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Book ; Online: Diatomeen in der Eembohrung Klixb?ller Koog, supplementary data to: Dittmer, Ernst; K?nig, D (1954): Eine eemzeitliche Austernbank bei Leck und die Entwicklung des Ober-Eems. Meyniana, 2, 70-80

Dittmer, Ernst / K?nig, D

2011

Abstract: Im Herbst 1952 wurde auf der Baustelle des Sch?pfwerkes Klixb?ller Koog, etwa 3 km westlich von Leck, bei der Errichtung einer Grundwasserabsenkungsanlage ein neues Eemvorkommen aufgeschlossen. Es ist hinsichtlich seiner petrographischen Ausbildung, ... ...

Abstract	Im Herbst 1952 wurde auf der Baustelle des Sch?pfwerkes Klixb?ller Koog, etwa 3 km westlich von Leck, bei der Errichtung einer Grundwasserabsenkungsanlage ein neues Eemvorkommen aufgeschlossen. Es ist hinsichtlich seiner petrographischen Ausbildung, seiner Lagerungsverh?ltnisse und seines Fossilinhalts besonders bemerkenswert und f?r die Entwicklungsgeschichte des oberen Eems von gro?er Bedeutung.
Language	English
Dates of publication	2011-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to doi:10.2312/meyniana.1954.2.70
DOI	10.1594/PANGAEA.769756
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: National resident survey in dermatopathology: The role of slide scanners in resident learning.

Rinck, Danielle / Dittmer, Martin / Tinker, Daniel / Smith, Kristin / Heinecke, Gillian

Journal of cutaneous pathology

2023 Volume 50, Issue 12, Page(s) 1078–1082

Abstract: Background: Dermatology residents gain exposure to dermatopathology through a variety of educational modalities. While virtual pathology applications have risen dramatically, resident utilization of digital libraries, slide scanner availability, and ... ...

Abstract	Background: Dermatology residents gain exposure to dermatopathology through a variety of educational modalities. While virtual pathology applications have risen dramatically, resident utilization of digital libraries, slide scanner availability, and comfort with virtual slides are not well-known. This study aims to assess the current landscape of educational resources used by dermatology residents. Methods: A 17-question survey was sent to dermatology residents through a national email database. The survey was a self-assessment of their experience in dermatopathology education and the use of departmental slide scanners. Results: The use of digital dermatopathology is high among trainees, despite only half of respondents reporting slide scanner access. Residents report using virtual images more often in non-clinical dermatopathology didactics and independent studies compared to clinical dermatopathology rotations. Public slide set use was common, while professional society and departmental slide sets may be underutilized. Over half of respondents report being extremely or very comfortable navigating interactive scanned slides. Conclusions: Survey data suggests digital slides are currently predominantly used in non-clinical dermatopathology rotations and independent studies. Incorporation of slide scanners into departments may benefit resident education through the development of high-quality, curated departmental slide sets.
MeSH term(s)	Humans ; Internship and Residency ; Surveys and Questionnaires
Language	English
Publishing date	2023-09-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	187078-6
ISSN	1600-0560 ; 0303-6987
ISSN (online)	1600-0560
ISSN	0303-6987
DOI	10.1111/cup.14538
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Article ; Online: Contributions, missed opportunities, and future directions: A critical reflection on global climate change and environmental sustainability in AJCP over five decades.

Dittmer, Livia D / Reimer-Watts, Kai / Dobai, Jennifer / Riemer, Manuel

American journal of community psychology

2023 Volume 72, Issue 3-4, Page(s) 288–301

Abstract: In this contribution to the 50th Anniversary Special Issue, the authors consider how global climate change and environmental sustainability have been addressed in the American Journal of Community Psychology (AJCP) over the last five decades. As we are ... ...

Abstract	In this contribution to the 50th Anniversary Special Issue, the authors consider how global climate change and environmental sustainability have been addressed in the American Journal of Community Psychology (AJCP) over the last five decades. As we are increasingly exceeding critical planetary boundaries (global climate change, biodiversity loss, land degradation, etc.) with disastrous impacts on human well-being-especially for peoples already marginalized-it is timely to consider the treatment of environmental issues in the history of the AJCP and in community psychology more broadly. This review of relevant articles is clustered into three topics derived from our critical understanding of the articles themselves: (a) public participation and power; (b) community-level responses to environmental change, including its disproportionate impacts on marginalized groups; and (c) frameworks and worldviews that integrate the natural world as necessary context for research and action. The commentary on the featured articles is framed in terms of their key contributions, missed opportunities up to this point, and future directions for the field. While looking back at the past 50 years, the authors also have an eye to the years ahead and what work can be done to mitigate the harms of climate change, adapt to the emerging new environmental reality, and promote just and inclusive sustainabilities worldwide.
MeSH term(s)	Humans ; United States ; Climate Change ; Forecasting ; Community Participation
Language	English
Publishing date	2023-11-05
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	222658-3
ISSN	1573-2770 ; 0091-0562
ISSN (online)	1573-2770
ISSN	0091-0562
DOI	10.1002/ajcp.12720
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Article: Undetectable vitamin D

Azarpeykan, Sara / Gee, Erica K / Thompson, Keith G / Dittmer, Keren E

Journal of equine science

2022 Volume 33, Issue 3, Page(s) 45–49

Abstract: Vitamin D requirements for most animals are expected to be fulfilled through daily exposure ... of the skin to solar ultraviolet B radiation. The synthesis of vitamin D ...

Abstract	Vitamin D requirements for most animals are expected to be fulfilled through daily exposure of the skin to solar ultraviolet B radiation. The synthesis of vitamin D
Language	English
Publishing date	2022-09-21
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2038890-1
ISSN	1347-7501 ; 1340-3516
ISSN (online)	1347-7501
ISSN	1340-3516
DOI	10.1294/jes.33.45
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Article ; Online: Enzootic calcinosis in Toggenburg goats in New Zealand.

Brown, S E / Collett, M G / Matthews, Z M / Marshall, J C / Dittmer, K E

New Zealand veterinary journal

2023 Volume 72, Issue 1, Page(s) 45–52

Abstract: ... Concentrations of calcium, phosphorus, 25-hydroxyvitamin D: Vegetation survey: All paddocks on the property ... perpendicularly to form a grid. No known calcinogenic species were identified. Known plant sources of vitamin D ... vitamin D toxicosis of non-plant origin. ...

Abstract	Case history: Necropsies on Toggenburg goats culled from a small farm in the Manawatū district of New Zealand, performed at Massey University (Palmerston North, NZ) over a period of 29 years (1991-2019), revealed soft tissue mineralisation, particularly of cardiovascular tissues. The farm spans 10 acres and runs between 15 and 30 Toggenburg goats. The goats are predominantly on pasture comprising a variety of types. Pathological findings: Necropsies were performed on all adult goats (n = 45) that died or were euthanised. Histopathology was performed on 42 goats (93%), of which 33 (73%) included sufficient tissues diagnostically relevant to soft tissue mineralisation. The most significant gross findings were in various arteries, with the aorta most commonly affected, followed by the heart and lungs. The aortic intima showed prominent, multifocal to coalescing, raised, wrinkled, white plaques. Microscopically there were multiphasic lesions of mineralisation, chondroid, and osseous metaplasia in the elastic arteries, aorta, heart and lungs. A lumbar vertebra from one goat had prominent, basophilic, fibrillar, tangled matrix lining Haversian canals and lamellae. Laboratory findings: Blood samples were collected from 15 adult goats in the affected herd and from 10 adult Toggenburg goats from an unaffected herd. Samples were collected by jugular venipuncture at 2-month intervals for 12 months (April 2018-March 2019). Concentrations of calcium, phosphorus, 25-hydroxyvitamin D Vegetation survey: All paddocks on the property were surveyed every 2 months along evenly spaced line transects, and then further traversed perpendicularly to form a grid. No known calcinogenic species were identified. Known plant sources of vitamin D identified on the farm included mushrooms (species not defined), Diagnosis: Soft tissue mineralisation and enzootic calcinosis. Clinical relevance: Veterinarians are alerted to the possibility of either enzootic calcinosis in goats and the potential occurrence of calcinogenic plants in New Zealand; or chronic vitamin D toxicosis of non-plant origin.
MeSH term(s)	Humans ; Animals ; New Zealand/epidemiology ; Vitamin D ; Calcifediol ; Calcinosis/pathology ; Calcinosis/veterinary ; Goats ; Goat Diseases/epidemiology
Chemical Substances	Vitamin D (1406-16-2) ; Calcifediol (P6YZ13C99Q)
Language	English
Publishing date	2023-12-10
Publishing country	England
Document type	Journal Article
ZDB-ID	415642-0
ISSN	1176-0710 ; 0048-0169
ISSN (online)	1176-0710
ISSN	0048-0169
DOI	10.1080/00480169.2023.2263399
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Article ; Online: A frameshift-deletion mutation in Reelin causes cerebellar hypoplasia in White Swiss Shepherd dogs.

Littlejohn, Mathew D / Sneddon, Nick / Dittmer, Keren / Keehan, Mike / Stephen, Melissa / Drögemüller, Michaela / Garrick, Dorian

Animal genetics

2023 Volume 54, Issue 5, Page(s) 632–636

Abstract: Cerebellar hypoplasia is a heterogeneous neurological condition in which the cerebellum is smaller than usual or not completely developed. The condition can have genetic origins, with Mendelian-effect mutations described in several mammalian species. ... ...

Abstract	Cerebellar hypoplasia is a heterogeneous neurological condition in which the cerebellum is smaller than usual or not completely developed. The condition can have genetic origins, with Mendelian-effect mutations described in several mammalian species. Here, we describe a genetic investigation of cerebellar hypoplasia in White Swiss Shepherd dogs, where two affected puppies were identified from a litter with a recent common ancestor on both sides of their pedigree. Whole genome sequencing was conducted for 10 dogs in this family, and filtering of these data based on a recessive transmission hypothesis highlighted five protein-altering candidate variants - including a frameshift-deletion of the Reelin (RELN) gene (p.Val947*). Given the status of RELN as a gene responsible for cerebellar hypoplasia in humans, sheep and mice, these data strongly suggest the loss-of-function variant as underlying these effects. This variant has not been found in other dog breeds nor in a cohort of European White Swiss Shepherds, suggesting a recent mutation event. This finding will support the genotyping of a more diverse sample of dogs, and should aid future management of the harmful allele through optimised mating schemes.
MeSH term(s)	Animals ; Dogs ; Humans ; Cerebellum/abnormalities ; Dog Diseases/genetics ; Frameshift Mutation ; Mammals ; Mutation ; Sequence Deletion ; Switzerland ; Reelin Protein/genetics
Chemical Substances	Reelin Protein
Language	English
Publishing date	2023-06-19
Publishing country	England
Document type	Journal Article
ZDB-ID	632766-7
ISSN	1365-2052 ; 0268-9146 ; 0268-9154
ISSN (online)	1365-2052
ISSN	0268-9146 ; 0268-9154
DOI	10.1111/age.13336
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Article ; Online: Fatty acids are crucial to fuel NK cells upon acute retrovirus infection.

Schimmer, Simone / Mittermüller, Daniela / Werner, Tanja / Görs, Paul E / Meckelmann, Sven W / Finlay, David K / Dittmer, Ulf / Littwitz-Salomon, Elisabeth

Frontiers in immunology

2023 Volume 14, Page(s) 1296355

Abstract: Natural killer (NK) cells are cytotoxic innate immune cells, able to recognize and eliminate virus-infected as well as cancer cells. Metabolic reprogramming is crucial for their activity as they have enhanced energy and nutritional demands for their ... ...

Abstract	Natural killer (NK) cells are cytotoxic innate immune cells, able to recognize and eliminate virus-infected as well as cancer cells. Metabolic reprogramming is crucial for their activity as they have enhanced energy and nutritional demands for their functions during an infection. Fatty acids (FAs) represent an important source of cellular energy and are essential for proliferation of immune cells. However, the precise role of FAs for NK cells activity in retrovirus infection was unknown. Here we show that activated NK cells increase the expression of the FA uptake receptor CD36 and subsequently the uptake of FAs upon acute virus infection. We found an enhanced flexibility of NK cells to utilize FAs as source of energy compare to naïve NK cells. NK cells that were able to generate energy from FAs showed an augmented target cell killing and increased expression of cytotoxic parameters. However, NK cells that were unable to generate energy from FAs exhibited a severely decreased migratory capacity. Our results demonstrate that NK cells require FAs in order to fight acute virus infection. Susceptibility to severe virus infections as it is shown for people with malnutrition may be augmented by defects in the FA processing machinery, which might be a target to therapeutically boost NK cell functions in the future.
MeSH term(s)	Humans ; Retroviridae ; Fatty Acids ; Killer Cells, Natural ; Retroviridae Infections
Chemical Substances	Fatty Acids
Language	English
Publishing date	2023-11-29
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1296355
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Article ; Online: A Variety of Mouse PYHIN Proteins Restrict Murine and Human Retroviruses.

Erdemci-Evin, Sümeyye / Bosso, Matteo / Krchlikova, Veronika / Bayer, Wibke / Regensburger, Kerstin / Mayer, Martha / Dittmer, Ulf / Sauter, Daniel / Kmiec, Dorota / Kirchhoff, Frank

Viruses

2024 Volume 16, Issue 4

Abstract: PYHIN proteins are only found in mammals and play key roles in the defense against bacterial and viral pathogens. The corresponding gene locus shows variable deletion and expansion ranging from 0 genes in bats, over 1 in cows, and 4 in humans to a ... ...

Abstract	PYHIN proteins are only found in mammals and play key roles in the defense against bacterial and viral pathogens. The corresponding gene locus shows variable deletion and expansion ranging from 0 genes in bats, over 1 in cows, and 4 in humans to a maximum of 13 in mice. While initially thought to act as cytosolic immune sensors that recognize foreign DNA, increasing evidence suggests that PYHIN proteins also inhibit viral pathogens by more direct mechanisms. Here, we examined the ability of all 13 murine PYHIN proteins to inhibit HIV-1 and murine leukemia virus (MLV). We show that overexpression of p203, p204, p205, p208, p209, p210, p211, and p212 strongly inhibits production of infectious HIV-1; p202, p207, and p213 had no significant effects, while p206 and p214 showed intermediate phenotypes. The inhibitory effects on infectious HIV-1 production correlated significantly with the suppression of reporter gene expression by a proviral Moloney MLV-eGFP construct and HIV-1 and Friend MLV LTR luciferase reporter constructs. Altogether, our data show that the antiretroviral activity of PYHIN proteins is conserved between men and mice and further support the key role of nuclear PYHIN proteins in innate antiviral immunity.
MeSH term(s)	Animals ; Mice ; Humans ; HIV-1/immunology ; HIV-1/genetics ; Leukemia Virus, Murine/genetics ; Leukemia Virus, Murine/immunology ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Nuclear Proteins/immunology ; Virus Replication ; Cell Line ; Retroviridae Infections/immunology ; Retroviridae Infections/virology ; Phosphoproteins
Chemical Substances	Ifi16 protein, mouse ; Nuclear Proteins ; Phosphoproteins
Language	English
Publishing date	2024-03-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v16040493
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Article: Preclinical Evaluation of Novel Folate Receptor 1-Directed CAR T Cells for Ovarian Cancer.

Daigre, Julie / Martinez-Osuna, Manuel / Bethke, Maria / Steiner, Larissa / Dittmer, Vera / Krischer, Katrin / Bleilevens, Cathrin / Brauner, Janina / Kopatz, Jens / Grundmann, Matthias David / Praveen, Paurush / Eckardt, Dominik / Bosio, Andreas / Herbel, Christoph

Cancers

2024 Volume 16, Issue 2

Abstract: Treatment options for ovarian cancer patients are limited, and a high unmet clinical need remains for targeted and long-lasting, efficient drugs. Genetically modified T cells expressing chimeric antigen receptors (CAR), are promising new drugs that can ... ...

Abstract	Treatment options for ovarian cancer patients are limited, and a high unmet clinical need remains for targeted and long-lasting, efficient drugs. Genetically modified T cells expressing chimeric antigen receptors (CAR), are promising new drugs that can be directed towards a defined target and have shown efficient, as well as persisting, anti-tumor responses in many patients. We sought to develop novel CAR T cells targeting ovarian cancer and to assess these candidates preclinically. First, we identified potential CAR targets on ovarian cancer samples. We confirmed high and consistent expressions of the tumor-associated antigen FOLR1 on primary ovarian cancer samples. Subsequently, we designed a series of CAR T cell candidates against the identified target and demonstrated their functionality against ovarian cancer cell lines in vitro and in an in vivo xenograft model. Finally, we performed additional in vitro assays recapitulating immune suppressive mechanisms present in solid tumors and developed a process for the automated manufacturing of our CAR T cell candidate. These findings demonstrate the feasibility of anti-FOLR1 CAR T cells for ovarian cancer and potentially other FOLR1-expressing tumors.
Language	English
Publishing date	2024-01-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16020333
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Article ; Online: Draft Whole-Genome Sequences of Seven Isolates of Klebsiella pneumoniae from New Zealand Sea Lions.

Pinpimai, Komkiew / Roe, Wendi D / Biggs, Patrick J / Dittmer, Keren E

Microbiology resource announcements

2018 Volume 7, Issue 20

Abstract: ... range of hosts. We report here the genome sequences of seven K. pneumoniae isolates from New Zealand sea lions. ...

Abstract	Klebsiella pneumoniae is a Gram-negative bacterium that may cause infection in a broad range of hosts. We report here the genome sequences of seven K. pneumoniae isolates from New Zealand sea lions.
Language	English
Publishing date	2018-11-21
Publishing country	United States
Document type	Journal Article
ISSN	2576-098X
ISSN (online)	2576-098X
DOI	10.1128/MRA.01270-18
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