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  1. Article: OECD-407 Driven 28-day-repeated-dose non-clinical safety evaluation of

    Balkrishna, Acharya / Haldar, Swati / Varshney, Anurag

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1095083

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-05-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1095083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Enhancement of Wheat (Triticum aestivum L.) Growth and Yield Attributes in a Subtropical Humid Climate through Treated Ganga Sludge-based Organic Fertilizers.

    Balkrishna, Acharya / Sharma, Nidhi / Gautam, Ajay / Arya, Vedpriya / Khelwade, Vikram

    Recent advances in food, nutrition & agriculture

    2024  

    Abstract: Background: Sewage sludge is a by-product of urbanization that poses environmental and health challenges. However, it can also be a valuable source of organic matter and nutrients for agriculture.: Method: This study aimed to assess the potential of ... ...

    Abstract Background: Sewage sludge is a by-product of urbanization that poses environmental and health challenges. However, it can also be a valuable source of organic matter and nutrients for agriculture.
    Method: This study aimed to assess the potential of five types of organic fertilizers derived from treated Ganga sludge on the growth of wheat plants. The Patanjali Organic Research Institute has developed five types of granulated organic fertilizer from the stabilized Ganga sludge.
    Results: The results showed that the organic fertilizers significantly improved the wheat performance in terms of plant height, biomass accumulation, chlorophyll content, leaf area and other yield parameters. Furthermore, the fertilizers ameliorated soil physicochemical attributes and augmented the availability of macro- and micronutrients. Importantly, levels of heavy metals in soil and wheat grains remained within permissible limits, affirming the safety and appropriateness of these fertilizers for wheat cultivation.
    Conclusion: This study underscores the efficient utilization of treated Ganga sludge as a valuable organic fertilizer source, proposing a sustainable and ecologically sound approach for sewage sludge management and enhancement of agricultural productivity.
    Language English
    Publishing date 2024-01-26
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 2772-5758
    ISSN (online) 2772-5758
    DOI 10.2174/012772574X280744240103044354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Traditional Formulations for Managing COVID-19: A Systematic Review.

    Bhandari, Rudra B / Balkrishna, Acharya / Maheshkumar, Kuppusamy / Arumugam, Velan A

    Journal of integrative and complementary medicine

    2023  

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Journal Article
    ISSN 2768-3613
    ISSN (online) 2768-3613
    DOI 10.1089/jicm.2023.0177
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  4. Article ; Online: Tumor Suppressive Role of MicroRNAs in Triple Negative Breast Cancer.

    Balkrishna, Acharya / Mittal, Rashmi / Arya, Vedpriya

    Current pharmaceutical design

    2023  Volume 29, Issue 42, Page(s) 3357–3367

    Abstract: Triple-negative breast cancers are highly aggressive, a heterogeneous form of breast cancer with a high re-occurrence rate that further lacks an efficient treatment strategy and prognostic marker. The tumor microenvironment of the disease comprises ... ...

    Abstract Triple-negative breast cancers are highly aggressive, a heterogeneous form of breast cancer with a high re-occurrence rate that further lacks an efficient treatment strategy and prognostic marker. The tumor microenvironment of the disease comprises cancer-associated fibroblasts, cancer stem cells, immunological molecules, epithelial-mesenchymal transition, and a metastatic microenvironment that contributes to disease progression and metastasis to distant sites. Emerging evidence indicated that miRNA clusters would be of clinical utility as they exert an oncogenic or tumor suppressor role in TNBC. The present review article aims to highlight the therapeutic significance of miRNA in targeting the above-mentioned signaling cascades and modulating the intracellular crosstalk in the tumor microenvironment of TNBC. Prognostic implications of miRNAs to depict disease-free survival, distant metastasis-free survival, relapse-free survival, and overall survival outcome were also unveiled.
    MeSH term(s) Humans ; Cell Line, Tumor ; Disease Progression ; Epithelial-Mesenchymal Transition/genetics ; MicroRNAs/genetics ; Neoplasm Recurrence, Local ; Prognosis ; Triple Negative Breast Neoplasms/genetics ; Tumor Microenvironment ; Female
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-12-01
    Publishing country United Arab Emirates
    Document type Review ; Journal Article
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/0113816128272489231124095922
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4714: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Unveiling Role of MicroRNAs in Metastasizing Triple Negative Breast Cancer: From Therapeutics to Delivery.

    Balkrishna, Acharya / Mittal, Rashmi / Arya, Vedpriya

    Current drug targets

    2023  Volume 24, Issue 6, Page(s) 509–520

    Abstract: Triple negative breast cancers are malignant, heterogeneous tumors with high histological grades, increased reoccurrence, and cancer-related death rates. TNBC metastasis to the brain, lungs, liver, and lymph nodes is a complex process regulated by ... ...

    Abstract Triple negative breast cancers are malignant, heterogeneous tumors with high histological grades, increased reoccurrence, and cancer-related death rates. TNBC metastasis to the brain, lungs, liver, and lymph nodes is a complex process regulated by epithelial to mesenchymal transition, intravasation, extravasation, stem cell niche, and migration. Aberrant expression of miRNAs, also known as a transcriptional regulators of genes, may function as oncogenes or tumor suppressors. In this review, we systematically elucidated the biogenesis and tumor suppressor role of miRNA in targeting distant metastasis of TNBC cells and the above-mentioned underlying mechanisms involved in complicating the disease. Apart from their therapeutic implications, the emerging roles of miRNAs as prognostic markers have also been discussed. To overcome delivery bottlenecks, RNA nanoparticles, nano-diamonds, exosomes, and mesoporous silica nanoparticle-mediated delivery of miRNAs have been contemplated. Altogether, the present review article uncovers the potential role of miRNA in antagonizing distant metastasis of TNBC cells, and highlights their clinical significance as prognostic markers and possible drug delivery strategies to enhance the likely outcome of miRNA-based therapy against the disease.
    MeSH term(s) Humans ; MicroRNAs/therapeutic use ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/genetics ; Epithelial-Mesenchymal Transition/genetics ; Drug Delivery Systems
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-03-06
    Publishing country United Arab Emirates
    Document type Review ; Journal Article
    ZDB-ID 2064859-5
    ISSN 1873-5592 ; 1389-4501
    ISSN (online) 1873-5592
    ISSN 1389-4501
    DOI 10.2174/1389450124666230308154551
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5578: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Livogrit prevents Amiodarone-induced toxicity in experimental model of human liver (HepG2) cells and

    Balkrishna, Acharya / Gohel, Vivek / Pathak, Nishit / Bhattacharya, Kunal / Dev, Rishabh / Varshney, Anurag

    Drug and chemical toxicology

    2024  , Page(s) 1–17

    Abstract: Treatment with cationic amphiphilic drugs like Amiodarone leads to development of phospholipidosis, a type of lysosomal storage disorder characterized by excessive deposition of phospholipids. Such disorder in liver enhances accumulation of drugs and its ...

    Abstract Treatment with cationic amphiphilic drugs like Amiodarone leads to development of phospholipidosis, a type of lysosomal storage disorder characterized by excessive deposition of phospholipids. Such disorder in liver enhances accumulation of drugs and its metabolites, and dysregulates lipid profiles, which subsequently leads to hepatotoxicity. In the present study, we assessed pharmacological effects of herbal medicine, Livogrit, against hepatic phospholipidosis-induced toxicity. Human liver (HepG2) cells and
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 548368-2
    ISSN 1525-6014 ; 0148-0545
    ISSN (online) 1525-6014
    ISSN 0148-0545
    DOI 10.1080/01480545.2024.2320189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1380: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Neuroprotection by Polyherbal Medicine Divya-Medha-Vati Against Scopolamine-Induced Cognitive Impairment Through Modulation of Oxidative Stress, Acetylcholine Activity, and Cell Signaling.

    Balkrishna, Acharya / Bhattacharya, Kunal / Shukla, Sunil / Varshney, Anurag

    Molecular neurobiology

    2023  Volume 61, Issue 3, Page(s) 1363–1382

    Abstract: Alzheimer disease is associated with cognitive impairments and neuronal damages. In this study, Scopolamine, a model drug used for the generation of Alzheimer-like symptoms induced cognitive dysfunction in C57BL/6 mice. It also elevated acetylcholine ... ...

    Abstract Alzheimer disease is associated with cognitive impairments and neuronal damages. In this study, Scopolamine, a model drug used for the generation of Alzheimer-like symptoms induced cognitive dysfunction in C57BL/6 mice. It also elevated acetylcholine esterase (AcHE) activity, and reduced antioxidant (superoxide dismutase and catalase) activity in cortex tissue. Scop reduced neuronal density and increased pyknotic neurons in hippocampus tissue. In mouse neuroblastoma (Neuro2a) cells, Scop triggered a dose-dependent loss of cell viability and neurite outgrowth reduction. Scop-treated Neuro2a cells showed oxidative stress and reduction in mRNA expression for brain-derived neurotrophic factor (BDNF), nerve growth factor-1 (NGF-1), and Synapsin-1 (SYN-1) genes. Mice treated with Divya-Medha-Vati (DMV), an Ayurvedic polyherbal medicine showed protection against Scop-induced cognitive impairment (Morris Water Maze Escape Latency, and Elevated Plus Maze Transfer Latency). DMV protected against Scop-induced AcHE activity, and loss of antioxidant activities in the mice brain cortex while sustaining neuronal density in the hippocampus region. In the Neuro2a cells, DMV reduced Scop-induced loss of cell viability and neurite outgrowth loss. DMV protected the cells against induction of oxidative stress and promoted mRNA expression of BDNF, NGF-1, and SYN-1 genes. Phytochemical profiling of DMV showed the presence of Withanolide A, Withanolide B, Bacopaside II, Jujubogenin, Apigenin, Gallic acid, Caffeic acid, and Quercetin that are associated with antioxidant and neurostimulatory activities. In conclusion, the study showed that Divya-Medha-Vati was capable of promoting neuronal health and inhibiting Alzheimer-like cognitive dysfunction through enhanced antioxidant activities and modulation of neuronal activities.
    MeSH term(s) Mice ; Animals ; Scopolamine ; Acetylcholine/metabolism ; Antioxidants/metabolism ; Brain-Derived Neurotrophic Factor/metabolism ; Nerve Growth Factor/metabolism ; Neuroprotection ; Alzheimer Disease/metabolism ; Mice, Inbred C57BL ; Oxidative Stress ; Cognitive Dysfunction/chemically induced ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/metabolism ; Signal Transduction ; Hippocampus/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Maze Learning ; Acetylcholinesterase/metabolism ; Memory Disorders/metabolism
    Chemical Substances Scopolamine (DL48G20X8X) ; Acetylcholine (N9YNS0M02X) ; Antioxidants ; Brain-Derived Neurotrophic Factor ; Nerve Growth Factor (9061-61-4) ; RNA, Messenger ; Acetylcholinesterase (EC 3.1.1.7)
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-023-03601-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2411: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Unraveling the therapeutic potential of

    Balkrishna, Acharya / Sharma, Darshita / Thapliyal, Manisha / Arya, Vedpriya / Dabas, Anurag

    In silico pharmacology

    2023  Volume 12, Issue 1, Page(s) 3

    Abstract: Pancreatic cancer (PC) presents challenges due to limited treatment options and patients seek complementary therapies alongside conventional treatments to improve well-being. This study uses computational drug discovery approaches to find potential ... ...

    Abstract Pancreatic cancer (PC) presents challenges due to limited treatment options and patients seek complementary therapies alongside conventional treatments to improve well-being. This study uses computational drug discovery approaches to find potential phytochemicals from
    Supplementary information: The online version contains supplementary material available at 10.1007/s40203-023-00179-9.
    Language English
    Publishing date 2023-12-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2702993-1
    ISSN 2193-9616
    ISSN 2193-9616
    DOI 10.1007/s40203-023-00179-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Livogrit, a herbal formulation of

    Balkrishna, Acharya / Lochab, Savita / Varshney, Anurag

    Toxicology reports

    2022  Volume 9, Page(s) 1056–1064

    Abstract: Research studies in the past years have shown encouraging therapeutic potential of herbal medicines in liver ailments. Livogrit is a well characterized formulation prepared by mixing extracts of plants, ...

    Abstract Research studies in the past years have shown encouraging therapeutic potential of herbal medicines in liver ailments. Livogrit is a well characterized formulation prepared by mixing extracts of plants,
    Language English
    Publishing date 2022-04-29
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2805786-7
    ISSN 2214-7500 ; 2214-7500
    ISSN (online) 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2022.03.053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Withania somnifera

    Balkrishna, Acharya / Tomar, Meenu / Bhattacharya, Kunal / Varshney, Anurag

    Nanoscale advances

    2022  Volume 5, Issue 5, Page(s) 1331–1344

    Abstract: Solar radiation comprising UVA and UVB regions is considered a skin-damaging factor inducing inflammation, oxidative stress, hyperpigmentation, and photo-aging. Photoluminescent carbon dots (CDs) were synthesized from the root extract of ... ...

    Abstract Solar radiation comprising UVA and UVB regions is considered a skin-damaging factor inducing inflammation, oxidative stress, hyperpigmentation, and photo-aging. Photoluminescent carbon dots (CDs) were synthesized from the root extract of a
    Language English
    Publishing date 2022-12-09
    Publishing country England
    Document type Journal Article
    ISSN 2516-0230
    ISSN (online) 2516-0230
    DOI 10.1039/d2na00545j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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