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Article ; Online: Strengthening Warfighter Resiliency Using Broad-Spectrum or Host-Directed Therapies within the Rapid Acquisition and Investigation of Drugs for Repurposing Program.

Quattrochi, Lauren / Cardile, Anthony / Love, Amanda / Glenn, Andrew / Almas, Micah / Coronado, Alicia / Clark, Matthew / Paschal, Charles / Ward, Lucy

The Journal of pharmacology and experimental therapeutics

2024 Volume 388, Issue 2, Page(s) 268–272

Abstract: To maintain cadence with looming threats in a prolonged field-care environment, the broader medical countermeasure (MCM) enterprise must adopt new strategies for chemical, biological, radiological, and nuclear (CBRN)-addressing drug development. The ... ...

Abstract	To maintain cadence with looming threats in a prolonged field-care environment, the broader medical countermeasure (MCM) enterprise must adopt new strategies for chemical, biological, radiological, and nuclear (CBRN)-addressing drug development. The Countering Emerging Threats - Rapid Acquisition and Investigation of Drugs for Repurposing (CET RAIDR) program within the Joint Program Manager for CBRN Medical is designed to rapidly tackle known, unknown, and emerging threats by utilizing late-stage or licensed therapeutics. The focus of the CET RAIDR effort is to bridge treatment gaps between threat identification and the implementation of licensed targeted MCMs, thereby strengthening warfighter resiliency. The repurposing approach conserves both time to market and funds by leveraging previous conventional development work as a launch point for repurposing efforts. The CET RAIDR program minimizes development and procurement costs by supplementing the military medical providers' toolbox with post-phase II therapies that demonstrate established safety and manufacturing processes, leading to a cost-sparing model for niche medicines (i.e., CBRN MCMs). SIGNIFICANCE STATEMENT: Countering Emerging Threats - Rapid Acquisition and Investigation of Drugs for Repurposing program candidates are selected based on several pillars: a proven human safety profile, the availability of tools and validated literature on the drug's mechanism of action, well defined assays, and/or animal models to demonstrate efficacy, as well as collaborations with willing and trusted industry partners. This broader repurposing approach to address the growing chemical, biological, radiological, and nuclear threat landscape will better safeguard the warfighter against well documented or unpredictable threats when a direct-acting medical countermeasure is unavailable or not yet conceived.
MeSH term(s)	Animals ; Humans ; Drug Repositioning ; Resilience, Psychological
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	3106-9
ISSN	1521-0103 ; 0022-3565
ISSN (online)	1521-0103
ISSN	0022-3565
DOI	10.1124/jpet.123.001721
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Uf I Zs.40: Show issues

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Article ; Online: Computerized Capability of Office-Based Physicians to Identify Patients Who Need Preventive or Follow-up Care - United States, 2017.

Ogburn, Damon F / Ward, Brian W / Ward, Alicia

MMWR. Morbidity and mortality weekly report

2020 Volume 69, Issue 44, Page(s) 1622–1624

Abstract: Preventive care or follow-up care have the potential to improve health outcomes, reduce disease in the population, and decrease health care costs in the long-term (1). Approximately one half of persons in the United States receive general recommended ... ...

Abstract	Preventive care or follow-up care have the potential to improve health outcomes, reduce disease in the population, and decrease health care costs in the long-term (1). Approximately one half of persons in the United States receive general recommended preventive services (2,3). Missed physician appointments can hinder the receipt of needed health care (4). With electronic health record (EHR) systems able to improve interaction and communication between patients and providers (5), electronic reminders are used to decrease missed care. These reminders can improve various types of preventive and follow-up care, such as immunizations (6) and cancer screening (7); however, computerized capability must exist to make use of these reminders. To examine this capability among U.S. office-based physicians, data from the National Electronic Health Records Survey (NEHRS) for 2017, the most recent data available, were analyzed. An estimated 64.7% of office-based physicians had computerized capability to identify patients who were due for preventive or follow-up care, with 72.9% of primary care physicians and 71.4% of physicians with an EHR system having this capability compared with surgeons (54.8%), nonprimary care physicians (58.5%), and physicians without an EHR system (23.4%). Having an EHR system is associated with the ability to send electronic reminders to increase receipt of preventive or follow-up care, which has been shown to improve patient health outcomes (8).
MeSH term(s)	Adult ; Aftercare ; Aged ; Aged, 80 and over ; Electronic Health Records/statistics & numerical data ; Female ; Health Services Needs and Demand ; Humans ; Male ; Middle Aged ; Physicians/statistics & numerical data ; Physicians' Offices/statistics & numerical data ; Preventive Health Services ; Reminder Systems/statistics & numerical data ; United States
Language	English
Publishing date	2020-11-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	412775-4
ISSN	1545-861X ; 0149-2195
ISSN (online)	1545-861X
ISSN	0149-2195
DOI	10.15585/mmwr.mm6944a2
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Zs.B 1827: Show issues

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Article ; Online: Patients Who Have Limited English Proficiency Have Decreased Utilization of Revision Surgeries After Hip and Knee Arthroplasty.

Nguyen, Kevin H / Suarez, Pablo / Sales, Chloe / Fernandez, Alicia / Ward, Derek T / Manuel, Solmaz P

The Journal of arthroplasty

2023 Volume 38, Issue 8, Page(s) 1429–1433

Abstract: Background: While racial and ethnic disparities are well documented in access to total joint arthroplasty (TJA), little is known about the association between having limited English proficiency (LEP) and postoperative care access. This study seeks to ... ...

Abstract	Background: While racial and ethnic disparities are well documented in access to total joint arthroplasty (TJA), little is known about the association between having limited English proficiency (LEP) and postoperative care access. This study seeks to correlate LEP status with rates of revision surgery after hip and knee arthroplasty. Methods: This was a retrospective cohort study of patients aged ≥ 18 years who underwent either total hip or total knee arthroplasty between January 2013 and December 2021 at a single academic medical center. The predictor variable was English proficiency status, where LEP was defined as having a primary language that was not English. Multivariable regressions controlling for potential demographic and clinical confounders were used to calculate adjusted odds ratios of undergoing revision surgery within 1 and 2 years after primary arthroplasty for patients who have LEP, compared to English proficient patients. Results: A total of 7,985 hip and knee arthroplasty surgeries were included in the analysis. There were 577 (7.2%) patients who were classified as having LEP. Patients who have LEP were less likely to undergo revision surgeries within 1 year (1.4% versus 3.2%, P = .01) and 2 years (1.7% versus 3.9%, P = .006) of primary TJA. Patients who have LEP had adjusted odds ratios of 0.45 (confidence interval: 0.22-0.92, P = .03) and 0.44 (confidence interval: 0.23-0.85, P = .01) of receiving revision surgery within 1 and 2 years, respectively. Conclusion: Patients who have LEP, compared to English proficient patients, were less likely to undergo revision surgeries at the same institution up to 2 years after hip and knee arthroplasty. These findings suggest that patients who have LEP may face barriers in accessing postoperative care.
MeSH term(s)	Humans ; Arthroplasty, Replacement, Knee ; Limited English Proficiency ; Reoperation ; Retrospective Studies ; Surveys and Questionnaires
Language	English
Publishing date	2023-02-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	632770-9
ISSN	1532-8406 ; 0883-5403
ISSN (online)	1532-8406
ISSN	0883-5403
DOI	10.1016/j.arth.2023.02.024
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Zs.A 2134: Show issues

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Article ; Online: Association of English Language Proficiency With Hospitalization Cost, Length of Stay, Disposition Location, and Readmission Following Total Joint Arthroplasty.

Manuel, Solmaz P / Nguyen, Kevin / Karliner, Leah S / Ward, Derek T / Fernandez, Alicia

JAMA network open

2022 Volume 5, Issue 3, Page(s) e221842

MeSH term(s)	Arthroplasty, Replacement, Hip ; Hospitalization ; Humans ; Language ; Length of Stay ; Patient Readmission
Language	English
Publishing date	2022-03-01
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Extramural
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2022.1842
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Article ; Online: Limited English proficiency correlates with postoperative complications after knee arthroplasty.

Nguyen, Kevin H / Sales, Chloe / Suarez, Pablo / Fernandez, Alicia / Ward, Derek T / Manuel, Solmaz P

Musculoskeletal care

2022 Volume 21, Issue 2, Page(s) 576–581

MeSH term(s)	Humans ; Limited English Proficiency ; Arthroplasty, Replacement, Knee/adverse effects ; Postoperative Complications/etiology ; Healthcare Disparities ; Retrospective Studies
Language	English
Publishing date	2022-12-19
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2171452-6
ISSN	1557-0681 ; 1478-2189
ISSN (online)	1557-0681
ISSN	1478-2189
DOI	10.1002/msc.1724
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Zs.A 6046: Show issues

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Article ; Online: Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.

Sarraf, Shireen A / Shah, Hetal V / Kanfer, Gil / Pickrell, Alicia M / Holtzclaw, Lynne A / Ward, Michael E / Youle, Richard J

Molecular cell

2022 Volume 82, Issue 7, Page(s) 1383–1385

Language	English
Publishing date	2022-04-08
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2022.03.020
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Zs.A 5055: Show issues

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Article ; Online: Interactive calculator to estimate insulin sensitivity in type 1 diabetes.

Januszewski, Andrzej S / Niedzwiecki, Pawel / Sachithanandan, Nirupa / Ward, Glenn M / O'Neal, David N / Zozulinska-Ziolkiewicz, Dorota A / Uruska, Aleksandra A / Jenkins, Alicia J

Journal of diabetes investigation

2024 Volume 15, Issue 5, Page(s) 594–597

Abstract: The gold standard for measuring insulin sensitivity (IS) is the hyperinsulinemic-euglycemic clamp, a time, costly, and labor-intensive research tool. A low insulin sensitivity is associated with a complication-risk in type 1 diabetes. Various formulae ... ...

Abstract	The gold standard for measuring insulin sensitivity (IS) is the hyperinsulinemic-euglycemic clamp, a time, costly, and labor-intensive research tool. A low insulin sensitivity is associated with a complication-risk in type 1 diabetes. Various formulae using clinical data have been developed and correlated with measured IS in type 1 diabetes. We consolidated multiple formulae into an online calculator (bit.ly/estimated-GDR), enabling comparison of IS and its probability of IS <4.45 mg/kg/min (low) or >6.50 mg/kg/min (high), as measured in a validation set of clamps in 104 adults with type 1 diabetes. Insulin sensitivity calculations using different formulae varied significantly, with correlations (R
MeSH term(s)	Humans ; Diabetes Mellitus, Type 1/blood ; Insulin Resistance ; Female ; Adult ; Glucose Clamp Technique ; Male ; Blood Glucose/analysis ; Middle Aged ; Insulin
Chemical Substances	Blood Glucose ; Insulin
Language	English
Publishing date	2024-02-17
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2625840-7
ISSN	2040-1124 ; 2040-1116
ISSN (online)	2040-1124
ISSN	2040-1116
DOI	10.1111/jdi.14161
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Zs.A 6920: Show issues

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Article ; Online: Primary augmentation pharyngoplasty with calcium hydroxylapatite for treatment of velopharyngeal insufficiency: Surgical and speech outcomes.

Munson, Patrick D / Ward, Alicia

International journal of pediatric otorhinolaryngology

2018 Volume 108, Page(s) 91–94

Abstract: Introduction: Augmentation pharyngoplasty (AP) is a technique that may effectively treat velopharyngeal insufficiency (VPI), while avoiding typical short and long term surgical risks. This study seeks to determine if children with VPI treated by AP with ...

Abstract	Introduction: Augmentation pharyngoplasty (AP) is a technique that may effectively treat velopharyngeal insufficiency (VPI), while avoiding typical short and long term surgical risks. This study seeks to determine if children with VPI treated by AP with calcium hydoxylapatite (CaHa) demonstrate clinically significant improvement in speech outcomes. Methods: Retrospective review (2012-2016) of prospectively collected database of children with VPI, cared for at a single tertiary children's hospital. Preoperative speech assessment, nasometry, and video nasendoscopy were used to identify patients with VPI treated by AP with CaHa. Demographics, surgical/speech outcomes, complications, novel surgical technique and follow-up were recorded. Main outcome measures included pre and postoperative nasality and perceptual speech assessments, based on the Pittsburgh Weighted Values for Speech (PWS). Results: 17 patients treated with AP with CaHa, as initial primary treatment for VPI, were identified. 8 patients had cleft palate, 9 patients had isolated VPI. Mean age at treatment was 6.6 years, with no operative complications. Mean nasality scores before and after surgery were 3.2 vs. 0.5 (p < 0.001). Mean PWS before and after surgery were 9.7 vs. 2.1 (p < 0.001). Based on the PWS scoring, 4/8 of cleft patients (50%) and 8/9 of isolated patients (89%) achieved a competent/borderline competent nasopharyngeal valve. 17/17 of patients (100%) had improvement in nasality. Mean length of follow-up was 32.8 months (range 10-64 months). Conclusion: In this largest series of patients to date, AP with CaHa is a safe, minimally invasive, enduring treatment for VPI in properly selected patients. Nasality and speech scores significantly improved, especially in patients with isolated VPI.
MeSH term(s)	Adolescent ; Calcium Compounds/adverse effects ; Calcium Compounds/therapeutic use ; Child ; Child, Preschool ; Female ; Humans ; Male ; Natural Orifice Endoscopic Surgery/adverse effects ; Natural Orifice Endoscopic Surgery/methods ; Pharynx/surgery ; Postoperative Complications/epidemiology ; Reconstructive Surgical Procedures/adverse effects ; Reconstructive Surgical Procedures/methods ; Retrospective Studies ; Speech/physiology ; Speech Disorders/etiology ; Treatment Outcome ; Velopharyngeal Insufficiency/surgery
Chemical Substances	Calcium Compounds ; calcium hypochlorite (11DXB629VZ)
Language	English
Publishing date	2018-05
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	754501-0
ISSN	1872-8464 ; 0165-5876
ISSN (online)	1872-8464
ISSN	0165-5876
DOI	10.1016/j.ijporl.2018.02.034
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Zs.A 1507: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 134: Show issues

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Article: Complications with oxycodone and naloxone.

Ward, Alicia / Del Campo, Michaela / Hauser, Kathy

Australian prescriber

2017 Volume 40, Issue 4, Page(s) 156–157

Language	English
Publishing date	2017-08-01
Publishing country	Australia
Document type	Case Reports
ZDB-ID	1075442-8
ISSN	0312-8008
ISSN	0312-8008
DOI	10.18773/austprescr.2017.018
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Article ; Online: Assessing the uptake of the type 1 diabetes core outcome set in randomized controlled trials: A Cross-Sectional study.

Kari, Karim / Thayani, Zohaib / Ward, Shaelyn / Magee, Trevor / Jones, Garrett / Fitzgerald, Kyle / Magana, Kimberly / Modi, Jay / Hughes, Griffin / Ito Ford, Alicia / Vassar, Matt

Diabetes research and clinical practice

2024 Volume 207, Page(s) 111085

Abstract: Aims: This study analyzed uptake of the core outcome set (COS) for type 1 diabetes (T1D) and trends in its use before and after its development in December 2017.: Methods: On June 26, 2023, ClinicalTrials.gov was systematically searched for T1D ... ...

Abstract	Aims: This study analyzed uptake of the core outcome set (COS) for type 1 diabetes (T1D) and trends in its use before and after its development in December 2017. Methods: On June 26, 2023, ClinicalTrials.gov was systematically searched for T1D randomized controlled trials. The Core Outcome Measures in Effectiveness Trials (COMET) database provided a COS of eight key outcomes for analysis. Included trials were analyzed for COS uptake before and after its release in December 2017 in a masked, duplicate fashion by independent reviewers. We also calculated the proportion of trials that measured the complete COS and assessed the most frequently reported COS outcomes. Results: Of 3,792 originally screened articles, 144 RCTs were included in the final sample. Following COS publication, its use steadily decreased. Within the COS, HbA1c and severe hypoglycemia were most frequently implemented as endpoints; other recommended outcomes were rarely used in the published trials. Conclusion: Despite the 2017 T1D COS publication, use has decreased over time. This inconsistency negatively influences evidence-based practices and care. Educating researchers on COS and promoting uptake is crucial. Wider COS adoption in T1D trials could enhance clinical research overall. Further study of barriers and facilitators influencing uptake is essential to support consistent use and reporting.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 1/therapy ; Cross-Sectional Studies ; Treatment Outcome ; Research Design ; Randomized Controlled Trials as Topic ; Outcome Assessment, Health Care
Language	English
Publishing date	2024-01-07
Publishing country	Ireland
Document type	Systematic Review ; Journal Article
ZDB-ID	632523-3
ISSN	1872-8227 ; 0168-8227
ISSN (online)	1872-8227
ISSN	0168-8227
DOI	10.1016/j.diabres.2023.111085
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