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  1. Article: Herpes Simplex Virus Pseudotumor Masking as Gastric Malignancy.

    Kripalani, Simran / Williams, Jennifer / Joneja, Upasana / Bansal, Preeti / Spitz, Francis

    ACG case reports journal

    2023  Volume 10, Issue 3, Page(s) e00985

    Abstract: Herpes simplex virus (HSV) pseudotumor is a rare presentation of HSV and has not been previously reported in the stomach. A 51-year-old man with a medical history of HIV presented with new-onset dysphagia. Endoscopy revealed an HSV-positive mass at the ... ...

    Abstract Herpes simplex virus (HSV) pseudotumor is a rare presentation of HSV and has not been previously reported in the stomach. A 51-year-old man with a medical history of HIV presented with new-onset dysphagia. Endoscopy revealed an HSV-positive mass at the gastroesophageal junction. After antiviral treatment, the patient returned with a 100-pound unintentional weight loss. Computed tomography showed an infiltrative mass with enlarged lymph nodes. The mass had progressed despite HSV treatment, and a repeat set of biopsies were negative for HSV with cells concerning for B-cell lymphoma. The patient was taken to the operating room for a full-thickness biopsy because of increasing concern for malignancy. The procedure was complicated by gastric perforation, leading to a total gastrectomy. Final pathology demonstrated an HSV-positive pseudotumor, negative for malignancy. It is important to diagnose gastric masses, especially in HIV-positive patients at high risk of infection and malignancy. However, immunocompromised patients with an HSV-positive mass should be treated for HSV pseudotumor with a longer than standard duration of antiviral therapy.
    Language English
    Publishing date 2023-03-08
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2814825-3
    ISSN 2326-3253
    ISSN 2326-3253
    DOI 10.14309/crj.0000000000000985
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pancreatic Neuroendocrine Tumors: Signaling Pathways and Epigenetic Regulation.

    Saleh, Zena / Moccia, Matthew C / Ladd, Zachary / Joneja, Upasana / Li, Yahui / Spitz, Francis / Hong, Young Ki / Gao, Tao

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: Pancreatic neuroendocrine tumors (PNETs) are characterized by dysregulated signaling pathways that are crucial for tumor formation and progression. The efficacy of traditional therapies is limited, particularly in the treatment of PNETs at an advanced ... ...

    Abstract Pancreatic neuroendocrine tumors (PNETs) are characterized by dysregulated signaling pathways that are crucial for tumor formation and progression. The efficacy of traditional therapies is limited, particularly in the treatment of PNETs at an advanced stage. Epigenetic alterations profoundly impact the activity of signaling pathways in cancer development, offering potential opportunities for drug development. There is currently a lack of extensive research on epigenetic regulation in PNETs. To fill this gap, we first summarize major signaling events that are involved in PNET development. Then, we discuss the epigenetic regulation of these signaling pathways in the context of both PNETs and commonly occurring-and therefore more extensively studied-malignancies. Finally, we will offer a perspective on the future research direction of the PNET epigenome and its potential applications in patient care.
    MeSH term(s) Humans ; Pancreatic Neoplasms/pathology ; Neuroendocrine Tumors/pathology ; Epigenesis, Genetic ; Signal Transduction ; Neuroectodermal Tumors, Primitive
    Language English
    Publishing date 2024-01-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25021331
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Erythema multiforme with unique dyshidrosiform presentation.

    Daneshpooy, Saba / Duffy, Robert F / Joneja, Upasana / Heymann, Warren R

    International journal of dermatology

    2021  Volume 62, Issue 1, Page(s) 130–131

    MeSH term(s) Humans ; Erythema Multiforme/diagnosis
    Language English
    Publishing date 2021-10-02
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.15927
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  4. Article ; Online: Identification and Treatment of SMARCA4 Deficient Poorly Differentiated Gastric Carcinoma.

    Bhat, Vipul / Koneru, Manisha / Knapp, Kristen / Joneja, Upasana / Morrison, Jamin / Hong, Young K

    The American surgeon

    2022  Volume 89, Issue 11, Page(s) 4987–4989

    Abstract: Loss of expression of ... ...

    Abstract Loss of expression of the
    MeSH term(s) Male ; Humans ; Aged ; Carcinoma/pathology ; Gastrointestinal Neoplasms ; Sarcoma ; Biomarkers, Tumor/genetics ; DNA Helicases ; Nuclear Proteins/genetics ; Transcription Factors/genetics
    Chemical Substances Biomarkers, Tumor ; SMARCA4 protein, human (EC 3.6.1.-) ; DNA Helicases (EC 3.6.4.-) ; Nuclear Proteins ; Transcription Factors
    Language English
    Publishing date 2022-12-19
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    DOI 10.1177/00031348221146972
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  5. Article: Intrapancreatic Accessory Spleen Diagnosed As Neuroendocrine Tumor: The Dangers of False Positives and Their Implications in Subsequent Management.

    Kripalani, Simran / Patel, Vikram / Joneja, Upasana / Talwar, Shikha / Parikh, Meet / Barshay, Veniamin / Chaaya, Adib

    Cureus

    2021  Volume 13, Issue 6, Page(s) e15891

    Abstract: This case serves as a reminder to consider ectopic splenic tissue in the differential diagnosis of pancreatic masses. The literature shows a lack of awareness and overtreatment of this condition due to clinical and radiologic concern for malignancy, ... ...

    Abstract This case serves as a reminder to consider ectopic splenic tissue in the differential diagnosis of pancreatic masses. The literature shows a lack of awareness and overtreatment of this condition due to clinical and radiologic concern for malignancy, namely neuroendocrine tumors (NETs) identified on positron emission tomography (PET)-CT NETSPOT. Given the vast difference in management and prognosis of ectopic splenic anomalies and malignant neoplasms involving the pancreas, accurate diagnosis is imperative to avoid unnecessary invasive procedures such as Whipple or distal pancreatectomy and splenectomy, which are associated with increased morbidity and mortality.
    Language English
    Publishing date 2021-06-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.15891
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  6. Article ; Online: Small Cell Carcinoma of the Rectum-An Unexpected Diagnosis: Current Treatment Options for a Rare and Aggressive Entity.

    Evangelisti, Taylor M / Platoff, Rebecca M / Khrizman, Polina / Morrison, Jamin C / Joneja, Upasana / Allen, Ashleigh A / Giugliano, Danica N / Kwiatt, Michael E / McClane, Steven J

    The American surgeon

    2023  Volume 89, Issue 12, Page(s) 6359–6361

    Abstract: Rectal small cell carcinoma is a rare and aggressive cancer subtype for which a consensus of optimal treatment has not yet been reached. This cancer presents a difficult surgical problem, and thus, the mainstay of treatment tends to mirror that of small ... ...

    Abstract Rectal small cell carcinoma is a rare and aggressive cancer subtype for which a consensus of optimal treatment has not yet been reached. This cancer presents a difficult surgical problem, and thus, the mainstay of treatment tends to mirror that of small cell carcinoma of the lung (chemotherapy, radiation therapy, and immune modulators). This brief report highlights current treatment options available for this rare and difficult entity. There is a significant need for large-center clinical trials and prospective studies to help determine the best treatment regimen to effectively care for patients with small cell carcinoma of the rectum.
    MeSH term(s) Humans ; Carcinoma, Small Cell/diagnosis ; Carcinoma, Small Cell/therapy ; Prospective Studies ; Rectum/pathology ; Rectal Neoplasms/diagnosis ; Rectal Neoplasms/therapy ; Rectal Neoplasms/pathology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
    Language English
    Publishing date 2023-05-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    DOI 10.1177/00031348231175116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Pseudo-Pelger-Huët anomaly in a patient on tacrolimus.

    Joneja, Upasana / Uppal, Guldeep

    Blood

    2015  Volume 126, Issue 2, Page(s) 277

    MeSH term(s) Bone Marrow Cells/drug effects ; Bone Marrow Cells/pathology ; Hematopoietic Stem Cell Transplantation ; Humans ; Immunosuppressive Agents/adverse effects ; Leukemia, Myeloid, Acute/pathology ; Leukemia, Myeloid, Acute/therapy ; Male ; Middle Aged ; Myelodysplastic Syndromes/pathology ; Myelodysplastic Syndromes/therapy ; Pelger-Huet Anomaly/chemically induced ; Pelger-Huet Anomaly/pathology ; Tacrolimus/adverse effects
    Chemical Substances Immunosuppressive Agents ; Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2015-09-14
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2015-04-631291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Novel treatment strategy of targeting epigenetic dysregulation in pancreatic neuroendocrine tumors.

    Zhu, Clara / Sandilos, Georgianna / Williamson, John / Emery, Robert / Platoff, Rebecca / Joneja, Upasana / Acharya, Nimish K / Lin, Andrew / Badach, Jeremy / Zilberman, Brian / Madzo, Jozef / Jelinek, Jaroslav / Zhang, Ping / Hong, Young Ki

    Surgery

    2023  Volume 173, Issue 4, Page(s) 1045–1051

    Abstract: Background: Epigenetic dysregulation is an integral step in the progression of pancreatic neuroendocrine tumors. We hypothesized that tumor suppressor repression by DNA methyltransferase 1 in pancreatic neuroendocrine tumors could be targeted with ... ...

    Abstract Background: Epigenetic dysregulation is an integral step in the progression of pancreatic neuroendocrine tumors. We hypothesized that tumor suppressor repression by DNA methyltransferase 1 in pancreatic neuroendocrine tumors could be targeted with epigenetic treatment.
    Methods: Resected pancreatic neuroendocrine tumors from 32 patients were stained for DNA methyltransferase 1 and scored. Human (BON1) and murine (STC) pancreatic neuroendocrine tumor cells were treated with DNA methyltransferase 1 inhibitor 5-azacytidine and chemotherapeutic agents 5-fluorouracil and temozolomide. Cell proliferation assay and tumor suppressor gene analysis were performed with qRT-PCR and Clarion S microarray. Tumor measurements were compared in a murine treatment model.
    Results: High DNA methyltransferase scores were associated with high Ki-67 (6.7% vs 70.6% P < .01), mitotic rate (0.0% vs 31.3%), and grade (20.0% vs 80.4%, P < .01). Treatment with 5-azacytidine and chemotherapy resulted in a reduction of cell proliferation compared to chemotherapy alone in BON1 (77.3% vs 53.1%, P < .001) and STC (73.4% vs 34.2%, P < .001). Treatment with 5-azacytidine and chemotherapy resulted in upregulation of tumor suppressors CDKN1A (7.6 rel. fold, P < .001), BRCA2 (4.3 rel. fold, P < .001), and CDH1 (6.0 rel. fold, P = .026) in BON1 and CDKN1a (14.5 rel. fold, P < .001) and CDH (17.5 rel. fold, P < .001) in STC. In microarray, 5-azacytidine drove global genetic changes in combination treatment. In vivo tumors treated with chemotherapy measured 88.6 ± 19.54 mm
    Conclusion: Epigenetic dysregulation with DNA methyltransferase 1 is associated with pancreatic neuroendocrine tumors and is a potential targetable strategy. 5-azacytidine and chemotherapy in combination can reduce cell proliferation, upregulate silenced tumor suppressor genes, and decrease in vivo tumors in pancreatic neuroendocrine tumors.
    MeSH term(s) Humans ; Animals ; Mice ; Neuroendocrine Tumors/pathology ; Pancreatic Neoplasms/pathology ; Azacitidine/therapeutic use ; Epigenesis, Genetic ; Methyltransferases/genetics ; Methyltransferases/therapeutic use ; DNA/therapeutic use
    Chemical Substances Azacitidine (M801H13NRU) ; Methyltransferases (EC 2.1.1.-) ; DNA (9007-49-2)
    Language English
    Publishing date 2023-01-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2022.12.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Results of Hemoglobin Variant Analysis in Patients Revealing Microcytic Erythrocytosis on Complete Blood Count.

    Joneja, Upasana / Gulati, Gene / Florea, Alina Dulau / Gong, Jerald

    Laboratory medicine

    2018  Volume 49, Issue 2, Page(s) 147–153

    Abstract: Background: Microcytic erythrocytosis is an underrecognized and underevaluated complete blood count (CBC) finding. The literature pertaining to the determination of its etiology specifically by hemoglobin variant analysis is limited.: Methods: We ... ...

    Abstract Background: Microcytic erythrocytosis is an underrecognized and underevaluated complete blood count (CBC) finding. The literature pertaining to the determination of its etiology specifically by hemoglobin variant analysis is limited.
    Methods: We performed hemoglobin variant analysis by high performance liquid chromatography on 137 patients who revealed microcytic erythrocytosis on CBC, and reviewed the results for the diagnosis of hemoglobin-associated disorders.
    Results: A diagnosis of thalassemia trait and/or a hemoglobinopathy was established in 93 of 137 (67.9%) patients. Amongst these, ß-thalassemia trait topped the list with 69 cases (74.1%), followed by hereditary persistence of fetal hemoglobin with 5 cases (5.5%), Hemoglobin E disease with 4 cases (4.3%), and ∂/ß-thalassemia with 2 cases (2.1%). Compound heterozygous conditions with 1 or more hemoglobinopathies and/or thalassemias were diagnosed in 13 cases (14.0%). Abnormal hemoglobins in the compound heterozygosity group included C, S, HPFH, and 2 unknowns.
    Conclusion: Hemoglobin variant analysis provided a very high positive yield in determining the etiology of microcytic erythrocytosis.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Blood Cell Count ; Chromatography, High Pressure Liquid ; Erythrocyte Indices ; Female ; Hematologic Tests ; Hemoglobinopathies/blood ; Hemoglobinopathies/diagnosis ; Hemoglobins, Abnormal/analysis ; Hemoglobins, Abnormal/chemistry ; Humans ; Male ; Middle Aged ; Thalassemia/blood ; Thalassemia/diagnosis
    Chemical Substances Hemoglobins, Abnormal
    Language English
    Publishing date 2018-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 391758-7
    ISSN 1943-7730 ; 0007-5027
    ISSN (online) 1943-7730
    ISSN 0007-5027
    DOI 10.1093/labmed/lmx071
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  10. Article: Disseminated tuberculosis with prostatic abscesses in an immunocompromised patient-A case report and review of literature.

    Joneja, Upasana / Short, William R / Roberts, Amity L

    IDCases

    2016  Volume 5, Page(s) 15–20

    Abstract: We describe a case of disseminated Mycobacterium tuberculosis (mTB) with prostatic abscess in a newly diagnosed HIV patient in the United States. The patient is a 34 year-old male who presented with respiratory symptoms and was diagnosed with HIV/AIDS ... ...

    Abstract We describe a case of disseminated Mycobacterium tuberculosis (mTB) with prostatic abscess in a newly diagnosed HIV patient in the United States. The patient is a 34 year-old male who presented with respiratory symptoms and was diagnosed with HIV/AIDS complicated by disseminated mTB infection of the lungs, liver, and prostate. His prostate showed abscess formation on imaging that required drainage however he did not present with any genitourinary complaints. Our literature review revealed that prostatic involvement in mTB in the form of granulomatous prostatitis is uncommon; however, abscess formation is extremely rare and only few such cases have been published. Nearly 50% of the patients with prostatic abscess formation present without symptoms and therefore a high level of suspicion should be maintained; imaging should be performed early and prophylactic antibiotics for non-specific urinary symptoms should be avoided as this may lead to drug resistance of mTB to flouroquinolones.
    Language English
    Publishing date 2016-06-23
    Publishing country Netherlands
    Document type Journal Article ; Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2016.06.002
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