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Article ; Online: Cleft Laterality Dental Arch Relationship Outcomes for Children with Unilateral Cleft Lip and Palate in New Zealand.

Fowler, Peter V / Keall, H / Kennedy, D / Healey, D / Thompson, J M D

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2024 , Page(s) 10556656241234599

Abstract: Objectives: To investigate cleft laterality dental arch relationship outcomes of children with non-syndromic complete unilateral cleft lip and palate (UCLP) in New Zealand.: Design: A retrospective nationwide study.: Settings: Virtual 3D ... ...

Abstract	Objectives: To investigate cleft laterality dental arch relationship outcomes of children with non-syndromic complete unilateral cleft lip and palate (UCLP) in New Zealand. Design: A retrospective nationwide study. Settings: Virtual 3D orthodontic study models collected prior to undertaking secondary alveolar bone grafting. Participants: A total of 104 patients with UCLP (L = 80: R = 24). Outcome measures: Four calibrated assessors used the GOSLON Yardstick and 100 mm Visual Analogue Scale (VAS) to score the randomised models on 2 separate assessment sessions. Weighted Kappa were used to determine the intra/inter-rater reliability for the GOSLON and correlations for the VAS. Results: Intra-rater reliability ranged from 0.57-0.88 (GOSLON) and 0.45-0.93 (VAS). Inter-rater reliability ranged from 0.62-0.86 (GOSLON) and 0.64-0.93 (VAS).GOSLON scores for the left UCLP were 31.2% for good/very good; 26.3% for fair; 42.5% for poor/very poor while the right UCLP scored 8.3% for good/very good; 37.5% for fair; 54.2% for poor/very poor. The mean VAS for left and right UCLP were 53.4 (sd 22.5) and 44.6 (sd 17.1) respectively. Neither the GOSLON nor VAS differences reached statistical significance (both Conclusions: From a clinical perspective right UCLP had worse dental arch relationship outcomes, however, these differences failed to reach statistical significance. Further studies using larger sample sizes are required to determine if cleft laterality is an important consideration when investigating UCLP dental arch outcomes.
Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1069409-2
ISSN	1545-1569 ; 0009-8701 ; 1055-6656
ISSN (online)	1545-1569
ISSN	0009-8701 ; 1055-6656
DOI	10.1177/10556656241234599
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Zs.A 451: Show issues

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Article ; Online: Small-for-size syndrome in a 9.7 kg pediatric recipient with a whole liver graft.

Maria, Haytham / Valentino, Pamela L / Healey, Patrick J / Kwon, Yong K

Pediatric transplantation

2024 Volume 28, Issue 2, Page(s) e14716

Abstract: Background: Small-for-size syndrome (SFSS) in pediatric liver transplant recipients, particularly those weighing less than 10 kg, is rare. This report describes a case of a 15-month-old whole liver transplant recipient who suffered SFSS, and systematic ... ...

Abstract	Background: Small-for-size syndrome (SFSS) in pediatric liver transplant recipients, particularly those weighing less than 10 kg, is rare. This report describes a case of a 15-month-old whole liver transplant recipient who suffered SFSS, and systematic literature review was performed to identify outcomes of such cases and potential risk factors for SFSS. Case presentation: A 15-month-old toddler with a history of biliary atresia underwent a deceased donor whole liver transplant. The graft weighed 160 g, resulting in a graft-to-recipient weight ratio (GRWR) of 1.6%. The post-operative course was complicated by SFSS, characterized by massive ascites causing hemodynamic instability and compromised hepatic artery flow. Pharmacological intervention with octreotide was initiated, and the patient eventually recovered. Conclusion: In small pediatric recipients, especially those weighing less than 10 kg, the native liver body weight ratio (LBWR) is significantly higher. When selecting an appropriately sized graft for these recipients, this higher ratio should be taken into consideration. The literature review suggests that a GRWR of less than 2% is associated with a higher incidence of small-for-size syndrome in small pediatric recipients weighing less than 10 kg.
MeSH term(s)	Humans ; Child ; Infant ; Living Donors ; Organ Size ; Liver Transplantation/methods ; Liver ; End Stage Liver Disease ; Syndrome ; Graft Survival ; Retrospective Studies
Language	English
Publishing date	2024-02-28
Publishing country	Denmark
Document type	Review ; Case Reports
ZDB-ID	1390284-2
ISSN	1399-3046 ; 1397-3142
ISSN (online)	1399-3046
ISSN	1397-3142
DOI	10.1111/petr.14716
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Article ; Online: Frequency and Clinical Utility of Alerts for Intra-Institutional Radiologist Discrepant Opinions.

DiPiro, Pamela J / Licaros, Andro / Zhao, Anna H / Glazer, Daniel I / Healey, Michael J / Curley, Patrick J / Giess, Catherine S / Khorasani, Ramin

Journal of the American College of Radiology : JACR

2023 Volume 20, Issue 4, Page(s) 431–437

Abstract: Objective: Determine the rate of documented notification, via an alert, for intra-institutional discrepant radiologist opinions and addended reports and resulting clinical management changes.: Methods: This institutional review board-exempt, ... ...

Abstract	Objective: Determine the rate of documented notification, via an alert, for intra-institutional discrepant radiologist opinions and addended reports and resulting clinical management changes. Methods: This institutional review board-exempt, retrospective study was performed at a large academic medical center. We defined an intra-institutional discrepant opinion as when a consultant radiologist provides a different interpretation from that formally rendered by a colleague at our institution. We implemented a discrepant opinion policy requiring closed-loop notification of the consulting radiologist's second opinion to the original radiologist, who must acknowledge this alert within 30 days. This study included all discrepant opinion alerts created December 1, 2019, to December 31, 2021, of which two radiologists and an internal medicine physician performed consensus review. Primary outcomes were degree of discrepancy and percent of discrepant opinions leading to change in clinical management. Secondary outcome was report addendum rate compared with an existing peer learning program using Fisher's exact test. Results: Of 114 discrepant opinion alerts among 1,888,147 reports generated during the study period (0.006%), 58 alerts were categorized as major (50.9%), 41 as moderate (36.0%), and 15 as minor discrepancies (13.1%). Clinical management change occurred in 64 of 114 cases (56.1%). Report addendum rate for discrepant opinion alerts was 4-fold higher than for peer learning alerts at our institution (66 of 315 = 21% versus 432 of 8,273 =5.2%; P < .0001). Discussion: Although discrepant intra-institutional radiologist second opinions were rare, they frequently led to changes in clinical management. Capturing these discrepancies by encouraging alert use may help optimize patient care and document what was communicated to the referring or consulting care team by consulting radiologists.
MeSH term(s)	Humans ; Retrospective Studies ; Radiologists ; Referral and Consultation ; Academic Medical Centers
Language	English
Publishing date	2023-02-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2274861-1
ISSN	1558-349X ; 1546-1440
ISSN (online)	1558-349X
ISSN	1546-1440
DOI	10.1016/j.jacr.2022.12.021
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Article ; Online: A Systematic Review of Glaucoma Diagnosis in Prevalence Studies and Quality of Reporting.

Al-Timimi, Zayn / Huang-Lung, Jessie / Keay, Lisa / Healey, Paul / Yang, Eleanor / Dunn, Hamish

Journal of glaucoma

2023 Volume 32, Issue 10, Page(s) 874–884

Abstract: Prcis: This systematic review has revealed that variable definitions of glaucoma continue to be used in prevalence studies, despite the introduction of the International Society of Geographic and Epidemiologic Ophthalmology (ISGEO) criteria.: Purpose!# ...

Abstract	Prcis: This systematic review has revealed that variable definitions of glaucoma continue to be used in prevalence studies, despite the introduction of the International Society of Geographic and Epidemiologic Ophthalmology (ISGEO) criteria. Purpose: To systematically review diagnostic criteria and examinations performed in glaucoma prevalence studies over time and determine the quality of reporting. Accurate estimates of glaucoma prevalence are crucial to inform resource allocation. However, diagnosis of glaucoma comprises inherently subjective examinations and the cross-sectional nature of prevalence studies precludes monitoring for progression. Methods: A systematic review of PubMed, Embase, Web of Science, and Scopus was performed to examine diagnostic protocols used by glaucoma prevalence studies and evaluate uptake of the ISGEO criteria, introduced in 2002 to standardize glaucoma diagnosis in prevalence studies. Detection bias and compliance with the Strengthening Reporting of Observational Studies in Epidemiology (STROBE) guidelines were evaluated. Results: Ten thousand five hundred forty-four articles were identified. After deduplication, 5589 articles were screened, yielding 136 articles pertaining to 123 studies. An absence of data in many countries was identified. Ninety-two percent of studies stated diagnostic criteria, and 62% used the ISGEO criteria since their publication. Weaknesses of the ISGEO criteria were identified. Temporal variations in the performance of various examinations were observed, including heterogeneity in angle assessment. Mean STROBE compliance was 82% (range 59-100%); 72 articles had a low risk of detection bias, 4 had a high risk, and 60 had some concerns. Conclusion: Heterogeneous diagnostic definitions persist in glaucoma prevalence studies, despite introduction of the ISGEO criteria. Standardization of criteria remains imperative and the development of new criteria represent a valuable opportunity to achieve this goal. In addition, methods of determining diagnoses are poorly reported, suggesting a need for improvement in study conduct and reporting. Accordingly, we propose the Reporting of quality Of GlaUcoma Epidemiological Studies (ROGUES) Checklist. We have also identified a need for further prevalence studies in regions with limited data and to update Australian angle closure glaucoma prevalence. Design and reporting of future studies can be informed by this review's insights into diagnostic protocols previously used.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Intraocular Pressure ; Australia ; Glaucoma/diagnosis ; Glaucoma/epidemiology ; Glaucoma, Angle-Closure ; Prevalence
Language	English
Publishing date	2023-06-27
Publishing country	United States
Document type	Systematic Review ; Journal Article
ZDB-ID	913494-3
ISSN	1536-481X ; 1057-0829
ISSN (online)	1536-481X
ISSN	1057-0829
DOI	10.1097/IJG.0000000000002248
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Zs.A 3795: Show issues

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Article: Complementary Effects of Surgery and Pexidartinib in the Management of Patients with Complex Diffuse-Tenosynovial Giant Cell Tumor.

Bernthal, Nicholas M / Randall, R Lor / Zeitlinger, Lauren N / Geiger, Erik J / Healey, John H

Case reports in orthopedics

2022 Volume 2022, Page(s) 7768764

Abstract: Tenosynovial giant cell tumor (TGCT) is a rare neoplasm of the joint synovium that has a wide clinical spectrum including pain and stiffness in the affected joint, joint swelling, periarticular erosions, and cartilage loss, which can severely impact ... ...

Abstract	Tenosynovial giant cell tumor (TGCT) is a rare neoplasm of the joint synovium that has a wide clinical spectrum including pain and stiffness in the affected joint, joint swelling, periarticular erosions, and cartilage loss, which can severely impact quality of life. The mainstay treatment for TGCT has been surgery involving partial or total synovectomy using arthroscopic or open techniques. However, surgical resection alone is associated with high recurrence rates, particularly in diffuse-TGCT (D-TGCT) cases. The 3 cases presented here summarize a combination approach (surgery+pexidartinib [tyrosine kinase inhibitor]) in patients with previously unresectable or inoperable D-TGCT.
Language	English
Publishing date	2022-12-03
Publishing country	United States
Document type	Case Reports
ZDB-ID	2684648-2
ISSN	2090-6757 ; 2090-6749
ISSN (online)	2090-6757
ISSN	2090-6749
DOI	10.1155/2022/7768764
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Article: Genetic analysis of

Treleven, Charles R / Kishe, Mary A / Silas, Mathew O / Ngatunga, Benjamin P / Kuboja, Bigeyo N / Mgeleka, Said S / Taylor, Amy L / Elsmore, Megan A M / Healey, Amy J E / Sauer, Warwick H H / Shaw, Paul W / McKeown, Niall J

Ecology and evolution

2024 Volume 14, Issue 4, Page(s) e11205

Abstract: ... Octopus ... ...

Abstract	Octopus cyanea
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2635675-2
ISSN	2045-7758
ISSN	2045-7758
DOI	10.1002/ece3.11205
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Book ; Online: Experts prefer text but videos help novices

Song, Hayeong / Healey, Jennifer / Siu, Alexa / Wigington, Curtis / Stasko, John

an analysis of the utility of multi-media content

2023

Abstract: Multi-media increases engagement and is increasingly prevalent in online content including news, web blogs, and social media, however, it may not always be beneficial to users. To determine what types of media users actually wanted, we conducted an ... ...

Abstract	Multi-media increases engagement and is increasingly prevalent in online content including news, web blogs, and social media, however, it may not always be beneficial to users. To determine what types of media users actually wanted, we conducted an exploratory study where users got to choose their own media augmentation. Our findings showed that users desired different amounts and types of media depending on their familiarity with the content. To further investigate this difference, we created two versions of a media augmented document, one designed for novices and one designed for experts. We evaluated these prototypes in a two-way between-subject study with 48 participants and found that while multi-media enhanced novice readers' perception of usability (p = .0100) and helped them with reading time (p = .0427), time on task (p= .0156), comprehension (p = .0161), experts largely ignored multi-media and primarily utilized text. Comment: in CHI'23 Extended Abstracts on Human Factors in Computing Systems, 2023
Keywords	Computer Science - Human-Computer Interaction ; Computer Science - Multimedia
Subject code	070
Publishing date	2023-04-23
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Adolescent intermittent ethanol (AIE) produces lasting, sex-specific changes in rat body fat independent of changes in white blood cell composition.

Vore, Andrew S / Marsland, Paige / Barney, Thaddeus M / Varlinskaya, Elena I / Landin, Justine D / Healey, Kati L / Kibble, Sandra / Swartzwelder, H S / Chandler, Lawrence J / Deak, Terrence

Frontiers in physiology

2024 Volume 15, Page(s) 1285376

Abstract: Early initiation of alcohol use during adolescence, and adolescent binge drinking are risk factors for the development of alcohol use disorder later in life. Adolescence is a time of rapid sex-dependent neural, physiological, and behavioral changes as ... ...

Abstract	Early initiation of alcohol use during adolescence, and adolescent binge drinking are risk factors for the development of alcohol use disorder later in life. Adolescence is a time of rapid sex-dependent neural, physiological, and behavioral changes as well as a period of heightened vulnerability to many effects of alcohol. The goal of the present studies was to determine age-related changes in blood (leukocyte populations) and body composition across adolescence and early adulthood, and to investigate whether adolescent intermittent ethanol (AIE) exposure would alter the trajectory of adolescent development on these broad physiological parameters. We observed significant ontogenetic changes in leukocyte populations that were mirrored by an age-related increase in cytokine expression among mixed populations of circulating leukocytes. Despite these developmental changes, AIE did not significantly alter overall leukocyte numbers or cytokine gene expression. However, AIE led to sex-specific changes in body fat mass and fat percentage, with AIE-exposed male rats showing significantly decreased fat levels and female rats showing significantly increased fat levels relative to controls. These changes suggest that while AIE may not alter overall leukocyte levels, more complex phenotypic changes in leukocyte populations could underlie previously reported differences in cytokine expression. Coupled with long-term shifts in adipocyte levels, this could have long-lasting effects on innate immunity and the capacity of individuals to respond to later immunological and physiological threats.
Language	English
Publishing date	2024-01-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2024.1285376
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Article ; Online: Finding meaning and purpose: a framework for the self-management of neurological conditions.

Kılınç, Stephanie / Erdem, Hannah / Healey, Rebecca / Cole, Joanne

Disability and rehabilitation

2020 Volume 44, Issue 2, Page(s) 219–230

Abstract: Purpose: Self-management has been proposed as the way forward in improving health outcomes for people with neurological conditions; yet the experience and meaning of self-management for people with neurological conditions has rarely been focused on ... ...

Abstract	Purpose: Self-management has been proposed as the way forward in improving health outcomes for people with neurological conditions; yet the experience and meaning of self-management for people with neurological conditions has rarely been focused on specifically. The current study addressed the question, what is the experience of self-managing a neurological condition? A secondary aim was to examine the feasibility of exploring self-management across neurological conditions. Materials and methods: A qualitative, phenomenological approach was adopted, which recognised service users as the experts on their conditions. Data-prompted interviews, using scrapbooks, were conducted with eight people with various neurological conditions, residing in the north-east of England. Results: Interpretative phenomenological analysis (IPA) identified two key themes. Theme one, "meaning and purpose," identified achieving meaning and purpose in life as central to the self-management experience. It comprised five sub-themes (what is important to me; me and my condition; embracing my body; connecting with others; taking charge) which represented areas that could influence finding meaning and purpose. Theme two, "finding the new normal," emphasised the centrality of reflection in an ongoing self-management process. Conclusions: The findings form the basis of a proposed framework for the self-management of neurological conditions which could inform practice and be developed into a self-management tool.IMPLICATIONS FOR REHABILITATIONSelf-management is an ongoing process requiring continuous reflection.A positive psychology approach to self-management can support people to find meaning and purpose in life.This framework could be adapted into a self-management tool for people with neurological conditions.This self-management framework can be applied across neurological conditions.
MeSH term(s)	England ; Humans ; Nervous System Diseases/therapy ; Qualitative Research ; Self-Management
Language	English
Publishing date	2020-05-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1104775-6
ISSN	1464-5165 ; 0963-8288
ISSN (online)	1464-5165
ISSN	0963-8288
DOI	10.1080/09638288.2020.1764115
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Article ; Online: The first international roundtable on "organ donation after circulatory death by medical assistance in dying" demonstrates increasing incidence of successful patient-driven procedure.

Mulder, Johannes / Sonneveld, Hans / Healey, Andrew / Van Raemdonck, Dirk

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2021 Volume 22, Issue 3, Page(s) 999–1000

MeSH term(s)	Brain Death ; Death ; Humans ; Incidence ; Medical Assistance ; Organ Transplantation/methods ; Tissue Donors ; Tissue and Organ Procurement
Language	English
Publishing date	2021-11-06
Publishing country	United States
Document type	Letter
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.16879
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