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Article ; Online: Comparative evaluation of Borrelia burgdorferi antibody detection between the VetScan Flex4 and SNAP 4Dx Plus.

Krcatovich, Elise H / Workman, Jason / Stasiak, Karen / Goldstein, Richard E

Topics in companion animal medicine

2024 Volume 59, Page(s) 100862

Abstract: Two studies were developed to compare Borrelia burgdorferi antibody detection between the VetScan Flex4 and SNAP 4Dx Plus tests. The objective of the first study was to evaluate the diagnostic sensitivity (Se) and specificity (Sp) of VetScan Flex4 and ... ...

Abstract	Two studies were developed to compare Borrelia burgdorferi antibody detection between the VetScan Flex4 and SNAP 4Dx Plus tests. The objective of the first study was to evaluate the diagnostic sensitivity (Se) and specificity (Sp) of VetScan Flex4 and SNAP 4Dx Plus B. burgdorferi results using field sourced samples compared to a Western Blot reference method. The sensitivity and specificity of VetScan Flex4 were 81.9 % (95 % CI: 71.9 %-89.5 %) and 89.3 % (95 % CI: 85.2 %-92.9 %) respectively, and SNAP 4Dx Plus's sensitivity and specificity were 80.7 % (95 % CI: 70.6 %-88.6 %) and 92.8 % (95 % CI: 89.1 %-95.5 %) respectively. When comparing VetScan Flex4 and Snap 4Dx Plus, the Simple Kappa Coefficient estimate was 0.76 (95 % CI: 0.69-0.84) indicating substantial agreement between the two methods. McNemar's Test revealed concordance between the two methods was not statistically significant (P = 0.05). The objective of the second study was to evaluate whether VetScan Flex4 differentiates between B. burgdorferi antibodies derived from infection versus vaccination with commonly used canine Lyme vaccines. The sensitivity and specificity of the VetScan Flex4 in differentiating canine Lyme vaccination from infection with Borrelia burgdorferi were 100 % (Se 95 % CI: 78.2 %-100 %; Sp 95 % CI: 91.2 %-100 %). In conclusion, the VetScan Flex4 is a reliably sensitive and specific point-of-care test that is similar to Snap 4Dx Plus, can differentiate between infection and Lyme vaccination, and can be utilized by veterinarians for Lyme disease diagnosis and surveillance of B. burgdorferi exposure.
MeSH term(s)	Animals ; Dogs ; Borrelia burgdorferi ; Dog Diseases/diagnosis ; Lyme Disease/diagnosis ; Lyme Disease/veterinary ; Antibodies, Bacterial ; Vaccines ; Blood Group Antigens
Chemical Substances	Antibodies, Bacterial ; Vaccines ; Blood Group Antigens
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Journal Article
ISSN	1946-9837
ISSN (online)	1946-9837
DOI	10.1016/j.tcam.2024.100862
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Article: Amygdala neurocircuitry at the interface between emotional regulation and narcolepsy with cataplexy.

Sardar, Haniyyah / Goldstein-Piekarski, Andrea N / Giardino, William J

Frontiers in neuroscience

2023 Volume 17, Page(s) 1152594

Abstract: Narcolepsy is a sleep disorder characterized by chronic and excessive daytime sleepiness, and sudden intrusion of sleep during wakefulness that can fall into two categories: type 1 and type 2. Type 1 narcolepsy in humans is widely believed to be caused ... ...

Abstract	Narcolepsy is a sleep disorder characterized by chronic and excessive daytime sleepiness, and sudden intrusion of sleep during wakefulness that can fall into two categories: type 1 and type 2. Type 1 narcolepsy in humans is widely believed to be caused as a result of loss of neurons in the brain that contain the key arousal neuropeptide Orexin (Orx; also known as Hypocretin). Patients with type 1 narcolepsy often also present with cataplexy, the sudden paralysis of voluntary muscles which is triggered by strong emotions (e.g., laughter in humans, social play in dogs, and chocolate in rodents). The amygdala is a crucial emotion-processing center of the brain; however, little is known about the role of the amygdala in sleep/wake and narcolepsy with cataplexy. A collection of reports across human functional neuroimaging analyses and rodent behavioral paradigms points toward the amygdala as a critical node linking emotional regulation to cataplexy. Here, we review the existing evidence suggesting a functional role for the amygdala network in narcolepsy, and build upon a framework that describes relevant contributions from the central nucleus of the amygdala (CeA), basolateral amygdala (BLA), and the extended amygdala, including the bed nucleus of stria terminalis (BNST). We propose that detailed examinations of amygdala neurocircuitry controlling transitions between emotional arousal states may substantially advance progress in understanding the etiology of narcolepsy with cataplexy, leading to enhanced treatment opportunities.
Language	English
Publishing date	2023-04-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2023.1152594
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Article ; Online: Incorporating testing volume into estimation of effective reproduction number dynamics.

Goldstein, Isaac H / Wakefield, Jon / Minin, Volodymyr M

ArXiv

2023

Abstract: Branching process inspired models are widely used to estimate the effective reproduction number -- a useful summary statistic describing an infectious disease outbreak -- using counts of new cases. Case data is a real-time indicator of changes in the ... ...

Abstract	Branching process inspired models are widely used to estimate the effective reproduction number -- a useful summary statistic describing an infectious disease outbreak -- using counts of new cases. Case data is a real-time indicator of changes in the reproduction number, but is challenging to work with because cases fluctuate due to factors unrelated to the number of new infections. We develop a new model that incorporates the number of diagnostic tests as a surveillance model covariate. Using simulated data and data from the SARS-CoV-2 pandemic in California, we demonstrate that incorporating tests leads to improved performance over the state-of-the-art.
Language	English
Publishing date	2023-10-01
Publishing country	United States
Document type	Preprint
ISSN	2331-8422
ISSN (online)	2331-8422
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Article ; Online: Novel agents in relapsed/refractory diffuse large B-cell lymphoma.

Varma, Gaurav / Goldstein, Jordan / Advani, Ranjana H

Hematological oncology

2023 Volume 41 Suppl 1, Page(s) 92–106

Abstract: Patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL), ineligible for or relapsing after autologous stem-cell transplant or chimeric antigen-receptor T-cell therapies have poor outcomes. Several novel agents, polatuzumab ... ...

Abstract	Patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL), ineligible for or relapsing after autologous stem-cell transplant or chimeric antigen-receptor T-cell therapies have poor outcomes. Several novel agents, polatuzumab vedotin, tafasitamab, loncastuximab tesirine, and selinexor, have been approved and offer new opportunities for this difficult to treat population. Studies are evaluating combination of these agents with chemotherapy and other emerging therapies. Additionally, advances in our understanding of DLBCL biology, genetics, and immune microenvironment have allowed for the identification of new therapeutic targets like Ikaros and Aiolos, IRAK4, MALT1, and CD47 with several agents in ongoing clinical trials. In this chapter we review updated data supporting the use of the approved agents and discuss other emerging novel therapies for patients with R/R DLBCL.
MeSH term(s)	Humans ; Antineoplastic Combined Chemotherapy Protocols ; Immunoconjugates/therapeutic use ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/etiology ; Lymphoma, Non-Hodgkin/drug therapy ; Neoplasm Recurrence, Local/drug therapy ; Tumor Microenvironment
Chemical Substances	Immunoconjugates
Language	English
Publishing date	2023-06-07
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	604884-5
ISSN	1099-1069 ; 0278-0232
ISSN (online)	1099-1069
ISSN	0278-0232
DOI	10.1002/hon.3143
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Article: Incorporating testing volume into estimation of effective reproduction number dynamics.

Goldstein, Isaac H / Wakefield, Jon / Minin, Volodymyr M

Journal of the Royal Statistical Society. Series A, (Statistics in Society)

2023 Volume 187, Issue 2, Page(s) 436–453

Abstract: Branching process inspired models are widely used to estimate the effective reproduction number-a useful summary statistic describing an infectious disease outbreak-using counts of new cases. Case data is a real-time indicator of changes in the ... ...

Abstract	Branching process inspired models are widely used to estimate the effective reproduction number-a useful summary statistic describing an infectious disease outbreak-using counts of new cases. Case data is a real-time indicator of changes in the reproduction number, but is challenging to work with because cases fluctuate due to factors unrelated to the number of new infections. We develop a new model that incorporates the number of diagnostic tests as a surveillance model covariate. Using simulated data and data from the SARS-CoV-2 pandemic in California, we demonstrate that incorporating tests leads to improved performance over the state of the art.
Language	English
Publishing date	2023-12-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1490715-X
ISSN	1467-985X ; 0964-1998 ; 0035-9238
ISSN (online)	1467-985X
ISSN	0964-1998 ; 0035-9238
DOI	10.1093/jrsssa/qnad128
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Article ; Online: How does cognitive behavior therapy for dissociative seizures work? A mediation analysis of the CODES trial.

Chalder, T / Landau, S / Stone, J / Carson, A / Reuber, M / Medford, N / Robinson, E J / Goldstein, L H

Psychological medicine

2024 , Page(s) 1–10

Abstract: Background: We compared dissociative seizure specific cognitive behavior therapy (DS-CBT) plus standardized medical care (SMC) to SMC alone in a randomized controlled trial. DS-CBT resulted in better outcomes on several secondary trial outcome measures ... ...

Abstract	Background: We compared dissociative seizure specific cognitive behavior therapy (DS-CBT) plus standardized medical care (SMC) to SMC alone in a randomized controlled trial. DS-CBT resulted in better outcomes on several secondary trial outcome measures at the 12-month follow-up point. The purpose of this paper is to evaluate putative treatment mechanisms. Methods: We carried out a secondary mediation analysis of the CODES trial. 368 participants were recruited from the National Health Service in secondary / tertiary care in England, Scotland, and Wales. Sixteen mediation hypotheses corresponding to combinations of important trial outcomes and putative mediators were assessed. Twelve-month trial outcomes considered were final-month seizure frequency, Work and Social Adjustment Scale (WSAS), and the SF-12v2, a quality-of-life measure providing physical (PCS) and mental component summary (MCS) scores. Mediators chosen for analysis at six months (broadly corresponding to completion of DS-CBT) included: (a) beliefs about emotions, (b) a measure of avoidance behavior, (c) anxiety and (d) depression. Results: All putative mediator variables except beliefs about emotions were found to be improved by DS-CBT. We found evidence for DS-CBT effect mediation for the outcome variables dissociative seizures (DS), WSAS and SF-12v2 MCS scores by improvements in target variables avoidance behavior, anxiety, and depression. The only variable to mediate the DS-CBT effect on the SF-12v2 PCS score was avoidance behavior. Conclusions: Our findings largely confirmed the logic model underlying the development of CBT for patients with DS. Interventions could be additionally developed to specifically address beliefs about emotions to assess whether it improves outcomes.
Language	English
Publishing date	2024-01-10
Publishing country	England
Document type	Journal Article
ZDB-ID	217420-0
ISSN	1469-8978 ; 0033-2917
ISSN (online)	1469-8978
ISSN	0033-2917
DOI	10.1017/S0033291723003665
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Article ; Online: A systematic meta-epidemiologic review on nonabstinence-inclusive interventions for substance use: inclusion of race/ethnicity and sex assigned at birth/gender.

Goldstein, Silvi C / Newberger, Noam G / Schick, Melissa R / Ferguson, Jewelia J / Collins, Susan E / Haeny, Angela M / Weiss, Nicole H

The American journal of drug and alcohol abuse

2024 , Page(s) 1–15

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	193086-2
ISSN	1097-9891 ; 0095-2990
ISSN (online)	1097-9891
ISSN	0095-2990
DOI	10.1080/00952990.2024.2308087
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Article ; Online: Transcatheter Intervention for Congenital Defects Involving the Great Vessels: JACC Review Topic of the Week.

Goldstein, Bryan H / Kreutzer, Jacqueline

Journal of the American College of Cardiology

2021 Volume 77, Issue 1, Page(s) 80–96

Abstract: Since the development of balloon angioplasty and balloon-expandable endovascular stent technology in the 1970s and 1980s, percutaneous transcatheter intervention has emerged as a mainstay of therapy for congenital heart disease (CHD) lesions throughout ... ...

Abstract	Since the development of balloon angioplasty and balloon-expandable endovascular stent technology in the 1970s and 1980s, percutaneous transcatheter intervention has emerged as a mainstay of therapy for congenital heart disease (CHD) lesions throughout the systemic and pulmonary vascular beds. Congenital lesions of the great vessels, including the aorta, pulmonary arteries, and patent ductus arteriosus, are each amenable to transcatheter intervention throughout the lifespan, from neonate to adult. In many cases, on-label devices now exist to facilitate these therapies. In this review, we seek to describe the contemporary approach to and outcomes from transcatheter management of major CHD lesions of the great vessels, with a focus on coarctation of the aorta, single- or multiple-branch pulmonary artery stenoses, and persistent patent ductus arteriosus. We further comment on the future of transcatheter therapies for these CHD lesions.
MeSH term(s)	Angiography ; Angioplasty, Balloon ; Aortic Coarctation/diagnostic imaging ; Aortic Coarctation/therapy ; Aortography ; Ductus Arteriosus, Patent/diagnostic imaging ; Ductus Arteriosus, Patent/therapy ; Humans ; Stenosis, Pulmonary Artery/congenital ; Stenosis, Pulmonary Artery/diagnostic imaging ; Stenosis, Pulmonary Artery/therapy ; Stents
Language	English
Publishing date	2021-01-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2020.11.019
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Zs.MO 196: Show issues

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Article ; Online: Carbohydrate-Protein drink is effective for restoring endurance capacity in masters class athletes after a two-Hour recovery.

Goldstein, Erica R / Stout, Jeffrey R / Wells, Adam J / Antonio, Jose / Vasenina, Ecaterina / Fukuda, David H

Journal of the International Society of Sports Nutrition

2023 Volume 20, Issue 1, Page(s) 2178858

Abstract: Background: Carbohydrate (CHO) and carbohydrate-protein co-ingestion (CHO-P) have been shown to be equally effective for enhancing glycogen resynthesis and subsequent same-day performance when CHO intake is suboptimal (≤0.8 g/kg). Few studies have ... ...

Abstract	Background: Carbohydrate (CHO) and carbohydrate-protein co-ingestion (CHO-P) have been shown to be equally effective for enhancing glycogen resynthesis and subsequent same-day performance when CHO intake is suboptimal (≤0.8 g/kg). Few studies have specifically examined the effect of isocaloric CHO vs CHO-P consumption on subsequent high-intensity aerobic performance with limited time to recover (≤2 hours) in masters class endurance athletes. Methods: This was a randomized, double-blind between-subject design. Twenty-two male masters class endurance athletes (age 49.1 ± 6.9 years; height 175.8 ± 4.8 cm; body mass 80.7 ± 8.6 kg; body fat (%) 19.1 ± 5.8; VO Results: A one-way ANCOVA indicated a significant difference among the group means for the posttest TTE (F Conclusions: Both CHO and CHO-P effectively promoted an increase in TTE performance with limited time to recover in this sample of masters class endurance athletes. Water and electrolytes alone were not effective for restoring endurance capacity during the second bout of exhaustive exercise.
MeSH term(s)	Humans ; Male ; Adult ; Middle Aged ; Physical Endurance ; Dietary Carbohydrates ; Exercise ; Athletes ; Polyesters/pharmacology
Chemical Substances	Dietary Carbohydrates ; Polyesters
Language	English
Publishing date	2023-02-26
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2162810-5
ISSN	1550-2783 ; 1550-2783
ISSN (online)	1550-2783
ISSN	1550-2783
DOI	10.1080/15502783.2023.2178858
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Article ; Online: Neutrophils drive pulmonary vascular leakage in MHV-1 infection of susceptible A/J mice.

Gong, Henry H / Worley, Matthew J / Carver, Kyle A / Goldstein, Daniel R / Deng, Jane C

Frontiers in immunology

2023 Volume 13, Page(s) 1089064

Abstract: ... for example.: Methods: In this study, we infected resistant C57BL/6 and susceptible A/J strains of mice ... susceptibility to pulmonary vascular leakage in a respiratory coronavirus infection model.: Results: A/J ... of other leukocytes early in the infection. Moreover, under basal conditions, A/J neutrophils overexpressed primary ...

Abstract	Background: Lung inflammation, neutrophil infiltration, and pulmonary vascular leakage are pathological hallmarks of acute respiratory distress syndrome (ARDS) which can lethally complicate respiratory viral infections. Despite similar comorbidities, however, infections in some patients may be asymptomatic while others develop ARDS as seen with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections for example. Methods: In this study, we infected resistant C57BL/6 and susceptible A/J strains of mice with pulmonary administration of murine hepatitis virus strain 1 (MHV-1) to determine mechanisms underlying susceptibility to pulmonary vascular leakage in a respiratory coronavirus infection model. Results: A/J animals displayed increased lung injury parameters, pulmonary neutrophil influx, and deficient recruitment of other leukocytes early in the infection. Moreover, under basal conditions, A/J neutrophils overexpressed primary granule protein genes for myeloperoxidase and multiple serine proteases. During infection, myeloperoxidase and elastase protein were released in the bronchoalveolar spaces at higher concentrations compared to C57BL/6 mice. In contrast, genes from other granule types were not differentially expressed between these 2 strains. We found that depletion of neutrophils led to mitigation of lung injury in infected A/J mice while having no effect in the C57BL/6 mice, demonstrating that an altered neutrophil phenotype and recruitment profile is a major driver of lung immunopathology in susceptible mice. Conclusions: These results suggest that host susceptibility to pulmonary coronaviral infections may be governed in part by underlying differences in neutrophil phenotypes, which can vary between mice strains, through mechanisms involving primary granule proteins as mediators of neutrophil-driven lung injury.
MeSH term(s)	Mice ; Animals ; Neutrophils ; Murine hepatitis virus ; Peroxidase ; Lung Injury ; Mice, Inbred C57BL ; COVID-19 ; SARS-CoV-2 ; Pneumonia ; Proteins ; Respiratory Distress Syndrome
Chemical Substances	Peroxidase (EC 1.11.1.7) ; Proteins
Language	English
Publishing date	2023-01-06
Publishing country	Switzerland
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.1089064
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