum GGT is related to the risk and prognosis of cerebrovascular diseases. Methods: A total of 200 patients (100 with acute ischemic stroke and 100 without stroke) were recruited from various medical wards and medical intensive care unit. Categorical variables were compared between two groups using Chi-squared test and odds ratio (OR). Independent sample Results: There was no statistical difference with respect to distribution of age groups ( Conclusions: Serum GGT was significantly higher in stroke patients than age-sex-matched nonstroke patients. Association remained significant in stroke patients irrespective of age, gender, and other risk factors. Stroke patients with diabetes, hypertension, dyslipidemia, obesity, and smoking had higher level serum GGT level than those without these risk factors. Prospective cohort studies can further explore the potential of GGT as a predictor of acute ischemic stroke.
Language	English
Publishing date	2021-05-29
Publishing country	India
Document type	Journal Article
ZDB-ID	2950273-1
ISSN	2455-4626 ; 2394-8108
ISSN (online)	2455-4626
ISSN	2394-8108
DOI	10.4103/bc.bc_47_20
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Article ; Online: Umbilical Cord Blood Culture in Diagnosis of Early Onset Neonatal Sepsis.

Meena, Ramraj / Meena, Kailash Kumar / Athwani, Vivek / Gothwal, Sunil / Bairwa, Ghan Shyam / Sitaraman, Sadasivam

Indian journal of pediatrics

2020 Volume 87, Issue 10, Page(s) 793–797

Abstract: Objective: To evaluate the use of umbilical cord blood culture (UCBC) as compared to neonatal blood culture (NBC) in the diagnosis of early onset neonatal sepsis (EONS).: Methods: This hospital based prospective observational study was conducted in ... ...

Abstract	Objective: To evaluate the use of umbilical cord blood culture (UCBC) as compared to neonatal blood culture (NBC) in the diagnosis of early onset neonatal sepsis (EONS). Methods: This hospital based prospective observational study was conducted in the Department of Pediatrics and Department of Obstetrics & Gynaecology at a tertiary care centre of North India from 2017 through 2018. A total of 80 newborns with presence of two or more risk factors for sepsis were included in the study. Blood culture samples were collected from the umbilical cord at delivery and from the neonate within 1 h of birth. Results: UCBC was positive in 17 (21.2%) neonates and NBC was positive in 15 (18.7%) neonates. Out of these positive cases, 10 (45.4%) neonates had similar bacteriological profile in both UCBC and NBC which included Burkholderia cepacia, Acinetobacter species, Enterobacter cloacae and Coagulase-negative Staphylococcus. UCBC had a sensitivity of 66.7%, a specificity of 89.2%, a positive predictive value 58.8% and a negative predictive value 92.1% for the diagnosis of EONS in high risk neonates, considering NBC as the gold standard test. Conclusions: UCBC is a reliable alternative to NBC for early etiological diagnosis of EONS in high risk neonates. Additional blood sampling from the newborn is suggested if there is any clinical sign of sepsis.
MeSH term(s)	Blood Culture ; Child ; Female ; Fetal Blood ; Humans ; India ; Infant, Newborn ; Neonatal Sepsis/diagnosis ; Pregnancy ; Sepsis/diagnosis
Language	English
Publishing date	2020-05-29
Publishing country	India
Document type	Journal Article ; Observational Study
ZDB-ID	218231-2
ISSN	0973-7693 ; 0019-5456
ISSN (online)	0973-7693
ISSN	0019-5456
DOI	10.1007/s12098-020-03345-5
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Article ; Online: Efficacy of transcutaneous bilirubinometry as compared to serum bilirubin in preterm newborn during phototherapy.

Gothwal, Sunil / Singh, Neelam / Sitaraman, Sadasivam / Choudhary, Ramesh / Meena, Kailash Kumar / Bairwa, Ghan Shyam / Bairwa, Mohan / Jeevan, Amrit

European journal of pediatrics

2021 Volume 180, Issue 8, Page(s) 2629–2636

Abstract: Transcutaneous measurement of bilirubin is being used for neonatal jaundice. Its utility during phototherapy in preterm babies is not established. The objective of our study was to assess the efficacy of transcutaneous bilirubin (TcB) measurement in ... ...

Abstract	Transcutaneous measurement of bilirubin is being used for neonatal jaundice. Its utility during phototherapy in preterm babies is not established. The objective of our study was to assess the efficacy of transcutaneous bilirubin (TcB) measurement in comparison to total serum bilirubin in preterm newborns at admission and during phototherapy at the covered skin area (glabella). It was a prospective observational study and conducted at the neonatal intensive care unit of a tertiary care hospital from January 2017 to January 2019. One hundred eligible preterm neonates were enrolled. Babies who were very sick, with poor peripheral circulation, edematous, having conjugated hyperbilirubinemia, with major congenital malformations, already received phototherapy or exchange transfusion were excluded. Paired total serum bilirubin and transcutaneous bilirubin were measured at admission and 6 h and 24 h during phototherapy. TcB was measured from the area (glabella) covered by an eye protector during phototherapy. The sample for TsB was taken within 10 min of TcB measurement. The mean differences between TsB and TcB values at admission and 6 h and 24 h of phototherapy were - 0.005 (0.353) mg/dl, - 0.350 (0.611) mg/dl, and - 0.592 (0.353) mg/dl, respectively. At admission or before starting of phototherapy, the difference (TsB-TcB) was statistically not significant (p = .125), while the difference in these values was statistically significant at 6 h and 24 h of phototherapy.Conclusion: TcB measurements from the covered skin area in jaundiced preterm infants during phototherapy were not correlated with TsB and cannot be used as an alternate of serum bilirubin testing. What is known • HPLC bilirubin measurement is a gold standard test for bilirubin measurement but impractical for day to day use. Serum total bilirubin is used for clinical testing.. • There is evidence for use of transcutaneous bilirubinometry for assessment of bilirubin in term newborn. What is new • TcB measurements from a covered skin area in jaundiced preterm newborns under phototherapy were not correlated significantly at 6 h and 24 h of phototherapy, but correlated before phototherapy. • TcB cannot be used as an alternate of serum bilirubin testing in preterm infants during phototherapy.
MeSH term(s)	Bilirubin ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Jaundice, Neonatal/diagnosis ; Jaundice, Neonatal/therapy ; Neonatal Screening ; Phototherapy ; Skin
Chemical Substances	Bilirubin (RFM9X3LJ49)
Language	English
Publishing date	2021-06-12
Publishing country	Germany
Document type	Journal Article ; Observational Study
ZDB-ID	194196-3
ISSN	1432-1076 ; 0340-6199 ; 0943-9676
ISSN (online)	1432-1076
ISSN	0340-6199 ; 0943-9676
DOI	10.1007/s00431-021-04148-2
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Article ; Online: Duration of Viral Clearance in Children With SARS-CoV-2 Infection in Rajasthan, India.

Gupta, Manohar Lal / Gothwal, Sunil / Gupta, Raj Kumar / Sharma, Ram Babu / Meena, Jeetam Singh / Sulaniya, Pawan Kumar / Dev, Deveshwar / Gupta, Deepak Kumar

Indian pediatrics

2020 Volume 58, Issue 2, Page(s) 123–125

Abstract: Objective: To study the clinical and laboratory profile and to assess period for viral clearance in COVID 19 children.: Methods: We reviewed hospital records of children (<18 years) admitted from 1 April to 31 May, 2020 at a tertiary-care public ... ...

Abstract	Objective: To study the clinical and laboratory profile and to assess period for viral clearance in COVID 19 children. Methods: We reviewed hospital records of children (<18 years) admitted from 1 April to 31 May, 2020 at a tertiary-care public hospital and identified those positive for severe acute respiratory syndrome corona virus (SARS-CoV-2) by RT-PCR of respiratory secretions. Results: 81.2% of the 85 children studied were asymptomatic and 3 (8.5%) died. Severe lymphopenia (43.8%), raised C-reactive protein (93.8%), raised erythrocyte sedimentation rate (75%) and high (>500ng/mL) levels of D-dimer (37.5%) were common. Median (IQR) duration of viral shedding was 7 (5-10) days, with range of 2 to 45 days; 96.3% had viral clearance within 14 days. Conclusions: Majority of children aged <18 years with SARS-CoV-2 infection had viral clearance within 14 days.
MeSH term(s)	Antibodies, Viral/blood ; Blood Sedimentation ; C-Reactive Protein/analysis ; COVID-19/blood ; COVID-19/epidemiology ; COVID-19/physiopathology ; COVID-19/therapy ; COVID-19 Testing/methods ; COVID-19 Testing/statistics & numerical data ; Child ; Female ; Fibrin Fibrinogen Degradation Products/analysis ; Hospitalization/statistics & numerical data ; Humans ; India/epidemiology ; Lymphocyte Count/methods ; Male ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/physiology ; Virus Shedding
Chemical Substances	Antibodies, Viral ; Fibrin Fibrinogen Degradation Products ; fibrin fragment D ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2020-11-29
Publishing country	India
Document type	Journal Article
ZDB-ID	402594-5
ISSN	0974-7559 ; 0019-6061
ISSN (online)	0974-7559
ISSN	0019-6061
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Article ; Online: Study of lung function test in association with laboratory findings of serum iron in patients with chronic obstructive pulmonary disease

Sunil Kumar Gothwal / Vikram Palsaniya / Harish Chandra Barjatiya / Ruchita Banseria / Piush Sharma / Pramod Kumar Goyal / Vasudeva Murthy Challakere Ramaswamy / Yogendra Singh / Gaurav Gupta

Clinical Epidemiology and Global Health, Vol 16, Iss , Pp 101091- (2022)

2022

Abstract: Background: The current cross-sectional study analyses patients' plasma iron measurements and spirometry to determine the relationship between serum iron, percent transferrin saturation, serum ferritin, total iron-binding capacity (TIBC), and forced ... ...

Abstract	Background: The current cross-sectional study analyses patients' plasma iron measurements and spirometry to determine the relationship between serum iron, percent transferrin saturation, serum ferritin, total iron-binding capacity (TIBC), and forced expiratory flow (FEF 25–75%), forced expiratory volume 1(FEV1)/Forced vital capacity (FVC), FVC, and FEV1. Methods: Spirometry measurements were assessed by comparing reference values based on age, height, sex, and race. Descriptive analysis of data included percentages, means, and standard deviations. Multivariate analyses were done using the Pearson correlation test and the multiple linear regression method. Results: According to the findings, the average age of those who participated in the study was 59.63 ± 10.32 years old. Serum iron concentrations were shown to be extremely significant and positively correlated with the percent anticipated values of FVC, FEV1/FVC FEV1, and FEF (25–75%). The total iron-binding capacity was extremely significant and linked strongly with the percent expected values of FVC, FEV1, FEF (25–75%), and FEV1/FVC. The percent transferrin saturation was extremely significant and linked positively with the percent anticipated values of FVC, FEV1, FEF (25–75%), and FEV1/FVC. Conclusion: Plasma iron levels were independently linked with both FEV1 and FEF (25–75%) percent predicted in the current investigation. Consequently, the blood iron concentration in COPD patients can be utilized as a biomarker for assessing disease severity because it is relatively simple and inexpensive.
Keywords	COPD ; FVC ; FEV1 ; Serum iron ; Public aspects of medicine ; RA1-1270
Subject code	630
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article: Changes in Hematological Parameters by Quantifying HRCT Chest Results in Patients With COVID-19 in Tertiary Care Hospital.

Banseria, Ruchita / Shrivastava, Mayank / Meena, Haradayal / Kumar Gothwal, Sunil / Meratwal, Gaurav / Singh, Veer Bahadur / Singh, Yogendra / Kazmi, Imran / Al-Abbasi, Fahad A / Almalki, Ziyad S / Khan, Mohd Faiyaz

Alternative therapies in health and medicine

2021 Volume 27, Issue S1, Page(s) 204–209

Abstract: Aim: To find changes in hematologic parameters in patients who are COVID-19-positive with respect to high resolution computed tomography (HRCT) chest scan so that the exact picture of the disease course can be identified and an adequate treatment ... ...

Abstract	Aim: To find changes in hematologic parameters in patients who are COVID-19-positive with respect to high resolution computed tomography (HRCT) chest scan so that the exact picture of the disease course can be identified and an adequate treatment protocol can be planned to combat the COVID-19 pandemic. Methods: Patients' health-related data including age, gender, symptomatology, associated co-morbidities, laboratory test results and HRCT results were collected. Results: The radiologic findings showed ground glass opacities (GGOs) was the most common manifestation. Analysis of HRCTs of patients with COVID-19 showed that lesions were mainly confined to the right and left lower lobes, suggesting that the COVID-19 virus is mainly harbored in the basal areas of the lungs. Conclusion: Radiologic and laboratory investigations can greatly help in early detection of COVID-19, thus allowing for timely interventions.
MeSH term(s)	COVID-19 ; Humans ; Pandemics ; Retrospective Studies ; SARS-CoV-2 ; Tertiary Care Centers
Language	English
Publishing date	2021-08-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
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