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Article ; Online: Targeting NKAα1 to treat Parkinson's disease through inhibition of mitophagy-dependent ferroptosis.

Zhang, Xiaoyan / Li, Guanghong / Chen, Hanbin / Nie, Xiao-Wei / Bian, Jin-Song

2024 Volume 218, Page(s) 190–204

Abstract: Dysfunction of the ... ...

Abstract	Dysfunction of the Na
Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2024.04.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Linking endangered species protection to construct and optimize ecological security patterns in the National ecological Civilization construction Demonstration Zone

Jixin Yang / Wei Deng / Guanghong Zhang / Xufeng Cui

Ecological Indicators, Vol 158, Iss , Pp 111579- (2024)

A case study of Yichang, China

2024

Abstract: Constructing an ecological security pattern (ESP) is an effective measure to ensure environmental safety and urban development. With the establishment of national ecological civilization construction demonstration zone in China, higher requirements are ... ...

Abstract	Constructing an ecological security pattern (ESP) is an effective measure to ensure environmental safety and urban development. With the establishment of national ecological civilization construction demonstration zone in China, higher requirements are put forward for biodiversity conservation. Previous studies have focused on the identification and construction of ESPs, while few studies have optimized ESPs based on endangered species protection. This study took Yichang as the research object, and used geospatial data and endangered species data to construct and optimize ESPs. We identified ecological sources through ecological sensitivity assessment and extracted ecological corridors based on minimum cumulative resistance model. On this basis, this study innovatively introduced endangered species information, optimized an ESP and discussed ecological function zones in order to play a greater role in biodiversity conservation. The results showed that: (1) The ESP of Yichang includes 12 ecological sources with a total area of 2,186.34 km2, 30 ecological corridors with a total length of 1120.44 km and 15 ecological nodes. (2) The optimization of ESP connects important nature reserves and scenic tourist areas, bringing endangered species into the corridor network. The corridors importance evaluation delineated 8 Level I corridors focusing on biological protection and 22 Level II corridors focusing on landscape construction. (3) The ecological function zones of Yichang are divided into ecological conservation zone, ecological control zone and ecological restoration zone, and the spatial control principles of each zone are clearly defined. The results can provide a reference for biodiversity conservation in species-rich cities.
Keywords	Ecological security pattern ; Endangered species ; Optimization evaluation ; Biodiversity conservation ; Ecological corridor ; Ecology ; QH540-549.5
Subject code	333
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Structural diversity in the membrane-bound hIAPP dimer correlated with distinct membrane disruption mechanisms.

Qiao, Qin / Wei, Guanghong / Song, Zhijian

Physical chemistry chemical physics : PCCP

2024 Volume 26, Issue 8, Page(s) 7090–7102

Abstract: Amyloid deposits of the human islet amyloid polypeptide (hIAPP) have been identified in 90% of patients with type II diabetes. Cellular membranes accelerate the hIAPP fibrillation, and the integrity of membranes is also disrupted at the same time, ... ...

Abstract	Amyloid deposits of the human islet amyloid polypeptide (hIAPP) have been identified in 90% of patients with type II diabetes. Cellular membranes accelerate the hIAPP fibrillation, and the integrity of membranes is also disrupted at the same time, leading to the apoptosis of β cells in pancreas. The molecular mechanism of hIAPP-induced membrane disruption, especially during the initial membrane disruption stage, has not been well understood yet. Herein, we carried out extensive all-atom molecular dynamics simulations investigating the hIAPP dimerization process in the anionic POPG membrane, to provide the detailed molecular mechanisms during the initial hIAPP aggregation stage in the membrane environment. Compared to the hIAPP monomer on the membrane, we observed not only an increase of α-helical structures, but also a substantial increase of β-sheet structures upon spontaneous dimerization. Moreover, the random coiled and α-helical dimer structures insert deep into the membrane interior with a few inter-chain contacts at the C-terminal region, while the β-sheet-rich structures reside on the membrane surface accompanied by strong inter-chain hydrophobic interactions. The coexistence of α and β structures constitutes a diverse structural ensemble of the membrane-bound hIAPP dimer. From α-helical to β-sheet structures, the degree of membrane disruption decreases gradually, and thus the membrane damage induced by random coiled and α-helical structures precedes that induced by β-sheet structures. We speculate that insertion of random coiled and α-helical structures contributes to the initial stage of membrane damage, while β-sheet structures on the membrane surface are more involved in the later stage of fibril-induced membrane disruption.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2 ; Islet Amyloid Polypeptide/chemistry ; Cell Membrane/chemistry ; Molecular Dynamics Simulation ; Membranes ; Amyloid/chemistry
Chemical Substances	Islet Amyloid Polypeptide ; Amyloid
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp05887e
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: ALS-Linked A315T and A315E Mutations Enhance β-Barrel Formation of the TDP-43

Liu, Xianshi / Li, Xuhua / Qiao, Qin / Li, Fangying / Wei, Guanghong

ACS chemical neuroscience

2023 Volume 14, Issue 7, Page(s) 1310–1320

Abstract: Pathogenic mutations of transactivation response element DNA-binding protein 43 (TDP-43) are closely linked with amyotrophic lateral sclerosis (ALS). It was recently reported that two ALS-linked familial mutants A315T and A315E of TDP- ... ...

Abstract	Pathogenic mutations of transactivation response element DNA-binding protein 43 (TDP-43) are closely linked with amyotrophic lateral sclerosis (ALS). It was recently reported that two ALS-linked familial mutants A315T and A315E of TDP-43
MeSH term(s)	Humans ; Amyotrophic Lateral Sclerosis/metabolism ; Mutation/genetics ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Computer Simulation
Chemical Substances	DNA-Binding Proteins
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1948-7193
ISSN (online)	1948-7193
DOI	10.1021/acschemneuro.3c00012
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The effect of EDTA solution on corneal endothelial cells in rabbits.

Wei, Qian / Qu, Chao / Jiang, Jun / Zhang, Guanghong

Heliyon

2023 Volume 9, Issue 6, Page(s) e16532

Abstract: Corneal disease threatens vision globally. Among corneal diseases, calcific band keratopathy has severe effects on vision owing to its unique location. Currently, ethylene diamine tetraacetic acid (EDTA) chelation remains the most important treatment. ... ...

Abstract	Corneal disease threatens vision globally. Among corneal diseases, calcific band keratopathy has severe effects on vision owing to its unique location. Currently, ethylene diamine tetraacetic acid (EDTA) chelation remains the most important treatment. However, only the safety of low-dose topical EDTA eye drops is well established in humans. Therefore, the purpose of this study was to determine the safe dose range of EDTA for calcific band keratopathy surgery and its toxic effects on rabbit eyes. Rabbits were administered different doses of EDTA solutions (0.50, 0.20, 0.10, 0.05, and 0.01 M) for twenty minutes. In day seven, the rabbits were euthanized and pathological examination was performed for cornea. We found severe corneal edema in 0.50 M group, while milder edema in lower-concentration treated groups. Followed by corneal thickness measurement, the measured values increase to the peak in post-operative three day (0.20 M group) or one day (lower-concentration groups), then decreased. Groups comparison shown significant difference between BSS control group and higher concentration groups (0.20 M and 0.10 M) (P < 0.001) in observation period, but no significance was observed between low concentration and control group in the day seven after surgery (P > 0.05). Confocal microscopy examination suggested, the number of corneal endothelial cells significantly decreased from 3428.6 ± 180.3 cells/mm
Language	English
Publishing date	2023-05-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e16532
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Epichloë

Yin, Lijia / Wei, Maoying / Wu, Guanghong / Ren, Anzhi

Frontiers in plant science

2022 Volume 13, Page(s) 968774

Abstract: Symbiotic relationships with microbes may influence how plants respond to environmental change. In the present study, we tested the hypothesis that symbiosis with the endophytes promoted salt tolerance of the native grass. In the field pot experiment we ... ...

Abstract	Symbiotic relationships with microbes may influence how plants respond to environmental change. In the present study, we tested the hypothesis that symbiosis with the endophytes promoted salt tolerance of the native grass. In the field pot experiment we compared the performance of endophyte-infected (E+) and endophyte-uninfected (E-)
Language	English
Publishing date	2022-10-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2022.968774
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Article ; Online: Elucidating the Mechanisms of R248Q Mutation-Enhanced p53 Aggregation and Its Inhibition by Resveratrol.

Liu, Qian / Li, Le / Yu, Yawei / Wei, Guanghong

The journal of physical chemistry. B

2023 Volume 127, Issue 36, Page(s) 7708–7720

Abstract: Aggregation of p53 mutants can result in loss-of-function, gain-of-function, and dominant-negative effects that contribute to tumor growth. Revealing the mechanisms underlying mutation-enhanced p53 aggregation and dissecting how small molecule inhibitors ...

Abstract	Aggregation of p53 mutants can result in loss-of-function, gain-of-function, and dominant-negative effects that contribute to tumor growth. Revealing the mechanisms underlying mutation-enhanced p53 aggregation and dissecting how small molecule inhibitors prevent the conversion of p53 into aggregation-primed conformations are fundamentally important for the development of novel therapeutics for p53 aggregation-associated cancers. A recent experimental study shows that resveratrol (RSV) has an inhibitory effect on the aggregation of hot-spot R248Q mutant of the p53 core domain (p53C), while pterostilbene (PT) exhibits a relatively poor inhibitory efficacy. However, the conformational properties of the R248Q mutant leading to its enhanced aggregation propensity and the inhibitory mechanism of RSV against p53C aggregation are not well understood. Herein, we performed extensive all-atom molecular dynamics simulations on R248Q p53C in the absence and presence of RSV/PT, as well as wild-type (WT) p53C. Our simulations reveal that loop L3, where the mutation resides, remains compact in WT p53C, while it becomes extended in the R248Q mutant. The extension of loop L3 weakens the interactions between loop L3 and two crucial aggregation-prone regions (APRs) of p53C, leading to impaired interactions within the APRs and their structural destabilization as well as p53C. The destabilized APRs in the R248Q mutant are more exposed than in WT p53C, which is conducive to p53C aggregation. RSV has a higher preference to bind to R248Q p53C than PT. This binding not only stabilizes loop L3 of R248Q mutant to its WT-like conformation, preventing L3-extension-caused APRs' destabilization but also reduces APRs' solvent exposure, thereby inhibiting R248Q p53C aggregation. However, PT exhibits a lower hydrogen-bonding capability and a higher self-association propensity, which would lead to a reduced p53C binding and a weakened inhibitory effect on R248Q mutant aggregation. Our study provides mechanistic insights into the R248Q mutation-enhanced aggregation propensity and RSV's potent inhibition against R248Q p53C aggregation.
MeSH term(s)	Resveratrol/pharmacology ; Tumor Suppressor Protein p53/genetics ; Mutation
Chemical Substances	Resveratrol (Q369O8926L) ; Tumor Suppressor Protein p53 ; 3,5-dimethoxy-4'-hydroxystilbene ; pterostilbene (26R60S6A5I)
Language	English
Publishing date	2023-09-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.3c04700
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dissecting the Effect of ALS Mutation G335D on the Early Aggregation of the TDP-43 Amyloidogenic Core Peptide: Helix-to-β-Sheet Transition and Conformational Shift.

Li, Fangying / Chen, Yujie / Tang, Yiming / Liu, Xianshi / Wei, Guanghong

Journal of chemical information and modeling

2023 Volume 63, Issue 11, Page(s) 3579–3590

Abstract: The aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) into fibrillary deposits is associated with amyotrophic lateral sclerosis (ALS). The 311-360 fragment of TDP-43 (TDP- ... ...

Abstract	The aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) into fibrillary deposits is associated with amyotrophic lateral sclerosis (ALS). The 311-360 fragment of TDP-43 (TDP-43
MeSH term(s)	Humans ; Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/metabolism ; DNA-Binding Proteins/chemistry ; Mutation ; Peptides/genetics ; Protein Conformation, beta-Strand
Chemical Substances	DNA-Binding Proteins ; Peptides ; TARDBP protein, human
Language	English
Publishing date	2023-05-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	190019-5
ISSN	1549-960X ; 0095-2338
ISSN (online)	1549-960X
ISSN	0095-2338
DOI	10.1021/acs.jcim.3c00513
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Zs.A 1230: Show issues

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Article ; Online: Spatial distribution, source apportionment, and assessment of marine water quality parameters in the Bohai Sea, China.

Wu, Guanghong / Li, Jianling / Luo, Wei

Marine pollution bulletin

2023 Volume 195, Page(s) 115526

Abstract: A two-year (2020-2021) survey dataset of six water quality parameters (pH, dissolved oxygen (DO), chemical oxygen demand (COD), dissolved inorganic nitrogen (DIN), soluble reactive phosphate (SRP), and petroleum pollutants) was used to investigate their ... ...

Abstract	A two-year (2020-2021) survey dataset of six water quality parameters (pH, dissolved oxygen (DO), chemical oxygen demand (COD), dissolved inorganic nitrogen (DIN), soluble reactive phosphate (SRP), and petroleum pollutants) was used to investigate their spatial distribution in the Bohai Sea and quantify their potential sources. There were significant differences in spatial distribution of the parameters. High concentrations of COD, DIN and SRP were found in three bays, with terrestrial input being the main pollution source. Phosphorus-limiting conditions were present in the Bohai Sea. High petroleum pollutant concentrations were identified in port areas, offshore oilfields, and adjacent areas. The pH was above the global oceanic average and there were no signs of acidification. The contribution of the mixed terrestrial inputs, maritime transportation, and offshore oil exploitation sources, oceanic and associated biotic sources, and seawater-atmosphere exchange and atmospheric deposition sources to water quality were 63.4 %, 8.0 %, and 28.6 %, respectively.
MeSH term(s)	Water Quality ; Water Pollutants, Chemical/analysis ; Environmental Monitoring ; Seawater ; Nitrogen/analysis ; China ; Petroleum
Chemical Substances	Water Pollutants, Chemical ; Nitrogen (N762921K75) ; Petroleum
Language	English
Publishing date	2023-09-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2023.115526
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Article ; Online: The effect of EDTA solution on corneal endothelial cells in rabbits

Wei, Qian / Qu, Chao / Jiang, Jun / Zhang, Guanghong

Heliyon. 2023 May 20, p.e16532-

2023

Abstract: Corneal disease threatens vision globally. Among corneal diseases, calcific band keratopathy has severe effects on vision owing to its unique location. Currently, ethylenediamine tetraacetic acid (EDTA) chelation remains the most important treatment. ... ...

Abstract	Corneal disease threatens vision globally. Among corneal diseases, calcific band keratopathy has severe effects on vision owing to its unique location. Currently, ethylenediamine tetraacetic acid (EDTA) chelation remains the most important treatment. However, only the safety of low-dose topical EDTA eye drops is well established in humans. Therefore, the purpose of this study was to determine the safe dose range of EDTA for calcific band keratopathy surgery and its toxic effects on rabbit eyes. Rabbits were administered different doses of EDTA solutions (0.50, 0.20, 0.10, 0.05, and 0.01 M) for seven days. In day seven, the rabbits were euthanized and pathological examination was performed for cornea. We found severe corneal edema in 0.50 M group, while milder edema in lower-concentration treated groups. Followed by corneal thickness measurement, the measured values increase to the peak in post-operative three day (0.50 M group) or one day (lower-concentration groups), then decreased. Groups comparison shown significant difference between BSS control group and high concentration groups (0.50 M and 0.20 M) (P < 0.001) in observation period, but no significance was observed between low concentration and control group in the day seven after surgery (P > 0.05). Confocal microscopy examination suggested, the number of corneal endothelial cells significantly decreased from 3428.6 ± 180.3 cells/mm² to 2808 ± 80.6 cells/mm² in the 0.50 M group, while the lower-concentration groups showed lesser toxic effects on corneal endothelial cells. Finally, our histological examination demonstrated inflammation in each experimental group and dose-dependent, compared with control group. Our study found 0.05 M and 0.01 M EDTA solutions had no obvious toxic effect on the corneal endothelium compared with higher concentration. However, further study of EDTA side effect by clinical trials, and therapeutic effect observation with different concentration are necessary.
Keywords	EDTA (chelating agent) ; adverse effects ; chelation ; confocal microscopy ; cornea ; corneal diseases ; dose response ; edema ; endothelium ; histology ; inflammation ; rabbits ; surgery ; toxicity ; vision ; Corneal endothelium cells (CECs) ; Calcific band keratopathy (CBK) ; Ethylenediaminetetraacetic acid (EDTA ; ) ; Solution concentration
Language	English
Dates of publication	2023-0520
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version ; Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e16532
Database	NAL-Catalogue (AGRICOLA)

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