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  1. Article ; Online: Inflammatory bowel disease serologies in ankylosing spondylitis patients: a pilot study.

    Mundwiler, Matthew L / Mei, Ling / Landers, Carol J / Reveille, John D / Targan, Stephan / Weisman, Michael H

    Arthritis research & therapy

    2009  Volume 11, Issue 6, Page(s) R177

    Abstract: Introduction: Ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) share similarities and are classified as spondyloarthropathies. In IBD, anti-Saccharomyces cerevisiae antibody (ASCA), anti-I2 (associated with anti-Pseudomonas activity), ... ...

    Abstract Introduction: Ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) share similarities and are classified as spondyloarthropathies. In IBD, anti-Saccharomyces cerevisiae antibody (ASCA), anti-I2 (associated with anti-Pseudomonas activity), anti-Escherichia coli outer membrane porin C (anti-OmpC), anti-flagellin (anti-CBir1), and antineutrophil cytoplasmic antibodies (ANCA) possess clinical significance. Because of the overlap between the two conditions, a pilot study was designed to compare the frequency of these antibodies in AS patients compared to normal controls.
    Methods: Serum stored from 80 AS patients and 80 control subjects was available for analysis. ASCA, anti-I2, anti-OmpC, anti-CBir1, and ANCA studies were completed on all serum samples using Enzyme-Linked Immunosorbent Assay (ELISA) methodology. The following analyses were performed: comparison of positivity based on the established values in IBD, median values, the number of subjects in each serology in the 4th quartile of a normal distribution, and the mean quartile sum of all the antibodies.
    Results: There was no difference in positivity rates between AS and control groups with the established IBD values. The median anti-I2 response was significantly higher in AS than in controls (11.78 vs 7.86, p = 0.017). Significantly more AS patients had quartile scores of 4 for the following antibody responses: ASCA IgG (26% vs 13%, p = 0.016, OR = 2.49, CI 1.168 - 5.313), ASCA IgG and IgA (27% vs 12%, p = 0.006, OR = 2.9, CI: 1.342 - 6.264), and anti - I2 (25% vs 14%, p = 0.0424, OR = 2.15, CI: 1.018 - 4.538). The mean quartile sum of the antibody responses was elevated in AS patients when ANCA was excluded (10.526 vs 9.519, p = 0.03). When ANCA was included, this difference lost significance.
    Conclusions: The data from this pilot study points towards mucosal dysregulation as an important pathway in AS. We were able to demonstrate that anti-I2 could play a pathologic role in AS. The elevated mean total antibody response being significant only with ANCA exclusion is consistent with the histopathological evidence that intestinal inflammation in AS is similar to Crohn's disease. To better define the roles of these antibodies in AS, larger studies with more precisely defined patient characteristics are required.
    MeSH term(s) Adult ; Antibodies, Antineutrophil Cytoplasmic/blood ; Antibodies, Bacterial/blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Flagellin/immunology ; Humans ; Inflammatory Bowel Diseases/blood ; Inflammatory Bowel Diseases/immunology ; Male ; Middle Aged ; Pilot Projects ; Porins/immunology ; Saccharomyces cerevisiae/immunology ; Spondylitis, Ankylosing/blood ; Spondylitis, Ankylosing/immunology ; Superantigens/immunology ; Young Adult
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic ; Antibodies, Bacterial ; CBir1 flagellin ; OmpC protein ; PfiT protein, Pseudomonas fluorescens ; Porins ; Superantigens ; Flagellin (12777-81-0)
    Language English
    Publishing date 2009-11-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2107602-9
    ISSN 1478-6362 ; 1478-6354
    ISSN (online) 1478-6362
    ISSN 1478-6354
    DOI 10.1186/ar2866
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  2. Article ; Online: Complications of the spine in ankylosing spondylitis with a focus on deformity correction.

    Mundwiler, Matthew L / Siddique, Khawar / Dym, Jeffrey M / Perri, Brian / Johnson, J Patrick / Weisman, Michael H

    Neurosurgical focus

    2008  Volume 24, Issue 1, Page(s) E6

    Abstract: Ankylosing spondylitis (AS) is a systemic inflammatory disorder with frequent spinal axis symptoms. In this paper, the authors explored the spinal manifestations of AS and its characteristic anatomical lesions, radiological findings, and complications. ... ...

    Abstract Ankylosing spondylitis (AS) is a systemic inflammatory disorder with frequent spinal axis symptoms. In this paper, the authors explored the spinal manifestations of AS and its characteristic anatomical lesions, radiological findings, and complications. They also offer a comprehensive report of the medical and surgical treatments with a focus on deformity correction.
    MeSH term(s) Algorithms ; Back Pain/diagnosis ; Back Pain/etiology ; Back Pain/surgery ; Humans ; Osteoporosis/diagnosis ; Osteoporosis/etiology ; Osteoporosis/surgery ; Osteotomy ; Spinal Diseases/diagnosis ; Spinal Diseases/etiology ; Spinal Diseases/surgery ; Spinal Fractures/diagnosis ; Spinal Fractures/etiology ; Spinal Fractures/surgery ; Spondylitis, Ankylosing/complications ; Spondylitis, Ankylosing/pathology ; Spondylitis, Ankylosing/surgery
    Language English
    Publishing date 2008
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2026589-X
    ISSN 1092-0684 ; 1092-0684
    ISSN (online) 1092-0684
    ISSN 1092-0684
    DOI 10.3171/FOC/2008/24/1/E6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Sinus of Valsalva aneurysm in a Göttingen minipig.

    Ko, Pamela P / Pritt, Stacy L / Mundwiler, Karen E / Ackley, Valerie K / Matthews, Ray V / Unverdorben, Martin

    Journal of the American Association for Laboratory Animal Science : JAALAS

    2011  Volume 50, Issue 1, Page(s) 94–97

    Abstract: A 26.6-kg, intact, 9-mo-old female Göttingen minipig was presented for a coronary stent study. Angiography revealed a sinus of Valsalva aneurysm (SVA) in the aortic root that involved both the left and noncoronary sinuses of the heart. Gross histologic ... ...

    Abstract A 26.6-kg, intact, 9-mo-old female Göttingen minipig was presented for a coronary stent study. Angiography revealed a sinus of Valsalva aneurysm (SVA) in the aortic root that involved both the left and noncoronary sinuses of the heart. Gross histologic examination of the heart revealed 2 regions of aneurysmal formation: one at the ostium to the left main coronary artery, with aortic sinus involvement, and the other at the dorsal aspect of the aortic root involving the noncoronary aortic sinus. With no history of any infectious diseases, and the microscopic findings showing no evidence of necrosis, degeneration, or infection, confirmed that the aneurysmal-like dilation of the sinuses was most likely a congenital anomaly. This case illustrates the diagnosis and comparative findings of a rare cardiac anomaly found in only a few species to date. To our knowledge, antemortem diagnosis of unruptured SVA involving both the left and noncoronary aortic sinuses of the minipig heart has not been reported previously.
    MeSH term(s) Angiography/veterinary ; Animals ; Aortic Aneurysm/diagnostic imaging ; Aortic Aneurysm/pathology ; Aortic Aneurysm/veterinary ; Female ; Sinus of Valsalva/diagnostic imaging ; Sinus of Valsalva/pathology ; Swine ; Swine Diseases/diagnostic imaging ; Swine Diseases/pathology ; Swine, Miniature
    Language English
    Publishing date 2011-02-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 1559-6109
    ISSN 1559-6109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The utility of MRI in predicting radiographic erosions in the metatarsophalangeal joints of the rheumatoid foot: a prospective longitudinal cohort study.

    Mundwiler, Matthew L / Maranian, Paul / Brown, Douglas H / Silverman, Jeffrey M / Wallace, Daniel / Khanna, Dinesh / Louie, James / Furst, Daniel E / Weisman, Michael H

    Arthritis research & therapy

    2009  Volume 11, Issue 3, Page(s) R94

    Abstract: Introduction: Magnetic resonance imaging (MRI) may reveal rheumatoid arthritis (RA) changes in the feet when hands are normal. The purpose of this study was to determine the sensitivity, specificity, positive predictive value (PPV), and negative ... ...

    Abstract Introduction: Magnetic resonance imaging (MRI) may reveal rheumatoid arthritis (RA) changes in the feet when hands are normal. The purpose of this study was to determine the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of a metatarsophalangeal (MTP) erosion on MRI to predict a subsequent radiographic erosion in the same joint. Similar analyses were performed for bone marrow edema, predicting a subsequent MRI erosion. Descriptive results of other lesions are reported.
    Methods: Fifty patients with RA of less than 5 years' duration who were rheumatoid factor-positive and/or anti-cyclic citrullinated peptide-positive were recruited. Patients on anti-tumor necrosis factor (TNF) therapy were excluded. Anti-TNF therapy could begin after enrollment. MRI and radiographs of the 3rd, 4th, and 5th MTP joints bilaterally were taken at baseline and at 6, 12, and 24 months. Clinical data were collected.
    Results: Fifty patients were recruited; 46 patients had suitable data. Results for MRI erosions predicting subsequent radiographic erosions for 6, 12, and 24 months, respectively, were as follows: sensitivity 0.75, 0.60, 0.75; specificity 0.93, 0.94, 0.94; PPV 0.086, 0.10, 0.17; NPV 0.998, 0.995, 0.995. Results for MRI bone marrow edema predicting MRI erosions at 6 and 12 months, respectively, revealed sensitivity 0.50, 0.67; specificity 0.97, 0.97; PPV 0.25, 0.50; NPV 0.99, 0.99. Synovitis was the most common finding and, when present in isolation, resolved on 67.3% of subsequent studies. MRI erosions persisted on subsequent studies with one exception. Forty-six percent of the cohort was on anti-TNF therapy after study inception.
    Conclusions: The PPV of MRI erosions to predict subsequent radiographic erosions was low. Similarly, the PPV of bone marrow edema to predict a later MRI erosion was low. Alternatively, the NPV of the absence of an MRI erosion or bone marrow edema predicts that a later radiographic erosion or MRI erosion will likely not develop. Anti-TNF therapies may have resulted in the lower-than-anticipated PPVs. MRI descriptions of bone edema may represent a more critical time to treat in order to avoid damage, whereas an MRI erosion represents more permanent damage. This study suggests that imaging modalities more sensitive than radiographs are necessary to monitor disease in the biologic era.
    MeSH term(s) Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/diagnostic imaging ; Arthritis, Rheumatoid/drug therapy ; Cohort Studies ; Female ; Humans ; Longitudinal Studies ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Imaging/statistics & numerical data ; Male ; Metatarsophalangeal Joint/diagnostic imaging ; Predictive Value of Tests ; Prospective Studies ; Radiography ; Sensitivity and Specificity
    Language English
    Publishing date 2009-06-22
    Publishing country England
    Document type Comparative Study ; Journal Article ; Multicenter Study
    ZDB-ID 2107602-9
    ISSN 1478-6362 ; 1478-6354
    ISSN (online) 1478-6362
    ISSN 1478-6354
    DOI 10.1186/ar2737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5490: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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