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Article ; Online: British Association of Oral and Maxillofacial Surgeons' National Facial Injury Surveys: hard tissue facial injuries presenting to UK emergency departments.

Davies, R / Hammond, D / Ridout, F / Hutchison, I / Magennis, P

The British journal of oral & maxillofacial surgery

2019 Volume 58, Issue 2, Page(s) 152–157

Abstract: The British Association of Oral and Maxillofacial Surgeons (BAOMS) and Saving Faces undertook two national prospective surveys 11 years apart. They recorded the facial injuries treated in UK emergency departments and collected data on 14872 patients. In ... ...

Abstract	The British Association of Oral and Maxillofacial Surgeons (BAOMS) and Saving Faces undertook two national prospective surveys 11 years apart. They recorded the facial injuries treated in UK emergency departments and collected data on 14872 patients. In this paper, which aims to act as a feasibility study for a third national survey of facial injuries, we have reviewed hard-tissue injuries and specifically focused on temporal changes in their morphology. The two sets of directly comparable, categorical, unpaired, cross-sectional data were evaluated independently for statistical significance. In 1997, there were 1977 hard-tissue facial injuries (33%) but in 2008 this had decreased to 1899 (22%) (p<0.05). In 1997, there were 1315 fractures (22%) and 662 dental injuries (11%) compared with 1462 (17%) fractures and 438 (5%) dental injuries in 2008 (p<0.05). There were proportional increases in orbital (21%), nasal (139%), and cranial fractures (340%) (p<0.05). The data showed a small reduction in the total number of hard-tissue injuries, but this was a considerable reduction as a proportion of the total injuries. Analysis of the type and subtype of injury generally pointed towards a reduction in their energy and severity, and to likely changes in mechanism. The project has proved the feasibility of a third national survey of facial injury.
MeSH term(s)	Cross-Sectional Studies ; Emergency Service, Hospital ; Facial Bones ; Facial Injuries ; Humans ; Maxillofacial Injuries ; Oral and Maxillofacial Surgeons ; Prospective Studies ; Skull Fractures ; United Kingdom
Language	English
Publishing date	2019-12-19
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	605685-4
ISSN	1532-1940 ; 0266-4356
ISSN (online)	1532-1940
ISSN	0266-4356
DOI	10.1016/j.bjoms.2019.11.002
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Article ; Online: Multiphoton characterization and live cell imaging using fluorescent adenine analogue 2CNqA.

Nilsson, Jesper R / Benitez-Martin, Carlos / Sansom, Henry G / Pfeiffer, Pauline / Baladi, Tom / Le, Hoang-Ngoan / Dahlén, Anders / Magennis, Steven W / Wilhelmsson, L Marcus

Physical chemistry chemical physics : PCCP

2023 Volume 25, Issue 30, Page(s) 20218–20224

Abstract: Fluorescent nucleobase analogues (FBAs) are established tools for studying oligonucleotide structure, dynamics and interactions, and have recently also emerged as an attractive option for labeling RNA-based therapeutics. A recognized drawback of FBAs, ... ...

Abstract	Fluorescent nucleobase analogues (FBAs) are established tools for studying oligonucleotide structure, dynamics and interactions, and have recently also emerged as an attractive option for labeling RNA-based therapeutics. A recognized drawback of FBAs, however, is that they typically require excitation in the UV region, which for imaging in biological samples may have disadvantages related to phototoxicity, tissue penetration, and out-of-focus photobleaching. Multiphoton excitation has the potential to alleviate these issues and therefore, in this work, we characterize the multiphoton absorption properties and detectability of the highly fluorescent quadracyclic adenine analogue 2CNqA as a ribonucleotide monomer as well as incorporated, at one or two positions, into a 16mer antisense oligonucleotide (ASO). We found that 2CNqA has a two-photon absorption cross section that, among FBAs, is exceptionally high, with values of
MeSH term(s)	Fluorescent Dyes/chemistry ; Oligonucleotides ; Spectrometry, Fluorescence/methods ; Purine Nucleosides ; Adenine/chemistry
Chemical Substances	Fluorescent Dyes ; Oligonucleotides ; Purine Nucleosides ; Adenine (JAC85A2161)
Language	English
Publishing date	2023-08-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp01147j
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Article ; Online: United Kingdom immigration and emigration of oral and maxillofacial Surgery (OMFS) specialists 2000-2020: how might Brexit impact on OMFS?

Magennis, P / Begley, A / Hölzle, F / Ulrich, H P / Brennan, P A / Hutchison, I

The British journal of oral & maxillofacial surgery

2020 Volume 58, Issue 10, Page(s) 1304–1309

Abstract: ... of current OMFS colleagues. Data were analysed using WinStat® (R. Fitch Software). Of 494 active surgeons ...

Abstract	The United Kingdom left the European Union (EU) in January 2020. As it is unclear how many of the rights of OMFS surgeons to travel and work will remain after the transition period, we have reviewed how these rights have been used in the past. The OMFS specialist list from the GMC was compared with a database of current OMFS colleagues. Data were analysed using WinStat® (R. Fitch Software). Of 494 active surgeons on the OMFS specialist list, 23 (5%) completed their OMFS training outside the UK. Of these, 22 were specialists from Europe of whom 12 were substantive NHS consultants with others working as Fellows or visiting the UK occasionally. Two per cent of UK OMFS consultants are -specialists from Europe, the majority from Greece. Of the OMFS specialists who completed training in the UK since 1995, 24 are currently working outside the UK, and of them, 16 left the UK to return to their nation of origin (all 11 of those working in the European Economic Area [EEA] were born there). Of the seven UK-born specialists working overseas, none was working in the EEA. Twenty per cent of UK trainees whose primary degree was known (n = 117) received their primary qualification outside the UK, 38 in from the EU, and 79 from further afield. The majority of these UK trained specialists with non-UK first degrees (n = 101) stayed in the UK to work after training. The most significant impact of Brexit on OMFS could be a restriction on the opportunity for non-UK doctors and dentists to come to the UK to train and stay to work.
MeSH term(s)	Emigration and Immigration ; European Union ; Humans ; Specialization ; Surgery, Oral ; United Kingdom
Language	English
Publishing date	2020-10-01
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	605685-4
ISSN	1532-1940 ; 0266-4356
ISSN (online)	1532-1940
ISSN	0266-4356
DOI	10.1016/j.bjoms.2020.09.030
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Article ; Online: The future of OMFS lies in creating pathways to implement the PMETB recommendations and inspiring our trainees. Enough time has been spent debating, we need to deliver!: Re: Newman L, Brown J, Kerawala C, et al. Our specialty. The future. Is the writing on the wall? Br J Oral Maxillofac Surg 2020 (online ahead of print).

Bentley, R / Parmar, S / Smith, A / Dhariwal, D K / Banks, R / Keith, D / Brennan, P A / Magennis, P

The British journal of oral & maxillofacial surgery

2020 Volume 58, Issue 10, Page(s) 1351–1352

Abstract: The British Association of Oral and Maxillofacial Surgeons (BAOMS) has been at the centre of the transition of our specialty in the UK from a branch of dentistry to one of the 10 UK surgical specialties. In this role it has, at different times, pushed ... ...

Abstract	The British Association of Oral and Maxillofacial Surgeons (BAOMS) has been at the centre of the transition of our specialty in the UK from a branch of dentistry to one of the 10 UK surgical specialties. In this role it has, at different times, pushed boundaries against resistance from other specialties, and redirected the ambitions of the deputy chair of the Postgraduate Medical Education and Training Board (PMETB) review to produce recommendations that were exactly what OMFS needed. The editorial Our specialty. The future. Is the writing on the wall? is just the most recent iteration of half a century of internal debate. Whilst there are some issues with how the authors have presented recruitment data (their figures omit ST1 run-through and do not recognise that the same single, unfilled post may be present for two or more national selection rounds) their first paragraph A debate that we feel is long overdue presents the greatest concern. In this short communication, we illustrate that in the last 20 years the specialty has not been short of debate. In the absence of new and specific evidence that any other route forward would be supported by our national training committee (OMFS SAC), our regulator (GMC), the breadth of our specialty (including our current specialists and our current and future trainees) and, most importantly, would actually address our problems, we should avoid putting energy into an empty debate. Our focus should be on delivering the PMETB recommendations and inspiring our future trainees.
MeSH term(s)	Education, Medical ; Humans ; Oral and Maxillofacial Surgeons ; Surgery, Oral ; Surveys and Questionnaires ; United Kingdom ; Writing
Language	English
Publishing date	2020-08-15
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	605685-4
ISSN	1532-1940 ; 0266-4356
ISSN (online)	1532-1940
ISSN	0266-4356
DOI	10.1016/j.bjoms.2020.08.010
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Article ; Online: Changing the Oral and Maxillofacial Surgery (OMFS) training pathway in the United Kingdom - an illustrative retrospective.

Magennis, P / Begley, A / Brennan, P A / Parmar, S / Keith, D J W / Banks, R J / Bentley, R / Smith, A

The British journal of oral & maxillofacial surgery

2020 Volume 58, Issue 10, Page(s) 1261–1267

Abstract: OMFS training is perceived as a long and expensive pathway although papers have shown it compares favourably with other surgical specialties. Every OMFS clinician has a vested interest and duty continually to improve the quality of training and minimise ... ...

Abstract	OMFS training is perceived as a long and expensive pathway although papers have shown it compares favourably with other surgical specialties. Every OMFS clinician has a vested interest and duty continually to improve the quality of training and minimise costs, especially to trainees at junior levels. Any serious proposal to fundamentally change the format of training, must be given due consideration by all stakeholders. In 2016, a British Medical Journal article whose authors included the BAOMS President of that year and OMFS Specialty Advisory Committee (SAC) Chair, posed the question - should the future of OMFS training revert to single dental degree, change to single medical degree - or continue as a dual degree specialty? The BMJ publication was discussed at the British Association of Oral and Maxillofacial Surgeons (BAOMS) Council in March 2016 and all present unanimously supported the dual degree pathway. Later that year a formal proposal was made by the BAOMS immediate past President that training in the UK change to single medical degree 'Maxillofacial Surgery' similar to the training in Spain, France or Italy. Evidence around the risks and benefits of making this change to OMFS training was assembled and reviewed by BAOMS Council in March 2017. BAOMS Council once again unanimously supported continuing OMFS as a dual degree specialty with the observation that the quality of patient care which this training provided was the specialty's Unique Selling Point or USP. The requirement for both degrees to provide care for OMFS patients had been confirmed by external scrutiny on two separate occasions by the responsible regulators. In this paper, we outline the key steps to be considered when making major changes in the OMFS training pathways using this event as an example and the suggestion that those proposing changes should assemble and present evidence to support their proposal using the template provided.
MeSH term(s)	Humans ; Italy ; Oral and Maxillofacial Surgeons ; Retrospective Studies ; Surgery, Oral ; United Kingdom
Language	English
Publishing date	2020-08-03
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	605685-4
ISSN	1532-1940 ; 0266-4356
ISSN (online)	1532-1940
ISSN	0266-4356
DOI	10.1016/j.bjoms.2020.07.037
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Article ; Online: A new twist on PIFE: photoisomerisation-related fluorescence enhancement.

Ploetz, Evelyn / Ambrose, Benjamin / Barth, Anders / Börner, Richard / Erichson, Felix / Kapanidis, Achillefs N / Kim, Harold D / Levitus, Marcia / Lohman, Timothy M / Mazumder, Abhishek / Rueda, David S / Steffen, Fabio D / Cordes, Thorben / Magennis, Steven W / Lerner, Eitan

ArXiv

2023

Abstract: PIFE was first used as an acronym for protein-induced fluorescence enhancement, which refers to the increase in fluorescence observed upon the interaction of a fluorophore, such as a cyanine, with a protein. This fluorescence enhancement is due to ... ...

Abstract	PIFE was first used as an acronym for protein-induced fluorescence enhancement, which refers to the increase in fluorescence observed upon the interaction of a fluorophore, such as a cyanine, with a protein. This fluorescence enhancement is due to changes in the rate of cis/trans photoisomerisation. It is clear now that this mechanism is generally applicable to interactions with any biomolecule and, in this review, we propose that PIFE is thereby renamed according to its fundamental working principle as photoisomerisation-related fluorescence enhancement, keeping the PIFE acronym intact. We discuss the photochemistry of cyanine fluorophores, the mechanism of PIFE, its advantages and limitations, and recent approaches to turn PIFE into a quantitative assay. We provide an overview of its current applications to different biomolecules and discuss potential future uses, including the study of protein-protein interactions, protein-ligand interactions and conformational changes in biomolecules.
Language	English
Publishing date	2023-07-10
Publishing country	United States
Document type	Preprint
ISSN	2331-8422
ISSN (online)	2331-8422
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Article ; Online: A new twist on PIFE: photoisomerisation-related fluorescence enhancement.

Methods and applications in fluorescence

2023 Volume 12, Issue 1

Abstract	PIFE was first used as an acronym for protein-induced fluorescence enhancement, which refers to the increase in fluorescence observed upon the interaction of a fluorophore, such as a cyanine, with a protein. This fluorescence enhancement is due to changes in the rate of
MeSH term(s)	DNA/chemistry ; Proteins/chemistry ; Fluorescence Resonance Energy Transfer
Chemical Substances	DNA (9007-49-2) ; Proteins
Language	English
Publishing date	2023-10-12
Publishing country	England
Document type	Journal Article ; Review
ISSN	2050-6120
ISSN (online)	2050-6120
DOI	10.1088/2050-6120/acfb58
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Article: Great expectations: a critical assessment of the managed care industry.

Magennis, R

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

1999 Volume 89, Issue 4, Page(s) 382–383

MeSH term(s)	Delivery of Health Care/economics ; Delivery of Health Care/standards ; Delivery of Health Care/trends ; Drug Prescriptions/standards ; Humans ; Insurance, Health/economics ; Managed Care Programs/economics ; Managed Care Programs/organization & administration ; Patient Care/standards ; Physician's Role
Language	English
Publishing date	1999-04
Publishing country	South Africa
Document type	Journal Article
ZDB-ID	390968-2
ISSN	2078-5135 ; 0256-9574 ; 0038-2469
ISSN (online)	2078-5135
ISSN	0256-9574 ; 0038-2469
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Article ; Online: Making Silicone Rubber Highly Resistant to Bacterial Attachment Using Thiol-ene Grafting.

Magennis, E Peter / Hook, Andrew L / Williams, Paul / Alexander, Morgan R

ACS applied materials & interfaces

2016 Volume 8, Issue 45, Page(s) 30780–30787

Abstract: Biomedical devices are indispensable in modern medicine yet offer surfaces that promote bacterial attachment and biofilm formation, resulting in acute and chronic healthcare-associated infections. We have developed a simple method to graft acrylates to ... ...

Abstract	Biomedical devices are indispensable in modern medicine yet offer surfaces that promote bacterial attachment and biofilm formation, resulting in acute and chronic healthcare-associated infections. We have developed a simple method to graft acrylates to silicone rubber, polydimethylsiloxane (PDMS), a commonly used device material that is often colonized by bacteria. We demonstrate a novel method whereby nontoxic bacteria attachment-resistant polymers can be readily grafted from and grafted to the surface using thiol-ene chemistry, substantially reducing bacterial colonization. With use of this approach, bacterial biofilm coverage can be reduced by 99% compared with standard PDMS in an in vitro assay. This grafting approach offers significant advantages over commonly used physisorbed coatings, especially in areas of high shear or mechanical stress. Furthermore, the approach is versatile such that the grafted material properties can be tailored for the desired final application.
MeSH term(s)	Bacteria ; Biofilms ; Silicone Elastomers/chemistry ; Sulfhydryl Compounds
Chemical Substances	Silicone Elastomers ; Sulfhydryl Compounds
Language	English
Publishing date	2016-11-02
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.6b10986
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Article ; Online: Metallation-Induced Heterogeneous Dynamics of DNA Revealed by Single-Molecule FRET.

Berrocal-Martin, Raul / Sanchez-Cano, Carlos / Chiu, Cookson K C / Needham, Russell J / Sadler, Peter J / Magennis, Steven W

Chemistry (Weinheim an der Bergstrasse, Germany)

2020 Volume 26, Issue 22, Page(s) 4980–4987

Abstract: The metallation of nucleic acids is key to wide-ranging applications, from anticancer medicine to nanomaterials, yet there is a lack of understanding of the molecular-level effects of metallation. Here, we apply single-molecule fluorescence methods to ... ...

Abstract	The metallation of nucleic acids is key to wide-ranging applications, from anticancer medicine to nanomaterials, yet there is a lack of understanding of the molecular-level effects of metallation. Here, we apply single-molecule fluorescence methods to study the reaction of an organo-osmium anticancer complex and DNA. Individual metallated DNA hairpins are characterised using Förster resonance energy transfer (FRET). Although ensemble measurements suggest a simple two-state system, single-molecule experiments reveal an underlying heterogeneity in the oligonucleotide dynamics, attributable to different degrees of metallation of the GC-rich hairpin stem. Metallated hairpins display fast two-state transitions with a two-fold increase in the opening rate to ≈2 s
MeSH term(s)	Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; DNA/chemistry ; DNA/metabolism ; Fluorescence ; Fluorescence Resonance Energy Transfer ; Nanotechnology ; Nucleic Acid Conformation
Chemical Substances	Antineoplastic Agents ; DNA (9007-49-2)
Language	English
Publishing date	2020-03-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202000458
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