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  1. Article ; Online: Immune-mediated inflammatory diseases as long-term sepsis complications: Long-term persistence of host dysregulation?

    Giamarellos-Bourboulis, Evangelos J

    Journal of internal medicine

    2023  Volume 295, Issue 2, Page(s) 123–125

    MeSH term(s) Humans ; Cytokines ; Signal Transduction ; Sepsis/complications
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-12-13
    Publishing country England
    Document type Editorial
    ZDB-ID 96274-0
    ISSN 1365-2796 ; 0954-6820
    ISSN (online) 1365-2796
    ISSN 0954-6820
    DOI 10.1111/joim.13761
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  2. Article ; Online: Interleukin-17A derived from mast cells: evidence for an autoinflammatory loop in hidradenitis suppurativa?

    Giamarellos-Bourboulis, Evangelos J

    The British journal of dermatology

    2023  Volume 189, Issue 6, Page(s) 651–652

    MeSH term(s) Humans ; Hidradenitis Suppurativa/etiology ; Interleukin-17 ; Mast Cells
    Chemical Substances Interleukin-17
    Language English
    Publishing date 2023-10-18
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljad400
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Adjunctive treatment in COVID-19 and sepsis-What did we learn?

    Giamarellos-Bourboulis, Evangelos J

    Medizinische Klinik, Intensivmedizin und Notfallmedizin

    2023  Volume 118, Issue Suppl 2, Page(s) 80–85

    Abstract: The introduction of anakinra, baricitinib and tocilizumab into the treatment armamentarium of severe coronavirus disease 2019 (COVID-19) reinforced the concept of immunotherapy for bacterial sepsis. The current review investigates how the example of ... ...

    Title translation Adjuvante Behandlung bei COVID-19 und Sepsis − was haben wir gelernt?
    Abstract The introduction of anakinra, baricitinib and tocilizumab into the treatment armamentarium of severe coronavirus disease 2019 (COVID-19) reinforced the concept of immunotherapy for bacterial sepsis. The current review investigates how the example of COVID-19 may be extrapolated to sepsis using a three-step approach. In the first step, the clinical evidence on how the immunotherapy of COVID-19 assisted viral clearance is presented. In a second step, the indications acquired from human and animal studies on the need to employ strategies with primary effective phagocytosis in sepsis are presented. In a final step, lessons learnt from COVID-19 immunotherapy are applied for sepsis. The end result is that sepsis immunotherapy should rely on the use of biomarkers which provide information on the activation of a specific prevailing mechanism in order to enable the selection of the appropriate drug.
    MeSH term(s) Humans ; COVID-19/therapy ; SARS-CoV-2 ; Sepsis/therapy
    Language English
    Publishing date 2023-11-15
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2636018-4
    ISSN 2193-6226 ; 1435-1420 ; 0723-5003 ; 2193-6218 ; 0175-3851
    ISSN (online) 2193-6226 ; 1435-1420
    ISSN 0723-5003 ; 2193-6218 ; 0175-3851
    DOI 10.1007/s00063-023-01089-6
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  4. Article ; Online: Keratinocytes as drivers of hidradenitis suppurativa inflammation: need for priming.

    Giamarellos-Bourboulis, Evangelos J

    The British journal of dermatology

    2022  Volume 188, Issue 3, Page(s) 318–319

    MeSH term(s) Humans ; Hidradenitis Suppurativa/immunology ; Inflammation ; Keratinocytes ; Epidermis ; Epidermal Cells
    Language English
    Publishing date 2022-12-30
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljac164
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  5. Article ; Online: Modulation of keratin deposition and pathogenesis of hidradenitis suppurativa: evidence coming from pachyonychia congenita.

    Giamarellos-Bourboulis, Evangelos J

    The British journal of dermatology

    2022  Volume 187, Issue 5, Page(s) e170–e171

    MeSH term(s) Humans ; Pachyonychia Congenita/diagnosis ; Pachyonychia Congenita/genetics ; Hidradenitis Suppurativa/etiology ; Keratins ; Pedigree ; Cytoskeletal Proteins ; Keratin-6/genetics ; Keratin-17/genetics ; Keratin-16
    Chemical Substances Keratins (68238-35-7) ; Cytoskeletal Proteins ; Keratin-6 ; Keratin-17 ; Keratin-16
    Language English
    Publishing date 2022-08-22
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.21807
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  6. Article ; Online: Community-acquired pneumonia: the best candidates for clarithromycin - Authors' reply.

    Giamarellos-Bourboulis, Evangelos J / Niederman, Michael S

    The Lancet. Respiratory medicine

    2024  Volume 12, Issue 4, Page(s) e17

    MeSH term(s) Humans ; Clarithromycin/therapeutic use ; Pneumonia/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Community-Acquired Infections/drug therapy
    Chemical Substances Clarithromycin (H1250JIK0A) ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Letter
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(24)00035-3
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  7. Article ; Online: Complex immune deregulation in severe COVID-19: More than a mechanism of pathogenesis.

    Giamarellos-Bourboulis, Evangelos J

    EBioMedicine

    2021  Volume 73, Page(s) 103673

    MeSH term(s) COVID-19/drug therapy ; COVID-19/immunology ; COVID-19/pathology ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/pathology ; HLA-DR Antigens/analysis ; HLA-DR Antigens/immunology ; Humans ; Interferon-gamma/therapeutic use ; Interleukin-6/blood ; Interleukin-6/immunology ; Macrophage Activation Syndrome/immunology ; Macrophage Activation Syndrome/pathology ; Prognosis ; SARS-CoV-2/immunology ; Viral Load/drug effects
    Chemical Substances HLA-DR Antigens ; IL6 protein, human ; Interleukin-6 ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2021-11-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2021.103673
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  8. Article ; Online: An evaluation of secukinumab for the treatment of moderate-to-severe hidradenitis suppurativa.

    Stergianou, Dimitra / Kanni, Theodora / Damoulari, Christina / Giamarellos-Bourboulis, Evangelos J

    Expert opinion on biological therapy

    2024  Volume 24, Issue 4, Page(s) 225–232

    Abstract: Introduction: Until recently, biological therapy for hidradenitis suppurativa was limited to anti-tumor necrosis factor (TNF) blockade with adalimumab (ADA). However, not all patients respond to treatment with ADA. This highlighted the need for more ... ...

    Abstract Introduction: Until recently, biological therapy for hidradenitis suppurativa was limited to anti-tumor necrosis factor (TNF) blockade with adalimumab (ADA). However, not all patients respond to treatment with ADA. This highlighted the need for more therapeutic options. Interleukin (IL)-17/T-helper 17 (Th17) axis may play an important role in the pathophysiology of HS. Recently, the IL-17A inhibitor secukinumab, which targets IL-17A specifically and prevents it from interacting with the IL-17 receptor, has been FDA-approved for HS.
    Areas covered: Secukinumab, represents a novel therapeutic strategy in HS management. An overview of structural and pharmacological characteristics is provided. Described efficacy in clinical trials and case reports and safety data from is presented.
    Expert opinion: As response to anti-TNFas is lost over time, secukinumab has provided an alternative HS treatment option in clinical practice. Overall, secukinumab has shown good efficacy and a favorable side effect profile in HS clinical trials but may be avoided in patients with inflammatory bowel disease. Long-term and real-life data on the use of secukinumab are essential for improving decision-making in HS therapy.
    MeSH term(s) Humans ; Hidradenitis Suppurativa/drug therapy ; Hidradenitis Suppurativa/immunology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antibodies, Monoclonal, Humanized/adverse effects ; Interleukin-17/antagonists & inhibitors ; Interleukin-17/immunology ; Severity of Illness Index
    Chemical Substances secukinumab (DLG4EML025) ; Antibodies, Monoclonal, Humanized ; Interleukin-17 ; IL17A protein, human
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2052501-1
    ISSN 1744-7682 ; 1471-2598
    ISSN (online) 1744-7682
    ISSN 1471-2598
    DOI 10.1080/14712598.2024.2343112
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  9. Article ; Online: Clinical evidence supporting ceftaroline fosamil and ceftobiprole for complicated skin and soft tissue infections.

    Leventogiannis, Konstantinos / Mouktaroudi, Maria / Giamarellos-Bourboulis, Evangelos J

    Current opinion in infectious diseases

    2023  Volume 36, Issue 2, Page(s) 89–94

    Abstract: Purpose of review: Ceftaroline and ceftobiprole are advanced generation cephalosporins with activity against methicillin-resistant Staphylococcus aureus (MRSA). This review summarizes their clinical efficacy for complicated skin and soft tissue ... ...

    Abstract Purpose of review: Ceftaroline and ceftobiprole are advanced generation cephalosporins with activity against methicillin-resistant Staphylococcus aureus (MRSA). This review summarizes their clinical efficacy for complicated skin and soft tissue infections (cSSTIs).
    Recent findings: Both these agents retain excellent in vitro activity against both MRSA and Gram-negative isolates from patients with CSSTIs. Both these agents are registered for the management of cSSTIs based on the results of large scale phase III noninferiority trials. Ceftaroline and ceftobiprole are noninferior to the combination of vancomycin and aztreonam as this was assessed by their clinical cure rate at the test-of-cure visits. Furthermore, ceftobiprole is noninferior to comparators for the achievement of early clinical success at 72 h. Ceftaroline achieves 81% clinical cure against diabetic foot infections.
    Summary: Ceftaroline and ceftobiprole can be used as monotherapy for the treatment of cSSTIs.
    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Soft Tissue Infections/drug therapy ; Methicillin-Resistant Staphylococcus aureus ; Cephalosporins/therapeutic use ; Staphylococcal Infections/drug therapy ; Microbial Sensitivity Tests ; Ceftaroline
    Chemical Substances ceftobiprole (5T97333YZK) ; Anti-Bacterial Agents ; Cephalosporins
    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000900
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  10. Article ; Online: Advancements in the pharmacological management of sepsis in the elderly.

    Psarrakis, Christos / Giamarellos-Bourboulis, Evangelos J

    Expert opinion on pharmacotherapy

    2023  Volume 24, Issue 10, Page(s) 1171–1187

    Abstract: Introduction: Sepsis is a global health threat with high associated mortality especially among the elderly. Population aging and sepsis have a tremendous negative impact on national health systems worldwide. Biomarkers have been used to guide early ... ...

    Abstract Introduction: Sepsis is a global health threat with high associated mortality especially among the elderly. Population aging and sepsis have a tremendous negative impact on national health systems worldwide. Biomarkers have been used to guide early diagnosis and treatment. Antibiotics have been the cornerstone for the treatment of sepsis while immune modulatory therapies, except hydrocortisone, have gained a lot of attention lately. This review attempts to give a fully detailed summary of the advancements in the pharmacological management of sepsis in the elderly.
    Areas covered: The authors conducted a systematic literature search in the PubMed database using the keywords 'sepsis in the elderly,' 'sepsis and biomarkers,' 'sepsis and antibiotics,' 'sepsis and renal dysfunction,' 'sepsis and hydrocortisone' for articles published only in English language from 2017 up to 2022. The search was restricted to clinical trials and meta-analyses covering the population of interest.
    Expert opinion: Despite the authorization of several novel antibiotic regimens targeting multidrug-resistant pathogens, mortality remains high. Adjunctive precision immunotherapy treatment is a new era of research which recently attracts much attention. Combination of antibiotics with precision immunotherapy in an individualized pattern may be the key for decreasing mortality and improve outcomes.
    MeSH term(s) Humans ; Aged ; Hydrocortisone/therapeutic use ; Sepsis/diagnosis ; Sepsis/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Biomarkers
    Chemical Substances Hydrocortisone (WI4X0X7BPJ) ; Anti-Bacterial Agents ; Biomarkers
    Language English
    Publishing date 2023-05-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2023.2213828
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