LIVIVO - Search results -

Search results

Result 1 - 10 of total 324

Search options

Article ; Online: Glomerulogenesis and the role of endothelium.

Nagata, Michio

Current opinion in nephrology and hypertension

2018 Volume 27, Issue 3, Page(s) 159–164

Abstract: Purpose of review: Earlier works of the glomerulogenesis described morphological steps and protein expression during in-vivo and in-vitro kidney development. Recent technologies using cell-specific or conditional knock-out mice for several factors ... ...

Abstract	Purpose of review: Earlier works of the glomerulogenesis described morphological steps and protein expression during in-vivo and in-vitro kidney development. Recent technologies using cell-specific or conditional knock-out mice for several factors provide important knowledge about cross-talk signaling among resident cells as local events. Based on the recent advancement, this review revisits comprehensive morphological development of the glomerulus. Recent findings: Interactions of presumptive podocyte vascular endothelial growth factor with vascular endothelial growth factor-2 on angioblasts initiate glomerular vascularization. In induced pluripotent stem cells or organoid-derived nephron formation, the lack of endothelium and mesangial cells under differentiated podocytes suggests the presence of another unknown mechanism for glomerular neovascularization. Mesangial cell migration is prerequisite for glomerular looping by interaction of endothelial platelet-derived grothe factor beta and mesangial platelet-derived growth factor receptor beta and requires the coreceptor neuropilin1. Development of the filtration barrier is promoted by cross-talk among resident cells and may need shear stress. The components of the glomerular basement membrane change during glomerulogenesis, and endothelium and podocytes produce laminin and type IV collagen α1 and α2, whereas type IV collagen α3, α4, α5 is derived only from podocytes. Summary: Glomerulogenesis progresses by dynamic cellular migration/differentiation induced by cross-talk signaling in resident cells. Glomerular vasculogenesis and subsequent capillary development provide insight into glomerular regeneration and remodeling for medical application.
MeSH term(s)	Animals ; Cell Communication ; Cell Differentiation ; Cell Movement ; Collagen Type IV/metabolism ; Endothelium/metabolism ; Endothelium/physiology ; Humans ; Kidney Glomerulus/blood supply ; Kidney Glomerulus/embryology ; Kidney Glomerulus/physiology ; Laminin/metabolism ; Neovascularization, Physiologic ; Signal Transduction ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	Collagen Type IV ; Laminin ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2018-02-05
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1151092-4
ISSN	1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
ISSN (online)	1473-6543 ; 1535-3842
ISSN	1062-4813 ; 1062-4821
DOI	10.1097/MNH.0000000000000402
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3686: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Podocyte injury and its consequences.

Nagata, Michio

Kidney international

2016 Volume 89, Issue 6, Page(s) 1221–1230

Abstract: Podocytes maintain the glomerular filtration barrier, and the stability of this barrier depends on their highly differentiated postmitotic phenotype, which also defines the particular vulnerability of the glomerulus. Recent podocyte biology and gene ... ...

Abstract	Podocytes maintain the glomerular filtration barrier, and the stability of this barrier depends on their highly differentiated postmitotic phenotype, which also defines the particular vulnerability of the glomerulus. Recent podocyte biology and gene disruption studies in vivo indicate a causal relationship between abnormalities of single podocyte molecules and proteinuria and glomerulosclerosis. Podocytes live under various stresses and pathological stimuli. They adapt to maintain homeostasis, but excessive stress leads to maladaptation with complex biological changes including loss of integrity and dysregulation of cellular metabolism. Podocyte injury causes proteinuria and detachment from the glomerular basement membrane. In addition to "sick" podocytes and their detachment, our understanding of glomerular responses following podocyte loss needs to address the pathways from podocyte injury to sclerosis. Studies have found a variety of glomerular responses to podocyte dysfunction in vivo, such as disruption of podocyte-endothelial cross talk and activation of podocyte-parietal cell interactions, all of which help us to understand the complex scenario of podocyte injury and its consequences. This review focuses on the cellular aspects of podocyte dysfunction and the adaptive or maladaptive glomerular responses to podocyte injury that lead to its major consequence, glomerulosclerosis.
MeSH term(s)	Apoptosis ; Bowman Capsule/cytology ; Bowman Capsule/pathology ; Cell Communication ; Cell Differentiation ; Endothelial Cells ; Glomerular Basement Membrane/cytology ; Glomerular Basement Membrane/metabolism ; Glomerular Basement Membrane/pathology ; Glomerulosclerosis, Focal Segmental/pathology ; Humans ; Oxidative Stress ; Podocytes/cytology ; Podocytes/metabolism ; Podocytes/pathology ; Proteinuria/pathology ; Sclerosis ; Stress, Mechanical
Language	English
Publishing date	2016-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2016.01.012
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 797: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Structural and Functional Analysis of the Amorphous Calcium Carbonate-Binding Protein Paramyosin in the Shell of the Pearl Oyster,

Futagawa, Kei / Ikeda, Haruka / Negishi, Lumi / Kurumizaka, Hitoshi / Yamamoto, Ayame / Furihata, Kazuo / Ito, Yutaka / Ikeya, Teppei / Nagata, Koji / Funabara, Daisuke / Suzuki, Michio

Langmuir : the ACS journal of surfaces and colloids

2024 Volume 40, Issue 16, Page(s) 8373–8392

Abstract: Amorphous calcium carbonate (ACC) is an important precursor phase for the formation of aragonite crystals in the shells ... ...

Abstract	Amorphous calcium carbonate (ACC) is an important precursor phase for the formation of aragonite crystals in the shells of
MeSH term(s)	Animals ; Pinctada/chemistry ; Pinctada/metabolism ; Calcium Carbonate/chemistry ; Calcium Carbonate/metabolism ; Animal Shells/chemistry ; Animal Shells/metabolism ; Tropomyosin/chemistry ; Tropomyosin/metabolism
Chemical Substances	Calcium Carbonate (H0G9379FGK) ; Tropomyosin
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.3c03820
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Effector and upstream mechanism of immune-mediated glomerulonephritis.

Manabe, Shun / Nagata, Michio

Nihon Jinzo Gakkai shi

2018 Volume 58, Issue 5, Page(s) 614–621

MeSH term(s)	Animals ; Glomerulonephritis/immunology ; Humans ; Immunoglobulins/immunology ; Receptors, Fc/immunology ; T-Lymphocytes/immunology
Chemical Substances	Immunoglobulins ; Receptors, Fc
Language	Japanese
Publishing date	2018-10-30
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1195538-7
ISSN	0385-2385
ISSN	0385-2385
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1383: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Glomerular filtrate affects the dynamics of podocyte detachment in a model of diffuse toxic podocytopathy.

Saga, Nobuyuki / Sakamoto, Kazuo / Matsusaka, Taiji / Nagata, Michio

Kidney international

2021 Volume 99, Issue 5, Page(s) 1149–1161

Abstract: Podocyte injury and subsequent detachment are hallmarks of progressive glomerulosclerosis. In addition to cell injury, unknown mechanical forces on the injured podocyte may promote detachment. To identify the nature of these mechanical forces, we studied ...

Abstract	Podocyte injury and subsequent detachment are hallmarks of progressive glomerulosclerosis. In addition to cell injury, unknown mechanical forces on the injured podocyte may promote detachment. To identify the nature of these mechanical forces, we studied the dynamics of podocyte detachment using sequential ultrastructural geometry analysis by transmission electron microscopy in NEP25, a mouse model of podocytopathy induced by anti-Tac(Fv)-PE38 (LMB2), a fusion protein attached to Pseudomonas exotoxin A, targeting CD25 on podocytes. After LMB2 injection, foot process effacement occurred on day three but detachment commenced on day eight and extended to day ten, reaching toward the urinary pole in clusters. Podocyte detachment was associated with foot process effacement covering over 60% of the glomerular basement membrane length. However, approximately 25% of glomeruli with diffuse (over 80%) foot process effacement showed no detachment. Blocking glomerular filtration via unilateral ureteral obstruction resulted in diffuse foot process effacement but no pseudocysts or detachment, whereas uninephrectomy increased pseudocysts and accelerated detachment, indicating that glomerular filtrate drives podocyte detachment via pseudocyst formation as a forerunner. Additionally, more detachment was observed in juxtamedullary glomeruli than in superficial glomeruli. Thus, glomerular filtrate drives the dynamics of podocyte detachment in this model of podocytopathy. Hence, foot process effacement may be a prerequisite allowing filtrate to generate local mechanical forces that expand the subpodocyte space forming pseudocysts, promote podocyte detachment and subsequent segmental sclerosis.
MeSH term(s)	Animals ; Disease Models, Animal ; Glomerular Basement Membrane ; Glomerulosclerosis, Focal Segmental/pathology ; Kidney Diseases/pathology ; Mice ; Podocytes/pathology ; Sclerosis/pathology
Language	English
Publishing date	2021-02-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2020.12.034
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 797: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Molecular mechanism of Fe

Lu, Peng / Jiang, Jinyan / Liu, Chang / Okuda, Suguru / Itoh, Hideaki / Okamoto, Ken / Suzuki, Michio / Nagata, Koji

Protein science : a publication of the Protein Society

2023 Volume 33, Issue 2, Page(s) e4881

Abstract: Global warming has increased the growth of pathogenic Vibrio bacteria, which can cause foodborne illnesses and death. Vibrio bacteria require iron for growth and survival. They utilize a ferric ion-binding protein (FbpA) to bind and transport ... ...

Abstract	Global warming has increased the growth of pathogenic Vibrio bacteria, which can cause foodborne illnesses and death. Vibrio bacteria require iron for growth and survival. They utilize a ferric ion-binding protein (FbpA) to bind and transport Fe
MeSH term(s)	Carrier Proteins ; Rosmarinic Acid ; Bacterial Proteins/chemistry ; Iron/metabolism ; Vibrio ; Lactates
Chemical Substances	Carrier Proteins ; 3,4-dihydroxyphenyllactic acid (4GF33A5PAJ) ; Rosmarinic Acid (MQE6XG29YI) ; Bacterial Proteins ; Iron (E1UOL152H7) ; Lactates
Language	English
Publishing date	2023-12-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1106283-6
ISSN	1469-896X ; 0961-8368
ISSN (online)	1469-896X
ISSN	0961-8368
DOI	10.1002/pro.4881
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3407: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 1: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Correction to: Renal involvement of monoclonal immunoglobulin deposition disease associated with an unusual monoclonal immunoglobulin A glycan profile.

Kaneko, Shuzo / Usui, Joichi / Narimatsu, Yoshiki / Ito, Hiromi / Narimatsu, Hisashi / Hagiwara, Masahiro / Tsuruoka, Shuichi / Nagata, Michio / Yamagata, Kunihiro

Clinical and experimental nephrology

2022 Volume 26, Issue 7, Page(s) 733

Language	English
Publishing date	2022-03-18
Publishing country	Japan
Document type	Published Erratum
ZDB-ID	1338768-6
ISSN	1437-7799 ; 1342-1751
ISSN (online)	1437-7799
ISSN	1342-1751
DOI	10.1007/s10157-022-02212-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4922: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: The oxidative folding of nascent polypeptides provides electrons for reductive reactions in the ER.

Uegaki, Kaiku / Tokunaga, Yuji / Inoue, Michio / Takashima, Seiji / Inaba, Kenji / Takeuchi, Koh / Ushioda, Ryo / Nagata, Kazuhiro

Cell reports

2023 Volume 42, Issue 7, Page(s) 112742

Abstract: The endoplasmic reticulum (ER) maintains an oxidative redox environment that is advantageous for the oxidative folding of nascent polypeptides entering the ER. Reductive reactions within the ER are also crucial for maintaining ER homeostasis. However, ... ...

Abstract	The endoplasmic reticulum (ER) maintains an oxidative redox environment that is advantageous for the oxidative folding of nascent polypeptides entering the ER. Reductive reactions within the ER are also crucial for maintaining ER homeostasis. However, the mechanism by which electrons are supplied for the reductase activity within the ER remains unknown. Here, we identify ER oxidoreductin-1α (Ero1α) as an electron donor for ERdj5, an ER-resident disulfide reductase. During oxidative folding, Ero1α catalyzes disulfide formation in nascent polypeptides through protein disulfide isomerase (PDI) and then transfers the electrons to molecular oxygen via flavin adenine dinucleotide (FAD), ultimately yielding hydrogen peroxide (H
MeSH term(s)	Electrons ; Hydrogen Peroxide/metabolism ; Membrane Glycoproteins/metabolism ; Oxidation-Reduction ; Oxidoreductases/metabolism ; Protein Disulfide-Isomerases/metabolism ; Endoplasmic Reticulum/metabolism ; Peptides/metabolism ; Disulfides/metabolism ; Oxidative Stress ; Protein Folding
Chemical Substances	Hydrogen Peroxide (BBX060AN9V) ; Membrane Glycoproteins ; Oxidoreductases (EC 1.-) ; Protein Disulfide-Isomerases (EC 5.3.4.1) ; Peptides ; Disulfides
Language	English
Publishing date	2023-07-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2023.112742
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Reconstruction of a Soil Microbial Network Induced by Stress Temperature.

Yang, Dailin / Kato, Hiromi / Kawatsu, Kazutaka / Osada, Yutaka / Azuma, Toyohiro / Nagata, Yuji / Kondoh, Michio

Microbiology spectrum

2022 Volume 10, Issue 5, Page(s) e0274822

Abstract: The microbial community is viewed as a network of diverse microorganisms connected by various interspecific interactions. While the stress gradient hypothesis (SGH) predicts that positive interactions are favored in more stressful environments, the ... ...

Abstract	The microbial community is viewed as a network of diverse microorganisms connected by various interspecific interactions. While the stress gradient hypothesis (SGH) predicts that positive interactions are favored in more stressful environments, the prediction has been less explored in complex microbial communities due to the challenges of identifying interactions. Here, by applying a nonlinear time series analysis to the amplicon-based diversity time series data of the soil microbiota cultured under less stressful (30°C) or more stressful (37°C) temperature conditions, we show how the microbial network responds to temperature stress. While the genera that persisted only under the less stressful condition showed fewer positive effects, the genera that appeared only under the more stressful condition received more positive effects, in agreement with SGH. However, temperature difference also induced reconstruction of the community network, leading to an increased proportion of negative interactions at the whole-community level. The anti-SGH pattern can be explained by the stronger competition caused by increased metabolic rate and population densities.
MeSH term(s)	Soil ; Soil Microbiology ; Temperature ; Microbiota ; Microbial Consortia
Chemical Substances	Soil
Language	English
Publishing date	2022-08-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.02748-22
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Caspase-3 regulates ureteric branching in mice via cell migration.

Awazu, Midori / Yamaguchi, Yoshifumi / Nagata, Michio / Miura, Masayuki / Hida, Mariko

Biochemical and biophysical research communications

2021 Volume 559, Page(s) 28–34

Abstract: Inhibition of caspase-3 (Casp3) reduces ureteric branching in organ culture but the mechanism remains unclear. Since Casp3 has non-apoptotic functions, we examined whether Casp3 regulates ureteric branching by promoting cell migration, using a ureteric ... ...

Abstract	Inhibition of caspase-3 (Casp3) reduces ureteric branching in organ culture but the mechanism remains unclear. Since Casp3 has non-apoptotic functions, we examined whether Casp3 regulates ureteric branching by promoting cell migration, using a ureteric bud (UB) cell line and Casp3-deficient (Casp3-/-) mice. Also, we examined whether Casp3 plays a role in the reduced ureteric branching of metanephroi from nutrient restricted mothers, in which Casp3 activity is suppressed. A Casp3 inhibitor Ac-DNLD-CHO reduced FGF2-induced cord formation of UB cells in 3D culture. UB cell migration assessed by Boyden chamber and wound healing assays was inhibited by Ac-DNLD-CHO. Glomerular number was reduced by ≈ 30%, and ureteric tip number was lower in Casp3-/- mice compared with controls. Maternal nutrient restriction decreased ureteric tip number in controls but not in Casp3-/-. In conclusion, Casp3 regulates ureteric branching by promoting UB cell migration. Inhibited ureteric branching by maternal nutrient restriction may be mediated by Casp3.
MeSH term(s)	Animals ; Apoptosis ; Caspase 3/metabolism ; Cell Movement ; Cells, Cultured ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Ureter/cytology
Chemical Substances	Casp3 protein, mouse (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-)
Language	English
Publishing date	2021-04-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2021.04.081
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 116: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito