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Article ; Online: "Gentlemen! This Is No Humbug": Did John Collins Warren, M.D., Proclaim These Words on October 16, 1846, at Massachusetts General Hospital, Boston?

Haridas, Rajesh P

2016 Volume 124, Issue 3, Page(s) 553–560

Abstract: The proclamation, "Gentlemen! this is no humbug," attributed to John Collins Warren, M.D., was not ... M.D., Robert Thompson Davis, M.D., and Isaac Francis Galloupe, M.D., reported Warren's alleged ...

Abstract	The proclamation, "Gentlemen! this is no humbug," attributed to John Collins Warren, M.D., was not identified in any contemporaneous eyewitness report of William T. G. Morton's October 16, 1846, demonstration of ether at Massachusetts General Hospital. The earliest known documentation of the proclamation is in Nathan P. Rice's biography of Morton, first published in 1859. Only three eyewitnesses, Washington Ayer, M.D., Robert Thompson Davis, M.D., and Isaac Francis Galloupe, M.D., reported Warren's alleged proclamation. However, their accounts first appeared in 1896, 50 yr after Morton's demonstration of etherization. Although Warren's alleged proclamation appears plausible, the overall impression from eyewitness statements and publications relating to the October 16, 1846, demonstration of etherization is that it may not have been made.
MeSH term(s)	Anesthesiology/history ; Anesthetics, Inhalation/history ; Boston ; Ether/history ; History, 18th Century ; History, 19th Century ; Hospitals, General/history ; Humans ; Male ; Massachusetts
Chemical Substances	Anesthetics, Inhalation ; Ether (0F5N573A2Y)
Language	English
Publishing date	2016-03
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article
ZDB-ID	269-0
ISSN	1528-1175 ; 0003-3022
ISSN (online)	1528-1175
ISSN	0003-3022
DOI	10.1097/ALN.0000000000000944
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Article ; Online: MUC16 induced rapid G2/M transition via interactions with JAK2 for increased proliferation and anti-apoptosis in breast cancer cells.

Lakshmanan, I / Ponnusamy, M P / Das, S / Chakraborty, S / Haridas, D / Mukhopadhyay, P / Lele, S M / Batra, S K

Oncogene

2011 Volume 31, Issue 7, Page(s) 805–817

Abstract: ... of MUC16 induced G2/M arrest in breast cancer cells through downregulation of Cyclin B1 and decreased ...

Abstract	MUC16/CA125 is a tumor marker currently used in clinics for the follow-up of patients with ovarian cancer. However, MUC16 expression is not entirely restricted to ovarian malignancies and has been reported in other cancers including breast cancer. Although it is well established as a biomarker, function of MUC16 in cancer remains to be elucidated. In the present study, we investigated the role of MUC16 in breast cancer and its underlying mechanisms. Interestingly, our results showed that MUC16 is overexpressed in breast cancer tissues whereas not expressed in non-neoplastic ducts. Further, stable knockdown of MUC16 in breast cancer cells (MDA MB 231 and HBL100) resulted in significant decrease in the rate of cell growth, tumorigenicity and increased apoptosis. In search of a mechanism for breast cancer cell proliferation we found that MUC16 interacts with the ezrin/radixin/moesin domain-containing protein of Janus kinase (JAK2) as demonstrated by the reciprocal immunoprecipitation method. These interactions mediate phosphorylation of STAT3 (Tyr705), which might be a potential mechanism for MUC16-induced proliferation of breast cancer cells by a subsequent co-transactivation of transcription factor c-Jun. Furthermore, silencing of MUC16 induced G2/M arrest in breast cancer cells through downregulation of Cyclin B1 and decreased phosphorylation of Aurora kinase A. This in turn led to enhanced apoptosis in the MUC16-knockdown breast cancer cells through Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated extrinsic apoptotic pathway with the help of c-Jun N-terminal kinase signaling. Collectively, our results suggest that MUC16 has a dual role in breast cancer cell proliferation by interacting with JAK2 and by inhibiting the apoptotic process through downregulation of TRAIL.
MeSH term(s)	Apoptosis ; Blotting, Western ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; CA-125 Antigen/genetics ; CA-125 Antigen/metabolism ; Cell Division ; Cell Line, Tumor ; Cell Proliferation ; Cyclin B1/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Female ; G2 Phase ; Humans ; Immunohistochemistry ; JNK Mitogen-Activated Protein Kinases/metabolism ; Janus Kinase 2/genetics ; Janus Kinase 2/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Models, Biological ; Phosphorylation ; Protein Binding ; RNA Interference ; STAT3 Transcription Factor/metabolism ; TNF-Related Apoptosis-Inducing Ligand/metabolism
Chemical Substances	CA-125 Antigen ; Cyclin B1 ; Cyclin-Dependent Kinase Inhibitor p21 ; MUC16 protein, human ; Membrane Proteins ; STAT3 Transcription Factor ; TNF-Related Apoptosis-Inducing Ligand ; TNFSF10 protein, human ; JAK2 protein, human (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2) ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2011-07-25
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	639046-8
ISSN	1476-5594 ; 0950-9232
ISSN (online)	1476-5594
ISSN	0950-9232
DOI	10.1038/onc.2011.297
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Article ; Online: Adipocyte-endothelial cell interplay in adipose tissue physiology.

Chaurasiya, Vaishali / Nidhina Haridas, P A / Olkkonen, Vesa M

Biochemical pharmacology

2024 Volume 222, Page(s) 116081

Abstract: Adipose tissue (AT) expansion through hyperplasia or hypertrophy requires vascular remodeling that involves angiogenesis. There is quite some evidence that obese white AT (WAT) displays altered vasculature. Some studies suggest that this is associated ... ...

Abstract	Adipose tissue (AT) expansion through hyperplasia or hypertrophy requires vascular remodeling that involves angiogenesis. There is quite some evidence that obese white AT (WAT) displays altered vasculature. Some studies suggest that this is associated with hypoxia, which is thought to play a role in inducing inflammatory activation of the excessively expanding WAT. Increasing evidence, based on genetic manipulations or treatments with inhibitory or activator pharmaceuticals, demonstrates that AT angiogenesis is crucial for AT metabolic function, and thereby for whole body metabolism and metabolic health. Despite some contradiction between studies, disturbance of WAT angiogenesis in obesity could be an important factor driving WAT dysfunction and the comorbidities of obesity. Endothelial cells (ECs) contribute to healthy WAT metabolism via transport of fatty acids and other plasma components, secretory signaling molecules, and extracellular vesicles (EVs). This communication is crucial for adipocyte metabolism and underscores the key role that the AT endothelium plays in systemic energy homeostasis and healthy metabolism. Adipocytes communicate towards the neighboring endothelium through several mechanisms. The pro-inflammatory status of hypertrophic adipocytes in obesity is reflected in ECs activation, which promotes chronic inflammation. On the other hand, adiponectin secreted by the adipocytes is important for healthy endothelial function, and adipocytes also secrete other pro- or anti-angiogenic effector molecules and a wealth of EVs - however, their detailed roles in signaling towards the endothelium are yet poorly understood. To conclude, targeting AT angiogenesis and promoting the healthy communication between adipocytes and ECs represent potentially promising strategies to treat obesity and its comorbidities.
MeSH term(s)	Humans ; Endothelial Cells/metabolism ; Adipose Tissue/metabolism ; Adipocytes/metabolism ; Adipose Tissue, White/metabolism ; Obesity/metabolism
Language	English
Publishing date	2024-02-24
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2024.116081
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Article ; Online: Synthesis and supramolecular properties of all-

Haridas, Shyamkumar V / von Delius, Max

Chemical communications (Cambridge, England)

2024 Volume 60, Issue 5, Page(s) 606–609

Abstract: We report the synthesis of all- ...

Abstract	We report the synthesis of all-
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d3cc05510h
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Article ; Online: Editorial Expression of Concern: Metal Ion Coordination Essential for Specific Molecular Interactions of Butea monosperma Lectin: ITC and MD Simulation Studies.

Abhilash, J / Haridas, M

Applied biochemistry and biotechnology

2022 Volume 195, Issue 2, Page(s) 1605

Language	English
Publishing date	2022-10-19
Publishing country	United States
Document type	Journal Article ; Expression of Concern
ZDB-ID	392344-7
ISSN	1559-0291 ; 0273-2289
ISSN (online)	1559-0291
ISSN	0273-2289
DOI	10.1007/s12010-022-04192-0
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Zs.A 3053: Show issues

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Article ; Online: A predictive score for severity in patients with confirmed dengue fever in a tertiary care hospital in Kerala, India.

Haridas, Sruthi / M, Gopalakrishna Pillai / Bhaskaran, Renjitha

Transactions of the Royal Society of Tropical Medicine and Hygiene

2023 Volume 117, Issue 10, Page(s) 741–750

Abstract: Background: The study aimed to identify predictors of severe dengue during the 2017 epidemic and to develop and validate a simple predictive score for severity.: Methods: A retrospective analytical study was conducted using clinical and laboratory ... ...

Abstract	Background: The study aimed to identify predictors of severe dengue during the 2017 epidemic and to develop and validate a simple predictive score for severity. Methods: A retrospective analytical study was conducted using clinical and laboratory data from adult dengue patients with a confirmed microbiological diagnosis. The study included patients who presented to a tertiary care centre in Kerala, India, during the febrile phase (≤4 d) between June 2017 and February 2019. Using appropriate statistical tests, we derived predictors of severe disease and computed a risk score model. Results: Of the 153 patients (mean age 50±17 y; 64% males), 31 (20%) had severe dengue and 4 (3%) died. Petechial lesions, hypoalbuminemia (<3.5 g/dl), elevated alanine aminotransferase (>40 IU/l) and urea >40 IU/l were significant predictors. Our scoring system (cut-off: 2) showed excellent performance, with an area under the receiver operating characteristics curve of 0.9741, sensitivity of 100%, specificity of 96% and accuracy of 98%. The risk score was secondarily validated on 48 patients hospitalized from March 2019 to June 2019. Conclusion: Our scoring system is easy to implement and will help primary healthcare practitioners in promptly identifying severe dengue cases upon hospital presentation.
MeSH term(s)	Male ; Adult ; Humans ; Middle Aged ; Aged ; Female ; Severe Dengue/diagnosis ; Severe Dengue/epidemiology ; Tertiary Care Centers ; Retrospective Studies ; Risk Factors ; India/epidemiology ; Dengue/diagnosis ; Dengue/epidemiology
Language	English
Publishing date	2023-08-23
Publishing country	England
Document type	Journal Article
ZDB-ID	441375-1
ISSN	1878-3503 ; 0035-9203
ISSN (online)	1878-3503
ISSN	0035-9203
DOI	10.1093/trstmh/trad058
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Article ; Online: Noncovalent Functionalization of Graphene Nanoplatelets and Their Applications in Supercapacitors.

Haridas, Haritha / Kader, Arsath Kose Abdul / Sellathurai, Andrew / Barz, Dominik P J / Kontopoulou, Marianna

ACS applied materials & interfaces

2024 Volume 16, Issue 13, Page(s) 16630–16640

Abstract: ... in a reduction of the specific surface area to 312 ± 9 m ...

Abstract	We demonstrate a simple noncovalent functionalization technique, which involves graphite exfoliation and subsequent coating of the resulting graphene nanoplatelets (GNPs) with trimellitic anhydride (TMA), using a thermomechanical exfoliation process. TMA adsorbs on the surface of the GNPs, resulting in a reduction of the specific surface area to 312 ± 9 m
Language	English
Publishing date	2024-03-20
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c18174
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Article: Joseph Jacobs: Apprentice to Crawford W. Long in Athens, GA; Pharmacist and Retailer of Soda Fountain Beverages in Atlanta, GA.

Haridas, Rajesh P

Journal of anesthesia history

2018 Volume 4, Issue 1, Page(s) 7–8

Abstract: ... in Jacobs' Pharmacy was owned by Willis E. Venable, who was related to James M. Venable, the first patient ...

Abstract	In the 1870s, Joseph Jacobs was employed as an apprentice in the Longs and Billups pharmacy in Athens, GA. Jacobs later established a chain of pharmacies in Atlanta, GA. Coca-Cola was first sold to the public on May 8, 1886, at Jacobs' Pharmacy in the Five Points district of Atlanta, GA. The soda fountain in Jacobs' Pharmacy was owned by Willis E. Venable, who was related to James M. Venable, the first patient etherized by Crawford Long in Jefferson, GA.
MeSH term(s)	Anesthetics/history ; Carbonated Beverages/history ; Georgia ; History, 19th Century ; Pharmacies/history ; Pharmacists/history
Chemical Substances	Anesthetics
Language	English
Publishing date	2018-02-02
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article ; Portrait
ISSN	2352-4529
ISSN	2352-4529
DOI	10.1016/j.janh.2018.01.005
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Article ; Online: Middle Cerebral Artery Aneurysm Clipping With Immersive 360° Virtual Reality Model: 2-Dimensional Operative Video.

Haridas, Abilash / Miller, Michael

Operative neurosurgery (Hagerstown, Md.)

2020 Volume 20, Issue 4, Page(s) E314

Abstract: This is a 50-yr-old female who presented with severe headaches and was found to have an unruptured middle cerebral artery (MCA) aneurysm. She was taken to the operating room for microsurgical clipping. Prior to surgery, an interactive 360° virtual ... ...

Abstract	This is a 50-yr-old female who presented with severe headaches and was found to have an unruptured middle cerebral artery (MCA) aneurysm. She was taken to the operating room for microsurgical clipping. Prior to surgery, an interactive 360° virtual reality (VR) model (Surgical Theatre Inc) rendered from the patient's volumetric computed tomography (CT) angiography (CTA) was used for patient education and operative planning. The aneurysm was located at the MCA trifurcation, and the VR model was used to rehearse clip options prior to surgery. A right pterional craniotomy was performed with a dissection through the sylvian fissure down the M1 segment of the MCA for proximal control. The surgical clips are placed and highlighted in the virtual platform simultaneously. Doppler and indocyanine green (ICG) confirmed patent flow through the MCA trifurcation. A postoperative angiogram confirmed no aneurysm filling. The immersive 360° VR models of pre- and postoperative CTA were shown to the patient at the 1-mo follow-up. The case presented here demonstrates the utilization of the 360° VR model for patient education, preoperative planning, and intraoperative visualization. It is imperative to remain flexible during surgery to change the strategy based on the aneurysm anatomy intraoperatively. Importantly, the interactive 360° VR model allowed for a detailed evaluation of the patient-specific anatomy prior to surgery and helped understand the complex anatomy in high resolution. The patient consented to the procedure and publication of this video for educational purposes.
MeSH term(s)	Female ; Humans ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/surgery ; Microsurgery ; Neurosurgical Procedures ; Surgical Instruments ; Virtual Reality
Language	English
Publishing date	2020-12-13
Publishing country	United States
Document type	Case Reports ; Journal Article ; Video-Audio Media
ZDB-ID	2767575-0
ISSN	2332-4260 ; 2332-4252
ISSN (online)	2332-4260
ISSN	2332-4252
DOI	10.1093/ons/opaa416
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Article ; Online: Efficacy of HDAC inhibitors and epigenetic modulation in the amelioration of synovial inflammation, cellular invasion, and bone erosion in rheumatoid arthritis pathogenesis.

Vijaykrishnaraj, M / Patil, Prakash / Ghate, Sudeep D / Bhandary, Adithi K / Haridas, Vikram M / Shetty, Praveenkumar

International immunopharmacology

2023 Volume 122, Page(s) 110644

Abstract: Rheumatoid arthritis (RA), an auto-immune disorder affected 1 % of the population around the globe. The pathophysiology of RA is highly concerted process including synovial hyperplasia, pannus formation, bone erosion, synovial cell infiltration in joints, ...

Abstract	Rheumatoid arthritis (RA), an auto-immune disorder affected 1 % of the population around the globe. The pathophysiology of RA is highly concerted process including synovial hyperplasia, pannus formation, bone erosion, synovial cell infiltration in joints, and cartilage destruction. However, recent reports suggest that epigenetics play a pivotal role in the formation and organization of immune response in RA. Particularly, altered DNA methylation and impaired microRNA (miRNA) were detected in several immune cells of RA patients, such as T regulatory cells, fibroblast-like synoviocytes, and blood mononuclear cells. All these processes can be reversed by regulating the ubiquitous or tissue-based expression of histone deacetylases (HDACs) to counteract and terminate them. Hence, HDAC inhibitors (HDACi) could serve as highly potent anti-inflammatory regulators in the uniform amelioration of inflammation. Therefore, this review encompasses the information mainly focussing on the epigenetic modulation in RA pathogenesis and the efficacy of HDACi as an alternative therapeutic option for RA treatment. Overall, these studies have reported the targeting of HDAC1, 2 & 6 molecules would attenuate synoviocyte inflammation, cellular invasion, and bone erosion. Further, the inhibitors such as trichostatin A, suberoyl bis-hydroxamic acid, suberoyl anilide hydroxamic acid, and other compounds are found to attenuate synovial inflammatory immune response, clinical arthritis score, paw swelling, bone erosion, and cartilage destruction. Insight to view this, more clinical studies are required to determine the efficacy of HDACi in RA treatment and to unravel the underlying molecular mechanisms.
MeSH term(s)	Humans ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/therapeutic use ; Arthritis, Rheumatoid ; Inflammation/metabolism ; Synoviocytes/metabolism ; Epigenesis, Genetic ; Fibroblasts/metabolism ; Synovial Membrane/pathology
Chemical Substances	Histone Deacetylase Inhibitors
Language	English
Publishing date	2023-07-14
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2023.110644
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