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  1. Article ; Online: Alzheimer's Disease-Related Epigenetic Changes: Novel Therapeutic Targets.

    Paniri, Alireza / Hosseini, Mohammad Mahdi / Akhavan-Niaki, Haleh

    Molecular neurobiology

    2023  Volume 61, Issue 3, Page(s) 1282–1317

    Abstract: Aging is a significant risk factor for Alzheimer's disease (AD), although the precise mechanism and molecular basis of AD are not yet fully understood. Epigenetic mechanisms, such as DNA methylation and hydroxymethylation, mitochondrial DNA methylation, ... ...

    Abstract Aging is a significant risk factor for Alzheimer's disease (AD), although the precise mechanism and molecular basis of AD are not yet fully understood. Epigenetic mechanisms, such as DNA methylation and hydroxymethylation, mitochondrial DNA methylation, histone modifications, and non-coding RNAs (ncRNAs), play a role in regulating gene expression related to neuron plasticity and integrity, which are closely associated with learning and memory development. This review describes the impact of dynamic and reversible epigenetic modifications and factors on memory and plasticity throughout life, emphasizing their potential as target for therapeutic intervention in AD. Additionally, we present insight from postmortem and animal studies on abnormal epigenetics regulation in AD, as well as current strategies aiming at targeting these factors in the context of AD therapy.
    MeSH term(s) Animals ; Alzheimer Disease/genetics ; Alzheimer Disease/therapy ; Alzheimer Disease/metabolism ; Epigenesis, Genetic ; DNA Methylation/genetics ; DNA, Mitochondrial/metabolism ; Mitochondria/metabolism
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2023-09-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-023-03626-y
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    Zs.A 2411: Show issues Location:
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  2. Article ; Online: Emerging role of IL-6 and NLRP3 inflammasome as potential therapeutic targets to combat COVID-19: Role of lncRNAs in cytokine storm modulation.

    Paniri, Alireza / Akhavan-Niaki, Haleh

    Life sciences

    2020  Volume 257, Page(s) 118114

    Abstract: The world has witnessed a high morbidity and mortality caused by SARS-CoV-2, and global death toll is still rising. Exaggerated inflammatory responses are thought to be more responsible for infiltrated immune cells accumulation, organ damage especially ... ...

    Abstract The world has witnessed a high morbidity and mortality caused by SARS-CoV-2, and global death toll is still rising. Exaggerated inflammatory responses are thought to be more responsible for infiltrated immune cells accumulation, organ damage especially lung, dyspnea, and respiratory failure rather than direct effect of viral replication. IL-6 and NLRP3 inflammasome are the major immune components in immune responses stimulation upon pathogen infection. It's noteworthy that the function and expression of these components are remarkably influenced by non-coding RNAs including long non-coding RNAs. Given the potential role of these components in organ damage and pathological manifestations of patients infected with COVID-19, their blockage might be a hopeful and promising treatment strategy. Notably, more study on long non-coding RNAs involved in inflammatory responses could elevate the efficacy of anti-inflammatory therapy. In this review we discuss the potential impact of IL-6 and NLRP3 inflammasome blocker drugs on inflammatory responses, viral clearance, and pathological and clinical manifestations. Collectively, anti-inflammatory strategy might pave the way to diminish clinical and pathological manifestations and thereby discharging patients infected with COVID-19 from hospital.
    MeSH term(s) Anti-Inflammatory Agents/pharmacology ; Betacoronavirus/genetics ; Betacoronavirus/immunology ; Betacoronavirus/metabolism ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/metabolism ; Cytokines/genetics ; Cytokines/immunology ; Humans ; Inflammasomes/immunology ; Inflammation/immunology ; Interleukin-6/immunology ; Interleukin-6/metabolism ; Interleukin-6/pharmacology ; NLR Family, Pyrin Domain-Containing 3 Protein/immunology ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/physiology ; SARS-CoV-2
    Chemical Substances Anti-Inflammatory Agents ; Cytokines ; Inflammasomes ; Interleukin-6 ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLRP3 protein, human ; RNA, Long Noncoding
    Keywords covid19
    Language English
    Publishing date 2020-07-18
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2020.118114
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  3. Article: Impact of new UK (B.1.1.7) SARS-Cov-2 variant on interacting with ACE2 and host immune response.

    Paniri, Alireza / Hosseini, Mohammad Mahdi / Akhavan-Niaki, Haleh

    Gene reports

    2021  Volume 25, Page(s) 101342

    Language English
    Publishing date 2021-09-03
    Publishing country United States
    Document type Journal Article
    ISSN 2452-0144
    ISSN 2452-0144
    DOI 10.1016/j.genrep.2021.101342
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  4. Article: Emerging role of IL-6 and NLRP3 inflammasome as potential therapeutic targets to combat COVID-19: Role of lncRNAs in cytokine storm modulation

    Paniri, Alireza / Akhavan-Niaki, Haleh

    Life sciences. 2020 Sept. 15, v. 257

    2020  

    Abstract: The world has witnessed a high morbidity and mortality caused by SARS-CoV-2, and global death toll is still rising. Exaggerated inflammatory responses are thought to be more responsible for infiltrated immune cells accumulation, organ damage especially ... ...

    Abstract The world has witnessed a high morbidity and mortality caused by SARS-CoV-2, and global death toll is still rising. Exaggerated inflammatory responses are thought to be more responsible for infiltrated immune cells accumulation, organ damage especially lung, dyspnea, and respiratory failure rather than direct effect of viral replication. IL-6 and NLRP3 inflammasome are the major immune components in immune responses stimulation upon pathogen infection. It's noteworthy that the function and expression of these components are remarkably influenced by non-coding RNAs including long non-coding RNAs. Given the potential role of these components in organ damage and pathological manifestations of patients infected with COVID-19, their blockage might be a hopeful and promising treatment strategy. Notably, more study on long non-coding RNAs involved in inflammatory responses could elevate the efficacy of anti-inflammatory therapy. In this review we discuss the potential impact of IL-6 and NLRP3 inflammasome blocker drugs on inflammatory responses, viral clearance, and pathological and clinical manifestations. Collectively, anti-inflammatory strategy might pave the way to diminish clinical and pathological manifestations and thereby discharging patients infected with COVID-19 from hospital.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; death ; dyspnea ; hospitals ; inflammasomes ; interleukin-6 ; lungs ; morbidity ; mortality ; pathogens ; therapeutics ; virus replication
    Language English
    Dates of publication 2020-0915
    Publishing place Elsevier Inc.
    Document type Article
    Note NAL-light
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2020.118114
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  5. Article ; Online: Insights into the Links between MYC and 3D Chromatin Structure and Epigenetics Regulation: Implications for Cancer Therapy.

    Amjadi-Moheb, Fatemeh / Paniri, Alireza / Akhavan-Niaki, Haleh

    Cancer research

    2021  Volume 81, Issue 8, Page(s) 1925–1936

    Abstract: ... ...

    Abstract MYC
    MeSH term(s) CCCTC-Binding Factor ; Chromatin/ultrastructure ; Chromosomes, Human, Pair 8/genetics ; Disease Progression ; Epigenesis, Genetic/physiology ; Gene Expression Regulation, Neoplastic ; Genes, Neoplasm ; Genes, myc/physiology ; Helix-Loop-Helix Motifs ; Humans ; MicroRNAs/physiology ; Neoplasms/genetics ; Promoter Regions, Genetic ; Proto-Oncogene Proteins c-myc ; RNA, Long Noncoding/metabolism ; RNA, Long Noncoding/physiology ; Regulatory Elements, Transcriptional ; Transcription Factors/physiology
    Chemical Substances CCCTC-Binding Factor ; CTCF protein, human ; Chromatin ; MEG3 non-coding RNA, human ; MicroRNAs ; Proto-Oncogene Proteins c-myc ; RNA, Long Noncoding ; Transcription Factors
    Language English
    Publishing date 2021-01-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-20-3613
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.135/5: Show issues Location:
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  6. Article ; Online: Genetic variations in IKZF3, LET7-a2, and CDKN2B-AS1: Exploring associations with metabolic syndrome susceptibility and clinical manifestations.

    Paniri, Alireza / Hosseini, Mohammad Mahdi / Fattahi, Sadegh / Amiribozorgi, Galia / Asouri, Mohsen / Maadi, Mansooreh / Motamed, Nima / Zamani, Farhad / Akhavan-Niaki, Haleh

    Journal of clinical laboratory analysis

    2024  Volume 38, Issue 1-2, Page(s) e24999

    Abstract: Background and aim: Metabolic syndrome (MetS) increases the risk of atherosclerosis and diabetes, but there are no approved predictive markers. This study assessed the role of specific genetic variations in MetS susceptibility and their impact on ... ...

    Abstract Background and aim: Metabolic syndrome (MetS) increases the risk of atherosclerosis and diabetes, but there are no approved predictive markers. This study assessed the role of specific genetic variations in MetS susceptibility and their impact on clinical manifestations.
    Method: In this study, a genotype-phenotype assessment was performed for IKZF3 (rs907091), microRNA-let-7a-2 (rs1143770), and lncRNA-CDKN2B-AS1 (rs1333045).
    Results: Analyses indicate that while rs907091 and rs1143770 may have potential associations with MetS susceptibility and an increased risk of atherosclerosis and diabetes, there is an observed trend suggesting that the rs1333045 CC genotype may be associated with a decreased risk of MetS. The genotypes and allele frequencies of rs1333045 were significantly different between studied groups (OR = 0.56, 95% CI 0.38-0.81, p = 0.002, and OR = 0.71, 95% CI 0.55-0.92, p = 0.008), with the CC genotype displaying increased levels of HDL. Furthermore, the rs907091 TT genotype was associated with increased triglyceride, cholesterol, and HOMA index in MetS patients. Subjects with the CC genotype for rs1143770 had higher HbA1c and BMI. In silico analyses illustrated that rs907091 C remarkably influences the secondary structure and the target site of a broad spectrum of microRNAs, especially hsa-miR-4497. Moreover, rs1333045 creates a binding site for seven different microRNAs.
    Conclusion: Further studies on other populations may help confirm these SNPs as useful predictive markers in assessing the MetS risk.
    MeSH term(s) Humans ; Atherosclerosis ; Diabetes Mellitus ; Genetic Predisposition to Disease/genetics ; Genotype ; Ikaros Transcription Factor/genetics ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Polymorphism, Single Nucleotide/genetics ; RNA, Long Noncoding ; RNA, Antisense/genetics
    Chemical Substances CDKN2B protein, human ; Ikaros Transcription Factor (148971-36-2) ; IKZF3 protein, human ; MicroRNAs ; mirnlet7 microRNA, human ; RNA, Long Noncoding ; RNA, Antisense
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645095-7
    ISSN 1098-2825 ; 0887-8013
    ISSN (online) 1098-2825
    ISSN 0887-8013
    DOI 10.1002/jcla.24999
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2471: Show issues Location:
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  7. Article: A deletion mutation along with a novel DNA variation in

    Paniri, Alireza / Fattahi, Sadegh / Rasoulinejad, Ahmad / Akhavan-Niaki, Haleh

    International journal of ophthalmology

    2021  Volume 14, Issue 4, Page(s) 636–638

    Language English
    Publishing date 2021-04-18
    Publishing country China
    Document type Journal Article
    ZDB-ID 2663246-9
    ISSN 2227-4898 ; 2222-3959
    ISSN (online) 2227-4898
    ISSN 2222-3959
    DOI 10.18240/ijo.2021.04.25
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  8. Article ; Online: First comprehensive computational analysis of functional consequences of

    Paniri, Alireza / Hosseini, Mohammad Mahdi / Akhavan-Niaki, Haleh

    Journal of biomolecular structure & dynamics

    2020  Volume 39, Issue 10, Page(s) 3576–3593

    Abstract: Current SARS-CoV-2 pandemy mortality created the hypothesis that some populations may be more susceptible to SARS-CoV-2. ...

    Abstract Current SARS-CoV-2 pandemy mortality created the hypothesis that some populations may be more susceptible to SARS-CoV-2.
    MeSH term(s) COVID-19/genetics ; Genetic Predisposition to Disease ; Humans ; Polymorphism, Single Nucleotide ; RNA, Viral ; Serine Endopeptidases/genetics
    Chemical Substances RNA, Viral ; Serine Endopeptidases (EC 3.4.21.-) ; TMPRSS2 protein, human (EC 3.4.21.-)
    Keywords covid19
    Language English
    Publishing date 2020-06-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2020.1767690
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  9. Article ; Online: Emerging role of IL-6 and NLRP3 inflammasome as potential therapeutic targets to combat COVID-19

    Paniri, Alireza / Akhavan-Niaki, Haleh

    Life Sciences

    Role of lncRNAs in cytokine storm modulation

    2020  Volume 257, Page(s) 118114

    Keywords General Pharmacology, Toxicology and Pharmaceutics ; General Biochemistry, Genetics and Molecular Biology ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2020.118114
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: The epigenetics orchestra of Notch signaling: a symphony for cancer therapy.

    Paniri, Alireza / Hosseini, Mohammad Mahdi / Amjadi-Moheb, Fatemeh / Tabaripour, Reza / Soleimani, Elnaz / Langroudi, Maryam Pilehchian / Zafari, Parisa / Akhavan-Niaki, Haleh

    Epigenomics

    2023  Volume 15, Issue 24, Page(s) 1337–1358

    Abstract: The aberrant regulation of the Notch signaling pathway, which is a fundamental developmental pathway, has been implicated in a wide range of human cancers. The Notch pathway can be activated by both canonical and noncanonical Notch ligands, and its role ... ...

    Abstract The aberrant regulation of the Notch signaling pathway, which is a fundamental developmental pathway, has been implicated in a wide range of human cancers. The Notch pathway can be activated by both canonical and noncanonical Notch ligands, and its role can switch between acting as an oncogene or a tumor suppressor depending on the context. Epigenetic modifications have the potential to modulate Notch and its ligands, thereby influencing Notch signal transduction. Consequently, the utilization of epigenetic regulatory mechanisms may present novel therapeutic opportunities for both single and combined therapeutics targeted at the Notch signaling pathway. This review offers insights into the mechanisms governing the regulation of Notch signaling and explores their therapeutic potential.
    MeSH term(s) Humans ; Receptors, Notch/genetics ; Receptors, Notch/metabolism ; Receptors, Notch/therapeutic use ; Neoplasms/drug therapy ; Neoplasms/genetics ; Signal Transduction ; Epigenesis, Genetic
    Chemical Substances Receptors, Notch
    Language English
    Publishing date 2023-12-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2537199-X
    ISSN 1750-192X ; 1750-1911
    ISSN (online) 1750-192X
    ISSN 1750-1911
    DOI 10.2217/epi-2023-0270
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