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Article ; Online: Unveiling Neurobrucellosis: A Case Report Emphasizing Early Diagnosis for Better Outcomes.

Haripriya, Sivakumar / Malhotra, Shikhir / Gadepalli, Ravisekhar / Tak, Vibhor / Kumar, Bharat

Access microbiology

2024 Volume 6, Issue 2

Abstract: Introduction: Brucellosis is a pervasive zoonotic disease causing considerable human morbidity worldwide. This report focuses on a case of neurobrucellosis in a rural Indian patient, emphasizing the need for timely microbiological confirmation given its ...

Abstract	Introduction: Brucellosis is a pervasive zoonotic disease causing considerable human morbidity worldwide. This report focuses on a case of neurobrucellosis in a rural Indian patient, emphasizing the need for timely microbiological confirmation given its nonspecific clinical presentation. Case presentation: A 55-year-old rural Indian farmer presented with a 3 week history of insidious, low-grade fever, myalgia, and arthralgia. He developed acute right-sided weakness and neurological symptoms, including disorientation and neck rigidity. Laboratory tests indicated abnormal blood counts, elevated inflammatory markers, and liver dysfunction. Cerebrospinal fluid analysis showed pleocytosis with lymphomononuclear cells and elevated protein levels. Blood cultures eventually grew Gram-negative coccobacilli. Serological tests confirmed neurobrucellosis. Prompt antibiotic therapy led to clinical and laboratory improvement. Conclusion: This case underscores the importance of recognizing neurobrucellosis, particularly in endemic areas, given its nonspecific clinical presentation. Early microbiological diagnosis, supported by positive blood cultures and serological tests, was crucial. The patient's rapid response to appropriate antibiotics emphasizes the significance of timely recognition and management.
Language	English
Publishing date	2024-02-13
Publishing country	England
Document type	Case Reports
ISSN	2516-8290
ISSN (online)	2516-8290
DOI	10.1099/acmi.0.000705.v3
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Article: Effect of Preoperative Dexamethasone on Postoperative Pain in Patients Undergoing Tonsillectomy.

Malhotra, Vibhor / Kumar, Vivek

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2022 Volume 75, Issue 2, Page(s) 249–254

Abstract: Tonsillectomy is one of the most commonly performed surgical procedures worldwide. Postoperative pain remains a significant problem for patients undergoing tonsillectomy and is the most typical reason for readmission after the procedure. We conducted the ...

Abstract	Tonsillectomy is one of the most commonly performed surgical procedures worldwide. Postoperative pain remains a significant problem for patients undergoing tonsillectomy and is the most typical reason for readmission after the procedure. We conducted the present study to investigate the efficacy of a single dose of dexamethasone administered intravenously before tonsillectomy on postoperative pain in a group of patients undergoing cold dissection tonsillectomy, using a standardised anaesthetic and surgical procedure.It was a prospective study done in the Department of ENT in a tertiary care centre in eastern India, from 1 st September 2017 to 31 st August 2019 (2 years). Subjects included in the study were patients who attended the OPD of ENT of the tertiary care centre in eastern India, with a history of throat pain,difficulty in deglutition, mouth breathing, snoring. Tonsillectomy operation was recommended to the patients who fit the inclusion criteria. A hundred patients were selected for the study and divided randomly into two groups. Patients in group A (50 patients) were administered preoperative intravenous dexamethasone (0.15 mg/kg)after the induction of anaesthesia, and Group B patients (50 patients)were not administered dexamethasone along with other drugs.RESULTS: A hundred patients were enrolled after excluding the patients not fulfilling the selection criteria. The majority of patients were female, with the majority patients between 9-19 years. There was a noteworthy decreased mean pain score postoperatively of Group A on the first, third, and fifth day. (
Language	English
Publishing date	2022-10-06
Publishing country	India
Document type	Journal Article
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-022-03195-x
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Article: Design Guidelines for Thin Diaphragm-Based Microsystems through Comprehensive Numerical and Analytical Studies.

Belwanshi, Vinod / Rane, Kedarnath / Kumar, Vibhor / Pramanick, Bidhan

Micromachines

2023 Volume 14, Issue 9

Abstract: This paper presents comprehensive guidelines for the design and analysis of a thin diaphragm that is used in a variety of microsystems, including microphones and pressure sensors. It highlights the empirical relations that can be utilized for the design ... ...

Abstract	This paper presents comprehensive guidelines for the design and analysis of a thin diaphragm that is used in a variety of microsystems, including microphones and pressure sensors. It highlights the empirical relations that can be utilized for the design of thin diaphragm-based microsystems (TDMS). Design guidelines developed through a Finite Element Analysis (FEA) limit the iterative efforts to fabricate TDMS. These design guidelines are validated analytically, with the assumption that the material properties are isotropic, and the deviation from anisotropic material is calculated. In the FEA simulations, a large deflection theory is taken into account to incorporate nonlinearity, such that a critical dimensional ratio of a/h or 2r/h can be decided to have the linear response of a thin diaphragm. The observed differences of 12% in the deflection and 13% in the induced stresses from the analytical calculations are attributed to the anisotropic material consideration in the FEA model. It suggests that, up to a critical ratio (a/h or 2r/h), the thin diaphragm shows a linear relationship with a high sensitivity. The study also presents a few empirical relations to finalize the geometrical parameters of the thin diaphragm in terms of its edge length or radius and thickness. Utilizing the critical ratio calculated in the static FEA analysis, the basic conventional geometries are considered for harmonic analyses to understand the frequency response of the thin diaphragms, which is a primary sensing element for microphone applications and many more. This work provides a solution to microelectromechanical system (MEMS) developers for reducing cost and time while conceptualizing TDMS designs.
Language	English
Publishing date	2023-09-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi14091725
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Article: An uncommon case of a fleeting rash from Western Rajasthan.

Jalootharia, Garima / Sivakumar, Haripriya / Soni, Bhavesh / Tak, Vibhor / Agrawal, Himanshu / Gonnade, Nitesh Manohar / Gaur, Ravi / Kumar, Deepak

Tropical parasitology

2024 Volume 14, Issue 1, Page(s) 54–56

Abstract: A 35 year old farmer presented with an erythematous serpiginous rash on dorsal aspect of left foot with intense pruritus and a feeling of something moving slowly in the rash. The photo of the rash is presented below and the case is discussed further. ...

Abstract	A 35 year old farmer presented with an erythematous serpiginous rash on dorsal aspect of left foot with intense pruritus and a feeling of something moving slowly in the rash. The photo of the rash is presented below and the case is discussed further.
Language	English
Publishing date	2024-02-15
Publishing country	India
Document type	Journal Article
ZDB-ID	2628177-6
ISSN	2229-7758 ; 2229-5070
ISSN (online)	2229-7758
ISSN	2229-5070
DOI	10.4103/tp.tp_64_23
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Article ; Online: Emerging Two-Dimensional Materials for Electromagnetic Interference Shielding Application.

Kumari, Suman / Dalal, Jasvir / Kumar, Vibhor / Kumar, Anand / Ohlan, Anil

International journal of molecular sciences

2023 Volume 24, Issue 15

Abstract: Graphene is the first two-dimensional material that becomes the center material in various research areas of material science, chemistry, condensed matter, and engineering due to its advantageous properties, including larger specific area, lower density, ...

Abstract	Graphene is the first two-dimensional material that becomes the center material in various research areas of material science, chemistry, condensed matter, and engineering due to its advantageous properties, including larger specific area, lower density, outstanding electrical conductivity, and ease of processability. These properties attracted the attention of material researchers that resulted in a large number of publications on EMI shielding in a short time and play a central role in addressing the problems and challenges faced in this modern era of electronics by electromagnetic interference. After the popularity of graphene, the community of material researchers investigated other two-dimensional materials like MXenes, hexagonal boron nitride, black phosphorous, transition metal dichalcogenides, and layered double hydroxides, to additionally enhance the EMI shielding response of materials. The present article conscientiously reviews the current progress in EMI shielding materials in reference to two-dimensional materials and addresses the future challenges and research directions to achieve the goals.
MeSH term(s)	Graphite ; Electric Conductivity ; Electronics ; Phosphorus
Chemical Substances	Graphite (7782-42-5) ; Phosphorus (27YLU75U4W)
Language	English
Publishing date	2023-07-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241512267
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Article: Improving Chromatin-Interaction Prediction Using Single-Cell Open-Chromatin Profiles and Making Insight Into the

Pandey, Neetesh / Omkar Chandra / Mishra, Shreya / Kumar, Vibhor

Frontiers in genetics

2021 Volume 12, Page(s) 738194

Abstract: Single-cell open-chromatin profiles have the potential to reveal the pattern of chromatin-interaction in a cell type. However, currently ... ...

Abstract	Single-cell open-chromatin profiles have the potential to reveal the pattern of chromatin-interaction in a cell type. However, currently available
Language	English
Publishing date	2021-10-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2021.738194
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Article ; Online: A Day Saved is a Life Saved: Direct Antimicrobial Susceptibility Testing from Positively Flagged Blood Culture Bottles and their Concordance with the Routine Method.

Aggarwal, Alisha / Abhishek, Kumar S / Tak, Vibhor / Mehrotra, Sukanya / Nag, Venkat Goutham / Jain, Vidhi

Infectious disorders drug targets

2024

Abstract: Background: Sepsis is a major health problem worldwide and is associated with high morbidity and mortality with every hour delay in initiation of therapy. A conventional method of blood culture and Antimicrobial Susceptibility Testing (AST) takes around ...

Abstract	Background: Sepsis is a major health problem worldwide and is associated with high morbidity and mortality with every hour delay in initiation of therapy. A conventional method of blood culture and Antimicrobial Susceptibility Testing (AST) takes around 48-72 hours. Empirical antibiotics need to be administered until the sensitivity report is made available. It has been estimated that 20-50% of the empirical antibiotics are inappropriate, resulting in prolonged hospital stays, adverse effects, and emergence of drug resistance. Additionally, this also puts an extra financial burden on both the patients and healthcare settings. Performing direct Antimicrobial Sensitivity Testing (dAST) is an important tool to reduce turn-around time (TAT) by at least 18-24 hours, thus reducing morbidity and mortality among critically ill patients. Methods: Direct AST (dAST) was performed from the positively flagged blood culture bottles received between December, 2021 to May, 2022 from Intensive Care Units (ICUs) on MuellerHinton Agar (MHA) using four drops of withdrawn blood. dAST was performed for six drugs: Ceftriaxone-30 µg (CTR), Piperacillin/Tazobactam-100/10 µg (PIT), Meropenem-10 µg (MRP), Ciprofloxacin-5 µg (CIP), Aztreonam-30 µg (AT), and Colistin (CL). The zone of inhibition was interpreted as per CLSI M100 ed32, 2022 guidelines. A parallel conventional method was also performed to examine for categorical agreement and disagreement. Identification was carried out using MALDI-TOF MS from the colonies that appeared on the dAST plate on the subsequent day. Results: A total of 162 positively flagged blood culture bottles were included in the study. The majority of the Gram-negative organisms were from Enterobacterales (n=109), followed by Acinetobacter spp. (n=28) and Pseudomonas aeruginosa (n=25). Out of the 972 isolate-antimicrobial combinations, overall Categorical Agreement (CA) was seen in 936 (96.3%), whereas disagreement was observed in 36 with minor error (mE) in 21 (2.2%), major error (ME) in 7 (0.7%), and very major error (VME) in 8 (0.8%) when compared to the routine method. Categorical agreement (CA) of > 99% was seen in ceftriaxone (CTR) and ciprofloxacin (CIP). In comparison, the lowest CA was observed with meropenem (MRP) at 92%. Colistin dAST was performed using the E-strip method, and the result obtained was highly convincing, with an overall disagreement of only 1.2%. Conclusion: Rapid dAST from positively flagged blood culture bottles proved to significantly reduce the TAT from the time of sample collection to the first availability of antimicrobial susceptibility report with excellent categorical agreement of > 95% using the conventional disc diffusion method. Results obtained were within the acceptance criteria set by U. S. Food and Drug Administration (FDA) guidelines of > 90% categorical agreement for a new method. We were able to obtain excellent concordance for colistin using the E-strip method. Performing dAST not only saves a "day", but its proper implementation would save a "life".
Language	English
Publishing date	2024-04-17
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2234298-9
ISSN	2212-3989 ; 1871-5265
ISSN (online)	2212-3989
ISSN	1871-5265
DOI	10.2174/0118715265280460240302165218
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Article: Evolving Essential and Desirable Requisites for Clinical Fellowship in Cochlear Implant Surgery.

Malhotra, Vibhor / Vadlamani, Swathi / Gaur, Sumit Kumar / Dutt, Sunil Narayan

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2023 Volume 75, Issue Suppl 1, Page(s) 518–522

Abstract: Studies from developed countries show the prevalence of permanent childhood hearing loss to be 1 to 2 per thousand children. The estimated number of Ear, Nose, and Throat (ENT) specialists and otologists in India were 7000 and 2000. There is a great need ...

Abstract	Studies from developed countries show the prevalence of permanent childhood hearing loss to be 1 to 2 per thousand children. The estimated number of Ear, Nose, and Throat (ENT) specialists and otologists in India were 7000 and 2000. There is a great need for trained CI surgeons to care for that burden. Currently, only a handful of centres in the country provide CI training. This study aims to put together essential and desirable requisites for a clinical fellowship in CI surgery for ENT surgeons. A questionnaire was prepared and validated by 25 senior CI surgeons in India. Then the sixteen-question questionnaire was prepared and administered to 100 practising CI Surgeons (Group A) and 100 probable CI Fellowship Candidates (Group B). Group B involved surgeons currently pursuing their ENT post-graduation or have completed their postgraduate training and are inclined towards otology and CI surgery in the future. The responses ranged from 1 (Strongly Disagree) to 5 (Strongly Agree) on a Likert Scale. The responses from both groups were analyzed, and statistical analysis was performed using SPSS(Statistical Package for the Social Sciences) software. The results were analysed and tabulated from both groups. The weighted mean response and mean opinion to all the questions were calculated for both groups. Based on the response, "Essential" and "Desirable" criteria are given.
Language	English
Publishing date	2023-03-02
Publishing country	India
Document type	Journal Article
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-023-03620-9
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Article: Measurement of micro-harmonic vibration from optical feedback interferometry using wavelet trend analysis.

Bhardwaj, Vibhor Kumar / Maini, Surita

Optics communications

2020 Volume 476, Page(s) 126330

Abstract: Self-mixed optical feedback interferometry based laser sensors show promising results in the measurement of the vibration frequency. To date several measurement methods have been developed to extract the vibration information from the self-mixed (SM) ... ...

Abstract	Self-mixed optical feedback interferometry based laser sensors show promising results in the measurement of the vibration frequency. To date several measurement methods have been developed to extract the vibration information from the self-mixed (SM) signal; however, the complexity and accuracy of the methods still need improvement. The presented work tries to fulfill the gap by realizing a novel method using maximal overlap discrete wavelet transformation (MODWT) and multi-resolution analysis (MRA). The proposed method can reconstruct the micro-harmonic (<
Keywords	covid19
Language	English
Publishing date	2020-07-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1468811-6
ISSN	1873-0310 ; 0030-4018
ISSN (online)	1873-0310
ISSN	0030-4018
DOI	10.1016/j.optcom.2020.126330
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Article ; Online: Compact and self-aligned fluid refractometer based on the Doppler-induced self-mixing effect.

Kumar Bhardwaj, Vibhor / Maini, Surita

Applied optics

2020 Volume 59, Issue 10, Page(s) 3064–3072

Abstract: The refractive index is one of the key parameters in non-invasive and label-free sensing applications. The past decade has witnessed various miniature optofluidic devices that offer several analytical functions with minuscule samples (picoliter or ... ...

Abstract	The refractive index is one of the key parameters in non-invasive and label-free sensing applications. The past decade has witnessed various miniature optofluidic devices that offer several analytical functions with minuscule samples (picoliter or nanoliter) through the fusion of optics and microfluidic sciences. However, the realization of a compact, wide-range, and less-expensive refractometer is still a great challenge. In this paper, the authors have proposed a novel, to the best of our knowledge, self-mixing optical feedback interferometry (SM-OFI)-based refractometer that correlates the refractive index of a flowing liquid to the induced Doppler frequency shift. The proposed method was experimentally tested on the saline water and benzyl chloride and found close agreement with the literature results. The refractive indices of the saline water and benzyl chloride were measured to be 1.3346 and 1.54079, respectively, with a standard deviation of the order of 10
Language	English
Publishing date	2020-05-13
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.388078
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