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  1. Book ; Online ; Thesis: Computergestützte Methoden in der Arzneimittel-Repositionierung und der Naturstoffbasierten Wirkstoffforschung

    Abel, Renata [Verfasser]

    2023  

    Author's details Renata Abel
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Medizinische Fakultät Charité - Universitätsmedizin Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article ; Online: Mitochondrial Dynamics, Diabetes, and Cardiovascular Disease.

    García-Peña, Luis Miguel / Abel, E Dale / Pereira, Renata O

    Diabetes

    2024  Volume 73, Issue 2, Page(s) 151–161

    MeSH term(s) Humans ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Mitochondrial Dynamics ; Mitochondria/metabolism ; Muscle, Skeletal/metabolism ; Mitochondrial Proteins/metabolism
    Chemical Substances Mitochondrial Proteins
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/dbi23-0003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.175: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Not All Is Lost: Career Options for Unmatched Plastic Surgery Applicants.

    Mohan, Vamsi C / Ferry, Andrew M / Smerica, Abel M / Edmonds, Joseph L / Maricevich, Renata S

    Plastic and reconstructive surgery

    2022  Volume 150, Issue 6, Page(s) 1370e–1371e

    MeSH term(s) Humans ; Surgery, Plastic/education ; Career Choice ; Internship and Residency ; Education, Medical, Graduate
    Language English
    Publishing date 2022-10-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208012-6
    ISSN 1529-4242 ; 0032-1052 ; 0096-8501
    ISSN (online) 1529-4242
    ISSN 0032-1052 ; 0096-8501
    DOI 10.1097/PRS.0000000000009689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.142: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 293: Show issues

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  4. Article ; Online: ATF4 expression in thermogenic adipocytes is required for cold-induced thermogenesis in mice via FGF21-independent mechanisms.

    Bjorkman, Sarah H / Marti, Alex / Jena, Jayashree / García-Peña, Luis Miguel / Weatherford, Eric T / Kato, Kevin / Koneru, Jivan / Chen, Jason / Sood, Ayushi / Potthoff, Matthew J / Adams, Christopher M / Abel, E Dale / Pereira, Renata O

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 1563

    Abstract: In brown adipose tissue (BAT), short-term cold exposure induces the activating transcription factor 4 (ATF4), and its downstream target fibroblast growth factor 21 (FGF21). Induction of ATF4 in BAT in response to mitochondrial stress is required for ... ...

    Abstract In brown adipose tissue (BAT), short-term cold exposure induces the activating transcription factor 4 (ATF4), and its downstream target fibroblast growth factor 21 (FGF21). Induction of ATF4 in BAT in response to mitochondrial stress is required for thermoregulation, partially by increasing FGF21 expression. In the present study, we tested the hypothesis that Atf4 and Fgf21 induction in BAT are both required for BAT thermogenesis under physiological stress by generating mice selectively lacking either Atf4 (ATF4 BKO) or Fgf21 (FGF21 BKO) in UCP1-expressing adipocytes. After 3 days of cold exposure, core body temperature was significantly reduced in ad-libitum-fed ATF4 BKO mice, which correlated with Fgf21 downregulation in brown and beige adipocytes, and impaired browning of white adipose tissue. Conversely, despite having reduced browning, FGF21 BKO mice had preserved core body temperature after cold exposure. Mechanistically, ATF4, but not FGF21, regulates amino acid import and metabolism in response to cold, likely contributing to BAT thermogenic capacity under ad libitum-fed conditions. Importantly, under fasting conditions, both ATF4 and FGF21 were required for thermogenesis in cold-exposed mice. Thus, ATF4 regulates BAT thermogenesis under fed conditions likely in a FGF21-independent manner, in part via increased amino acid uptake and metabolism.
    MeSH term(s) Animals ; Mice ; Activating Transcription Factor 4/genetics ; Activating Transcription Factor 4/metabolism ; Adipocytes/metabolism ; Adipose Tissue, Brown/metabolism ; Adipose Tissue, White/metabolism ; Amino Acids/metabolism ; Cold Temperature ; Fibroblast Growth Factors ; Mice, Inbred C57BL ; Thermogenesis/genetics ; Uncoupling Protein 1/genetics ; Uncoupling Protein 1/metabolism
    Chemical Substances Activating Transcription Factor 4 (145891-90-3) ; Amino Acids ; fibroblast growth factor 21 ; Fibroblast Growth Factors (62031-54-3) ; Uncoupling Protein 1 ; Atf4 protein, mouse
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-52004-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Allosteric Modulation of the CB1 Cannabinoid Receptor by Cannabidiol-A Molecular Modeling Study of the N-Terminal Domain and the Allosteric-Orthosteric Coupling.

    Jakowiecki, Jakub / Abel, Renata / Orzeł, Urszula / Pasznik, Paweł / Preissner, Robert / Filipek, Sławomir

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 9

    Abstract: ... The ... ...

    Abstract The CB
    MeSH term(s) Allosteric Regulation/physiology ; Allosteric Site ; Animals ; Cannabidiol/metabolism ; Humans ; Magnetic Resonance Spectroscopy ; Models, Molecular ; Molecular Dynamics Simulation ; Protein Binding ; Protein Structure, Secondary ; Receptor, Cannabinoid, CB1/chemistry ; Receptor, Cannabinoid, CB1/metabolism
    Chemical Substances Receptor, Cannabinoid, CB1 ; Cannabidiol (19GBJ60SN5)
    Language English
    Publishing date 2021-04-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26092456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  6. Article: ATF4 Expression in Thermogenic Adipocytes is Required for Cold-Induced Thermogenesis in Mice via FGF21-Independent Mechanisms.

    Bjorkman, Sarah H / Marti, Alex / Jena, Jayashree / Garcia Pena, Luis M / Weatherford, Eric T / Kato, Kevin / Koneru, Jivan / Chen, Jason / Sood, Ayushi / Potthoff, Matthew J / Adams, Christopher M / Abel, E Dale / Pereira, Renata O

    bioRxiv : the preprint server for biology

    2023  

    Abstract: In brown adipose tissue (BAT), short-term cold exposure induces the activating transcription factor 4 (ATF4), and its downstream target fibroblast growth factor 21 (FGF21). Induction of ATF4 in BAT in response to mitochondrial stress is required for ... ...

    Abstract In brown adipose tissue (BAT), short-term cold exposure induces the activating transcription factor 4 (ATF4), and its downstream target fibroblast growth factor 21 (FGF21). Induction of ATF4 in BAT in response to mitochondrial stress is required for thermoregulation, partially via upregulation of FGF21. In the present study, we tested the hypothesis that
    Language English
    Publishing date 2023-09-13
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.09.531964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Inter-library loan at ZB MED

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  7. Book ; Online: Korpora in Lehre und Forschung

    Zanin, Renata / Abel, Andrea / Oberhammer, Margit / Gelmi, Rita / Saxalber, Annemarie / Drumbl, Hans / Geyken, Alexander / Petrakis, Stefanos / Belica, Cyril / Anstein, Stefanie

    2011  

    Abstract: Today, the teaching of knowledge is facing a twofold challenge: the demand for comprehensibility despite the high complexity of contents and the achievement of acceptable results in school in situations of ever-growing diversity. This opens up new ... ...

    Abstract Today, the teaching of knowledge is facing a twofold challenge: the demand for comprehensibility despite the high complexity of contents and the achievement of acceptable results in school in situations of ever-growing diversity. This opens up new research areas for linguistics: on the one hand, the communicative acts of members of a language community in everyday life and in specialized settings; on the other hand, the variable contexts of the speech acts, which require the co-orientation of social actors, which in turn also needs to be acquired and practiced like the languages with their formal and structural characteristics. Based upon these premises, this volume presents findings and theoretical approaches which make corpus findings available for the study and the didactics of language teaching concerning the the three school languages ??of German, Italian and English. Special emphasis is put on the varieties of the German language in South Tyrol and the interface problem
    Keywords Philology. Linguistics
    Size 1 electronic resource (200 p.)
    Publisher bu,press
    Document type Book ; Online
    Note German ; Open Access
    HBZ-ID HT020096462
    ISBN 9788860460400 ; 9788860460950 ; 8860460409 ; 8860460956
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: Allosteric Modulation of the CB1 Cannabinoid Receptor by Cannabidiol—A Molecular Modeling Study of the N-Terminal Domain and the Allosteric-Orthosteric Coupling

    Jakub Jakowiecki / Renata Abel / Urszula Orzeł / Paweł Pasznik / Robert Preissner / Sławomir Filipek

    Molecules, Vol 26, Iss 2456, p

    2021  Volume 2456

    Abstract: The CB 1 cannabinoid receptor (CB 1 R) contains one of the longest N termini among class A G protein-coupled receptors. Mutagenesis studies suggest that the allosteric binding site of cannabidiol (CBD) involves residues from the N terminal domain. In ... ...

    Abstract The CB 1 cannabinoid receptor (CB 1 R) contains one of the longest N termini among class A G protein-coupled receptors. Mutagenesis studies suggest that the allosteric binding site of cannabidiol (CBD) involves residues from the N terminal domain. In order to study the allosteric binding of CBD to CB 1 R we modeled the whole N-terminus of this receptor using the replica exchange molecular dynamics with solute tempering (REST2) approach. Then, the obtained structures of CB 1 R with the N terminus were used for ligand docking. A natural cannabinoid receptor agonist, Δ 9 -THC, was docked to the orthosteric site and a negative allosteric modulator, CBD, to the allosteric site positioned between extracellular ends of helices TM1 and TM2. The molecular dynamics simulations were then performed for CB 1 R with ligands: (i) CBD together with THC, and (ii) THC-only. Analyses of the differences in the residue-residue interaction patterns between those two cases allowed us to elucidate the allosteric network responsible for the modulation of the CB 1 R by CBD. In addition, we identified the changes in the orthosteric binding mode of Δ 9 -THC, as well as the changes in its binding energy, caused by the CBD allosteric binding. We have also found that the presence of a complete N-terminal domain is essential for a stable binding of CBD in the allosteric site of CB 1 R as well as for the allosteric-orthosteric coupling mechanism.
    Keywords CB1 ; cannabinoid receptor ; GPCRs ; allosteric modulation ; CBD ; THC ; Organic chemistry ; QD241-441
    Subject code 570
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Reynoutria

    Nawrot-Hadzik, Izabela / Zmudzinski, Mikolaj / Matkowski, Adam / Preissner, Robert / Kęsik-Brodacka, Małgorzata / Hadzik, Jakub / Drag, Marcin / Abel, Renata

    Pharmaceuticals (Basel, Switzerland)

    2021  Volume 14, Issue 8

    Abstract: More than a year has passed since the world began to fight the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the Coronavirus disease 2019 (COVID-19) pandemic, and still it spreads around the world, mutating at the ... ...

    Abstract More than a year has passed since the world began to fight the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the Coronavirus disease 2019 (COVID-19) pandemic, and still it spreads around the world, mutating at the same time. One of the sources of compounds with potential antiviral activity is Traditional Chinese Medicinal (TCM) plants used in China in the supportive treatment of COVID-19.
    Language English
    Publishing date 2021-07-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph14080742
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: GDF15 is required for cold-induced thermogenesis and contributes to improved systemic metabolic health following loss of OPA1 in brown adipocytes.

    Jena, Jayashree / García-Peña, Luis Miguel / Weatherford, Eric T / Marti, Alex / Bjorkman, Sarah H / Kato, Kevin / Koneru, Jivan / Chen, Jason H / Seeley, Randy J / Abel, E Dale / Pereira, Renata O

    eLife

    2023  Volume 12

    Abstract: We previously reported that mice lacking the protein optic atrophy 1 (OPA1 BKO) in brown adipose tissue (BAT) display induction of the activating transcription factor 4 (ATF4), which promotes fibroblast growth factor 21 (FGF21) secretion as a batokine. ... ...

    Abstract We previously reported that mice lacking the protein optic atrophy 1 (OPA1 BKO) in brown adipose tissue (BAT) display induction of the activating transcription factor 4 (ATF4), which promotes fibroblast growth factor 21 (FGF21) secretion as a batokine. FGF21 increases metabolic rates under baseline conditions but is dispensable for the resistance to diet-induced obesity (DIO) reported in OPA1 BKO mice (Pereira et al., 2021). To determine alternative mediators of this phenotype, we performed transcriptome analysis, which revealed increased levels of growth differentiation factor 15 (GDF15), along with increased protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) levels in BAT. To investigate whether ATF4 induction was mediated by PERK and evaluate the contribution of GDF15 to the resistance to DIO, we selectively deleted PERK or GDF15 in OPA1 BKO mice. Mice with reduced OPA1 and PERK levels in BAT had preserved ISR activation. Importantly, simultaneous deletion of OPA1 and GDF15 partially reversed the resistance to DIO and abrogated the improvements in glucose tolerance. Furthermore, GDF15 was required to improve cold-induced thermogenesis in OPA1 BKO mice. Taken together, our data indicate that PERK is dispensable to induce the ISR, but GDF15 contributes to the resistance to DIO, and is required for glucose homeostasis and thermoregulation in OPA1 BKO mice by increasing energy expenditure.
    MeSH term(s) Animals ; Mice ; Activating Transcription Factor 4/metabolism ; Adipocytes, Brown/metabolism ; Adipose Tissue, Brown/metabolism ; Glucose/metabolism ; Growth Differentiation Factor 15/genetics ; Growth Differentiation Factor 15/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Obesity/genetics ; Thermogenesis/physiology
    Chemical Substances Activating Transcription Factor 4 (145891-90-3) ; Glucose (IY9XDZ35W2) ; Growth Differentiation Factor 15 ; Gdf15 protein, mouse ; Opa1 protein, mouse (EC 3.6.1.-)
    Language English
    Publishing date 2023-10-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.86452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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