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Article ; Online: Women, work, and water.

Caruso, Bethany A / Chipungu, Jenala / Kulkarni, Seema / Ray, Isha

2023 Volume 401, Issue 10383, Page(s) 1139–1141

MeSH term(s)	Female ; Humans ; Water ; Water Supply ; Surveys and Questionnaires
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2023-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(23)00572-X
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Zs.MG 94: Show issues

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Article ; Online: Using ecological momentary assessment to understand associations between daily physical activity and symptoms in breast cancer patients undergoing chemotherapy.

Whitaker, Madelyn / Welch, Whitney A / Fanning, Jason / Santa-Maria, Cesar A / Auster-Gussman, Lisa A / Solk, Payton / Khan, Seema A / Kulkarni, Swati A / Gradishar, William / Siddique, Juned / Phillips, Siobhan M

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

2022 Volume 30, Issue 8, Page(s) 6613–6622

Abstract: Purpose: Understanding real-time relationships between physical activity (PA) and symptoms during chemotherapy (CT) could have important implications for intervention. This study used ecological momentary assessment to examine the relationship between ... ...

Abstract	Purpose: Understanding real-time relationships between physical activity (PA) and symptoms during chemotherapy (CT) could have important implications for intervention. This study used ecological momentary assessment to examine the relationship between objective PA and symptoms during CT. Methods: Breast cancers patients (n = 67; M Results: On days when individuals engaged in more LPA or MVPA, separately, they reported improved affect, anxiety, fatigue, physical functioning (walking and activities of daily living), pain, and cognition that day (p < 0.001 for all). Findings were consistent for next-day symptom ratings with the exception that only previous day LPA was related to next-day fatigue and neither LPA nor MVPA were related to next-day cognition (p < 0.001 for all). No between-person effects were found. Conclusions: Within person higher than usual PA on a given day, regardless of intensity, is associated with improved symptoms ratings on the current and next day. Implications for cancer survivors: Encouraging breast cancer patients undergoing CT to engage in daily PA could help manage CT-associated symptoms.
MeSH term(s)	Activities of Daily Living ; Breast Neoplasms/drug therapy ; Ecological Momentary Assessment ; Exercise ; Fatigue/etiology ; Female ; Humans ; Middle Aged
Language	English
Publishing date	2022-04-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1134446-5
ISSN	1433-7339 ; 0941-4355
ISSN (online)	1433-7339
ISSN	0941-4355
DOI	10.1007/s00520-022-07071-w
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Zs.A 3697: Show issues

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Article ; Online: Longitudinal Sedentary Time and Symptoms in Breast Cancer Patients during Chemotherapy Using Ecological Momentary Assessment.

Welch, Whitney A / Solk, Payton / Auster-Gussman, Lisa / Whitaker, Madelyn / Siddique, Juned / Fanning, Jason / Mishory, Abby / Khan, Seema / Santa-Maria, Cesar / Kulkarni, Swati / Phillips, Siobhan M

Medicine and science in sports and exercise

2022 Volume 55, Issue 5, Page(s) 966–974

Abstract: Purpose: To examine the relationship between daily fluctuations in symptoms and sedentary behavior (SB) during chemotherapy (CT) for breast cancer.: Methods: Breast cancer patients ( N = 68, M age = 48.5 ± 10.4 yr) undergoing CT wore an activity ... ...

Abstract	Purpose: To examine the relationship between daily fluctuations in symptoms and sedentary behavior (SB) during chemotherapy (CT) for breast cancer. Methods: Breast cancer patients ( N = 68, M age = 48.5 ± 10.4 yr) undergoing CT wore an activity monitor on their hip to assess daily SB and completed prompts assessing symptoms (affect, anxiety, depression, fatigue, pain, and physical and cognitive functioning) for 10 consecutive days (3 d pre-CT, day of, and 6 d post-CT) at the beginning, middle and end cycles of CT. Mixed models assessed the bidirectional between-person (BP) and within-person (WP) associations of current day symptoms with minutes of SB measured on 1) the same day and 2) the next day, controlling for relevant covariates. Results: Within person same-day results revealed a significant association between affect, anxiety, fatigue, physical functioning, pain, and cognitive functioning and same-day SB. Worse than average symptom ratings on a given day were associated with more SB that day. There was a significant WP relationship between previous-day anxiety, depression, and physical function and next-day SB (i.e., worse than average symptom ratings the previous day were associated with more SB the next day). Within person same-day results revealed a significant association between same-day SB and affect, anxiety, fatigue, pain, physical functioning, and cognitive functioning. The WP relationships were significant for previous-day SB and next-day affect and pain (i.e., higher than average SB associated with lower ratings). Relationships persisted when controlling for moderate-to-vigorous physical activity. There were no significant BP results. Conclusions: Higher symptom ratings were associated with increased SB and higher SB was associated with worse symptoms. Future work should identify SB reduction intervention approaches tailoring to daily symptom burden during CT for breast cancer.
MeSH term(s)	Humans ; Adult ; Middle Aged ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/psychology ; Sedentary Behavior ; Ecological Momentary Assessment ; Pain ; Fatigue
Language	English
Publishing date	2022-12-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	603994-7
ISSN	1530-0315 ; 0195-9131 ; 0025-7990
ISSN (online)	1530-0315
ISSN	0195-9131 ; 0025-7990
DOI	10.1249/MSS.0000000000003115
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Zs.A 869: Show issues

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Article ; Online: Social cognitive variables and physical activity during chemotherapy for breast cancer: An intensive longitudinal examination.

Auster-Gussman, Lisa A / Gavin, Kara L / Siddique, Juned / Welch, Whitney A / Solk, Payton / Whitaker, Madelyn / Cullather, Erin / Fanning, Jason / Maria, Cesar Santa / Gradishar, William / Khan, Seema / Kulkarni, Swati / Phillips, Siobhan M

Psycho-oncology

2021 Volume 31, Issue 3, Page(s) 425–435

Abstract: Objective: Although physical activity is associated with better health outcomes in breast cancer survivors (BCS), activity often declines during cancer treatment. Social cognitive theory (SCT) constructs have been associated with physical activity in ... ...

Abstract	Objective: Although physical activity is associated with better health outcomes in breast cancer survivors (BCS), activity often declines during cancer treatment. Social cognitive theory (SCT) constructs have been associated with physical activity in post-treatment BCS, but little is known about the relation between these constructs and physical activity during chemotherapy. Methods: BCS (n = 67; M Results: Within-person differences in all SCT variables were statistically significantly related to same-day MVPA (p's < 0.001) and LPA (p's < 0.001). Every one-point increase in SCT construct related to an increase in MVPA ranging from (a) 3.70 (self-efficacy) to 8.02 (physical outcome expectations) minute increase in MVPA and (b) 12.72 (self-efficacy) to 20.38 (physical outcome expectations) increase in LPA that day. No same-day between-person effects nor any next-day effects were significant. Conclusion: MVPA and LPA were related to same-day within-person differences in SCT variables. Interventions targeted at increasing or mitigating chemotherapy-related declines in daily within-person changes in SCT constructs could help to increase physical activity among BCS during chemotherapy.
MeSH term(s)	Breast Neoplasms/drug therapy ; Cancer Survivors/psychology ; Cognition ; Exercise/psychology ; Female ; Humans ; Middle Aged ; Self Efficacy
Language	English
Publishing date	2021-10-06
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1118536-3
ISSN	1099-1611 ; 1057-9249
ISSN (online)	1099-1611
ISSN	1057-9249
DOI	10.1002/pon.5820
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Zs.A 3550: Show issues

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Article: Antifungal activity of wild bergamot (Monarda fistulosa) essential oil against postharvest fungal pathogens of banana fruits

Kulkarni, Seema A. / Sellamuthu, Periyar Selvam / Nagarajan, Santhosh Kumar / Madhavan, Thirumurthy / Sadiku, Emmanuel Rotimi

SAAB South African journal of botany. 2022 Jan., v. 144

2022

Abstract: This study aimed to examine the antifungal activity of wild bergamot (Monarda fistulosa) essential oil on Colletotrichum musae and Lasiodiplodia theobromae, the causative organisms of anthracnose and crown-rot diseases of banana fruits, respectively. ... ...

Abstract	This study aimed to examine the antifungal activity of wild bergamot (Monarda fistulosa) essential oil on Colletotrichum musae and Lasiodiplodia theobromae, the causative organisms of anthracnose and crown-rot diseases of banana fruits, respectively. Chitin synthase is a promising target for antifungal compounds, since it is involved in synthesizing chitin, which forms a major proportion of the fungal cell wall. Disc volatilisation method was employed to assess the in vitro antifungal activity of the oil. The vapours of this essential oil at 4 μL per Petriplate exhibited 100% growth inhibition of both the fungal pathogens, and at 66.66 μLL⁻¹ , it significantly (P <0.05) reduced the incidence and severity of anthracnose and crown-rot diseases in artificially wounded and infected fruits. The chemical composition of wild bergamot essential oil was determined by GC-MS technique and the components of the essential oil were docked against chitin synthase to determine the components responsible for antifungal activity. Chitin synthase was modelled by de novo approach due to non-availability of the 3D structure. The in silico techniques such as molecular docking and conceptual DFT revealed that the major components of the essential oil namely thymol, carvacrol and cinnamyl carbanilate manifested the best antifungal activity. This illustrates effective inhibition of the major postharvest diseases of banana by wild bergamot essential oil.
Keywords	Colletotrichum musae ; Lasiodiplodia theobromae ; Monarda fistulosa ; anthracnose ; antifungal properties ; bananas ; carvacrol ; cell walls ; chemical composition ; chitin ; chitin synthase ; computer simulation ; crown rot ; essential oils ; fungi ; growth retardation ; oils ; thymol ; volatilization
Language	English
Dates of publication	2022-01
Size	p. 166-174.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2126918-X
ISSN	0254-6299
ISSN	0254-6299
DOI	10.1016/j.sajb.2021.08.019
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Daily Physical Activity and Symptom Reporting in Breast Cancer Patients Undergoing Chemotherapy: An Intensive Longitudinal Examination.

Phillips, Siobhan M / Welch, Whitney A / Fanning, Jason / Santa-Maria, Cesar A / Gavin, Kara L / Auster-Gussman, Lisa A / Solk, Payton / Lu, Marilyn / Cullather, Erin / Khan, Seema A / Kulkarni, Swati A / Gradishar, William / Siddique, Juned

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

2020 Volume 29, Issue 12, Page(s) 2608–2616

Abstract: Background: Increased activity is beneficial during chemotherapy, but treatment-related symptoms may be a barrier. This study examines the relationship between daily fluctuations in symptoms and activity during chemotherapy.: Methods: Women ... ...

Abstract	Background: Increased activity is beneficial during chemotherapy, but treatment-related symptoms may be a barrier. This study examines the relationship between daily fluctuations in symptoms and activity during chemotherapy. Methods: Women undergoing chemotherapy for breast cancer [ Results: For MVPA and LPA, within-person associations were statistically significant for same day affect, fatigue, pain, walking, activities of daily living (ADL) physical function, and cognitive function. Previous day anxiety was associated with next day LPA. Every one point worse symptom rating than an individual's overall average was associated with: (i) between 1.49 (pain) and 4.94 (fatigue) minutes less MVPA and between 4.48 (pain) and 24.72 (ADL physical function) minutes less LPA that day, and (ii) 11.28 minutes less LPA the next day. No between-person effects were significant for MVPA or LPA. Conclusions: Daily within-person variations in symptoms were associated with MVPA and LPA during chemotherapy for breast cancer. Impact: Future work should explore relationships between symptoms and activity further and identify whether tailoring to symptoms enhances efficacy of physical activity promotion interventions during chemotherapy.
MeSH term(s)	Accelerometry/methods ; Breast Neoplasms/drug therapy ; Exercise/physiology ; Female ; Humans ; Longitudinal Studies ; Middle Aged ; Prospective Studies
Language	English
Publishing date	2020-09-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1153420-5
ISSN	1538-7755 ; 1055-9965
ISSN (online)	1538-7755
ISSN	1055-9965
DOI	10.1158/1055-9965.EPI-20-0659
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Zs.A 3693: Show issues

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Article ; Online: Breast cancer risk assessment and management programs: A practical guide.

Sciaraffa, Theresa / Guido, Barbara / Khan, Seema A / Kulkarni, Swati

The breast journal

2020 Volume 26, Issue 8, Page(s) 1556–1564

Abstract: Breast cancer risk assessment continues to evolve as emerging knowledge of breast cancer risk drivers and modifiers enables better identification of high-risk women who may benefit from increased screening or targeted risk-reduction protocols. The ... ...

Abstract	Breast cancer risk assessment continues to evolve as emerging knowledge of breast cancer risk drivers and modifiers enables better identification of high-risk women who may benefit from increased screening or targeted risk-reduction protocols. The ongoing development of breast cancer Risk Assessment and Management Programs (RAMPs) presents an opportunity to decrease breast cancer disease incidence with evidence-based interventions. The goal of this review was to provide a practical guide for providers seeking to establish or update a breast cancer risk assessment and management program. We outline genetic/familial, personal, reproductive, and lifestyle-related factors while discussing the incorporation of risk modeling for precise risk estimate personalization. We further describe the process for determining a risk management plan: information gathering, generation of a risk profile, and articulation and implementation of risk reduction. We also include an overview of clinical workflows in breast cancer management programs and underlines the logistics of establishing a program as well as general principles for guiding the formulation of an individualized risk management plan. We discuss practical considerations, such as clinic structure and operation, allocation of resources, and patient education. Other critical aspects of program design, including identification of the target population, delineation of the core components of the clinical experience, definition of provider roles, description of referral mechanisms, and the launching of a marketing plan are also addressed. The process of risk assessment is both anxiety-provoking and empowering for women at increased risk. New knowledge has enabled strategies to both understand the risk and control it through evidence-based risk management. These benefits can now be realized by an increasing number of unaffected, high-risk patients collaborating with risk management practitioners. Continuation of these efforts will lead to further progress in both risk stratification and risk management of women at elevated breast cancer risk in the near future.
MeSH term(s)	Breast Neoplasms/diagnosis ; Breast Neoplasms/epidemiology ; Breast Neoplasms/therapy ; Female ; Humans ; Mass Screening ; Referral and Consultation ; Risk Assessment
Language	English
Publishing date	2020-07-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1289960-4
ISSN	1524-4741 ; 1075-122X
ISSN (online)	1524-4741
ISSN	1075-122X
DOI	10.1111/tbj.13967
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Zs.A 4483: Show issues

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Article: Characterization of Phytochemicals in

Kulkarni, Seema A / Krishnan, Sabari B B / Chandrasekhar, Bavya / Banerjee, Kaushani / Sohn, Honglae / Madhavan, Thirumurthy

Frontiers in chemistry

2021 Volume 9, Page(s) 735768

Abstract: ... ...

Abstract	Coronavirus
Language	English
Publishing date	2021-09-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2021.735768
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Article ; Online: Feasibility and acceptability of intensive longitudinal data collection of activity and patient-reported outcomes during chemotherapy for breast cancer.

Solk, Payton / Gavin, Kara / Fanning, Jason / Welch, Whitney / Lloyd, Gillian / Cottrell, Alison / Nielsen, Anne / Santa Maria, Cesar A / Gradishar, William / Khan, Seema A / Kulkarni, Swati / Siddique, Juned / Phillips, Siobhan M

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

2019 Volume 28, Issue 12, Page(s) 3333–3346

Abstract: Purpose: Ecological momentary assessment (EMA) may help us better understand biopsychosocial determinants and outcomes of physical activity during chemotherapy, but may be burdensome for patients. The purpose of this study was to determine the ... ...

Abstract	Purpose: Ecological momentary assessment (EMA) may help us better understand biopsychosocial determinants and outcomes of physical activity during chemotherapy, but may be burdensome for patients. The purpose of this study was to determine the feasibility and acceptability of using EMA to assess activity, symptoms, and motivation among early-stage breast cancer patients undergoing chemotherapy. Methods: Women were instructed to wear an accelerometer 24/7 (hip during day and wrist overnight). Text message prompts were sent 4 times/day concerning patient-reported symptoms and motivational factors for 10 consecutive days (3 days pre-, day of, and 6 days post-chemotherapy dose). These measures occurred at the beginning, middle, and end of a full course of chemotherapy. At study conclusion, participants reported on perceived study acceptability, burden, and reactivity. Results: Of the 75 women who consented to participate, 63 (84%) completed all 3 assessment time points. Participants responded to 86% of total text prompts and had valid accelerometer data on 82% of study days. Compliance was similar across all time points. The majority (78%) rated their study experience as positive; 100% were confident in their ability to use study technology. Reactivity varied with 27% indicating answering symptom questions did not affect how they felt and 44% and 68% indicated answering questions and wearing the accelerometer, respectively, made them want to increase activity. Conclusions: Findings indicate EMA methods are feasible for breast cancer patients undergoing chemotherapy. EMA may help us better understand the biopsychosocial processes underlying breast cancer patients' activity in the context of daily life.
MeSH term(s)	Accelerometry ; Adult ; Breast Neoplasms/drug therapy ; Breast Neoplasms/psychology ; Ecological Momentary Assessment ; Exercise/psychology ; Feasibility Studies ; Female ; Humans ; Middle Aged ; Patient Compliance ; Patient Reported Outcome Measures ; Quality of Life/psychology ; Surveys and Questionnaires
Language	English
Publishing date	2019-09-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1161148-0
ISSN	1573-2649 ; 0962-9343
ISSN (online)	1573-2649
ISSN	0962-9343
DOI	10.1007/s11136-019-02278-7
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Zs.A 3796: Show issues

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Article ; Online: What does risk of future cancer mean to breast cancer patients?

Kaiser, Karen / Cameron, Kenzie A / Beaumont, Jennifer / Garcia, Sofia F / Lacson, Leilani / Moran, Margaret / Karavites, Lindsey / Rodgers, Chiara / Kulkarni, Swati / Hansen, Nora M / Khan, Seema A

Breast cancer research and treatment

2019 Volume 175, Issue 3, Page(s) 579–584

Abstract: Purpose: Newly diagnosed breast cancer patients greatly overestimate their risk of developing contralateral breast cancer (CBC). Better understanding of patient conceptions of risk would facilitate doctor-patient communication and surgical decision ... ...

Abstract	Purpose: Newly diagnosed breast cancer patients greatly overestimate their risk of developing contralateral breast cancer (CBC). Better understanding of patient conceptions of risk would facilitate doctor-patient communication and surgical decision making. In this mixed methods study, we prospectively examined breast cancer patients' perceived risk of future cancer and the reported factors that drove their risk perceptions. Methods: Women age 21-60 diagnosed with breast cancer without a BRCA mutation or known distant metastases completed a study interview between surgical consult and surgical treatment. Participants completed a 12-item Perceived Risk Questionnaire, which assessed 10-year and lifetime risks of ipsilateral local recurrence, CBC, and distant recurrence. Patients provided qualitative explanations for their answers. Results: Sixty-three patients completed study interviews (mean age 50.3). Participants were primarily White (85.7%) and 90.5% had attended college. Patients estimated their 10-year risk of CBC as 22.0%, nearly 4 times the established 10-year risk. Women attributed their risk perceptions to "gut feelings" about future cancer, even when women knew those feelings contradicted medically established risk. Perceptions of risk also reflected beliefs that cancer is random and that risk for local recurrence, CBC, and distant recurrence are the same. Conclusions: Our findings point to the need for novel ways of presenting factual information regarding both risk of recurrence and of new primary cancers, as well as the necessity of acknowledging cognitive and affective processes many patients use when conceptualizing risk. By differentiating women's intuitive feelings about risk from their knowledge of medically estimated risk, doctors can enhance informed decision making.
MeSH term(s)	Adult ; Breast Neoplasms/ethnology ; Breast Neoplasms/psychology ; Breast Neoplasms/surgery ; Clinical Decision-Making ; Female ; Humans ; Mastectomy/methods ; Middle Aged ; Patient Education as Topic ; Perception ; Physician-Patient Relations ; Prophylactic Mastectomy ; Prospective Studies ; Social Class ; Surveys and Questionnaires ; Young Adult
Language	English
Publishing date	2019-03-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-019-05182-3
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