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  1. Article: Incidentally Diagnosed Type 2 Youssef's Syndrome with Migrated Postcesarean Postpartum Intrauterine Contraceptive Device.

    Mishra, Vibha / Pandey, Himanshu / Shekhar, Shashank / Sharma, Charu

    Gynecology and minimally invasive therapy

    2022  Volume 11, Issue 1, Page(s) 67–69

    Abstract: Vesicouterine fistula (VUF) also called Youssef's syndrome is a rare and the least commonly encountered entity among genitourinary fistulae. Treatment options range from excision of the fistulous tract with hysterectomy and primary closure of the urinary ...

    Abstract Vesicouterine fistula (VUF) also called Youssef's syndrome is a rare and the least commonly encountered entity among genitourinary fistulae. Treatment options range from excision of the fistulous tract with hysterectomy and primary closure of the urinary bladder to fistula repair. Migrated postpartum intrauterine contraceptive device is one of the rarest causes for VUF. Here, we are describing a case of incidentally diagnosed VUF with Type 2 Youssef's syndrome with migrated postplacental (postcesarean) intrauterine contraceptive device, treated with uterus-sparing laparoscopic VUF closure.
    Language English
    Publishing date 2022-02-14
    Publishing country India
    Document type Case Reports
    ZDB-ID 2696587-2
    ISSN 2213-3070
    ISSN 2213-3070
    DOI 10.4103/GMIT.GMIT_107_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: In silico guided screening of active components of

    Sharma, Ganesh / Kumar, Neeraj / Sharma, Chandra Shekhar / Mishra, Shashank Shekher

    3 Biotech

    2023  Volume 13, Issue 10, Page(s) 324

    Abstract: Despite the intense worldwide efforts towards the identification of potential anti-CoV therapeutics, no antiviral drugs have yet been discovered. Numerous vaccines are now approved for use, but they all serve as preventative measures. To effectively ... ...

    Abstract Despite the intense worldwide efforts towards the identification of potential anti-CoV therapeutics, no antiviral drugs have yet been discovered. Numerous vaccines are now approved for use, but they all serve as preventative measures. To effectively treat viral infections, it is crucial to find new antiviral drugs that are derived from natural sources. Various compounds with potential activity against 3 chymotrypsin-like protease (3CLpro) were reported and some are validated by bioassay studies. Therefore, we performed the computational screening of phytoconstituents of
    Supplementary information: The online version contains supplementary material available at 10.1007/s13205-023-03745-2.
    Language English
    Publishing date 2023-08-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-023-03745-2
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  3. Article: Molecular Insights of 1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazole as CRF-1 Receptor Antagonists: Combined QSAR, Glide Docking, Molecular Dynamics, and

    Kumar, Sunil / Kumar, Neeraj / Sharma, Chandra Shekhar / Mishra, Shashank Shekher

    Iranian journal of pharmaceutical research : IJPR

    2021  Volume 20, Issue 2, Page(s) 22–34

    Abstract: Stress-dependent disorders cause severe harm to human health and trigger the risk of neurodegenerative disorder. Corticotropin-releasing factor-1 receptor was found to be a potent drug target.We evaluate the essential structural residues for ... ...

    Abstract Stress-dependent disorders cause severe harm to human health and trigger the risk of neurodegenerative disorder. Corticotropin-releasing factor-1 receptor was found to be a potent drug target.We evaluate the essential structural residues for pharmacophore identification through 2D and 3D QSAR analysis and identify the binding residues for a possible mechanism of CRF-1 binding with 1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazole derivatives through molecular docking and molecular dynamics simulations. The best 2D QSAR model was obtained through the MLR method with an r
    Language English
    Publishing date 2021-07-24
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2578271-X
    ISSN 1726-6890 ; 1735-0328 ; 1735-0328
    ISSN (online) 1726-6890 ; 1735-0328
    ISSN 1735-0328
    DOI 10.22037/ijpr.2020.113746.14464
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Heavy Metal Contamination in the Aquatic Ecosystem: Toxicity and Its Remediation Using Eco-Friendly Approaches.

    Singh, Veer / Singh, Nidhi / Rai, Sachchida Nand / Kumar, Ashish / Singh, Anurag Kumar / Singh, Mohan P / Sahoo, Ansuman / Shekhar, Shashank / Vamanu, Emanuel / Mishra, Vishal

    Toxics

    2023  Volume 11, Issue 2

    Abstract: Urbanization and industrialization are responsible for environmental contamination in the air, water, and soil. These activities also generate large amounts of heavy metal ions in the environment, and these contaminants cause various types of health ... ...

    Abstract Urbanization and industrialization are responsible for environmental contamination in the air, water, and soil. These activities also generate large amounts of heavy metal ions in the environment, and these contaminants cause various types of health issues in humans and other animals. Hexavalent chromium, lead, and cadmium are toxic heavy metal ions that come into the environment through several industrial processes, such as tanning, electroplating, coal mining, agricultural activities, the steel industry, and chrome plating. Several physical and chemical methods are generally used for the heavy metal decontamination of wastewater. These methods have some disadvantages, including the generation of secondary toxic sludge and high operational costs. Hence, there is a need to develop a cost-effective and eco-friendly method for the removal of heavy metal ions from polluted areas. Biological methods are generally considered eco-friendly and cost-effective. This review focuses on heavy metal contamination, its toxicity, and eco-friendly approaches for the removal of heavy metals from contaminated sites.
    Language English
    Publishing date 2023-02-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics11020147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Highly Sensitive and Selective Triethylamine Sensing through High-Entropy Alloy (Ti-Zr-Cr-V-Ni) Nanoparticle-Induced Fermi Energy Control of MoS

    V, Jishnu / Mishra, Shashank Shekhar / Mb, Kusuma Urs / Thomas, Sanchu P / Tiwary, Chandra Sekhar / Biswas, Krishanu / Kamble, Vinayak B

    ACS applied materials & interfaces

    2022  Volume 14, Issue 11, Page(s) 13653–13664

    Abstract: A giant enhancement of nearly 100 times is seen in triethylamine response through Ti-Zr-Cr-V-Ni high-entropy alloy nanoparticle (HEA NP)-induced fermi energy control of two-dimensional molybdenum disulfide ( ... ...

    Abstract A giant enhancement of nearly 100 times is seen in triethylamine response through Ti-Zr-Cr-V-Ni high-entropy alloy nanoparticle (HEA NP)-induced fermi energy control of two-dimensional molybdenum disulfide (MoS
    Language English
    Publishing date 2022-03-11
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.2c00531
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  6. Article: Hydrus-1D for Simulating Potassium Transport in Flooded Paddy Soils

    Shekhar, Shashank / Mailapalli, Damodhara Rao / Das, Bhabani Sankar / Mishra, Ashok / Raghuwanshi, Narendra Singh

    Communications in soil science and plant analysis. 2021 Dec. 16, v. 52, no. 22

    2021  

    Abstract: Understanding the transport of potassium (K) in flooded rice fields is important for the efficient management of K fertilizers. In this study, the data from lysimeter experiments were used for simulating the water flow and K transport using Hydrus-1D and ...

    Abstract Understanding the transport of potassium (K) in flooded rice fields is important for the efficient management of K fertilizers. In this study, the data from lysimeter experiments were used for simulating the water flow and K transport using Hydrus-1D and the influence of split doses of recommended K fertilizer on its availability to paddy crop was investigated. Paddy crop was grown in non-weighing-type lysimeters. The depth of ponding water, soil matric potential heads, K concentration of ponding water and soil solution were measured during three paddy growing seasons. The Hydrus-1D model was calibrated and validated using the lysimeter data and simulated the water flow and K concentrations well. The deep percolation was 51–56% of the applied water and the K load in deep percolation was 0.3–0.7% of the total available K. About 56–62% of K is utilized by rice crop. The applied K was observed to be remained mostly within the top 20 cm soil depth and did not transport to deeper layers. The recommended dose of K fertilizer with four equal splits applied at four crop growth stages could increase the K availability to paddy throughout its growing period, and it may be the best K management practice for paddy.
    Keywords lysimeters ; models ; paddies ; plant analysis ; potassium ; potassium fertilizers ; rice ; soil depth ; soil matric potential ; soil solution ; water flow
    Language English
    Dates of publication 2021-1216
    Size p. 2803-2820.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 419718-5
    ISSN 1532-2416 ; 0010-3624
    ISSN (online) 1532-2416
    ISSN 0010-3624
    DOI 10.1080/00103624.2021.1966437
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  7. Article ; Online: Synthesis of 2-methoxy-3-(thiophen-2-ylmethyl)quinoline containing amino carbinols as antitubercular agents.

    Karkara, Bidhu Bhusan / Mishra, Shashank Shekhar / Singh, Bhupendra N / Panda, Gautam

    Bioorganic chemistry

    2020  Volume 99, Page(s) 103775

    Abstract: We have designed and synthesized 2-methoxy-3-(thiophen-2-ylmethyl)quinoline containing amino carbinols as possible anti-tubercular agents to combat the disease. These molecules were synthesized by tethering amino ether linkage with hydroxyl group to ... ...

    Abstract We have designed and synthesized 2-methoxy-3-(thiophen-2-ylmethyl)quinoline containing amino carbinols as possible anti-tubercular agents to combat the disease. These molecules were synthesized by tethering amino ether linkage with hydroxyl group to diarylquinoline skeleton; hydroxyl and amine chains were engrafted on diaryl ring. They were evaluated against strain (H
    MeSH term(s) Antitubercular Agents/chemical synthesis ; Antitubercular Agents/chemistry ; Antitubercular Agents/pharmacology ; Dose-Response Relationship, Drug ; Methanol/analogs & derivatives ; Methanol/chemistry ; Methanol/pharmacology ; Microbial Sensitivity Tests ; Molecular Structure ; Mycobacterium tuberculosis/drug effects ; Structure-Activity Relationship
    Chemical Substances Antitubercular Agents ; Methanol (Y4S76JWI15)
    Language English
    Publishing date 2020-03-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2020.103775
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Pre-COVID and COVID experience of objective structured clinical examination as a learning tool for post-graduate residents in Obstetrics & Gynecology-a quality improvement study.

    Sharma, Charu / Singh, Pratibha / Shekhar, Shashank / Bhardwaj, Abhishek / Jhirwal, Manisha / Ghuman, Navdeep Kaur / Gothwal, Meenakshi / Yadav, Garima / Kathuria, Priyanka / Mishra, Vibha

    Obstetrics & gynecology science

    2023  Volume 66, Issue 4, Page(s) 316–326

    Abstract: Objective: Due to its comprehensive, reliable, and valid format, the objective structured clinical examination (OSCE) is the gold standard for assessing the clinical competency of medical students. In the present study, we evaluated the importance of ... ...

    Abstract Objective: Due to its comprehensive, reliable, and valid format, the objective structured clinical examination (OSCE) is the gold standard for assessing the clinical competency of medical students. In the present study, we evaluated the importance of the OSCE as a learning tool for postgraduate (PG) residents assessing their junior undergraduate students. We further aimed to analyze quality improvement during the pre-coronavirus disease (COVID) and COVID periods.
    Methods: This quality-improvement interventional study was conducted at the Department of Obstetrics and Gynecology. The PG residents were trained to conduct the OSCE. A formal feedback form was distributed to 22 participants, and their responses were analyzed using a five-point Likert scale. Fishbone analysis was performed, and the 'plan-do-study-act' (PDSA) cycle was implemented to improve the OSCE.
    Results: Most of the residents (95%) believed that this examination system was extremely fair and covered a wide range of clinical skills and knowledge. Further, 4.5% believed it was more labor- and resource intensive and time-consuming. Eighteen (81.8%) residents stated that they had learned all three domains: communication skills, time management skills, and a stepwise approach to clinical scenarios. The PDSA cycle was run eight times, resulting in a dramatic improvement (from 30% to 70%) in the knowledge and clinical skills of PGs and the standard of OSCE.
    Conclusion: The OSCE can be used as a learning tool for young assessors who are receptive to novel tools. The involvement of PGs in the OSCE improved their communication skills and helped overcome human resource limitations while manning various OSCE stations.
    Language English
    Publishing date 2023-04-19
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2814367-X
    ISSN 2287-8580 ; 2287-8572
    ISSN (online) 2287-8580
    ISSN 2287-8572
    DOI 10.5468/ogs.22266
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  9. Article ; Online: Computational investigation of potential inhibitors of novel coronavirus 2019 through structure-based virtual screening, molecular dynamics and density functional theory studies.

    Mishra, Shashank Shekhar / Ranjan, Shashi / Sharma, Chandra Shekhar / Singh, Hemendra Pratap / Kalra, Sourav / Kumar, Neeraj

    Journal of biomolecular structure & dynamics

    2020  Volume 39, Issue 12, Page(s) 4449–4461

    Abstract: Despite the intensive research efforts towards antiviral drug against COVID-19, no potential drug or vaccines has not yet discovered. Initially, the binding site of COVID-19 main protease was predicted which located between regions 2 and 3. Structure- ... ...

    Abstract Despite the intensive research efforts towards antiviral drug against COVID-19, no potential drug or vaccines has not yet discovered. Initially, the binding site of COVID-19 main protease was predicted which located between regions 2 and 3. Structure-based virtual screening was performed through a hierarchal mode of elimination technique after generating a grid box. This led to the identification of five top hit molecules that were selected on the basis of docking score and visualization of non-bonding interactions. The docking results revealed that the hydrogen bonding and hydrophobic interactions are the major contributing factors in the stabilization of complexes. The docking scores were found between -7.524 and -6.711 kcal/mol indicating strong ligand-protein interactions. Amino acid residues Phe140, Leu141, Gly143, Asn142, Thr26, Glu166 and Thr190 (hydrogen bonding interactions) and Phe140, Cys145, Cys44, Met49, Leu167, Pro168, Met165, Val42, Leu27 and Ala191 (hydrophobic interactions) formed the binding pocket of COVID-19 main protease. From identified hits, ZINC13144609 and ZINC01581128 were selected for atomistic MD simulation and density functional theory calculations. MD simulation results confirm that the protein interacting with both hit molecules is stabilized in the chosen POPC lipid bilayer membrane. The presence of lowest unoccupied molecular orbital (LUMO) and highest occupied molecular orbital (HOMO) in the hydrophobic region of the hit molecules leads to favorable ligand-protein contacts. The calculated pharmacokinetic descriptors were found to be in their acceptable range and therefore confirming their drug-like properties. Hence, the present investigation can serve as the basis for designing and developing COVID-19 inhibitors. Communicated by Ramaswamy H. Sarma.
    MeSH term(s) COVID-19 ; Density Functional Theory ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2020.1791957
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Omics-Based Mechanistic Insight Into the Role of Bioengineered Nanoparticles for Biotic Stress Amelioration by Modulating Plant Metabolic Pathways.

    Kumari, Madhuree / Pandey, Shipra / Mishra, Shashank Kumar / Giri, Ved Prakash / Agarwal, Lalit / Dwivedi, Sanjay / Pandey, Alok Kumar / Nautiyal, Chandra Shekhar / Mishra, Aradhana

    Frontiers in bioengineering and biotechnology

    2020  Volume 8, Page(s) 242

    Abstract: Bioengineered silver nanoparticles can emerge as a facile approach to combat plant pathogen, reducing the use of pesticides in an eco-friendly manner. The plants' response during tripartite interaction of plant, pathogen, and nanoparticles remains ... ...

    Abstract Bioengineered silver nanoparticles can emerge as a facile approach to combat plant pathogen, reducing the use of pesticides in an eco-friendly manner. The plants' response during tripartite interaction of plant, pathogen, and nanoparticles remains largely unknown. This study demonstrated the use of bioengineered silver nanoparticles in combating black spot disease caused by necrotrophic fungus
    Language English
    Publishing date 2020-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2020.00242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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