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Article ; Online: Pharmacoinformatics approach for type 2 diabetes mellitus therapeutics using phytocompounds from

Bhavsar, Drashti / Kutre, Suraj / Shikhare, Priti / Kumar, Sunil / Behera, Santosh Kumar / Chauthe, Siddheshwar Kisan

Journal of biomolecular structure & dynamics

2024 , Page(s) 1–17

Abstract: Type 2 Diabetes Mellitus (T2DM), as a significant health concern globally, particularly in India, underscoring the vital need for effective therapeutics. Current drug therapies for T2DM may have limitations, leading researchers to explore natural ... ...

Abstract	Type 2 Diabetes Mellitus (T2DM), as a significant health concern globally, particularly in India, underscoring the vital need for effective therapeutics. Current drug therapies for T2DM may have limitations, leading researchers to explore natural products as alternatives. In this study. We have investigated the anti-diabetic compounds from the
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2024.2330712
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Article ; Online: Experimental and

Panda, Itishree / Behera, Bikash Ranjan / Jena, Debasmita / Behera, Santosh Kumar / Samal, Sangram Keshari / Pradhan, Sanghamitra

RSC advances

2024 Volume 14, Issue 4, Page(s) 2453–2465

Abstract: Ionic liquids have gained attention as 'designer solvents' since they offer a broad spectrum of properties that can be tuned by altering the constituent ions. In this work, 1-alkyl-2-methyl imidazolium-based ionic liquids with two different alkyl chains ( ...

Abstract	Ionic liquids have gained attention as 'designer solvents' since they offer a broad spectrum of properties that can be tuned by altering the constituent ions. In this work, 1-alkyl-2-methyl imidazolium-based ionic liquids with two different alkyl chains (alkyl = hexyl and octyl) have been synthesized and characterized. Since the binary mixture of ionic liquids with molecular solvents can give rise to striking physicochemical properties, the interaction of the synthesized room temperature ionic liquids, 1-hexyl-2-methyl imidazolium bromide [HMIM][Br]/1-octyl-2-methyl imidazolium bromide [OMIM][Br] with DMSO has been examined through density and specific conductance at
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra07417j
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Article ; Online: Severe Retinopathy of Prematurity and Moyamoya Disease- A Possible Association.

Panda, Santosh Kumar / Kundu, Aheli / Kumar Das, Manmath / Kumar Behera, Chinmay

Indian journal of pediatrics

2023 Volume 91, Issue 2, Page(s) 208

MeSH term(s)	Infant, Newborn ; Humans ; Retinopathy of Prematurity/complications ; Retinopathy of Prematurity/diagnosis ; Moyamoya Disease/diagnosis ; Moyamoya Disease/diagnostic imaging ; Infant, Premature ; Infant, Very Low Birth Weight ; Gestational Age
Language	English
Publishing date	2023-09-30
Publishing country	India
Document type	Letter
ZDB-ID	218231-2
ISSN	0973-7693 ; 0019-5456
ISSN (online)	0973-7693
ISSN	0019-5456
DOI	10.1007/s12098-023-04868-3
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Article ; Online: Media optimization, extraction, purification and characterization of exopolysaccharide from Fusarium proliferatum

Smita Behera / Amrita Kumari Panda / Santosh Kumar Behera / Nibha Gupta

Results in Chemistry, Vol 5, Iss , Pp 100923- (2023)

A novel source bioactive polysaccharide

2023

Abstract: Polysaccharides from fungal source have been proved to be effective in different plethora of biomedical fields. The present study was carried out on exopolysaccharide (EPS) production by Fusarium proliferatum, considered novel fungus as no reports on its ...

Abstract	Polysaccharides from fungal source have been proved to be effective in different plethora of biomedical fields. The present study was carried out on exopolysaccharide (EPS) production by Fusarium proliferatum, considered novel fungus as no reports on its EPS production capability has been reported yet. The main objective of this study was to optimize media for better EPS production extracellularly under submerged culture conditions. Among all malt extract broth was selected as favorable medium for EPS yielding 81.4 ± 0.48 mg/l. Optimization revealed 9 days of incubation period, pH 6.0 and temperature 25 °C best for the growth and EPS yield. The medium 12 out of sixteen media was selected as best for the EPS yield which was ensured by various permutation and combinations of chemical factors. The optimized medium includes: malt extract medium (basal medium), xylose 4%, glucose 4%, tryptophan 0.1%, olive oil 3%, Tween 80 0.2%, vitamin C 0.2%, K2HPO4 0.2%, CaCl2 0.5%, pH 6.0, incubation period of 9 days at temperature 25 °C yielding 4067 ± 153.08 mg/l of EPS. HPTLC, FTIR and LCMS analysis exhibited the monomeric composition of maltose, fructose, xylose, galactose, glucose, raffinose and sorbose with functional group of –OH, C=O, C–O–C, C–O, –C–H, COO– with glycosidic likanges and suggested the production of glycan by these fungi. Owing to the existing reports of anti-cancerous property of β-Glycan an in-silico investigation was carried out to which indicatedits higher reactivity and lower binding affinityin comparison to imatinib, an oral chemotherapy drug to treat cancer.
Keywords	Fusarium proliferatum ; Medium optimization ; Exopolysaccharide ; Glycan ; Chemistry ; QD1-999
Subject code	660
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Exploring the possible sources of fiscal space for health in India: insights from political regimes.

Behera, Deepak Kumar / Dash, Umakant / Sahu, Santosh Kumar

Health research policy and systems

2022 Volume 20, Issue 1, Page(s) 32

Abstract: Background: Rising healthcare costs and poor access to health services have become a significant concern for policy-makers; therefore, efforts must be made to generate fiscal space through alternative revenue measures in resource-poor economies. This ... ...

Abstract	Background: Rising healthcare costs and poor access to health services have become a significant concern for policy-makers; therefore, efforts must be made to generate fiscal space through alternative revenue measures in resource-poor economies. This study attempts to identify possible sources of fiscal space for health in India across political regimes. Methods: The study followed a descriptive approach to examine the political commitment towards health sector development by estimating the trend of growth in fiscal space indicators over the political regimes from 1998-1999 to 2021-2022 using a dummy variable regression model. Results: We found four possible sources of fiscal space for health, which include (1) raising domestic revenue mobilization, (2) generating alternative revenue collection mechanisms, (3) prioritizing health through expenditure management and (4) effective utilization of central transfer. Fiscal space measures such as goods and services tax reform, collection of health-specific tax, higher excise duty on tobacco products, cooking gas subsidies to poor people, tax administration reform and direct beneficiary transfer of health services could be alternative revenue mobilization channels for fiscal space for health. Conclusion: The study reveals that the central government has a political commitment to generating revenue through various fiscal policy reforms. Health has been prioritized over the period, but there is less evidence of health-related political commitment for an increased share of health expenditure to total budgetary allocation. During the last 2 years, however, the health budget has been prioritized due to the COVID-19 pandemic crisis despite slower economic growth in India. This study will be a policy document for fiscal space analysis from a political-economic perspective, and the role of the ministry of finance can be assessed through administrative data and documents.
MeSH term(s)	COVID-19 ; Federal Government ; Health Expenditures ; Humans ; India ; Pandemics
Language	English
Publishing date	2022-03-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2101196-5
ISSN	1478-4505 ; 1478-4505
ISSN (online)	1478-4505
ISSN	1478-4505
DOI	10.1186/s12961-022-00831-4
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Article ; Online: Synthesis and Characterization of Far-Red Emissive Boron-Based Triads Showing Large Stokes Shifts: Optical, TRANES, and Electrochemical Studies.

Sarkar, Samir Kumar / Jena, Satyam / Behera, Santosh Kumar / Thilagar, Pakkirisamy

The Journal of organic chemistry

2022 Volume 87, Issue 6, Page(s) 3967–3977

Abstract: Herein, we report the design and synthesis of far-red emissive boryl-thiophene-BODIPY ... ...

Abstract	Herein, we report the design and synthesis of far-red emissive boryl-thiophene-BODIPY triads
MeSH term(s)	Boranes/chemistry ; Boron/chemistry ; Fluorides ; Spectrometry, Fluorescence
Chemical Substances	Boranes ; Boron (N9E3X5056Q) ; Fluorides (Q80VPU408O)
Language	English
Publishing date	2022-03-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.1c02595
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Article ; Online: Computational Biology of BRCA2 in Male Breast Cancer, through Prediction of Probable nsSNPs, and Hit Identification.

Shinde, Sangita Dattatray / Satpute, Dinesh Parshuram / Behera, Santosh Kumar / Kumar, Dinesh

ACS omega

2022 Volume 7, Issue 34, Page(s) 30447–30461

Abstract: Male breast cancer (MBC) is a relatively rare disease, but emerging data recommend the development of novel therapeutics considering its alarming threats. Compared to female breast cancer (FBC), MBC is reportedly associated with inferior outcomes (poor ... ...

Abstract	Male breast cancer (MBC) is a relatively rare disease, but emerging data recommend the development of novel therapeutics considering its alarming threats. Compared to female breast cancer (FBC), MBC is reportedly associated with inferior outcomes (poor survival) owing to their late diagnosis and lack of adequate treatment. Treatment typically correlates with FBC, involving surgical removal of the breast tissue along with chemo/hormonal/radiation therapy, the tamoxifen being a standard adjuvant. Considering the distinct immunophenotypic (implying different pathogenesis and progression) differences from FBC, the identification of diagnostics, prognostics, and therapeutics for MBC is highly desirable. In this context, we have analyzed the most deleterious nsSNPs of
Language	English
Publishing date	2022-08-17
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c03851
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Article ; Online: Exploring the possible sources of fiscal space for health in India

Deepak Kumar Behera / Umakant Dash / Santosh Kumar Sahu

Health Research Policy and Systems, Vol 20, Iss 1, Pp 1-

insights from political regimes

2022 Volume 16

Abstract: Abstract Background Rising healthcare costs and poor access to health services have become a significant concern for policy-makers; therefore, efforts must be made to generate fiscal space through alternative revenue measures in resource-poor economies. ... ...

Abstract	Abstract Background Rising healthcare costs and poor access to health services have become a significant concern for policy-makers; therefore, efforts must be made to generate fiscal space through alternative revenue measures in resource-poor economies. This study attempts to identify possible sources of fiscal space for health in India across political regimes. Methods The study followed a descriptive approach to examine the political commitment towards health sector development by estimating the trend of growth in fiscal space indicators over the political regimes from 1998–1999 to 2021–2022 using a dummy variable regression model. Results We found four possible sources of fiscal space for health, which include (1) raising domestic revenue mobilization, (2) generating alternative revenue collection mechanisms, (3) prioritizing health through expenditure management and (4) effective utilization of central transfer. Fiscal space measures such as goods and services tax reform, collection of health-specific tax, higher excise duty on tobacco products, cooking gas subsidies to poor people, tax administration reform and direct beneficiary transfer of health services could be alternative revenue mobilization channels for fiscal space for health. Conclusion The study reveals that the central government has a political commitment to generating revenue through various fiscal policy reforms. Health has been prioritized over the period, but there is less evidence of health-related political commitment for an increased share of health expenditure to total budgetary allocation. During the last 2 years, however, the health budget has been prioritized due to the COVID-19 pandemic crisis despite slower economic growth in India. This study will be a policy document for fiscal space analysis from a political-economic perspective, and the role of the ministry of finance can be assessed through administrative data and documents.
Keywords	Fiscal space ; Health financing ; Health policy ; Political regimes ; Political commitment ; India ; Public aspects of medicine ; RA1-1270
Subject code	336 ; 360
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: Instability and fault analysis of arc plasma using advanced signal processing methods.

Sethi, Shakti Prasad / Das, Debi Prasad / Behera, Santosh Kumar / Ray, Nigamananda

The Review of scientific instruments

2023 Volume 94, Issue 10

Abstract: This study focuses on the instability and fault analysis of transferred arc plasma, utilizing advanced signal processing methods. Transferred arc plasma systems find significant applications in various industries, including material processing, ... ...

Abstract	This study focuses on the instability and fault analysis of transferred arc plasma, utilizing advanced signal processing methods. Transferred arc plasma systems find significant applications in various industries, including material processing, metallurgy, and waste management. However, the occurrence of instabilities and fault events can severely impact system performance and reliability. To address instabilities in arc plasma, various conditions were experimented. The operating parameters, such as arc voltage, arc current, acoustic, optical, and spectroscopic signals, were simultaneously recorded at a higher sampling rate. The proposed approach employs advanced signal processing methods, such as the Lyapunov exponent, fast-Fourier transform, short-time-Fourier transform, and power spectral density, to analyze the characteristics and instabilities of the transferred arc plasma process. By capturing and analyzing signals from multiple sensors, it becomes possible to identify deviations, irregularities, and fault patterns that arise during plasma operation. The outcomes of this research will have significant implications for the optimization and control of transferred arc plasma processes. By identifying and characterizing instabilities due to fault events at an early stage, system operators can take timely corrective actions, preventing potential damage and improving the overall system efficiency.
Language	English
Publishing date	2023-10-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0161187
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Article ; Online: Bifunctional backbone modified squaramide dipeptides as amyloid beta (Aβ) aggregation inhibitors.

Dattatray Shinde, Suchita / Kumar Behera, Santosh / Kulkarni, Neeraj / Dewangan, Bhaskar / Sahu, Bichismita

Bioorganic & medicinal chemistry

2023 Volume 97, Page(s) 117538

Abstract: Alzheimer's disease (AD) is a devastating neurodegenerative condition with complex pathophysiology. Aggregated amyloid beta (Aβ) peptide plaques and higher concentrations of bio-metals such as copper (Cu), zinc (Zn), and iron (Fe) are the most ... ...

Abstract	Alzheimer's disease (AD) is a devastating neurodegenerative condition with complex pathophysiology. Aggregated amyloid beta (Aβ) peptide plaques and higher concentrations of bio-metals such as copper (Cu), zinc (Zn), and iron (Fe) are the most significant hallmarks of AD observed in the brains of AD patients. Therefore simultaneous inhibition of Aβ peptide aggregation and reduction of metal stress may serve as an effective therapeutic approach for treating Alzheimer's disease. A series of bifunctional dipeptides bearing squaramide backbone were synthesized and investigated for their ability to chelate metal ions and prevent Aβ peptide aggregation. Dipeptides with Valine (V) and Threonine (T) substitutions at the C-terminus exhibited preferential chelation with Cu(II), Zn(II), and Fe(III) metal ions in the presence of other metal ions. They were also found to inhibit the aggregation of Aβ peptide in-vitro. A further molecular dynamics (MD) simulation study demonstrated that these two dipeptides interact with the Aβ peptide in the hydrophobic core (KLVFF) region. Circular dichroism (CD) study revealed slight conformational change in the Aβ peptide upon the interactions with dipeptides. Apart from metal chelation and inhibition of Aβ peptide aggregation, the selected dipeptides were found to possess anti-oxidant properties. Therefore, the squaramide backbone-modified dipeptides may serve as an active bifunctional scaffold towards the development of new chemical entities for the treatment of Alzheimer's disease.
MeSH term(s)	Humans ; Amyloid beta-Peptides/chemistry ; Alzheimer Disease/drug therapy ; Dipeptides/pharmacology ; Ferric Compounds ; Metals ; Copper/pharmacology ; Copper/chemistry ; Chelating Agents/pharmacology ; Chelating Agents/chemistry ; Ions ; Amyloid
Chemical Substances	Amyloid beta-Peptides ; Dipeptides ; squaramide ; Ferric Compounds ; Metals ; Copper (789U1901C5) ; Chelating Agents ; Ions ; Amyloid
Language	English
Publishing date	2023-11-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2023.117538
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