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  1. Article ; Online: Determining the transfer function of a reconstructive spectrometer using measurements at two wavelengths.

    Sharma, Naresh / Khare, Kedar / Gupta, Shilpi

    Optics letters

    2023  Volume 48, Issue 14, Page(s) 3753–3756

    Abstract: The transfer function is the characteristic function of the dispersive element of a reconstructive spectrometer. It maps the transmitted spatial intensity profile to the incident spectral intensity profile of an input. Typically, a widely tunable and ... ...

    Abstract The transfer function is the characteristic function of the dispersive element of a reconstructive spectrometer. It maps the transmitted spatial intensity profile to the incident spectral intensity profile of an input. Typically, a widely tunable and narrowband source is required to determine the transfer function across the entire operating wavelength range, which increases the developmental cost of these reconstructive spectrometers. In this Letter, we utilize the parabolic dispersion relation of a planar one-dimensional photonic crystal cavity, which acts as the dispersive element, to determine the entire transfer function of the spectrometer using measurements made at only two wavelengths. Using this approach, we demonstrate reliable reconstruction of input spectra in simulations, even in the presence of noise. The experimentally reconstructed spectra also follow the spectra measured using a commercial spectrometer.
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.494412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Prey selection by leopards (

    Baral, Kedar / Bhandari, Shivish / Adhikari, Binaya / Kunwar, Ripu M / Sharma, Hari P / Aryal, Achyut / Ji, Weihong

    Ecology and evolution

    2024  Volume 14, Issue 2, Page(s) e10924

    Abstract: Information on prey selection and the diet of the leopard ( ...

    Abstract Information on prey selection and the diet of the leopard (
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2635675-2
    ISSN 2045-7758
    ISSN 2045-7758
    DOI 10.1002/ece3.10924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Effect of bed roughness on flow field around spur dyke in a rigid bed meandering channel

    Sharma, Kedar / Mohapatra, Pranab K.

    ISH journal of hydraulic engineering. 2022 Apr. 03, v. 28, no. 2

    2022  

    Abstract: Effect of bed roughness on flow field and turbulence characteristics due to spur dyke in rigid bed meandering channel is presented in this study. This is an extension of authors’ earlier work. In the experiments, cement mortar, sand particles on cement ... ...

    Abstract Effect of bed roughness on flow field and turbulence characteristics due to spur dyke in rigid bed meandering channel is presented in this study. This is an extension of authors’ earlier work. In the experiments, cement mortar, sand particles on cement mortar and small aggregates on the cement mortar surfaces are used to generate different bed roughness. 3-D velocity measurements are obtained with Acoustic Doppler Velocimeter (ADV). In a rigid bed meandering channel without spur dyke, flow concentrates near the convex bank up to inflection point in the downstream of Apex. Inflection point moves towards the upstream with increase in the roughness of the channel. The water surface slope along the center line increases with increase in bed roughness. In presence of spur dyke, the maximum velocity in the channel decreases with increase in bed roughness. When the spur dyke is located on the convex bank of Apex, the length and width of separation zone decrease with increase in bed roughness. The magnitude of turbulence intensities decreases with increase in roughness.
    Keywords acoustics ; cement ; roughness ; sand ; turbulent flow
    Language English
    Dates of publication 2022-0403
    Size p. 127-134.
    Publishing place Taylor & Francis
    Document type Article
    ISSN 2164-3040
    DOI 10.1080/09715010.2020.1835565
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Elabela Peptide: An Emerging Target in Therapeutics.

    Sharma, Maneesha / Prabhavalkar, Kedar S / Bhatt, Lokesh Kumar

    Current drug targets

    2022  Volume 23, Issue 14, Page(s) 1304–1318

    Abstract: Elabela, a bioactive micropeptide, is recognized as the second endogenous ligand for the Apelin receptor and is widely distributed in different tissues and organs. Elabela plays an important role in various physiological processes, such as blood pressure ...

    Abstract Elabela, a bioactive micropeptide, is recognized as the second endogenous ligand for the Apelin receptor and is widely distributed in different tissues and organs. Elabela plays an important role in various physiological processes, such as blood pressure control, heart morphogenesis, apoptosis, angiogenesis, cell proliferation, migration, etc. Elabela is also implicated in pathological conditions, like cardiac dysfunctions, heart failure, hypertension, kidney diseases, cancer and CNS disorders. The association of Elabela with these disease conditions makes it a potential target for their therapy. This review summarizes the physiological role of Elabela peptide as well as its implication in various disease conditions.
    MeSH term(s) Humans ; Apelin ; Peptide Hormones ; Apelin Receptors ; Hypertension ; Heart Failure
    Chemical Substances Apelin ; Peptide Hormones ; Apelin Receptors
    Language English
    Publishing date 2022-09-03
    Publishing country United Arab Emirates
    Document type Review ; Journal Article
    ZDB-ID 2064859-5
    ISSN 1873-5592 ; 1389-4501
    ISSN (online) 1873-5592
    ISSN 1389-4501
    DOI 10.2174/1389450123666220826160123
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  5. Article: Impact of climate change on distribution of common leopard (

    Baral, Kedar / Adhikari, Binaya / Bhandari, Shivish / Kunwar, Ripu M / Sharma, Hari P / Aryal, Achyut / Ji, Weihong

    Heliyon

    2023  Volume 9, Issue 1, Page(s) e12807

    Abstract: Climate change is projected to create alterations in species distributions over the planet. The common leopard ( ...

    Abstract Climate change is projected to create alterations in species distributions over the planet. The common leopard (
    Language English
    Publishing date 2023-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e12807
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  6. Article ; Online: A Quality by Design Approach for Developing SNEDDS Loaded with Vemurafenib for Enhanced Oral Bioavailability.

    Jvus, Chakradhar / Kothuri, Naresh / Singh, Sanjay / Verma, Sonia / Shafi, Hasham / Reddy, D V Siva / Kedar, Ashwini / Rana, Rafquat / Mishra, Keerti / Sharma, Deepak / Chourasia, Manish K

    AAPS PharmSciTech

    2024  Volume 25, Issue 1, Page(s) 14

    Abstract: Vemurafenib (VMF) is a practically insoluble (< 0.1 μg/mL) and least bioavailable (1%) drug. To enhance its oral bioavailability and solubility, we formulated a reliable self-nano emulsifying drug delivery system (SNEDDS). A Quality by Design (QbD) ... ...

    Abstract Vemurafenib (VMF) is a practically insoluble (< 0.1 μg/mL) and least bioavailable (1%) drug. To enhance its oral bioavailability and solubility, we formulated a reliable self-nano emulsifying drug delivery system (SNEDDS). A Quality by Design (QbD) approach was used to optimize the ratio of Capryol 90, Tween 80, and Transcutol HP. VMF-loaded SNEDDS was characterized for its size, polydispersity index (PDI), zeta potential, drug content, and transmittance. The in vitro release profile of the drug loaded in SNEDDS was compared to the free drug in two media, pH 6.8 and 1.2, and the data obtained were analyzed with different mathematical models. A reverse-phase ultra-pressure liquid chromatography (UPLC) technique with high sensitivity and selectivity was developed and validated for the quantification of VMF in analytical and bioanalytical samples. Dissolution efficiency for SNEDDS was estimated using different models, which proved that the developed novel SNEDDS formulation had a better in vitro dissolution profile than the free drug. A 2.13-fold enhanced oral bioavailability of VMF-loaded SNEDDS compared to the free drug demonstrates the superiority of the developed formulation. This work thus presents an overview of VMF-loaded SNEDDS as a promising alternative to improve the oral bioavailability of the drug.
    MeSH term(s) Biological Availability ; Vemurafenib ; Chromatography, Reverse-Phase ; Polysorbates ; Solubility
    Chemical Substances Vemurafenib (207SMY3FQT) ; Polysorbates
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2052070-0
    ISSN 1530-9932 ; 1530-9932
    ISSN (online) 1530-9932
    ISSN 1530-9932
    DOI 10.1208/s12249-023-02725-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Hypertension and its association with body mass index among the Indian population. Findings from a nationwide survey (NFHS-4), 2015-16

    Shailja Sharma / Harshvardhan Singh / Kedar Mehta / Madhur Verma / Sonu Goel

    Journal of Family Medicine and Primary Care, Vol 11, Iss 9, Pp 5826-

    2022  Volume 5833

    Abstract: Background: Globally, hypertension (HTN) and obesity are two cardinal causes of morbidity and mortality. The Asian population shows comorbidities associated with obesity at a much lower body mass index (BMI) than the western population. Aim: The primary ... ...

    Abstract Background: Globally, hypertension (HTN) and obesity are two cardinal causes of morbidity and mortality. The Asian population shows comorbidities associated with obesity at a much lower body mass index (BMI) than the western population. Aim: The primary objective of the present study was to evaluate the association between BMI and HTN among the adult population. Material and Methods: We did a cross-sectional secondary data analysis of the NFHS-4 datasets, conducted during 2015–16. We included the adult population, that is, ≥19 years of age (93,040 men and 5,46,066 women), and excluded adolescents and pregnant women from our analysis. HTN was the primary dependent variable, while BMI was the primary predictor variable. Other covariates included age, education, place of residence, wealth index, use of alcohol and tobacco, and diabetes. Weighted analysis was done to depict our results. Results: Around 18.7% of men and 13.5% of women were hypertensive, of which 53.86% of males and 38.7% females were either overweight or obese. The odds of living with HTN among obese men and women increased with age, wealth, use of alcohol and tobacco, and comorbidities such as diabetes. The prevalence of HTN was higher even among the underweight adults living with diabetes and those consuming alcohol and tobacco. Conclusion: We reaffirm the significant association between BMI and HTN among adults. The use of the Asian classification of BMI for India and its neighboring countries to assess the burden of obesity would help in planning better interventions. A community-based targeted approach would help in controlling and reducing the prevalence of HTN.
    Keywords bmi ; htn ; india ; nfhs-4 ; obesity ; overweight ; Medicine ; R
    Subject code 950
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Hypertension and its association with body mass index among the Indian population. Findings from a nationwide survey (NFHS-4), 2015-16.

    Sharma, Shailja / Singh, Harshvardhan / Mehta, Kedar / Verma, Madhur / Goel, Sonu

    Journal of family medicine and primary care

    2022  Volume 11, Issue 9, Page(s) 5826–5833

    Abstract: Background: Globally, hypertension (HTN) and obesity are two cardinal causes of morbidity and mortality. The Asian population shows comorbidities associated with obesity at a much lower body mass index (BMI) than the western population.: Aim: The ... ...

    Abstract Background: Globally, hypertension (HTN) and obesity are two cardinal causes of morbidity and mortality. The Asian population shows comorbidities associated with obesity at a much lower body mass index (BMI) than the western population.
    Aim: The primary objective of the present study was to evaluate the association between BMI and HTN among the adult population.
    Material and methods: We did a cross-sectional secondary data analysis of the NFHS-4 datasets, conducted during 2015-16. We included the adult population, that is, ≥19 years of age (93,040 men and 5,46,066 women), and excluded adolescents and pregnant women from our analysis. HTN was the primary dependent variable, while BMI was the primary predictor variable. Other covariates included age, education, place of residence, wealth index, use of alcohol and tobacco, and diabetes. Weighted analysis was done to depict our results.
    Results: Around 18.7% of men and 13.5% of women were hypertensive, of which 53.86% of males and 38.7% females were either overweight or obese. The odds of living with HTN among obese men and women increased with age, wealth, use of alcohol and tobacco, and comorbidities such as diabetes. The prevalence of HTN was higher even among the underweight adults living with diabetes and those consuming alcohol and tobacco.
    Conclusion: We reaffirm the significant association between BMI and HTN among adults. The use of the Asian classification of BMI for India and its neighboring countries to assess the burden of obesity would help in planning better interventions. A community-based targeted approach would help in controlling and reducing the prevalence of HTN.
    Language English
    Publishing date 2022-10-14
    Publishing country India
    Document type Journal Article
    ZDB-ID 2735275-4
    ISSN 2278-7135 ; 2249-4863
    ISSN (online) 2278-7135
    ISSN 2249-4863
    DOI 10.4103/jfmpc.jfmpc_168_22
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  9. Article ; Online: Antiviral drug recognition and elevator-type transport motions of CNT3.

    Wright, Nicholas J / Zhang, Feng / Suo, Yang / Kong, Lingyang / Yin, Ying / Fedor, Justin G / Sharma, Kedar / Borgnia, Mario J / Im, Wonpil / Lee, Seok-Yong

    Nature chemical biology

    2024  

    Abstract: Nucleoside analogs have broad clinical utility as antiviral drugs. Key to their systemic distribution and cellular entry are human nucleoside transporters. Here, we establish that the human concentrative nucleoside transporter 3 (CNT3) interacts with ... ...

    Abstract Nucleoside analogs have broad clinical utility as antiviral drugs. Key to their systemic distribution and cellular entry are human nucleoside transporters. Here, we establish that the human concentrative nucleoside transporter 3 (CNT3) interacts with antiviral drugs used in the treatment of coronavirus infections. We report high-resolution single-particle cryo-electron microscopy structures of bovine CNT3 complexed with antiviral nucleosides N
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2202962-X
    ISSN 1552-4469 ; 1552-4450
    ISSN (online) 1552-4469
    ISSN 1552-4450
    DOI 10.1038/s41589-024-01559-8
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  10. Article: Higher coronavirus disease-19 mortality linked to comorbidities: A comparison between low-middle income and high-income countries.

    Jindal, Har Ashish / Sahoo, Soumya Swaroop / Jamir, Limalemla / Kedar, Ashwini / Sharma, Sugandhi / Bhatt, Bhumika

    Journal of education and health promotion

    2021  Volume 10, Page(s) 377

    Abstract: Background: Global burden of disease (GBD) provides the estimates of mortality and morbidity, while case fatality rate (CFR) helps in understanding the severity of the disease. People infected with severe acute respiratory syndrome coronavirus 2 (SARS ... ...

    Abstract Background: Global burden of disease (GBD) provides the estimates of mortality and morbidity, while case fatality rate (CFR) helps in understanding the severity of the disease. People infected with severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) with underlying medical conditions have shown higher levels of unfavorable outcomes including mortality. We assessed the association of SARS-CoV-2 CFR with disability-adjusted life years (DALY) of various comorbidities in the low-middle income countries (LMIC) and high-income countries (HIC) to study the relationship of coronavirus disease-19 (COVID-19) mortality with GBDs and to understand the linkage between COVID-19 mortality and comorbidities.
    Materials and methods: This was an ecological study with secondary data analysis comparing the DALY of various morbidities from GBD with CFR of COVID-19. Gross domestic product was the basis of stratifying 177 countries into low-middle income (LMIC) and high-income groups (HIC). The mortality was analyzed using Pearson correlation and linear regression.
    Results: The median global CFR of SARS-CoV-2 was 2.15. The median CFR among LMIC (
    Conclusions: SARS-CoV-2 infection appears to be a systemic disease. Individuals with comorbidities, such as maternal disorders, neurological diseases, musculoskeletal disorders, and nutritional deficiencies, have poorer outcomes with COVID-19, leading to higher mortality.
    Language English
    Publishing date 2021-10-29
    Publishing country India
    Document type Journal Article
    ZDB-ID 2715449-X
    ISSN 2319-6440 ; 2277-9531
    ISSN (online) 2319-6440
    ISSN 2277-9531
    DOI 10.4103/jehp.jehp_142_21
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