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  1. Article: In silico identification of compounds from

    Dao, Tran Nhat Phong / Onikanni, Sunday Amos / Fadaka, Adewale Oluwaseun / Klein, Ashwil / Tran, Van De / Le, Minh Hoang / Wang, Chih-Hao / Chang, Hen-Hong

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1358037

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2024-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1358037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Computational Target-Based Screening of Anti-MRSA Natural Products Reveals Potential Multitarget Mechanisms of Action through Peptidoglycan Synthesis Proteins.

    Oselusi, Samson Olaitan / Fadaka, Adewale Oluwaseun / Wyckoff, Gerald J / Egieyeh, Samuel Ayodele

    ACS omega

    2022  Volume 7, Issue 42, Page(s) 37896–37906

    Abstract: Methicillin- ... ...

    Abstract Methicillin-resistant
    Language English
    Publishing date 2022-10-14
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c05061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Phytotherapeutic potential of compounds identified from fractionated extracts of

    Dao, Tran Nhat Phong / Onikanni, Sunday Amos / Fadaka, Adewale Oluwaseun / Sibuyi, Nicole Remaliah Samantha / Le, Minh Hoang / Chang, Hen-Hong

    Journal of biomolecular structure & dynamics

    2024  , Page(s) 1–14

    Abstract: The presence of HLA-DRB1 alleles that encode critical points associated with environmental interactions is associated with increased risk of rheumatoid arthritis caused by anti-citrullinated protein antibodies. Therefore, interleukin-6 (IL-6), a ... ...

    Abstract The presence of HLA-DRB1 alleles that encode critical points associated with environmental interactions is associated with increased risk of rheumatoid arthritis caused by anti-citrullinated protein antibodies. Therefore, interleukin-6 (IL-6), a multifunctional cytokine that controls both local and systemic acute inflammatory responses through its ability to induce a phase response, plays a serious role. Its overexpression leads to pathological challenges such as rheumatoid arthritis and menopausal osteoporosis. However, targeting the IL-6 receptor and its region could be the major step in controlling the overexpression of this cytokine for therapeutic importance. Therefore, our research explored the computational insight needed to investigate the anti-RFA potential of phytochemicals from fractionated extracts of
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2024.2330713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Stage-specific treatment of colorectal cancer: A microRNA-nanocomposite approach.

    Fadaka, Adewale Oluwaseun / Akinsoji, Taiwo / Klein, Ashwil / Madiehe, Abram Madimabe / Meyer, Mervin / Keyster, Marshall / Sikhwivhilu, Lucky Mashudu / Sibuyi, Nicole Remaliah Samantha

    Journal of pharmaceutical analysis

    2023  Volume 13, Issue 11, Page(s) 1235–1251

    Abstract: Colorectal cancer (CRC) is among the leading causes of cancer mortality. The lifetime risk of developing CRC is about 5% in adult males and females. CRC is usually diagnosed at an advanced stage, and at this point therapy has a limited impact on cure ... ...

    Abstract Colorectal cancer (CRC) is among the leading causes of cancer mortality. The lifetime risk of developing CRC is about 5% in adult males and females. CRC is usually diagnosed at an advanced stage, and at this point therapy has a limited impact on cure rates and long-term survival. Novel and/or improved CRC therapeutic options are needed. The involvement of microRNAs (miRNAs) in cancer development has been reported, and their regulation in many oncogenic pathways suggests their potent tumor suppressor action. Although miRNAs provide a promising therapeutic approach for cancer, challenges such as biodegradation, specificity, stability and toxicity, impede their progression into clinical trials. Nanotechnology strategies offer diverse advantages for the use of miRNAs for CRC-targeted delivery and therapy. The merits of using nanocarriers for targeted delivery of miRNA-formulations are presented herein to highlight the role they can play in miRNA-based CRC therapy by targeting different stages of the disease.
    Language English
    Publishing date 2023-07-17
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2630174-X
    ISSN 2214-0883 ; 2095-1779
    ISSN (online) 2214-0883
    ISSN 2095-1779
    DOI 10.1016/j.jpha.2023.07.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Nanotechnology-Based Delivery Systems for Antimicrobial Peptides.

    Fadaka, Adewale Oluwaseun / Sibuyi, Nicole Remaliah Samantha / Madiehe, Abram Madimabe / Meyer, Mervin

    Pharmaceutics

    2021  Volume 13, Issue 11

    Abstract: Antimicrobial resistance (AMR) is a significant threat to global health. The conventional antibiotic pool has been depleted, forcing the investigation of novel and alternative antimicrobial strategies. Antimicrobial peptides (AMPs) have shown potential ... ...

    Abstract Antimicrobial resistance (AMR) is a significant threat to global health. The conventional antibiotic pool has been depleted, forcing the investigation of novel and alternative antimicrobial strategies. Antimicrobial peptides (AMPs) have shown potential as alternative diagnostic and therapeutic agents in biomedical applications. To date, over 3000 AMPs have been identified, but only a fraction of these have been approved for clinical trials. Their clinical applications are limited to topical application due to their systemic toxicity, susceptibility to protease degradation, short half-life, and rapid renal clearance. To circumvent these challenges and improve AMP's efficacy, different approaches such as peptide chemical modifications and the development of AMP delivery systems have been employed. Nanomaterials have been shown to improve the activity of antimicrobial drugs by providing support and synergistic effect against pathogenic microbes. This paper describes the role of nanotechnology in the targeted delivery of AMPs, and some of the nano-based delivery strategies for AMPs are discussed with a clear focus on metallic nanoparticle (MNP) formulations.
    Language English
    Publishing date 2021-10-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics13111795
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Prospects of Using Gum Arabic Silver Nanoparticles in Toothpaste to Prevent Dental Caries.

    Ahmed, Omnia Abdelmoneim Khidir / Sibuyi, Nicole Remaliah Samantha / Fadaka, Adewale Oluwaseun / Maboza, Ernest / Olivier, Annette / Madiehe, Abram Madimabe / Meyer, Mervin / Geerts, Greta

    Pharmaceutics

    2023  Volume 15, Issue 3

    Abstract: There is growing interest in the use of green synthesized silver nanoparticles (AgNPs) to control and prevent dental diseases. The incorporation of green synthesized AgNPs into dentifrices to reduce pathogenic oral microbes is motivated by their presumed ...

    Abstract There is growing interest in the use of green synthesized silver nanoparticles (AgNPs) to control and prevent dental diseases. The incorporation of green synthesized AgNPs into dentifrices to reduce pathogenic oral microbes is motivated by their presumed biocompatibility and broad-spectrum antimicrobial activity. In the present study, gum arabic AgNPs (GA-AgNPs) were formulated into a toothpaste (TP) using a commercial TP at a non-active concentration, to produce GA-AgNPs_TP. The TP was selected after evaluating the antimicrobial activity of four commercial TPs 1-4 on selected oral microbes using agar disc diffusion and microdilution assays. The less active TP-1 was then used in the formulation of GA-AgNPs_TP-1; thereafter, the antimicrobial activity of GA-AgNPs_0.4g was compared to GA-AgNPs_TP-1. The cytotoxicity of GA-AgNPs_0.4g and GA-AgNPs_TP-1 was also assessed on the buccal mucosa fibroblast (BMF) cells using the MTT assay. The study demonstrated that antimicrobial activity of GA-AgNPs_0.4g was retained after being combined with a sub-lethal or inactive concentration of TP-1. The non-selective antimicrobial activity and cytotoxicity of both GA-AgNPs_0.4g and GA-AgNPs_TP-1 was demonstrated to be time and concentration dependent. These activities were instant, reducing microbial and BMF cell growth in less than one hour of exposure. However, the use of dentifrice commonly takes 2 min and rinsed off thereafter, which could prevent damage to the oral mucosa. Although, GA-AgNPs_TP-1 has a good prospect as a TP or oral healthcare product, more studies are required to further improve the biocompatibility of this formulation.
    Language English
    Publishing date 2023-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15030871
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Computational and Preclinical Prediction of the Antimicrobial Properties of an Agent Isolated from

    Onikanni, Sunday Amos / Lawal, Bashir / Fadaka, Adewale Oluwaseun / Bakare, Oluwafemi / Adewole, Ezekiel / Taher, Muhammad / Khotib, Junaidi / Susanti, Deny / Oyinloye, Babatunji Emmanuel / Ajiboye, Basiru Olaitan / Ojo, Oluwafemi Adeleke / Sibuyi, Nicole Remaliah Samantha

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 4

    Abstract: The African nutmeg ( ...

    Abstract The African nutmeg (
    MeSH term(s) Annonaceae/chemistry ; Anti-Infective Agents/pharmacology ; DNA Gyrase ; Levofloxacin ; Topoisomerase II Inhibitors/pharmacology
    Chemical Substances Anti-Infective Agents ; DNA Gyrase (EC 5.99.1.3) ; Levofloxacin (6GNT3Y5LMF) ; Topoisomerase II Inhibitors
    Language English
    Publishing date 2023-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28041593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  8. Article ; Online: Anticancer and Drug-Sensitizing Activities of Gold Nanoparticles Synthesized from Cyclopia genistoides (Honeybush) Extracts

    Jyoti Rajan Sharma / Nicole Remaliah Samantha Sibuyi / Adewale Oluwaseun Fadaka / Samantha Meyer / Abram Madimabe Madiehe / Kattesh Katti / Mervin Meyer

    Applied Sciences, Vol 13, Iss 3973, p

    2023  Volume 3973

    Abstract: Synthesis of gold nanoparticles (AuNPs) using phytochemicals has become tremendously prominent in biomedical applications because of its enhanced bioactivity and biocompatibility. In this study, water extracts from the leaves of Cyclopia genistoides ( C . ...

    Abstract Synthesis of gold nanoparticles (AuNPs) using phytochemicals has become tremendously prominent in biomedical applications because of its enhanced bioactivity and biocompatibility. In this study, water extracts from the leaves of Cyclopia genistoides ( C . genistoides ), commonly known as honeybush (HB), were used to synthesize honeybush gold nanoparticles (HB-AuNPs). The HB water extracts (HBE) served as both reducing and capping agents in the synthesis of HB-AuNPs. The HB-AuNPs were characterized by UV–Vis spectrophotometry, dynamic light scattering (DLS), and transmission electron microscopy (TEM). The cytotoxicity and apoptotic effects of the HBE and HB-AuNPs, alone and in combination with doxorubicin (Dox), were examined against various human cell lines. Spherical-shaped HB-AuNPs with a hydrodynamic diameter range of 63 to 121 nm were produced. The HB-AuNPs conferred selective cytotoxicity against colon (Caco-2), breast (MCF-7), and prostate (PC-3) cancer cells and did not display any cytotoxicity to non-cancerous skin fibroblast (KMST-6) and human embryonic kidney (HEK)-293 cells. Moreover, co-treatment of Caco-2 cells with HB-AuNPs and Dox (at non-toxic concentrations) significantly enhanced the anti-cancer effects of Dox towards the Caco-2 cells. Furthermore, it was demonstrated that HB-AuNPs induced PC-3 cell death through apoptosis. Further studies are warranted to elucidate the mechanisms by which the HB-AuNPs influence cell death when used alone or in combination with drugs, as well as the type of phytochemicals involved in AuNPs synthesis and activity.
    Keywords Cyclopia genistoides ; gold nanoparticles ; green synthesis ; medicinal plants ; phytochemicals ; phytotherapy ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 500
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article ; Online: Profiling the Antidiabetic Potential of Compounds Identified from Fractionated Extracts of

    Onikanni, Sunday Amos / Lawal, Bashir / Munyembaraga, Valens / Bakare, Oluwafemi Shittu / Taher, Muhammad / Khotib, Junaidi / Susanti, Deny / Oyinloye, Babatunji Emmanuel / Noriega, Lloyd / Famuti, Ayodeji / Fadaka, Adewale Oluwaseun / Ajiboye, Basiru Olaitan

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 15

    Abstract: Glucokinase plays an important role in regulating the blood glucose level and serves as an essential therapeutic target in type 2 diabetes management. ...

    Abstract Glucokinase plays an important role in regulating the blood glucose level and serves as an essential therapeutic target in type 2 diabetes management.
    MeSH term(s) Humans ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Molecular Docking Simulation ; Glucokinase/metabolism ; Ligands ; Diabetes Mellitus, Type 2/drug therapy
    Chemical Substances Hypoglycemic Agents ; Glucokinase (EC 2.7.1.2) ; Ligands
    Language English
    Publishing date 2023-07-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28155752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  10. Article ; Online: Development of Effective Therapeutic Molecule from Natural Sources against Coronavirus Protease.

    Fadaka, Adewale Oluwaseun / Sibuyi, Nicole Remaliah Samantha / Martin, Darius Riziki / Klein, Ashwil / Madiehe, Abram / Meyer, Mervin

    International journal of molecular sciences

    2021  Volume 22, Issue 17

    Abstract: The SARS-CoV-2 main protease ( ... ...

    Abstract The SARS-CoV-2 main protease (M
    MeSH term(s) Binding Sites ; Biological Products/chemistry ; Biological Products/metabolism ; Biological Products/therapeutic use ; COVID-19/drug therapy ; COVID-19/pathology ; COVID-19/virology ; Catalytic Domain ; Drug Design ; Humans ; Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protease Inhibitors/chemistry ; Protease Inhibitors/metabolism ; Protease Inhibitors/therapeutic use ; Quercetin/analogs & derivatives ; Quercetin/chemistry ; Quercetin/metabolism ; Quercetin/therapeutic use ; SARS-CoV-2/enzymology ; SARS-CoV-2/isolation & purification ; Viral Matrix Proteins/chemistry ; Viral Matrix Proteins/metabolism
    Chemical Substances Biological Products ; Ligands ; Protease Inhibitors ; Viral Matrix Proteins ; membrane protein, SARS-CoV-2 ; quercetin-3-O-neohesperidose (29322-06-3) ; Quercetin (9IKM0I5T1E)
    Language English
    Publishing date 2021-08-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22179431
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