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  1. Book ; Online: Malaria

    Paolo Piccaluga, Pier

    Recent Advances and New Perspectives

    (Infectious Diseases ; 20)

    2023  

    Series title Infectious Diseases ; 20
    Keywords Infectious & contagious diseases ; plasmodium falciparum ; oxidative stress ; pathogenesis ; mortality ; antioxidant activity ; pcr
    Language English
    Size 1 electronic resource (256 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030381049
    ISBN 9781803567938 ; 1803567937
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Acute Leukemias

    Paolo Piccaluga, Pier

    2021  

    Keywords Oncology
    Size 1 electronic resource (322 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021049001
    ISBN 9781838811730 ; 1838811737
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Peripheral T-cell Lymphomas

    Paolo Piccaluga, Pier

    2019  

    Keywords Oncology ; epigenetics, genomics, targeted therapy, precision medicine, transcriptomics, tyrosine kinase inhibitors
    Language English
    Size 1 electronic resource (132 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030645025
    ISBN 9781838812270 ; 183881227X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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    Inter-library loan at ZB MED

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  4. Article: Editorial: Oncolytic virotherapy.

    Al-Shammari, Ahmed Majeed / Piccaluga, Pier Paolo

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1287885

    Language English
    Publishing date 2023-11-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1287885
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Comparison of the Fifth World Health Organization and the International Consensus Classifications of Mature T-Cell Lymphomas.

    Piccaluga, Pier Paolo / Khattab, Shaimaa S

    International journal of molecular sciences

    2023  Volume 24, Issue 18

    Abstract: Peripheral T-cell lymphomas (PTCLs) are a rare subset of non-Hodgkin lymphomas that often carry significant difficulty in diagnosis and classification because of their rarity and biological complexity. Previous editions of the World Health Organization ( ... ...

    Abstract Peripheral T-cell lymphomas (PTCLs) are a rare subset of non-Hodgkin lymphomas that often carry significant difficulty in diagnosis and classification because of their rarity and biological complexity. Previous editions of the World Health Organization (WHO) classifications of hemopoietic neoplasms in 2001, 2008, and 2017 aimed to standardize hemopoietic neoplasm diagnosis in general. Since then, crucial clinico-pathological, immunophenotypic, and recent molecular discoveries have been made in the field of lymphomas, contributing to refining diagnostic criteria of several diseases, upgrading entities previously defined as provisional, and identifying new entities. In 2022, two different models were proposed to classify hematolymphoid neoplasms: the 5th edition of the WHO classification (WHO-HAEM5) and the International Consensus Classification (ICC). Of note, a common nosography is mandatory to ensure progress in health science and ensure the basis for a real precision medicine. In this article, the authors summarized the main differences with the previous fourth WHO edition and reviewed the main discrepancies between the two newest classifications, as far as PTCLs are concerned.
    MeSH term(s) Humans ; Lymphoma, T-Cell, Peripheral ; Consensus ; Hematologic Neoplasms ; Immunophenotyping ; World Health Organization
    Language English
    Publishing date 2023-09-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241814170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Editorial: Role of the SUMOylation in cancer regulation.

    Chen, Xu / Smaldone, Giovanni / Piccaluga, Pier Paolo / Qi, Yitao

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1236230

    Language English
    Publishing date 2023-08-31
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1236230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Editorial

    Ahmed Majeed Al-Shammari / Pier Paolo Piccaluga

    Frontiers in Molecular Biosciences, Vol

    Oncolytic virotherapy

    2023  Volume 10

    Keywords immuno-virotherapy ; newcastle disease virus (NDV) ; combination therapies ; hsv ; T-VEC ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article: Tyrosine kinases in nodal peripheral T-cell lymphomas.

    Piccaluga, Pier Paolo / Cascianelli, Chiara / Inghirami, Giorgio

    Frontiers in oncology

    2023  Volume 13, Page(s) 1099943

    Abstract: Nodal peripheral T-cell lymphomas (PTCL) are uncommon and heterogeneous tumors characterized by a dismal prognosis. Targeted therapy has been proposed. However, reliable targets are mostly represented by a few surface antigens (e.g., CD52 and CD30), ... ...

    Abstract Nodal peripheral T-cell lymphomas (PTCL) are uncommon and heterogeneous tumors characterized by a dismal prognosis. Targeted therapy has been proposed. However, reliable targets are mostly represented by a few surface antigens (e.g., CD52 and CD30), chemokine receptors (e.g., CCR4), and epigenetic gene expression regulation. In the last two decades, however, several studies have supported the idea that tyrosine kinase (TK) deregulation might be relevant for both the pathogenesis and treatment of PTCL. Indeed, they can be expressed or activated as a consequence of their involvement in genetic lesions, such as translocations, or by ligand overexpression. The most striking example is ALK in anaplastic large-cell lymphomas (ALCL). ALK activity is necessary to support cell proliferation and survival, and its inhibition leads to cell death. Notably, STAT3 was found to be the main downstream ALK effector. Other TKs are consistently expressed and active in PTCLs, such as PDGFRA, and members of the T-cell receptor signaling family, such as SYK. Notably, as in the case of ALK, STAT proteins have emerged as key downstream factors for most of the involved TK.
    Language English
    Publishing date 2023-02-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1099943
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cardiotoxicity of Tyrosine Kinase Inhibitors in Philadelphia-Positive Leukemia Patients

    Adriatik Berisha / Angelo Placci / Pier Paolo Piccaluga

    Hemato, Vol 4, Iss 7, Pp 68-

    2023  Volume 75

    Abstract: In the past twenty years, tyrosine kinase inhibitors (TKIs) have substantially changed the therapeutic landscape and the clinical outcome of several cancers, including Philadelphia-chromosome positive chronic myeloid leukemia and acute lymphoblastic ... ...

    Abstract In the past twenty years, tyrosine kinase inhibitors (TKIs) have substantially changed the therapeutic landscape and the clinical outcome of several cancers, including Philadelphia-chromosome positive chronic myeloid leukemia and acute lymphoblastic leukemia, chronic eosinophilic syndromes, gastrointestinal stromal tumors, and others. Despite the obvious advantages offered in terms of efficacy and the overall safety profile, this new class of agents presents novel side effects, sometimes different from those induced by conventional chemotherapy. Among others, the potential cardiac toxicity, characterized by possible arrhythmias and the highest rates of cardiac ischemic disease and heart failure, were predominantly investigated. In this article, the authors review the most significant evidence in this regard, highlighting the overall benefit of TKI usage and the need for careful monitoring, especially in elderly patients.
    Keywords tyrosine kinase inhibitors ; chronic myeloid leukemia ; acute lymphoblastic leukemia ; BCR:ABL1 ; cardiotoxicity ; ponatinib ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Antigen Receptors Gene Analysis for Minimal Residual Disease Detection in Acute Lymphoblastic Leukemia

    Pier Paolo Piccaluga / Stefania Paolini / Giuseppe Visani

    Hemato, Vol 4, Iss 4, Pp 42-

    The Role of High Throughput Sequencing

    2023  Volume 55

    Abstract: The prognosis of adult acute lymphoblastic leukemia (ALL) is variable but more often dismal. Indeed, its clinical management is challenging, current therapies inducing complete remission in 65–90% of cases, but only 30–40% of patients being cured. The ... ...

    Abstract The prognosis of adult acute lymphoblastic leukemia (ALL) is variable but more often dismal. Indeed, its clinical management is challenging, current therapies inducing complete remission in 65–90% of cases, but only 30–40% of patients being cured. The major determinant of treatment failure is relapse; consequently, measurement of residual leukemic blast (minimal residual disease, MRD) has become a powerful independent prognostic indicator in adults. Numerous evidences have also supported the clinical relevance of MRD assessment for risk class assignment and treatment selection. MRD can be virtually evaluated in all ALL patients using different technologies, such as polymerase chain reaction amplification of fusion transcripts and clonal rearrangements of antigen receptor genes, flow cytometric study of leukemic immunophenotypes and, the most recent, high throughput sequencing (HTS). In this review, the authors focused on the latest developments on MRD monitoring with emphasis on the use of HTS, as well as on the clinical impact of MRD monitoring.
    Keywords acute lymphoblastic leukemia ; minimal residual disease ; next generation sequencing ; targeted therapy ; antigen receptor ; IGVH ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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