LIVIVO - Suchergebnisse -

Suchergebnis

Treffer 1 - 10 von insgesamt 1047

Suchoptionen

Buch: Behandlungstechniken bei Schizophrenie

Cancro, Robert / Fox, Norma / Shapiro, Lester E.

neuere Methoden im Überblick

1978

Verfasserangabe	Robert Cancro ; Norma Fox ; Lester E. Shapiro
Schlagwörter	Schizophrenia / therapy ; Schizophrenie ; Behandlung ; Therapie
Schlagwörter	Spaltungsirresein ; Schizophrene Psychose ; Medizinische Behandlung ; Behandlung ; Krankenbehandlung
Sprache	Deutsch
Umfang	134 S.
Ausgabenhinweis	1. Aufl.
Verlag	Reinhardt
Erscheinungsort	München u.a.
Dokumenttyp	Buch
Anmerkung	Aus dem Engl. übers.
HBZ-ID	HT000028420
ISBN	3-497-00794-3 ; 978-3-497-00794-3
Datenquelle	Katalog ZB MED Medizin, Gesundheit

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Signatur	Leihstatus	Standort
1978 B 628	bestellbar zur Ausleihe	Magazin

Über subito bestellen

Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Details ▾
- Im ZB MED-Bestand
- Kostenpflichtig bestellen

Artikel ; Online: Psychometric Properties of Instruments that Measure Vaping Outcome Expectancies: A Systematic Review.

Wall, Nicole / Fox, Susan / Mirza, Noeman / Ralph, Jody

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

2024

Abstract: ... the evidence explaining e-cigarette use etiology.: Methods: This systematic review was guided by an adapted ... negative health consequences. Many of the outcome expectancy subscales were associated with e-cigarette ... version of the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN ...

Abstract	Introduction: Vaping is a growing public health concern. Interventions that address vaping must build upon rigorous research that uses psychometrically sound instruments to measure vaping-associated outcome expectancies. The primary aim was to appraise the reporting of psychometric properties of instruments used to measure vaping outcome expectancies. Secondary aims were to distinguish the different types of outcome expectancies assessed across the measures, the conceptual underpinnings, and the evidence explaining e-cigarette use etiology. Methods: This systematic review was guided by an adapted version of the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) guideline and Risk of Bias Checklist. Five electronic databases were searched for peer-reviewed studies, dissertations, and theses that psychometrically evaluated instruments that measure vaping outcome expectancies. Studies that met the inclusion criteria were appraised based on their reporting of nine psychometric properties outlined in the COSMIN checklist. Results: The review included 11 studies that described eight instruments and reported on two to five of nine pre-determined psychometric properties. Structural validity, construct validity, and internal consistency were the most commonly reported properties. No studies reported test-retest, intra-rater, or inter-rater reliability, measurement error or responsiveness. Content validity and measurement invariance were only reported by two and four studies, respectively. The most commonly included subscales in the instruments were affect regulation, positive sensory experience, and negative health consequences. Many of the outcome expectancy subscales were associated with e-cigarette behaviors. Conclusions: There is limited reporting of psychometric testing of instruments that measure vaping outcome expectancies; however, utilization of the COSMIN guideline could enhance the quality of such reporting. Implications: Appraising the reporting of psychometric properties of instruments that measure vaping outcome expectancies is a first step to ensuring valid and reliable instruments are used to support rigorous research and build evidence-based knowledge. Future research should focus on testing for responsiveness, measurement error, and reliability, and on quality appraisal of the instruments. Studying vaping outcome expectancies may improve understanding of factors that influence and deter vaping. This may contribute to the development of effective interventions aimed at vaping cessation and prevention.
Sprache	Englisch
Erscheinungsdatum	2024-01-02
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	1452315-2
ISSN	1469-994X ; 1462-2203
ISSN (online)	1469-994X
ISSN	1462-2203
DOI	10.1093/ntr/ntad261
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.A 5789: Hefte anzeigen

Standort:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Über subito bestellen

Details ▾
- Im ZB MED-Bestand
- Kostenpflichtig bestellen

Artikel ; Online: Measuring Cellular Ploidy In Situ by Light Microscopy.

Clay, Delisa E / Stormo, Benjamin M / Fox, Donald T

Methods in molecular biology (Clifton, N.J.)

2023 Band 2545, Seite(n) 401–412

Abstract: ... condensation. These techniques can be completed in 1 day and require standard lab supplies as well ...

Abstract	Determining cellular DNA content is valuable in the study of numerous biological processes, including organ development and injury repair. While FACS analysis of dissociated cells is a widely used method for assaying ploidy in a tissue cell population, for many tissue samples, it is possible and convenient to measure ploidy in situ using light microscopy. Here, we present two protocols for measuring cellular ploidy in tissues. These protocols are based on our studies in Drosophila melanogaster, but these are applicable to other settings as well. We present example results from Drosophila hindgut, midgut, and wing imaginal disc as examples. The first protocol focuses on measuring DNA content from decondensed interphase nuclei, while the second protocol details the visualization of condensed chromosomes for ploidy determination, either from mitotic cells or from interphase cells with drug-induced chromosome condensation. These techniques can be completed in 1 day and require standard lab supplies as well as a fluorescence light microscope.
Mesh-Begriff(e)	Animals ; Microscopy ; Drosophila melanogaster/genetics ; Cell Nucleus/genetics ; Drosophila ; Ploidies ; DNA
Chemische Substanzen	DNA (9007-49-2)
Sprache	Englisch
Erscheinungsdatum	2023-01-26
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-2561-3_21
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Über subito bestellen

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Details ▾
- Kostenpflichtig bestellen

Artikel: Engagement of integrin alpha4beta1 enhances thrombopoietin-induced megakaryopoiesis.

Fox, Norma E / Kaushansky, Kenneth

Experimental hematology

2005 Band 33, Heft 1, Seite(n) 94–99

Abstract: Objective: Studies in numerous adherent cell systems have indicated that engagement of integrins is required for cell survival and proliferation. Although not classically thought of as an adherent cell type, megakaryocytes in the marrow develop in ... ...

Abstract	Objective: Studies in numerous adherent cell systems have indicated that engagement of integrins is required for cell survival and proliferation. Although not classically thought of as an adherent cell type, megakaryocytes in the marrow develop in juxtaposition to endothelial cells which display a number of integrin counter-receptors. Moreover, a number of other hematopoietic cell types, including stem cells and erythroid progenitors, have been shown to engage and be affected by integrin ligands. Methods: The role of beta1 integrins in thrombopoietin-mediated megakaryopoiesis was studied using both gain-of-function and loss-of-function strategies. Results: We found that pan-blockade of integrins with a relatively nonspecific disintegrin blocked TPO-induced MK growth, but that an alpha5beta1 disintegrin, and a function-blocking monoclonal antibody, failed to affect megakaryopoiesis in vitro. In contrast, a neutralizing alpha4beta1 monoclonal antibody blocked TPO-induced MK growth, and an integrin alpha4beta1 ligand, the H296 fragment of fibronectin, enhanced MK growth at all concentrations of TPO. Conclusions: These findings have important implications for thrombopoiesis in general, and potentially for the enhanced platelet production found in states of systemic inflammation and following the use of therapeutic strategies designed to block alpha4beta1 integrin engagement in states of chronic inflammation and autoimmunity.
Mesh-Begriff(e)	Animals ; Antibodies, Monoclonal/metabolism ; Antibodies, Monoclonal/pharmacology ; Bone Marrow Cells/cytology ; Cell Proliferation/drug effects ; Disintegrins/pharmacology ; Dose-Response Relationship, Drug ; Endothelial Cells/cytology ; Fibronectins/metabolism ; Fibronectins/pharmacology ; Integrin alpha4beta1/antagonists & inhibitors ; Integrin alpha4beta1/metabolism ; Integrin alpha4beta1/physiology ; Megakaryocytes/cytology ; Mice ; Thrombopoiesis/drug effects ; Thrombopoietin/pharmacology ; Thrombopoietin/physiology
Chemische Substanzen	Antibodies, Monoclonal ; Disintegrins ; Fibronectins ; Integrin alpha4beta1 ; Thrombopoietin (9014-42-0)
Sprache	Englisch
Erscheinungsdatum	2005-01
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	185107-x
ISSN	1873-2399 ; 0301-472X ; 0531-5573
ISSN (online)	1873-2399
ISSN	0301-472X ; 0531-5573
DOI	10.1016/j.exphem.2004.10.002
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Volltext online

Zugriff für angemeldete ZB MED Nutzerinnen und Nutzer

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.A 922: Hefte anzeigen

Standort:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Über subito bestellen

Details ▾

Artikel ; Online: Relative Bioavailability of a Single Dose of Belimumab Administered Subcutaneously by Prefilled Syringe or Autoinjector in Healthy Subjects.

Struemper, Herbert / Murtaugh, Thomas / Gilbert, Jane / Barton, Matthew E / Fire, Joseph / Groark, James / Fox, Norma Lynn / Roth, David / Gordon, David

Clinical pharmacology in drug development

2016 Band 5, Heft 3, Seite(n) 208–215

Abstract: Intravenous belimumab is approved for the treatment of systemic lupus erythematosus; subcutaneous self-administration would enable greater patient access. This study assessed relative bioavailability, tolerability, and safety of 1 subcutaneous dose of ... ...

Abstract	Intravenous belimumab is approved for the treatment of systemic lupus erythematosus; subcutaneous self-administration would enable greater patient access. This study assessed relative bioavailability, tolerability, and safety of 1 subcutaneous dose of self-administered belimumab by healthy subjects using a single-use autoinjector or prefilled syringe. Subjects (randomized 1:1:1:1) self-administered belimumab 200 mg subcutaneously (abdomen or thigh) by prefilled syringe or autoinjector. Pharmacokinetics, adverse events (AEs), injection-site pain, and administration errors were recorded. Of 81 subjects, 5 experienced administration errors and were excluded from pharmacokinetic analyses. Mean serum belimumab concentration profiles were similar for both devices, with a weak trend toward higher concentrations for thigh injection compared with abdominal injections. Maximum observed serum concentration was slightly higher with the autoinjector (27.0 vs 25.3 µg/mL) and area under the concentration-time curve slightly lower (701 vs 735 day · μg/mL), compared with the prefilled syringe. Incidence of AEs was 51% (41 of 81 subjects; headache was most common), with no serious or severe AEs. Median injection-site pain scores were low (0 after 1 hour). Device handling was reported as acceptable by ≥95% of autoinjector users and ≥90% of prefilled syringe users for each characteristic assessed. These results support the use of either device for belimumab subcutaneous administration.
Sprache	Englisch
Erscheinungsdatum	2016-05
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2649010-9
ISSN	2160-7648 ; 2160-763X
ISSN (online)	2160-7648
ISSN	2160-763X
DOI	10.1002/cpdd.219
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Volltext online

Zugriff für angemeldete ZB MED Nutzerinnen und Nutzer

Zusatzmaterialien

Über subito bestellen

Details ▾
- Volltext online
- Kostenpflichtig bestellen

Artikel ; Online: Nonstandard RNA/RNA interactions likely enhance folding and stability of segmented ribosomes.

Rivas, Mario / Fox, George E

RNA (New York, N.Y.)

2021 Band 28, Heft 3, Seite(n) 340–352

Abstract: ... of standard base pairs that can hold them together. However, such regions of interaction are not observed ...

Abstract	The ribosome is the molecular factory that catalyzes all coded protein synthesis in extant organisms. Eukaryotic ribosomes are typically assembled out of four rRNAs; namely, 5S, 5.8S, 18S, and 28S. However, the 28S rRNA of some trypanosomatid organisms has been found to be segmented into six independent rRNAs of different sizes. The two largest segments have multiple sites where they jointly form stems comprised of standard base pairs that can hold them together. However, such regions of interaction are not observed among the four smaller RNAs. Early reports suggested that trypanosomatid segmented ribosome assembly was essentially achieved thanks to their association with rProteins. However, examination of cryo-EM ribosomal structures from
Mesh-Begriff(e)	Leishmania donovani/genetics ; Leishmania donovani/metabolism ; RNA Folding ; RNA Stability ; RNA, Ribosomal/chemistry ; RNA, Ribosomal/metabolism ; Ribosomes/chemistry ; Ribosomes/metabolism ; Trypanosoma brucei brucei/genetics ; Trypanosoma brucei brucei/metabolism ; Trypanosoma cruzi/genetics ; Trypanosoma cruzi/metabolism
Chemische Substanzen	RNA, Ribosomal
Sprache	Englisch
Erscheinungsdatum	2021-12-07
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1241540-6
ISSN	1469-9001 ; 1355-8382
ISSN (online)	1469-9001
ISSN	1355-8382
DOI	10.1261/rna.079006.121
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.A 4777: Hefte anzeigen

Standort:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Über subito bestellen

Details ▾
- Im ZB MED-Bestand
- Kostenpflichtig bestellen

Artikel: Evaluation of a novel autoinjector for subcutaneous self-administration of belimumab in systemic lupus erythematosus .

Sheikh, Saira Z / Hammer, Anne E / Fox, Norma Lynn / Groark, James / Struemper, Herbert / Roth, David / Gordon, David

International journal of clinical pharmacology and therapeutics

2016 Band 54, Heft 11, Seite(n) 914–922

Abstract: Objective: To study self-administration and pharmacokinetics (PK) of subcutaneous (SC) belimumab in patients with systemic lupus erythematosus (SLE).: Methods: Patients previously treated with belimumab self-administered belimumab 200 mg SC weekly ... ...

Abstract	Objective: To study self-administration and pharmacokinetics (PK) of subcutaneous (SC) belimumab in patients with systemic lupus erythematosus (SLE). Methods: Patients previously treated with belimumab self-administered belimumab 200 mg SC weekly for 8 weeks using an autoinjector. The primary endpoint was the proportion of patients able to self-administer their first and second dose (weeks 1 and 2) in the clinic. The proportion able to self-administer at weeks 4 and 8 (clinic) and weeks 3, 5, 6, and 7 (home) were secondary endpoints. Belimumab PK, safety, and injection-site pain were assessed. Results: 91/95 patients completed the study (withdrawals: adverse events (AEs): 3; lost to follow-up: 1). 93% were female, and mean (SD) age was 44.8 (12.50) years. The majority (99%, 89/90; no attempt, n = 5) successfully self-administered belimumab SC at weeks 1 and 2 (5 had clinic staff assistance), and 98% (85/87) successfully self-administered at weeks 4 and 8. Home-administration success rates were high (93%, (81/87) at weeks 3, 5, 6, and 7). Week 8 median trough concentration was 113 µg/mL. For patients with a ≤ 1.5-week interval between IV SC administration, week-1 concentrations were higher vs. week 8 (+ 51% median) but within a range observed with IV dosing; those with a ≥ 2.5-week interval had median differences close to 0. AEs and serious AEs were low, with no deaths; pain levels were low and decreased with subsequent injections. Conclusion: Patients with SLE successfully self-administered belimumab SC using a novel autoinjector; the PK profile was stable following a switch from IV with acceptable AE and pain levels. The recommended dosing interval between IV to SC dosing is 1 - 4 weeks. .
Mesh-Begriff(e)	Adult ; Aged ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antibodies, Monoclonal, Humanized/adverse effects ; Antibodies, Monoclonal, Humanized/therapeutic use ; Endpoint Determination ; Equipment Failure/statistics & numerical data ; Female ; Home Care Services ; Humans ; Immunosuppressive Agents/administration & dosage ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Injections, Intravenous ; Injections, Subcutaneous/adverse effects ; Injections, Subcutaneous/instrumentation ; Lupus Erythematosus, Systemic/drug therapy ; Male ; Middle Aged ; Pain/epidemiology ; Pain/etiology ; Patient Safety ; Self Administration ; Treatment Outcome ; Young Adult
Chemische Substanzen	Antibodies, Monoclonal, Humanized ; Immunosuppressive Agents ; belimumab (73B0K5S26A)
Sprache	Englisch
Erscheinungsdatum	2016-11
Erscheinungsland	Germany
Dokumenttyp	Evaluation Studies ; Journal Article
ZDB-ID	124384-6
ISSN	0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
ISSN	0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
DOI	10.5414/CP202623
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.A 467: Hefte anzeigen

Standort:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Über subito bestellen

Details ▾
- Im ZB MED-Bestand
- Kostenpflichtig bestellen

Artikel ; Online: F104S c-Mpl responds to a transmembrane domain-binding thrombopoietin receptor agonist: proof of concept that selected receptor mutations in congenital amegakaryocytic thrombocytopenia can be stimulated with alternative thrombopoietic agents.

Fox, Norma E / Lim, Jihyang / Chen, Rose / Geddis, Amy E

Experimental hematology

2010 Band 38, Heft 5, Seite(n) 384–391

Abstract: Objective: To determine whether specific c-Mpl mutations might respond to thrombopoietin receptor agonists.: Materials and methods: We created cell line models of type II c-Mpl mutations identified in congenital amegakaryocytic thrombocytopenia. We ... ...

Abstract	Objective: To determine whether specific c-Mpl mutations might respond to thrombopoietin receptor agonists. Materials and methods: We created cell line models of type II c-Mpl mutations identified in congenital amegakaryocytic thrombocytopenia. We selected F104S c-Mpl for further study because it exhibited surface expression of the receptor. We measured proliferation of cell lines expressing wild-type or F104S c-Mpl in response to thrombopoietin receptor agonists targeting the extracellular (m-AMP4) or transmembrane (LGD-4665) domains of the receptor by 1-methyltetrazole-5-thiol assay. We measured thrombopoietin binding to the mutant receptor using an in vitro thrombopoietin uptake assay and identified F104 as a potentially critical residue for the interaction between the receptor and its ligand by aligning thrombopoietin and erythropoietin receptors from multiple species. Results: Cells expressing F104S c-Mpl proliferated in response to LGD-4665, but not thrombopoietin or m-AMP4. Compared to thrombopoietin, LGD-4665 stimulates signaling with delayed kinetics in both wild-type and F104S c-Mpl-expressing cells. Although F104S c-Mpl is expressed on the cell surface in our BaF3 cell line model, the mutant receptor does not bind thrombopoietin. Comparison to the erythropoietin receptor suggests that F104 engages in hydrogen-bonding interactions that are critical for binding to thrombopoietin. Conclusions: These findings suggest that a small subset of patients with congenital amegakaryocytic thrombocytopenia might respond to treatment with thrombopoietin receptor agonists, but that responsiveness will depend on the type of mutation and agonist used. We postulate that F104 is critical for thrombopoietin binding. The kinetics of signaling in response to a transmembrane domain-binding agonist are delayed in comparison to thrombopoietin.
Mesh-Begriff(e)	Animals ; Cell Line ; Cell Membrane/metabolism ; Humans ; Hydrogen Bonding ; Interleukin-3/pharmacology ; Lymphocytes/metabolism ; Mice ; Mutagenesis, Site-Directed ; Peptides/pharmacology ; Phosphorylation ; Point Mutation ; Protein Binding ; Protein Interaction Mapping ; Protein Processing, Post-Translational ; Protein Structure, Tertiary ; Receptors, Thrombopoietin/agonists ; Receptors, Thrombopoietin/chemistry ; Receptors, Thrombopoietin/genetics ; Recombinant Fusion Proteins/agonists ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/genetics ; Recombinant Proteins/pharmacology ; Thrombocytopenia/congenital ; Thrombocytopenia/drug therapy ; Thrombocytopenia/genetics ; Thrombocytopenia/pathology ; Thrombopoiesis/drug effects ; Thrombopoietin/metabolism
Chemische Substanzen	Interleukin-3 ; Peptides ; Receptors, Thrombopoietin ; Recombinant Fusion Proteins ; Recombinant Proteins ; MPL protein, human (143641-95-6) ; Thrombopoietin (9014-42-0)
Sprache	Englisch
Erscheinungsdatum	2010-02-24
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	185107-x
ISSN	1873-2399 ; 0531-5573 ; 0301-472X
ISSN (online)	1873-2399
ISSN	0531-5573 ; 0301-472X
DOI	10.1016/j.exphem.2010.02.007
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Volltext online

Zugriff für angemeldete ZB MED Nutzerinnen und Nutzer

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.A 922: Hefte anzeigen

Standort:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Über subito bestellen

Details ▾

Artikel ; Online: Brief Interventions for Self-injurious Thoughts and Behaviors in Young People: A Systematic Review.

Dobias, Mallory L / Chen, Sharon / Fox, Kathryn R / Schleider, Jessica L

Clinical child and family psychology review

2023 Band 26, Heft 2, Seite(n) 482–568

Abstract: ... experimental trials conducted in the past 50 years that evaluated effects of "brief interventions" (i.e., not ... outcome, and only one intervention was identified as "probably efficacious" per standard criteria ...

Abstract	Rates of self-injurious thoughts and behaviors (SITBs) increase sharply across adolescence and remain high in young adulthood. Across 50 years of research, existing interventions for SITBs remain ineffective and inaccessible for many young people in particular need of mental healthcare. Briefer intervention options may increase access to care. However, many traditional interventions for SITBs take 6 months or more to complete-making it difficult for providers to target SITBs under real-world time constraints. The present review (1) identifies and (2) summarizes evaluations of brief psychosocial interventions for SITBs in young people, ages 10-24 years. We conducted searches for randomized and quasi-experimental trials conducted in the past 50 years that evaluated effects of "brief interventions" (i.e., not exceeding 240 min, or four 60-min sessions in total length) on SITBs in young people. Twenty-six articles were identified for inclusion, yielding a total of 23 brief interventions. Across all trials, results are mixed; only six interventions reported any positive intervention effect on at least one SITB outcome, and only one intervention was identified as "probably efficacious" per standard criteria for evidence-based status. While brief interventions for SITBs exist, future research must determine if, how, and when these interventions should be disseminated.
Mesh-Begriff(e)	Adolescent ; Child ; Humans ; Young Adult ; Crisis Intervention ; Psychosocial Intervention/methods ; Self-Injurious Behavior/epidemiology ; Self-Injurious Behavior/therapy ; Randomized Controlled Trials as Topic ; Treatment Outcome ; Health Services Accessibility ; Male ; Female
Sprache	Englisch
Erscheinungsdatum	2023-01-30
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S. ; Systematic Review
ZDB-ID	1445774-x
ISSN	1573-2827 ; 1096-4037
ISSN (online)	1573-2827
ISSN	1096-4037
DOI	10.1007/s10567-023-00424-9
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Volltext online

Zugriff für angemeldete ZB MED Nutzerinnen und Nutzer

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.A 5047: Hefte anzeigen

Standort:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Über subito bestellen

Details ▾

Artikel: Practical considerations for laboratories: Implementing a holistic quality management system.

Pillai, Segaran / Calvert, Jennifer / Fox, Elizabeth

Frontiers in bioengineering and biotechnology

2022 Band 10, Seite(n) 1040103

Abstract: ... that accommodates laboratory activities (e.g., basic and applied research; regulatory, clinical, or proficiency ... thus compromising the integrity and credibility of the institution. While there are many LQMS frameworks (e.g ... a model such as a consensus standard, guideline, or regulation) that may apply, ensuring ...

Abstract	A laboratory quality management system (LQMS) is an essential element for the effective operation of research, clinical, testing, or production/manufacturing laboratories. As technology continues to rapidly advance and new challenges arise, laboratories worldwide have responded with innovation and process changes to meet the continued demand. It is critical for laboratories to maintain a robust LQMS that accommodates laboratory activities (e.g., basic and applied research; regulatory, clinical, or proficiency testing), records management, and a path for continuous improvement to ensure that results and data are reliable, accurate, timely, and reproducible. A robust, suitable LQMS provides a framework to address gaps and risks throughout the laboratory path of workflow that could potentially lead to a critical error, thus compromising the integrity and credibility of the institution. While there are many LQMS frameworks (e.g., a model such as a consensus standard, guideline, or regulation) that may apply, ensuring that the appropriate framework is adopted based on the type of work performed and that key implementation steps are taken is important for the long-term success of the LQMS and for the advancement of science. Ultimately, it ensures accurate results, efficient operations, and increased credibility, enabling protection of public health and safety. Herein, we explore LQMS framework options for each identified laboratory category and discuss prerequisite considerations for implementation. An analysis of frameworks' principles and conformity requirements demonstrates the extent to which they address basic components of effective laboratory operations and guides optimal implementation to yield a holistic, sustainable framework that addresses the laboratory's needs and the type of work being performed.
Sprache	Englisch
Erscheinungsdatum	2022-11-03
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2022.1040103
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Über subito bestellen

Details ▾
- Kostenpflichtig bestellen

Zum Seitenanfang

Ihre letzten Suchen

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Zusatzmaterialien

Kategorien

Über subito bestellen

Fernleihe an ZB MED

Volltext online

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Volltext online

Zusatzmaterialien

Kategorien

Über subito bestellen

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Volltext online

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Volltext online

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Zusatzmaterialien

Kategorien

Über subito bestellen