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  1. Article ; Online: Performance of Carbapenemase Nordmann-Poirel, Modified Carbapenem Inactivation, and EDTA Carbapenem Inactivation Methods for Detecting Carbapenem-Resistant

    Sarva, Kamalakar / Marimuthu Ragavan, Rameshkumar / Tadi, Lakshmi Jyothi / Raja, Sundaramurthy / Narasingam, Arunagirinathan

    Microbial drug resistance (Larchmont, N.Y.)

    2023  Volume 29, Issue 11, Page(s) 504–509

    Abstract: Infections caused by carbapenem- ... ...

    Abstract Infections caused by carbapenem-resistant
    MeSH term(s) Humans ; Carbapenems/pharmacology ; Klebsiella pneumoniae/genetics ; Anti-Bacterial Agents/pharmacology ; Edetic Acid/pharmacology ; Microbial Sensitivity Tests ; Bacterial Proteins/genetics ; beta-Lactamases/genetics ; Carbapenem-Resistant Enterobacteriaceae/genetics ; Klebsiella Infections/drug therapy
    Chemical Substances Carbapenems ; carbapenemase (EC 3.5.2.6) ; Anti-Bacterial Agents ; Edetic Acid (9G34HU7RV0) ; Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2023-09-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1290490-9
    ISSN 1931-8448 ; 1076-6294
    ISSN (online) 1931-8448
    ISSN 1076-6294
    DOI 10.1089/mdr.2023.0040
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4435: Show issues Location:
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  2. Article ; Online: Report of multidrug resistant bloodstream bacterial infections in systemic lupus erythematosus patients in Southern India.

    Natesan, Manikandan / Ganesh, Balasubramanian / Narasingam, Arunagirinathan / Ragavan, Rameshkumar Marimuthu

    The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

    2020  Volume 24, Issue 5, Page(s) 470–472

    MeSH term(s) Bacterial Infections ; Drug Resistance, Multiple, Bacterial ; Humans ; India/epidemiology ; Lupus Erythematosus, Systemic/complications
    Language English
    Publishing date 2020-08-07
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2041400-6
    ISSN 1678-4391 ; 1413-8670
    ISSN (online) 1678-4391
    ISSN 1413-8670
    DOI 10.1016/j.bjid.2020.07.005
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    Zs.A 5633: Show issues Location:
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  3. Article ; Online: Antibacterial, Antioxidant, Larvicidal and Anticancer Activities of Silver Nanoparticles Synthesized Using Extracts from Fruits of

    Babu, Venkatadri / Arokiyaraj, Selvaraj / Sakthi Sri, Swathi Pon / George, Mary / Ragavan, Rameshkumar Marimuthu / Dharmalingam, Dinesh / Oh, Taehwan / Ramasundaram, Subramaniyan / Agastian, Paul

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 22

    Abstract: The present study aimed to analyze the in vitro antibacterial, antioxidant, larvicidal and cytotoxicity properties of green synthesized silver nanoparticles (Ag NPs) using aqueous extracts from fruits of Lagerstroemia speciosa and flowers ... ...

    Abstract The present study aimed to analyze the in vitro antibacterial, antioxidant, larvicidal and cytotoxicity properties of green synthesized silver nanoparticles (Ag NPs) using aqueous extracts from fruits of Lagerstroemia speciosa and flowers of
    MeSH term(s) Humans ; Silver/chemistry ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Lagerstroemia ; Metal Nanoparticles/chemistry ; Fruit ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Gram-Negative Bacteria ; Gram-Positive Bacteria ; Flowers
    Chemical Substances Silver (3M4G523W1G) ; Antioxidants ; Anti-Bacterial Agents ; Plant Extracts
    Language English
    Publishing date 2022-11-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27227792
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    Zs.MO 81: Show issues

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  4. Article ; Online: Could Perturbation of Gut Microbiota Possibly Exacerbate the Severity of COVID-19

    Vignesh, Ramachandran / Swathirajan, Chinnambedu Ravichandran / Tun, Zaw Htet / Rameshkumar, Marimuthu Ragavan / Solomon, Sunil Suhas / Balakrishnan, Pachamuthu

    Frontiers in immunology

    2021  Volume 11, Page(s) 607734

    MeSH term(s) Age Factors ; Animals ; COVID-19/immunology ; COVID-19/microbiology ; COVID-19/virology ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/microbiology ; Cytokine Release Syndrome/virology ; Cytokines/immunology ; Dysbiosis ; Gastrointestinal Microbiome ; Host-Pathogen Interactions ; Humans ; Inflammation Mediators/immunology ; Intestines/immunology ; Intestines/microbiology ; Intestines/virology ; Risk Factors ; SARS-CoV-2/pathogenicity ; Severity of Illness Index
    Chemical Substances Cytokines ; Inflammation Mediators
    Language English
    Publishing date 2021-01-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.607734
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  5. Article: Retrospective Analysis of Antibiotic Resistance in

    Swathirajan, Chinnambedu Ravichandran / Rameshkumar, Marimuthu Ragavan / Solomon, Sunil Suhas / Vignesh, Ramachandran / Balakrishnan, Pachamuthu

    Advanced biomedical research

    2019  Volume 8, Page(s) 1

    Language English
    Publishing date 2019-01-21
    Publishing country India
    Document type Journal Article
    ZDB-ID 2672524-1
    ISSN 2277-9175
    ISSN 2277-9175
    DOI 10.4103/abr.abr_185_18
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  6. Article ; Online: Exploring potential anti-chikungunya virus activity of phytocompounds

    Prushothaman Indu / Narasingam Arunagirinathan / Marimuthu Ragavan Rameshkumar / Kodhandan Sangeetha / Swaminathan Rajarajan / Reem M. Aljowaie / Saeedah Musaed Almutairi / Kuppusamy Palaniselvam

    Journal of King Saud University: Science, Vol 34, Iss 6, Pp 102157- (2022)

    Computational docking and in vitro studies

    2022  

    Abstract: Objective: This study aimed to identify phytocompounds that possess anti-chikungunya virus activity using computational docking and in vitro studies. Methods: A total of 6050 phytocompounds were retrieved from PubChem and other online databases. ... ...

    Abstract Objective: This study aimed to identify phytocompounds that possess anti-chikungunya virus activity using computational docking and in vitro studies. Methods: A total of 6050 phytocompounds were retrieved from PubChem and other online databases. Compounds were virtually screened against E (3N42) and nsP2 (3TRK) proteins of CHIKV using iGEMDOCK. Molecular docking was performed for the screened compounds using the Maestro Glide module. Finally, screened lead compounds were studied for their in vitro antiviral activity against the Asian and African strains of CHIKV. Results: Among the three lead phytocompounds screened, astragaloside II showed the highest binding energy value of −10.603 kcal/mol, followed by astragaloside IV (-9.007 kcal/mol) and astragaloside III (-6.197 kcal/mol) against the 3TRK target protein whereas astragaloside II showed the highest binding energy value of −10.603 kcal/mol, followed by astragaloside IV (-10.548 kcal/mol) and astragaloside III (-9.539 kcal/mol) against the 3N42 target protein. ADMET analysis revealed that all three lead compounds have non-mutagenic and non-carcinogenic properties. Antiviral studies showed that astragaloside II exhibited antiviral activity at 1.56 µg/mL and 3.12 µg/mL, astragaloside IV at 3.12 µg/mL and 6.25 µg/mL, and astragaloside III at 3.12 µg/mL and 12.5 µg/mL against Asian and African strains of CHIKV, respectively. Conclusion: From the findings of this study, it is concluded that the phytocompounds such as astragaloside II, astragaloside III, and astragaloside IV possess promising in vitro antiviral activity against Asian and African strains of CHIKV.
    Keywords Chikungunya virus ; Antiviral activity ; Phytocompounds ; Astragaloside ; Molecular docking ; Science (General) ; Q1-390
    Subject code 500
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Molecular characterization of biosurfactant producing marine bacterium isolated from hydrocarbon-contaminated soil using 16S rRNA gene sequencing

    Sethuramalingam Balakrishnan / Narasingam Arunagirinathan / Marimuthu Ragavan Rameshkumar / Purushothaman Indu / Nallusamy Vijaykanth / Khalid S. Almaary / Saeedah Musaed Almutairi / Tse-Wei Chen

    Journal of King Saud University: Science, Vol 34, Iss 3, Pp 101871- (2022)

    2022  

    Abstract: Objectives: This study was aimed to isolate and identify the biosurfactant producing marine bacteria from petroleum hydrocarbons contaminated sediments by 16S rRNA gene sequencing. Methods: Soil sample was enriched with diesel (2%) as the sole source of ... ...

    Abstract Objectives: This study was aimed to isolate and identify the biosurfactant producing marine bacteria from petroleum hydrocarbons contaminated sediments by 16S rRNA gene sequencing. Methods: Soil sample was enriched with diesel (2%) as the sole source of carbon in minimal salt medium for 3 weeks at 28 °C ± 2. Enriched sample was plated on nutrient agar and the organisms are selected based on the colony morphology. Biosurfactant producing efficiency of the isolates was assessed using blood haemolysis, oil displacement test, microplate assay (drop collapse test) and emulsification activity. Identification of the efficient biosurfactant producing isolate was done by gram staining and biochemical tests. Molecular characterization was done using 16S rRNA gene sequencing. Results: Totally seven isolates were selected based on colony morphology and among them, the isolate ADY2b was able to reduce surface tension significantly in the oil displacement test and also formed a stable emulsion. The emulsification index (E24) had shown a promising result of 58.33%. The isolate ADY2b was a motile, gram negative rod shaped bacterium and positive for catalase and oxidase. Sequence alignment of the 16S rRNA of the ADY2b strain and database search revealed 98% similarity to Pseudomonas mendocina by BLAST analysis. Conclusion: Seven bacteria were isolated from petroleum hydrocarbon contaminated sediments. Strain ADY2b had shown promising results on the production of biosurfactants and it is capable of increasing the bioavailability of poorly soluble petroleum hydrocarbons. The isolate Pseudomonas mendocina ADY2b obtained in the study had potential to be used in oil degradation purposes.
    Keywords Biosurfactants ; Petroleum hydrocarbons ; 16S rRNA ; Microplate assay ; Emulsification activity (E24) ; Pseudomonas species ; Science (General) ; Q1-390
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Retrospective Analysis of Antibiotic Resistance in Streptococcus spp. from HIV Patients (2012–2017) from Southern India

    Chinnambedu Ravichandran Swathirajan / Marimuthu Ragavan Rameshkumar / Sunil Suhas Solomon / Ramachandran Vignesh / Pachamuthu Balakrishnan

    Advanced Biomedical Research, Vol 8, Iss 1, Pp 1-

    2019  Volume 1

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
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  9. Article ; Online: Antiviral activity of astragaloside II, astragaloside III and astragaloside IV compounds against dengue virus: Computational docking and in vitro studies.

    Indu, Purushothaman / Arunagirinathan, Narasingam / Rameshkumar, Marimuthu Ragavan / Sangeetha, Kodhandan / Divyadarshini, Angamuthu / Rajarajan, Swaminathan

    Microbial pathogenesis

    2020  Volume 152, Page(s) 104563

    Abstract: This study was aimed to identify the phytocompounds possessing anti-dengue virus activity using in silico and in vitro approaches. A total of 7000 phytocompounds were virtually screened against protein targets (envelope, NS2b/NS3, and NS5) of dengue ... ...

    Abstract This study was aimed to identify the phytocompounds possessing anti-dengue virus activity using in silico and in vitro approaches. A total of 7000 phytocompounds were virtually screened against protein targets (envelope, NS2b/NS3, and NS5) of dengue virus using iGEMDOCK and individually docked using Maestro 10.7 module of Schrödinger software. In vitro cytotoxicity and antiviral studies were performed using vero cell line. Finally, three phytocompounds namely astragaloside II, astragaloside III, and astragaloside IV were screened based on their highest binding energy values against protein targets. Astragaloside III exhibited the highest interaction energy value of -8.718 kcal/mol and -8.447 kcal/mol against envelope, and NS2b/NS3 targets, respectively. Astragaloside IV exhibited -7.244 kcal/mol against SAM site, and -9.179 kcal/mol against RNA cap site of NS5 targets. In silico ADMET analysis revealed that astragaloside II, III, and IV were non-mutagenic and non-carcinogenic in nature and these compounds were also non-toxic to vero cells upto 1000 μg/mL. Against dengue virus serotype 3, astragaloside II exhibited substantial antiviral activity at the concentration of 1.56 μg/mL followed by astragaloside III at 6.25 μg/mL and astragaloside IV at 12.5 μg/mL. Also, against dengue serotype 1, astragaloside II showed the maximum antiviral activity at 1.56 μg/mL followed by astragaloside III and IV at 3.125 μg/mL. This study concludes that astragaloside II, III, and IV compounds had potential in vitro anti-dengue virus activity.
    MeSH term(s) Animals ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Chlorocebus aethiops ; Dengue/drug therapy ; Dengue Virus ; Molecular Docking Simulation ; Saponins ; Triterpenes ; Vero Cells ; Viral Nonstructural Proteins
    Chemical Substances Antiviral Agents ; Saponins ; Triterpenes ; Viral Nonstructural Proteins ; astragaloside II ; astragaloside A (3A592W8XKE) ; astragaloside III (WVP53009FC)
    Language English
    Publishing date 2020-10-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2020.104563
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    Zs.A 2136: Show issues Location:
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  10. Article: Computational selection of flavonoid compounds as inhibitors against SARS-CoV-2 main protease, RNA-dependent RNA polymerase and spike proteins: A molecular docking study.

    Rameshkumar, Marimuthu Ragavan / Indu, Purushothaman / Arunagirinathan, Narasingam / Venkatadri, Babu / El-Serehy, Hamed A / Ahmad, Ajaz

    Saudi journal of biological sciences

    2020  Volume 28, Issue 1, Page(s) 448–458

    Abstract: An outbreak of Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has been recognized as a global health concern. Since, no specific antiviral drug is proven effective for treatment against COVID-19, identification of new therapeutics is an urgent ... ...

    Abstract An outbreak of Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has been recognized as a global health concern. Since, no specific antiviral drug is proven effective for treatment against COVID-19, identification of new therapeutics is an urgent need. In this study, flavonoid compounds were analyzed for its inhibitory potential against important protein targets of SARS-CoV-2 using computational approaches. Virtual docking was performed for screening of flavonoid compounds retrieved from PubChem against the main protease of SARS-CoV-2 using COVID-19 docking server. The cut off of dock score was set to >-9 kcal/mol and screened compounds were individually docked against main protease, RNA-dependent RNA polymerase, and spike proteins using AutoDock 4.1 software. Finally, lead flavonoid compounds were subjected to ADMET analysis. A total of 458 flavonoid compounds were virtually screened against main protease target and 36 compounds were selected based on the interaction energy value >-9 kcal/mol. Furthermore, these compounds were individually docked against protein targets and top 10 lead compounds were identified. Among the lead compounds, agathisflavone showed highest binding energy value of -8.4 kcal/mol against main protease, Albireodelphin showed highest dock score of -9.8 kcal/mol and -11.2 kcal/mol against RdRp, and spike proteins, respectively. Based on the high dock score and ADMET properties, top 5 lead molecules such as Albireodelphin, Apigenin 7-(6″-malonylglucoside), Cyanidin-3-(p-coumaroyl)-rutinoside-5-glucoside, Delphinidin 3-O-beta-D-glucoside 5-O-(6-coumaroyl-beta-D-glucoside) and (-)-Maackiain-3-O-glucosyl-6″-O-malonate were identified as potent inhibitors against main protease, RdRp, and spike protein targets of SARS-CoV-2. These all compounds are having non-carcinogenic and non-mutagenic properties. This study finding suggests that the screened compounds include Albireodelphin, Apigenin 7-(6″-malonylglucoside), Cyanidin-3-(p-coumaroyl)-rutinoside-5-glucoside, Delphinidin 3-O-beta-D-glucoside 5-O-(6-coumaroyl-beta-D-glucoside) and (-)-Maackiain-3-O-glucosyl-6″-O-malonate could be the potent inhibitors of SARS-CoV-2 targets.
    Keywords covid19
    Language English
    Publishing date 2020-10-22
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 2515206-3
    ISSN 2213-7106 ; 1319-562X
    ISSN (online) 2213-7106
    ISSN 1319-562X
    DOI 10.1016/j.sjbs.2020.10.028
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